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| Product | Description | |
|---|---|---|
| Calcium ionophore iv | Heterocyclic Organic Compound. Alternative Names: Calcium ionophore IV, ETH 5234, 126572-74-5, AC1LCKLT, SureCN599431, 21198_FLUKA, CTK8E7826, Acetamide, 2-[2-(dicyclohexylamino)-2-oxoethoxy]-N,N-dioctadecyl-, N,N-Dicyclohexyl-N,N-dioctadecyl-diglycolic diamide, N,N-Dicyclohexyl-N,N-dioctadecyl-3-oxapentanediamide, 2-[2-(dicyclohexylamino)-2-oxoethoxy]-N,N-dioctadecylacetamide, N,N-Dicyclohexyl-N inverted exclamation marka,N inverted exclamation marka-dioctadecyl-3-oxapentanediamide, N,N-Dicyclohexyl-N inverted exclamation marka,N inverted exclamation marka-dioctadecyl-diglycolic diamide. CAS No. 126572-74-5. Molecular formula: C52H100N2O3. Mole weight: 801.36. Purity: ≥95%. IUPACName: 2-[2-(dicyclohexylamino)-2-oxoethoxy]-N,N-dioctadecylacetamide. Density: 0.94g/cm³. Catalog: ACM126572745. |  |
| Antibiotic A23187 (Calcimycin, Calcium Ionophore A23187) | Antibiotic A23187 is a calcium ionophore. It causes rapid influx of calcium in various cells across biological membranes. Calcimycin was isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium regulated cellular events. Group: Biochemicals. Alternative Names: Calcimycin, Calcium Ionophore A23187. Grades: Molecular Biology Grade. CAS No. 52665-69-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C29H37N3O6, Molecular Weight: 523.6. US Biological Life Sciences. |  Worldwide |
| 14,15-Epoxyeicosatrienoic Acid (±14,15-EET) | Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,?N'-?dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore. Also, it is derived from Arachidonic Acid, which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z)-13-(3-Pentyl-2-oxiranyl)-5,8,11-tridecatrienoic Acid; 14(15)-EET; 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; (±)14,15-EET; (±)14,15-EpETrE; (all-Z)-13-(3-Pentyloxiranyl)-5,8,11-tridecatrienoic Acid. Grades: Highly Purified. CAS No. 197508-62-6. Pack Sizes: 50ug, 100ug, 500ug. Molecular Formula: C??H??O?, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
| 4-Bromo A23187 | 4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 76455-48-6. Pack Sizes: 1 mg. Product ID: HY-N6694. |  |
| 4-Bromo-A23187 | 4-Bromo-calcimycin, a halogenated analog of A-2318, is a non-fluorescent Ca2+ ionophore which could be commonly used in fluorescent probes experiments as a modutor of the quantitation of free Ca2+. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Synonyms: A23187, 4-Bromo; 4-Bromocalcimycin; 4-Benzoxazolecarboxylic acid. Grades: ≥98%. CAS No. 76455-48-6. Molecular formula: C29H36BrN3O6. Mole weight: 602.50. |  |
| A23187 Ca-Mg | A23187 Ca-Mg, the calcium-magnesium salt of A23187, has been found to be a Ca2+ ionophore and shows pro-inflammatory and allergic activities. Uses: Used in cell activation experiments when calcium dose-response data are not required. Synonyms: Calcimycin calcium magnesium salt; Antibiotic A23187 calcium magnesium salt; Ionophore A23187 calcium magnesium salt. Grades: ≥99%. Molecular formula: (C29H36N3O6)2Mg.(C29H36N3O6)2Ca. Mole weight: 2154.87. | |
| AACOCF3 | AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl trifluoromethyl ketone. CAS No. 149301-79-1. Pack Sizes: 5 mg (28.05 mM * 500 μL in Ethanol); 10 mg (28.05 mM * 1 mL in Ethanol). Product ID: HY-108611. | |
| AM-643 | AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E;3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grades: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79. | |
| CAY10606 | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 with IC50 of 1.6 μM. Synonyms: CAY 10606; CAY-10606. Grades: ≥98%. CAS No. 1159576-98-3. Molecular formula: C22H18ClNO3. Mole weight: 379.8. | |
| Chlortetracycline hydrochloride | Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic , inhibiting binding of aminoacyl-tRNA to ribosomes [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Chlorotetracycline hydrochloride. CAS No. 64-72-2. Pack Sizes: 1 g; 5 g. Product ID: HY-B1327. | |
| EA4 | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grades: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
| Ferutinin | Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC 50 s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+ -ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 41743-44-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125703. | |
| GI 254023X | GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H929 cells, and calcium ionophore-induced betacellulin shedding in IMPE cells. It prevents E-cadherin cleavage in A549 cells, and suppresses ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro. Synonyms: GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023. (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide. Grades: ≥98% by HPLC. CAS No. 260264-93-5. Molecular formula: C21H33N3O4. Mole weight: 391.5. | |
| HA1077 (Fasudil Dihydrochloride) | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences. | Worldwide |
