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| Product | Description | |
|---|---|---|
| Btk inhibitor 1 | Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1. Grade: >98%. CAS No. 1412418-47-3. Molecular formula: C22H22N6O. Mole weight: 386.45. |  |
| BTK inhibitor 10 | BTK inhibitor 10, a potent and orally active BTK inhibitor, has a potential for rheumatoid arthritis treatment. (Extracted from patent WO2018145525, example 33). Synonyms: BTK-030; N-[3-({6-[4-(4-Morpholinyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]acrylamide; 2-Propenamide, N-[3-[[6-[4-(4-morpholinyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-. Grade: 98%. CAS No. 2241732-30-7. Molecular formula: C25H23N5O3. Mole weight: 441.48. | |
| BTK inhibitor 13 | BTK inhibitor 13 is a potent and selective BTK inhibitor with an IC50 of 1.2 nM. Synonyms: N-{3-[5-(N-Acryloyl-N-methylglycyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-5-fluoro-2-methylphenyl}-4-cyclopropylbenzamide; Benzamide, 4-cyclopropyl-N-[5-fluoro-2-methyl-3-[5-[2-[methyl(1-oxo-2-propen-1-yl)amino]acetyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-. Grade: 98%. CAS No. 2376726-26-8. Molecular formula: C29H26FN5O3. Mole weight: 511.55. | |
| BTK inhibitor 19 | BTK inhibitor 19 is a highly selective and covalent BTK inhibitor with an IC50 of 2.7 nM. Synonyms: 1H-Imidazole-5-carboxamide, 1-amino-2-[(2S)-1-(1-oxo-2-propen-1-yl)-2-piperidinyl]-4-[4-[[[4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]phenyl]-; (S)-2-(1-acryloylpiperidin-2-yl)-1-amino-4-(4-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)-1H-imidazole-5-carboxamide. CAS No. 2557174-19-1. Molecular formula: C25H24F3N7O3. Mole weight: 527.50. | |
| BTK inhibitor 1 (Compound 27) | BTK inhibitor 1 is an inhibitor of BTK with IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with IC50 of 2 nM. Synonyms: DC20199; Compound 27. Grade: ≥98%. CAS No. 2230724-66-8. Molecular formula: C24H23FN8O2. Mole weight: 474.49. | |
| Btk inhibitor 1 R enantiomer | Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: 3-(4-phenoxyphenyl)-1-[(3R)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine; (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-. Grade: ≥98% by HPLC. CAS No. 1022150-12-4. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| Btk inhibitor 1 R enantiomer hydrochloride | Btk inhibitor 1R enantiomer Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1 R enantiomer hydrochloride. Grade: >98%. CAS No. 1553977-42-6. Molecular formula: C22H23ClN6O. Mole weight: 422.91. | |
| BTK inhibitor 2 | Bruton's tyrosine kinase (BTK), also known as tyrosine-protein kinase BTK, is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. Btk inhibitor 2 is a BTK inhibitor. Grade: ≥98%. CAS No. 1558036-85-3. Molecular formula: C24H25N5O3. Mole weight: 431.49. | |
| 1-Azetidinecarboxamide, 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]- | BIIB068 is a potent, selective, reversible and orally active BTK inhibitor with an IC50 of 1 nM and Kd of 0.3 nM. BIIB068 shows more >400-fold selectivity for BTK than other kinases, and has the potential for autoimmune diseases research. Synonyms: 3-Isopropoxy-N-(2-methyl-4-{2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl}benzyl)-1-azetidinecarboxamide. Grade: ≥99%. CAS No. 1798787-27-5. Molecular formula: C23H29N7O2. Mole weight: 435.52. | |
| 1-Boc-pyrazole-4-boronic Acid Pinacol Ester | 1-Boc-pyrazole-4-boronic Acid Pinacol Ester is used as a reagent in the synthesis of several inhibitors including thieno[3,2-c]pyridin-4-amines which are a novel series of Brutons tyrosine kinase (BTK) inhibitors which can be used in drug design. Group: Biochemicals. Grades: Highly Purified. CAS No. 552846-17-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C14H23BN2O4, Molecular Weight: 294.149999999999. US Biological Life Sciences. |  Worldwide |
| 2-(4-Phenoxybenzoyl)malononitrile | An impurity of Ibrutinib, a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity 36. Grade: ≥95%. CAS No. 2055156-76-6. Molecular formula: C16H10N2O2. Mole weight: 262.26. | |
| 2-Aminomethyl-3-chloropyrazine | 2-Aminomethyl-3-chloropyrazine is used in the discovery of 8-Amino-imidazo[1,5-a]pyrazine-based Brutons tyrosine kinase (BTK) inhibitors for treating rheumatoid arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 771581-15-8. Pack Sizes: 50mg, 250mg. Molecular Formula: C5H6ClN3, Molecular Weight: 143.57. US Biological Life Sciences. | Worldwide |
