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| Product | Description | |
|---|---|---|
| Calcium Channel antagonist 2 | Calcium Channel antagonist 2 (Compound 154) is a calcium channel antagonist ( IC 50 =5-20 μM). Calcium Channel antagonist 2 can be used in study of calcium channel-mediated diseases such as pain and diabetes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874370-15-7. Pack Sizes: 10 mg. Product ID: HY-156663. |  |
| Calcium Channel antagonist 3 | Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687573-14-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156664. | |
| Calcium Channel antagonist 4 | Calcium Channel antagonist 4 (compound 189) is an inhibitor of voltage-gated calcium channels with an IC 50 value of 5-20μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 687574-49-8. Pack Sizes: 10 mg. Product ID: HY-156669. | |
| 2-(3-Chlorophenyl)-2-methylpropan-1-amine | 2-(3-Chlorophenyl)-2-methylpropan-1-amine was used for the preparation of pyrimidinediones as antagonists of L-type calcium channels (LTCC) for potential use in the treatment of Parkinsons disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 92015-24-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H14ClN. US Biological Life Sciences. |  Worldwide |
| 2-APB | A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42uM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10uM) and inhibits it at higher concentrations (up to 50uM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes. Group: Biochemicals. Grades: Highly Purified. CAS No. 524-95-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. |  |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grades: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| Amauromine | Antibiotic. Hypotensive vasodilator. Calcium channel antagonist. Potent and selective CB1 receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 88360-87-6. Pack Sizes: 250ug, 1mg. Molecular Formula: C32H36N4O2. US Biological Life Sciences. | Worldwide |
| Aminophylline Anhydrous USP | α1-adrenoceptor antagonist, calcium channel blocke. Grades: USP. CAS No. 317-34-0. Product ID: 8-04696. Molecular formula: C16H24N10O4. Mole weight: 420.43. |  |
| AZD1305 | AZD1305 is a potassium channel and sodium channel antagonist. It can inhibit rapidly the activating delayed-rectifier potassium current, L-type calcium current, and inward sodium current. Phase II clinical trials for Arrhythmias, Atrial fibrillation, Atrial flutter and Left ventricular dysfunction were discontinued. Uses: Arrhythmias; atrial fibrillation; atrial flutter; left ventricular dysfunction. Synonyms: AZD-1305; AZD 1305; AZD1305; UNII-CZO834LXQM; UNII-CZO834LXQM; (2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester. Grades: 98%. CAS No. 872045-91-5. Molecular formula: C22H31FN4O4. Mole weight: 434.51. | |
| Barnidipine HCl | Barnidipine HCl is 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. It is a potential candidate in the treatment of patients with renal parenchymal hypertension. Uses: Calcium channel blockers. Synonyms: Mepirodipinehydrochloride; (+)-(3's,4s)-1-benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-[(3S)-1-(phenylmethyl)-3-py. Grades: > 95%. CAS No. 104757-53-1. Molecular formula: C27H30N3O6Cl. Mole weight: 528.01. | |
| Benidipine hydrochloride | Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-3049. CAS No. 91599-74-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1448. | |
| Bepridil hydrochloride | Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. Synonyms: Angopril; Bepadin; Bepridil HCl. CAS No. 68099-86-5. Molecular formula: C24H34N2O.HCl. Mole weight: 403.007. | |
| Bepridil hydrochloride hydrate | Bepridil is an amine Calcium channel antagonist that used to treat angina. But it is no longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation. Uses: Antihypertensive agents. Synonyms: Hydrogen Bepridil Hydrate Chloride; Bepridil Chloride Monohydrate. CAS No. 74764-40-2. Molecular formula: C24H34N2O.HCl.H2O. Mole weight: 421.022. | |
| Brompheniramine maleate | Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a K d of 6.06 nM. Brompheniramine maleate can block the hERG channels , calcium channels , and sodium channels with IC 50 s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Brompheniramine maleate. CAS No. 980-71-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0480. | |
| Calcium Antagonist Library | A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; - Targeting different subtypes of calcium channels, such as L-type, T-type, N-type, and receptor-operated calcium channels. - Bioactivity and safety confirmed by pre-clinical research and clinical trials, some of which are FDA approved; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7200. Categories: Calcium Antagonist Libraries. |  |
