Calcium Ions Enzyme Suppliers USA
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Product | Description | |
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8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - ATTO-465 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - ATTO-465 is a fluorescently labeled derivative of ATP analog that is widely used in biochemical and cellular studies. It is a useful tool for monitoring the activity of enzymes involved in ATP hydrolysis and lipid signaling pathways. Additionally, this product is commonly employed for calcium ion detection, receptor-ligand binding assays, and diagnostic purposes in the field of biomedicine. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with ATTO 465, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C33H44N10O11P2 (free acid). Mole weight: 818.71 (free acid). | |
A-740003 Quick inquiry Where to buy Suppliers range | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
AM-643 Quick inquiry Where to buy Suppliers range | AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E;3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grades: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79. | |
Amrinone Quick inquiry Where to buy Suppliers range | Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed. Uses: Amrinone is a simple, non-glycoside cardiotonic agent. it provides protection against ischemia-reperfusion injury in kidney, liver, and heart. it is used in the treatment of congestive heart failure. it increases cardiac contractility as a vasodilator. Synonyms: Inamrinone; Wincoram; Inocor; Cordemcura; Win-40680; Win40680; 3-Amino-5-pyridin-4-yl-1H-pyridin-2-one. Grades: 98%. CAS No. 60719-84-8. Molecular formula: C10H9N3O. Mole weight: 187.20. | |
cAMP (Cyclic Adenosine Monophosphate, Cyclic AMP, Adenosine 3'5'-cyclic Monophosphate) (HRP) Quick inquiry Where to buy Suppliers range | Cyclic Adenosine Monophosphate is a hydrophilic secondary messenger that is part of the cellular signal transduction pathway. It is produced by enzymatic methods on the molecule ATP by the enzyme adenylyl cyclase. It interacts with receptor proteins on the surface of a cell membrane following an intracellular signal produced by hormones or neurotransmitters. Cyclic AMP activates Protein Kinase A (PKA) catalytic ability. This activated PKA molecule transfers phosphate from ATP to different amino acid sequences. These phosphorylated amino acids can regulate calcium ion channels allowing calcium to move across the cellular membrane. Group: Biochemicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences. | Worldwide |
CAY10606 Quick inquiry Where to buy Suppliers range | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 with IC50 of 1.6 μM. Synonyms: CAY 10606; CAY-10606. Grades: ≥98%. CAS No. 1159576-98-3. Molecular formula: C22H18ClNO3. Mole weight: 379.8. | |
Ι-Carrageenan, commercial grade, Type II Quick inquiry Where to buy Suppliers range | Ι-Carrageenan has many advantages over κ-Carrageenan. The gel formed by the interaction of Ι-Carrageenan with calcium ions is soft, elastic, thixotropic and anti-melt stable, and also has good water retention. Ι-Carrageenan is soluble in hot water and its sodium salt is soluble in cold water. However, Ι-Carrageenan is hardly soluble or insoluble in cold milk, mainly because the higher the content of 3,6-lactone-galactose and the lower the content of sulfate group, the more difficult it is to dissolve in cold milk. Both Ι-Carrageenan and λ-Carrageenan are insoluble in organic solvents. As a renewable natural polysaccharide polymer, Ι-Carrageenan has the advantages of naturalness, safety and abundant sources, and is widely used in the fields of food, cosmetics, biomedicine and paints and coatings. Uses: ·Adhesives, thickeners, emulsifiers and stabilizers in the food industry ·Culture medium, medicament, anticoagulant, hypolipidemic agent and laxative in the field of medicine ·Used as an antistatic agent for photosensitive emulsions and photosensitive emulsion layers ·Embedding material for immobilized enzyme carrier and bacteria ·For leather industry, ceramic industry, textile industry and paper industry. Group: Plant Hydrocolloids. CAS No. 9062-7-1. Molecular Weight: 788.66 g/mol. Density: H2O: 5 mg/mL hot, soluble. | |
L+Lactic Acid, Calcium Salt, Pentahydrate Quick inquiry Where to buy Suppliers range | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic acid or (R)-lactic acid. L-(+)-Lactic acid is the biologically important isomer.In animals, L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. The concentration of blood lactate is usually 1-2 mmol/L at rest, but can rise to over 20 mmol/L during intense exertion. Industrially, lactic acid fermentation is performed by Lactobacillus bacteria, among others. These bacteria can operate in the mouth; the acid they produce is responsible for the tooth decay known as caries.In medicine, lactate is one of the main components of Ringer's lactate or lactated Ringer's solution (Compound Sodium Lactate or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
Pyrrophenone Quick inquiry Where to buy Suppliers range | Pyrrophenone is an inhibitor of cytosolic phospholipase A2α (cPLA2α) with an IC50 of 4.2 nM in enzyme assays. It potently inhibited arachidonic acid release in calcium ionophore (A23187)-stimulated human monocytic cells (THP-1 cells) in a dose-dependent manner with IC50 value of 0.024 mM. Synonyms: N-[[(2S,4R)-1-[2-(2,4-Difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide. Grades: ≥95%. CAS No. 341973-06-6. Molecular formula: C49H37F2N3O5S2. Mole weight: 850. |