| (2E)-4-(1-Pyrrolidinyl)-2-butenoic Acid Hydrochloride | (2E)-4-(1-Pyrrolidinyl)-2-butenoic Acid is used in the preparation of pyridine and pyrimidine compounds as BTK inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 848133-09-5. Pack Sizes: 100mg, 1g. Molecular Formula: C8H14ClNO2, Molecular Weight: 191.66. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-nitrophenol | 3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-11-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C6H4ClNO3, Molecular Weight: 173.55. US Biological Life Sciences. | Worldwide |
| Acalabrutinib | Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) [1] [2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACP-196. CAS No. 1420477-60-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17600. |  |
| Acalabrutinib | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Synonyms: ACP-196; ACP196; ACP 196; Acalabrutinib; 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide. Grade: >98%. CAS No. 1420477-60-6. Molecular formula: C26H23N7O2. Mole weight: 465.52. | |
| Acalabrutinib-[d4] | Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Synonyms: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl-d4)benzamide; Acalabrutinib D4; Acalabrutinib-d4; 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide-d4; ACP 196-d4; Calquence-d4. Grade: >95%. CAS No. 2699608-18-7. Molecular formula: C26H19D4N7O2. Mole weight: 469.53. | |
| Ack1 Inhibitor, AIM-100 (Activated Cdc42 Kinase 1 Inhibitor, (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine) | A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Group: Biochemicals. Grades: Highly Purified. CAS No. 873305-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ACP-5862 | ACP-5862 is a metabolite of Acalabrutinib, a second-generation BTK inhibitor used as a medication indicated for the treatment of non-Hodgkin lymphoma known as mantle cell lymphoma. Synonyms: ACP 5862; ACP5862. CAS No. 2230757-47-6. Molecular formula: C26H23N7O3. Mole weight: 481.52. | |
| ARQ 531 | ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity. ARQ 531 is a reversible non-covalent inhibitor of Bruton's Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases. In GCB-DLBCL cell lines (SUDHL-4 and DOHH-2), ARQ 531 potently suppressed expression of anti-apoptotic c-Myc and BCL6 oncoproteins in a dose-dependent fashion, and concomitantly induced apoptotic cleavage of PARP protein. Synonyms: ARQ-531. Grade: ≥98%. CAS No. 2095393-15-8. Molecular formula: C25H23ClN4O4. Mole weight: 478.93. | |
| Aurora Kinase Inhibitor III | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grade: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| Avitinib | Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib; AC0010. CAS No. 1557267-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19816. | |
| Avitinib maleate | Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib maleate; AC0010 maleate. CAS No. 1557268-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19816A. | |
| AVL-292 | AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Synonyms: CC-292; CC292; CC 292; AVL292; AVL 292; spebrutinib. Grade: 98%. CAS No. 1202757-89-8. Molecular formula: C22H22FN5O3. Mole weight: 423.44. | |
| AVL-292 benzenesulfonate | AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed. Synonyms: Spebrutinib besylate; CC-292 besylate; AVL-292 benzenesulfonate; CC 292 besylate; AVL 292 benzenesulfonate; CC292 besylate; AVL292 benzenesulfonate. Grade: >98%. CAS No. 1360053-81-1. Molecular formula: C28H28FN5O6S. Mole weight: 581.62. | |
| BAY 61-3606 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606; BAY 613606; BAY 61 3606; BAY-61-3606; BAY613606; BAY61 3606. Grade: >98%. CAS No. 732983-37-8. Molecular formula: C20H18N6O3. Mole weight: 390.4. | |
| BAY 61-3606 dihydrochloride | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606 dihydrochloride; BAY-61-3606 dihydrochloride; BAY61-3606 dihydrochloride. Grade: >98%. CAS No. 648903-57-5. Molecular formula: C20H18N6O3.2HCl. Mole weight: 463.32. | |
| BAY 61-3606 hydrochloride | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grade: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