| Calmidazolium chloride | Calmidazolium chloride has been found to be a calcium channel protein inhibitor as well as a calmodulin antagonist. Synonyms: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride. Grades: ≥98% by HPLC. CAS No. 57265-65-3. Molecular formula: C31H23Cl7N2O. Mole weight: 687.70. | |
| CALP2 | CALP2 is a cell-permeable calmodulin (CaM) antagonist binding to the EF-hand/Ca2+-binding site. CALP2 exhibits an inhibitory effect on CaM-dependant phosphodiesterase activity, and leads to an increase on intracellular Ca2+ level by modulating Ca2+-channel activity. CALP2 was also shown to be a potent activator of alveolar macrophages. Synonyms: Calcium-like peptide 2. CAS No. 261969-04-4. Molecular formula: C68H104N14O13S. Mole weight: 1357.72. | |
| Clevidipine | Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ). Uses: Scientific research. Group: Signaling pathways. CAS No. 167221-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17436. | |
| Darodipine | Darodipine, also known as PY 108-068, is an antagonist of calcium channel. Synonyms: diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; darodipine; PY-108068; PY108068; PY108068; PY108-068; PY-108-068; PY 108-068; Darodipine. CAS No. 72803-02-2. Molecular formula: C19H21N3O5. Mole weight: 371.39. | |
| Diltiazem-d3 hydrochloride | Diltiazem-d 3 (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1217623-80-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14656S. | |
| Diltiazem hydrochloride | Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CRD-401. CAS No. 33286-22-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14656. | |
| Diltiazem Malate | Diltiazem is a calcium channel antagonist. It can relax the smooth muscles in the walls of arteries, allow blood to flow more easily, and lower blood pressure. Meanwhile, it can lower blood pressure through acting on the heart itself to reduce the rate, strength, and conduction speed of each beat. Diltiazem can be used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. Uses: Hypertension, angina pectoris, and some types of arrhythmia. Synonyms: MK-793; MK 793; MK793; Tiamate; UNII-14Y6444DRP.;(+)-(2S,3S)-5-(2-(Dimethylamino)ethyl)-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester),(S)-malate (1:1);1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-, (S)-hydoxybutanedioate (1:1). Grades: 98%. CAS No. 144604-00-2. Molecular formula: C26H32N2O9S. Mole weight: 548.61. | |
| Ethosuximide | Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by itself or with other antiseizure medications such as valproic acid. Uses: Absence epilepsy;absence seizures. Synonyms: 3-Ethyl-3-methyl-2,5-pyrrolidinedione; 2-Ethyl-2-methylsuccinimide; Atysmal; Capitus; Emeside; Etosuximid; H 940; Mesentol; NSC 64013; Simatin; Succimal; Succimitin; Suxilep; Suximal. Grades: >95%. CAS No. 77-67-8. Molecular formula: C7H11NO2. Mole weight: 141.17. | |
| Etripamil | Etripamil, a benzoates derivative, has been found to be a calcium channel antagonist that could be used against hypertension and arrhythmic. It is currently under Phase II trail against paroxysmal supraventricular tachycardia. Synonyms: (-)-MSP-2017; MSP-2017; MSP 2017; MSP2017; MSP-2017A; MSP-2017B; Etripamil; UNII-S82A18Y42P; MSP-2017; (-)-MSP-2017; S82A18Y42P; Etripamil [USAN:INN]; methyl 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-methylamino]ethyl]benzoate. Grades: 98%. CAS No. 1593673-23-4. Molecular formula: C27H36N2O4. Mole weight: 452.60. | |
| Etripamil | Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist, can be used for the research of Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MSP-2017; (-)-MSP-2017. CAS No. 1593673-23-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17611. | |
| Fantofarone | Fantofarone is a highly potent Calcium Channel antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR 33557. CAS No. 114432-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105117. | |
| Felodipine | Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 72509-76-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0309. | |
| Fendiline hydrochloride | The hydrochloride salt form of Fendiline, a benzenepropanamine derivative, has been found to be a calcium channel blocker and alpha2-adrenergic receptor antagonist. It could probably restrain the proliferation of tumor cells transformed by K-Ras. IC50: 17. Uses: The hydrochloride salt form of fendiline has been found to be a calcium channel blocker and alpha2-adrenergic receptor antagonist. it could probably restrain the proliferation of tumor cells transformed by k-ras. Synonyms: FENDILINE HYDROCHLORIDE;N-[3,3-DIPHENYLPROPYL]-ALPHA-METHYLBENZYLAMINE HYDROCHLORIDE; difmecor; gamma-phenyl-n- (1-phenylethyl) benzenepropanaminehydrochloride; gamma-phenyl-n- (1-phenylethyl) -benzenepropanaminhydrochloride; hk137; n- (1-phenylethyl) -3, 3-diphenyl. Grades: 95%. CAS No. 13636-18-5. Molecular formula: C23H25N.HCl. Mole weight: 351.91. | |