| Ionomycin | Ionomycin is a selective calcium ionophore antibiotic isolated from Streptomyces species. Anti-Gram-positive activity. Synonyms: 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-; (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2'R, 5S, 5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2, 5'-dimethyl[2, 2'-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic acid; 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[octahydro-5'-(1-hydroxyethyl)-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, [2S-[2α[2'S*, 5'R*(S*)], 5β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-; [2S-[2α[2'S*, 5'R*(S*)], 5β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[octahydro-5'-(1-hydroxyethyl)-2, 5'-dimethyl[2, 2'-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic acid; SQ 23377; EM 94. Grades: >98% by HPLC. CAS No. 56092-81-0. Molecular formula: C41H72O9. Mole weight: 709.00. | |
| Ionomycin | Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SQ23377. CAS No. 56092-81-0. Pack Sizes: 1 mg (14.1 mM * 100 μL in Ethanol); 5 mg (14.1 mM * 500 μL in Ethanol); 10 mg (14.1 mM * 1 mL in Ethanol). Product ID: HY-13434. | |
| Ionomycin | Ionomycin was isolated from Streptomyces conglobatus as a potent antibiotic selective for Gram +ve bacteria. During the isolation it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ionomycin calcium | Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SQ23377 calcium. CAS No. 56092-82-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-13434A. | |
| Ionomycin Calcium Salt | Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Ionomycin Calcium is a polyether antibiotic obtained from Streptomyces conglobatus by solvent extraction. It is different from other antibiotics of its class as it absorbs UV light at 300nm maximum. Gram-positive antibiotic. Group: Biochemicals. Alternative Names: Calcium Ionomycin; (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2R, 5S, 5S)-octahydro-5-[(1R)-1-hydroxyethyl]-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-Docosadienoic Acid Calcium Salt. Grades: Highly Purified. CAS No. 56092-82-1. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C41H70O9 Ca, Molecular Weight: 747.07. US Biological Life Sciences. | Worldwide |
| Ionomycin Calcium Salt | The Calcium Salt of Ionomycin, a kind of polyether antibiotic, is a selective calcium ionophore obtained from Streptomyces conglobatus by solvent extraction. It is more effective than A23187 as a calcium ionophore. It is used to study the transport of calcium ions on biological membranes. It can induce apoptotic degeneration of embryonic cortical neurons. Synonyms: Calcium ionophore; Calcium Ionomycin; (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2'R, 5S, 5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2, 5'-dimethyl[2, 2'-bifuran]-5-yl]-9-oxo-10, 16-Docosadienoic Acid Calcium Salt; 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-; Ionomycin, calcium salt (1:1). Grades: ≥98%. CAS No. 56092-82-1. Molecular formula: C41H70O9Ca. Mole weight: 747.07. | |
| Ionomycin (Free Acid) | Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARy ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes. Group: Biochemicals. Alternative Names: SQ 23377; EM 94; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic Acid; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*,. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Lasalocid sodium | Lasalocid sodium is a cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry. Synonyms: Lasalocid A Sodium Salt; Avatec; Bovatec. Grades: >95% by HPLC. CAS No. 25999-20-6. Molecular formula: C34H53NaO8. Mole weight: 612.77. | |
| Pyrrophenone | Pyrrophenone is an inhibitor of cytosolic phospholipase A2α (cPLA2α) with an IC50 of 4.2 nM in enzyme assays. It potently inhibited arachidonic acid release in calcium ionophore (A23187)-stimulated human monocytic cells (THP-1 cells) in a dose-dependent manner with IC50 value of 0.024 mM. Synonyms: N-[[(2S,4R)-1-[2-(2,4-Difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide. Grades: ≥95%. CAS No. 341973-06-6. Molecular formula: C49H37F2N3O5S2. Mole weight: 850. | |
| Beauvericin | Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin has been shown to exhibit ionophoric properties and inhibits acyl- CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels. Group: Biochemicals. Grades: Highly Purified. CAS No. 26048-05-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Beauvericin | Beauvericin is produced by the strain of Streptomyces sp. Ba cyclic depsipeptide isolated from several fungal genera, notably beauveria and fusarium; exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities; exhibits ionophoric properties, and inhibits acyl-coa:Cholesterol acyltransferase activity; induces apoptosis by elevating intracellular calcium levels. Synonyms: Cyclo(-D-alpha-hydroxyisovaleryl-N-Me-Phe)3. Grades: >97% by HPLC. CAS No. 26048-05-5. Molecular formula: C45H57N3O9. Mole weight: 783.95. | |
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