| Bay 61-3606 Hydrochloride (2-[[7- (3, 4-Dimethoxyphenyl) imidazo[1, 2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl) | Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50 = 10nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7uM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Group: Biochemicals. Alternative Names: 2-[[7- (3, 4-Dimethoxyphenyl) imidazo[1, 2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl. Grades: Highly Purified. CAS No. 732938-37-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BIIB091 | BIIB091 is a potent, selective, orally active and reversible BTK inhibitor, with an IC 50 of <0.5 nM. BIIB091 binds the BTK protein to sequester TYR-551 into an inactive conformation with excellent affinity. BIIB091 can be used for the research of multiple sclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247614-80-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139984. | |
| Biotin-PEG3-amine | Biotin-PEG3-Amine (CAS# 359860-27-8) is a biotin derivative and is used as a reagent in the synthesis of a potent, covalent BTK inhibitor for B-cell lymphoma. Synonyms: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]pentanamide; 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]pentanamide. Grade: >98%. CAS No. 359860-27-8. Molecular formula: C18H34N4O5S. Mole weight: 418.55. | |
| BMS-935177 | BMS-935177 is a potent and selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 3 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. BMS-935177 inhibited calcium flux in human Ramos B cells with IC50 of 27 nM and inhibited CD69 surface expression in peripheral B cells stimulated with anti-IgM and anti-IgG. Synonyms: BMS-935177; BMS935177. Grade: ≥98%. CAS No. 1231889-53-4. Molecular formula: C31H26N4O3. Mole weight: 502.56. | |
| BMS-986142 | Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase. It is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling. BMS-986142 is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM. It potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90 nM. Synonyms: BMS-986142; BMS986142. Grade: ≥98%. CAS No. 1643368-58-4. Molecular formula: C32H30F2N4O4. Mole weight: 572.60. | |
| BMS-986143 | BMS-986143 is an orally active, reversible BTK inhibitor with an IC50 of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1 and ITK with IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM, 19 nM and 21 nM, respectively. BMS-986143 can be used in the study of autoimmune diseases. Synonyms: 3-chloro-4-(3-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide; 9H-Carbazole-1-carboxamide, 3-chloro-4-[3-(5-chloro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl]-7-(1-hydroxy-1-methylethyl)-. Grade: ≥98%. CAS No. 1643372-95-5. Molecular formula: C31H24Cl2N4O4. Mole weight: 587.45. | |
| BMS-986195 | BMS-986195 is a Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 0.1 nM. Synonyms: Branebrutinib; BMS 986195; BMS986195. Grade: ≥98% by HPLC. CAS No. 1912445-55-6. Molecular formula: C20H23FN4O2. Mole weight: 370.42. | |
| BMS986195 R-isomer | An R isomer of BMS-986195, a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Synonyms: (R)-4-(3-(But-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; (R)-Branebrutinib; (R)-BMS-986195. CAS No. 1912445-70-5. Molecular formula: C20H23FN4O2. Mole weight: 370.42. | |
| BMX-IN-1 | A cell-permeable tricyclic quinoline-acrylamide compound that potently inhibits BMX and BTK kinase activity (IC50 = 8 and 10.4nM, respectively) by covalently targeting ATP-binding site cysteine, while being less potent against TEC family kinases TEC, JAK3, BLK with the same conserved cysteine (IC50 = 175, 377, and 653nM, respectively). Only PI 3-K gamma/PIK3CG, SBK1, PIP5K2C (by ≥94% at 1uM), and TXK (by 75% at 1uM) are significantly inhibited by BMX-IN-1 in a selectivity profiling against 437 other kinase constructs. Potently inhibits the proliferation of TEL-BMX transformed Ba/F3 Ba/F3 (GI50 = 25nM), while being much less effective against TEL-BLK, TEL-JAK1, TEL-JAK2, TEL-JAK3, or TEL-TYK2E957D transformed Ba/F3 (GI50 = ≥3.64uM) or a panel of 5 prostate cancer cell lines (GI50 ≥2.46uM). Group: Biochemicals. Alternative Names: N- (2-Methyl-5- (9- (4- (methylsulfonamido) phenyl) -2-oxobenzo[h][1, 