| Flavoxate | Flavoxate is an anticholinergic with antimuscarinic effects. Flavoxate blocks L-type calcium channels and acts an antagonist of muscarinic acetylcholine receptors. Uses: Parasympatholytics. Synonyms: Flavoxato; Flavoxatum; 2-(1-piperidyl)ethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate; 2-piperidinoethyl 3-methylflavone-8-carboxylate. Grades: > 95%. CAS No. 15301-69-6. Molecular formula: C24H25NO. Mole weight: 391.47. | |
| Fluspirilene | Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC 50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 6218; Redeptin. CAS No. 1841-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1655. | |
| Fluspirilene | Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 μM). Fluspirilene is also a dopamine inhibitor. Synonyms: R6218; R-6218; R 6218; FLUSPIRILENE;8-(4,4-BIS[P-FLUOROPHENYL]BUTYL)-1-PHENYL-1,3,8-TRIAZINO(4,5)DECAN-4-ONE;R 6218;1-phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane;8-(4,4-bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one;8-triaza. Grades: >98%. CAS No. 1841-19-6. Molecular formula: C29H31F2N3O. Mole weight: 475.57. | |
| HA1077 (Fasudil Dihydrochloride) | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences. | Worldwide |
| Isradipine | Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PN 200-110. CAS No. 75695-93-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0233. | |
| Lamotrigine | Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Uses: Anticonvulsants; calcium channel blockers; excitatory amino acid antagonists; voltage-gated sodium channel blockers. Synonyms: lamotrigine; 84057-84-1; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamineLamictalLamictal Cd. Grades: >98%. CAS No. 84057-84-1. Molecular formula: C9H7Cl2N5. Mole weight: 256.09. | |
| Lercanadipine | Lercanidipine hydrochloride, a dihydropyridine compound, is a third generation calcium channel antagonist which shows longer duration of action of the past two generations' in the treatment of mild-to-moderate hypertension. Uses: Lercanidipine hydrochloride is a third generation calcium channel antagonist which shows longer duration of action of the past two generations' in the treatment of mild-to-moderate hypertension. Synonyms: Lercanidipine; Lercanidipine; masnidipine; Lercanil; Lercanidipine. Grades: >98%. CAS No. 100427-26-7. Molecular formula: C36H41N3O6. Mole weight: 611.73. | |
| Lercanidipine Hydrochloride | Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine. Group: Biochemicals. Alternative Names: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[ (3, 3-diphenylpropyl) methylamino]-1, 1-dimethylethyl methyl ester hydrochloride; Cardiovasc; Carmen. Grades: Highly Purified. CAS No. 132866-11-6. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C36H42ClN3O6. US Biological Life Sciences. | Worldwide |
| Lomerizine dihydrochloride | Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KB-2796. CAS No. 101477-54-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-B0768A. | |
| Manidipine dihydrochloride | Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist ( IC 50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CV-4093. CAS No. 89226-75-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17403. | |
| Memantine Hydrochloride | A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) ofnMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54uM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimers disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated bynMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer's disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity). Group: Biochemicals. Alternative Names: Akatinol, 3,5-Dimethyltricyclo-[3,3,1,13,7]decan-1-amine, 3,5-Dimethyl-1-adamantanamine. Grades: Highly Purified. CAS No. 41100-52-1. Pack Sizes: 10g, 25g, 50g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Mitiglinide calcium | Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAD-1229 anhydrous; S21403 anhydrous. CAS No. 145525-41-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-17398. | |
| Mitiglinide calcium hydrate | Mitiglinide calcium hydrate, a derivative of benzylsuccinic acid, is a highly selective KATP channel antagonist. Uses: Hypoglycemic agents. Synonyms: calcium;(2S)-4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoate;dihydrate 207844-01-7 C38H48CaN2O6.2H2O Mitiglinidecalcium Calcium Mitiglinide 2150AH. Grades: >99.0%. CAS No. 207844-01-7. Molecular formula: C38H52CaN2O8. Mole weight: 704.91. | |
| Mitiglinide calcium hydrate | Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAD-1229; S-21403. CAS No. 207844-01-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0682A. | |