6]naphthyridin-1 (2H) -yl) phenyl) acrylamide, BMX/BTK Inhibitor, Bruton's Tyrosine Kinase Inhibitor IV, BLK Inhibitor I, BMX Inhibitor I, JAK3 Inhibitor XIII, PI 3-K Inhibitor XX, PIP5K2C Inhibitor I, SBK1 Inhibitor I, TEC Inhibitor I, TXK Inhibitor I. Grades: Highly Purified. CAS No. 1431525-23-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Branebrutinib | Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Brutons tyrosine kinase (BTK) , with an IC 50 of 0.1 nM [1] [2]. Branebrutinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-986195. CAS No. 1912445-55-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112161. | |
| BTK IN-1 | BTK IN-1 is a non-covalently binding inhibitor of Bruton's tyrosine kinase (BTK). Synonyms: SNS062-analog; SNS-062 analog; N-(1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-2-((3-chlorophenyl)amino)acetamide. Grade: 98%. CAS No. 1270014-40-8. Molecular formula: C19H21ClN6O. Mole weight: 384.86. | |
| BTK-IN-5 | BTK-IN-5 is a covalent BTK inhibitor for the treatment of cardiovascular disease, respiratory disease, inflammation and diabetes. Synonyms: (S)-N-((2S,3R)-3-(tert-butoxy)-1-(((R)-3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)-2-methyloxirane-2-carboxamide. CAS No. 2145152-06-1. Molecular formula: C23H32N4O5. Mole weight: 444.52. | |
| CGI1746 | CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. CGI1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. Synonyms: CGI1746; CGI-1746; CGI 1746. 4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide. Grade: 98%. CAS No. 910232-84-7. Molecular formula: C34H37N5O4. Mole weight: 579.69. | |
| CGI1746 | CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. CGI1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CGI1746; CGI-1746; CGI 1746. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 910232-84-7. Molecular formula: C34H37N5O4. Mole weight: 579.69. Purity: >98%. IUPACName: 4-(tert-butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide. Canonical SMILES: O=C(NC1=CC=CC(C(N=C2NC3=CC=C(C(N4CCOCC4)=O)C=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5. Product ID: ACM910232847. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CGI560 | CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK. Synonyms: CGI-560; CGI 560; 4-(tert-Butyl)-N-(3-(8-(phenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)benzamide. CAS No. 845269-74-1. Molecular formula: C29H27N5O. Mole weight: 461.57. | |
| CHMFL-BMX-078 | CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor that exhibits an IC50 of 11 nM against BMX kinase and exhibits great selectivity over kinases such as BTK, JAK3, EGFR, and MAP2K7 that bore a structurally identical cysteine residue in BMX kinase. Uses: Protein kinase inhibitors. Synonyms: CHMFL-BMX-078; CHMFL-BMX 078; CHMFL BMX 078; CHMFLBMX078; 4-(methylamino)-2-[4-methyl-3-(prop-2-enoylamino)anilino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]pyrimidine-5-carboxamide; 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide. CAS No. 1808288-51-8. Molecular formula: C33H35N7O6. Mole weight: 625.67. | |
| CHMFL-FLT3-122 | CHMFL-FLT3-122 is a potent and selective FLT3 inhibitor (IC50 = 40 nM) with >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase. It causes apoptosis via cell cycle arrest in G0/G1 phase in vitro. In MV4-11 cell inoculated xenograft model, it suppressed tumor growth. Uses: Antitumor agent. Synonyms: CHMFL-FLT3-122; CHMFL FLT3 122; CHMFLFLT3122; 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone. CAS No. 1839150-56-9. Molecular formula: C26H29N7O2. Mole weight: 471.55. | |
| CNX-500 | CNX-500, a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin, still has inhibitory activity against Btk (IC50 = 0.5 nM) and forms a covalent bond with Btk. CNX-500 has a low inhibitory effect on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn. Synonyms: N1-[19-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-N5-[3-[3-[[5-methyl-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]propyl]pentanediamide; N-(3-{3-[(4-{[3-(Acryloylamino)phenyl]amino}-5-methyl-2-pyrimidinyl)amino]phenoxy}propyl)-N'-{15-oxo-19-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-14-azanonadec-1-yl}pentanediamide. Grade: ≥98%. CAS No. 1202758-21-1. Molecular formula: C48H68N10O9S. Mole weight: 961.18. | |