| ML-SI3 | ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. Product Category: Antagonists. Appearance: Solid powder. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Purity: >98%. IUPACName: N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O. Product ID: ACM891016027. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ML-SI3 | ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. | |
| Nicainoprol | Nicainoprol is a sodium channel blocking drug, which is a potent antiarrhythmic agent. Uses: Nicainoprol is an antagonist of calcium channel and a putative class i antiarrhythmic agent. Synonyms: 1,2,3,4-tetrahydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-1-nicotinoylquinoline; RU-42924. Grades: 98%. CAS No. 76252-06-7. Molecular formula: C21H27N3O3. Mole weight: 369.46. | |
| (+)-Niguldipine hydrochloride | (+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID 50 of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED 30 of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-Niguldipine hydrochloride. CAS No. 113145-69-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101390. | |
| Niludipine | Niludipine, a safe antianginal Ca2+-antagonist, is a drug with broad effectiveness for various types of angina pectoris. Uses: Calcium channel blockers. Synonyms: BAY-a 7168; Bay a 7168; NILUDIPINE;(2-propoxyethyl)ester; 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-bis; bay-a7168; bis(2-propoxyethyl)1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi;niludipin; Bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl). Grades: >98%. CAS No. 22609-73-0. Molecular formula: C25H34N2O8. Mole weight: 490.55. | |
| Nilvadipine | Nilvadipine is a potent calcium channel antagonist, and the IC 50 value is around 0.1 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FK235; FR34235. CAS No. 75530-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14284. | |
| Nisoldipine | Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity [1] [2] [7] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-k 5552. CAS No. 63675-72-9. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-17402. | |
| OPC 13463 | OPC 13463 is one of the metabolites of pranidipine. Pranidipine is a long acting calcium channel antagonist of the dihydropyridine group. Synonyms: 5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3-carboxylate;MP2689; MP-2689; MP 2689; OPC13463; OPC-13463; OPC 13463. Grades: 98%. CAS No. 73372-63-1. Molecular formula: C16H13N2O6-. Mole weight: 329.29. | |
| PD 122860 | This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular contractility, decrease coronary resistance and alter the shape of the electrocardiogram T-wave in the animal model. PD 122860 can relax potassium-contracted aortic rings selectively and inhibit [3H] nitrendipine binding to rat brain membranes. But it is discontinued for Heart failure and Ischaemic heart disorders preclinical treatment in USA in 2000. Uses: Heart failure; ischaemic heart disorders. Synonyms: PD122860; PD-122860; PD 122860; ethyl 5-cyano-6-methyl-2-((pyridin-4-ylsulfonyl)methyl)-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate. Grades: 98%. CAS No. 122576-86-7. Molecular formula: C23H20F3N3O4S. Mole weight: 491.48. | |
| Pranidipine | A novel calcium channel antagonist; cardiovascular agent. Group: Biochemicals. Alternative Names: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(2E)-3-phenyl-2-propen-1-yl] Ester; FRC 8411; OPC 13340. Grades: Highly Purified. CAS No. 99522-79-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Pranidipine | Pranidipine is a long acting calcium channel antagonist that can be used as a cardiovascular agent. Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(2E)-3-phenyl-2-propen-1-yl] Ester; FRC 8411; OPC 13340. Grades: 95%. CAS No. 99522-79-9. Molecular formula: C25H24N2O6. Mole weight: 448.473. | |
| Propiverine Hydroxy Impurity | An impurity of Propiverine Propiverine. Propiverine is a muscarinic antagonist. It is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence. Uses: Calcium channel blockers. Synonyms: Enpiperate; 3608-67-1; 1-methylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate; 1-Methyl-4-piperidyl diphenylglycolate; 4-NMPB; [3H]4NMPB; N-Methyl-4-piperidyl benzilate; 1-Methyl-4-piperidyl benzilate; NSC 172167; CHEMBL143228; QWK86805EB; N-methyl-4-piperidinyl benzilate; NSC-172167; Benzeneacetic acid. alpha.-hydroxy-.alpha.-phenyl-, 1-methyl-4-piperidinyl ester; Hydroxy-diphenyl-acetic acid 1-methyl-piperidin-4-yl ester; [3H]enpiperate. Grades: > 95%. CAS No. 3608-67-1. Molecular formula: C20H23NO3. Mole weight: 325.41. | |
| (R)-(-)-Niguldipine Hydrochloride | (R)-(-)-Niguldipine Hydrochloride, the less active enantiomer of Niguldipine Hydrochloride, is an L-type calcium channel protein inhibitor and α1A-AR (α1A-adrenoceptor) antagonist. Synonyms: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (4R)-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester, monohydrochloride, (R)-; (-)-Niguldipine hydrochloride; (R)-Niguldipine hydrochloride; B 8509-035; B 859-35; BY 935; Dexniguldipine hydrochloride. Grades: ≥95%. CAS No. 113145-70-3. Molecular formula: C36H39N3O6.HCl. Mole weight: 646.18. | |
| SET2 | SET2 is a selective TRPV2 antagonist ( IC 50 =0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2313525-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132222. | |
| Spiperone hydrochloride | Spiperone hydrochloride is a 5-HT2A and selective dopamine D2 receptor antagonist (Ki = 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) used as an antipsychotic. It also acts as an activator of calcium-activated chloride channels (EC50 = 9.3 μM). Uses: Antipsychotic. Synonyms: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride; SR-01000000261. Grades: ≥98% by HPLC. CAS No. 2022-29-9. Molecular formula: C23H26FN3O2.HCl. Mole weight: 431.94. | |
| Spiperone hydrochloride | Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D 2 receptor ( K i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors, respectively) and 5-HT 2A /5-HT 1A receptor ( K i s of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Spiroperidol hydrochloride. CAS No. 2022-29-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1371A. | |
| Tilmicosin | Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY-177370; EL-870. CAS No. 108050-54-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0905. | |
| Tilmicosin phosphate | Tilmicosin (LY-177370) phosphate is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin phosphate mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin phosphate is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin phosphate has immunomodulatory and anti-inflammatory effects [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY-177370 phosphate; EL-870 phosphate. CAS No. 137330-13-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0905A. | |
| Topiramate | Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels , increases in potassium conductance, and inhibition of carbonic anhydrase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: McN 4853; RWJ 17021. CAS No. 97240-79-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0122. | |
| TTA-A2 | TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 953778-63-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111828. | |
| TTA-A2 | TTA-A2 is a selective T-type calcium channel antagonist and an effective anticonvulsant. Synonyms: (R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide. Grades: 98%. CAS No. 953778-63-7. Molecular formula: C20H21F3N2O2. Mole weight: 378.4. | |
| UK-1745 | UK-1745, an indole derivative, has been found to be a Calcium channel antagonist that was once studied in the treatment of arrhythmias as well as heart failure. Synonyms: 2-Aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo(2,3-e)indole-7-one hydrochloride; CTK0H6059; UK 1745; UK1745; UK-1745. Grades: 98%. CAS No. 170684-14-7. Molecular formula: C16H23ClN2O2. Mole weight: 310.82. | |
| Ulixacaltamide | Ulixacaltamide (Z944) is an orally available T-type calcium channel antagonist that can slow the progression of epilepsy. Ulixacaltamide effectively reduces tremor in a normal alkaline tremor animal model. Ulixacaltamide reverses thermal hyperalgesia and mediates pain relief [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z944; PRAX-944. CAS No. 1199236-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120546. | |
| Watanipidine monohydrochloride | Watanipidine, also called as AE 0047 or Calbren, is a calcium channel antagonist. Synonyms: 5-O-[2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4-(diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, monohydrochloride; Watanipidine HCl. CAS No. 116308-56-6. Molecular formula: C41H43ClN4O6. Mole weight: 723.26. | |
| YS-201 | YS-201, also known as Diperdipine, is a dihydropyridine-type calcium channel antagonist potentially for the treatment of angina pectoris and hypertension. Synonyms: Diperdipine; YS-201; YS201; YS 201; Epddnp. 3-O-ethyl 5-O-(2-piperidin-1-ylethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; diperdipine; EPDDNP; ethyl-2-(1-piperidino)ethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate. CAS No. 108852-42-2. Molecular formula: C24H31N3O6. Mole weight: 457.52. | |
| Ziconotide acetate | Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research [1]. Uses: Scientific research. Group: Peptides. Alternative Names: SNX-111 acetate. CAS No. 914454-03-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0062B. | |
| Ziconotide Polyacetate | Α selective antagonist of N-type voltage sensitive calcium channels (VSCC). Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective. Group: Biochemicals. Alternative Names: ω-Conotoxin M VIIA Acetate; ω-Conopeptide MVIIA Acetate; Prialt Acetate; SNX 111. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
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