| CNX-500 | CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk ( IC 50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1202758-21-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100338. | |
| CNX-774 | CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Synonyms: CNX-774; CNX 774; CNX774. CAS No. 1202759-32-7. Molecular formula: C26H22FN7O3. Mole weight: 499.49638. | |
| CTA056 | CTA056 is a potent and selective ITK inhibitor (interleukin-2-inducible T-cell kinase inhibitor). ITK is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases, plays an important role in normal T-cell functions and in the pathophysiology of both autoimmune diseases and T-cell malignancies. CTA056 exhibits the highest inhibitory effects toward Itk, followed by Btk and endothelial and epithelial tyrosine kinase. Among the 41 cancer cell lines analyzed, CTA056 selectively targets acute lymphoblastic T-cell leukemia and cutaneous T-cell lymphoma. CTA056 may be potential therapeutic agent for the treatment of T-cell leukemia and lymphoma. Synonyms: CTA-056; CTA 056; 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one. Grade: 98%. CAS No. 1265822-30-7. Molecular formula: C35H34N6O. Mole weight: 554.69. | |
| CZC-8004 | CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grade: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3. | |
| Dihydrodiol-Ibrutinib | Dihydrodiol-Ibrutinib, the dihydrodiol active metabolite of Ibrutinib, has about 15 times lower inhibitory activity against BTK than Ibrutinib. Synonyms: PCI-45227; Ibrutinib metabolite M37; 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2,3-dihydroxy-1-propanone; Ibrutinib Dihydrodiol R-Isomer; 1-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one. Grade: ≥95%. CAS No. 1654820-87-7. Molecular formula: C25H26N6O4. Mole weight: 474.51. | |
| EDA-m7GTP - DYQ-660 | EDA-m7GTP, a guanosine triphosphate derivative, acts as a ligand, facilitating the study of mRNA cap recognition mechanisms and development of antiviral drugs effective against RNA virus-caused diseases. Meanwhile, DYQ-660, a reversible BTK inhibitor, provides therapeutic relief against autoimmune diseases. An exploration of the compounds' inherent properties may offer novel ailments, presenting newfound potential in drug development. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-7-methyl-guanosine-5'-triphosphate, labeled with DYQ 660, Triethylammonium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C53H66N9O20P3S (free acid). Mole weight: 1274.13 (free acid). | |
| Edralbrutinib | Edralbrutinib is a potent BTK inhibitor. Synonyms: TG-1701; 4-Amino-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-1-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-7H-pyrrolo(2,3-d)pyridazin-7-one; 7H-Pyrrolo(2,3-d)pyridazin-7-one, 4-amino-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-1-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-; 4-Amino-1-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-3-[4-(2,6-difluorophenoxy)phenyl]-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one. Grade: ≥98%. CAS No. 1858206-58-2. Molecular formula: C26H21F2N5O3. Mole weight: 489.47. | |
| (E)-Rilzabrutinib | Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Brutons Tyrosine Kinase (BTK) , with an IC 50 of 1.3 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-PRN1008. CAS No. 1575596-29-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112166. | |
| Evobrutinib | Evobrutinib (M2951) is an orally active, potent, highly selective and irreversibly covalent BTK inhibitor, with an IC 50 of 8.9 nM. Evobrutinib (M2951) can be used for the research of autoimmune diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: M2951; MSC2364447C. CAS No. 1415823-73-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101215. | |
| Fenebrutinib | Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase ( Btk ) inhibitor with K i s of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0853. CAS No. 1434048-34-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19834. | |
| GDC-0834 | GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. In vitro metabolite identification studies in hepatocytes revealed predominant formation of an inactive metabolite (M1) via amide hydrolysis in human. Synonyms: GDC-0834; GDC0834; GDC 0834. CAS No. 1133432-46-8. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
| GDC-0837 | GDC-0834 is a small molecule inhibitor of Btk potentially useful in the treatment of RA and lymphoid malignancies. Administration of GDC-0834 (30 -- 100 mg/kg) in a rat CIA model induced a decrease of ankle swelling and reduction of morphologic pathology in a dose-dependent manner. Synonyms: GDC-0837; GDC 0837; GDC0837. CAS No. 1133432-49-1. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
| GDC-0853 | GDC-0853 is a Bruton's tyrosine kinase (BTK) inhibitor originated by Genentech. GDC-0853 can inhibit the activity of BTK and prevent the activation of the B-cell antigen receptor (BCR) signaling pathway. This leads to the inhibition of the growth of malignant B-cells that overexpress BTK. Phase III clinical trials for the treatment of Multiple sclerosis and Phase II clinical trials for the treatment of Chronic urticaria and Systemic lupus erythematosus are on-going. Uses: Rheumatoid arthritis; autoimmune disorders. Synonyms: Fenebrutinib; RG 7845; RG7845; GDC0853; RG-7845; GDC 0853; (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one. Grade: 98%. CAS No. 1434048-34-6. Molecular formula: C37H44N8O4. Mole weight: 664.81. | |
| GSK 2250665A | GSK 2250665A is an Itk inhibitor (pKi = 9.2) displaying selectivity for Itk over Aurora B kinase and Btk (pIC50 = 6.4 and 6.5, respectively) and a panel of other kinases. GSK 2250665A was shown to inhibit IFNγ production in PBMCs. Synonyms: GSK-2250665A; GSK 2250665A; GSK2250665A; GSK-2250665; GSK 2250665; GSK2250665; trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol. Grade: ≥97% by HPLC. CAS No. 1246030-96-5. Molecular formula: C26H29N5OS. Mole weight: 459.61. | |
| Ibrutinib | Ibrutinib is a potent and selective BTK inhibitor (IC50=0.5 nM). Synonyms: PCI-32765; PCI 32765; (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grade: ≥95%. CAS No. 936563-96-1. Molecular formula: C25H24N6O2. Mole weight: 440.50. | |
| Ibrutinib | Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765. CAS No. 936563-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10997. | |
| Ibrutinib-d4 | Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective BrutonÂs tyrosine kinase (Btk) irreversible inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H20D4N6O2, Molecular Weight: 444.52. US Biological Life Sciences. | Worldwide |
| Ibrutinib deacryloylpiperidine | Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib [1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IBT4A. CAS No. 330786-24-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-78727. | |
| Ibrutinib, Free Base | Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007). Group: Biochemicals. Alternative Names: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; PCI 32765; PCI 32765-00; CRA 032765; (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; Imbruvica. Grades: Purified. CAS No. 936563-96-1. Pack Sizes: 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ibrutinib Impurity 3-d5 | One of the isotopic labelled impurities of Ibrutinib, which has been found to be an irreversible inhibitor against Bruton's tyrosine kinase (Btk). Synonyms: 1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2,3-dihydroxy-1-propanone-d5. Molecular formula: C25H21N6O4D5. Mole weight: 479.55. | |
| Ibrutinib Impurity 8 | Ibrutinib Impurity 8 is a useful synthetic intermediate in the synthesis of Ibrutinib, a highly selective Bruton's tyrosine kinase (BTK) irreversible inhibitor. Synonyms: 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-; Ibrutinib intermeidate N-2. Grade: ≥97% by HPLC. CAS No. 330786-24-8. Molecular formula: C17H13N5O. Mole weight: 303.33. | |
| Ibrutinib Racemate | Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC 50 value of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765 Racemate. CAS No. 936563-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10997A. | |
| JH-X-119-01 | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3. Product ID: ACM2227368547. Alfa Chemistry ISO 9001:2015 Certified. | |
| JNJ-64264681 | JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101524-34-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153245. | |
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