Camptothecin Suppliers USA
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Product | Description | |
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Camptothecin Quick inquiry Where to buy Suppliers range | Camptothecin. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; Camptothecine. Grades: Highly Purified. CAS No. 7689-3-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O4. US Biological Life Sciences. | Worldwide |
Camptothecin Quick inquiry Where to buy Suppliers range | Camptothecin - Product ID: NST-10-81. Category: Alkaloids. Purity: 98%. Test method: HPLC. CAS No. 7689-3-4. Pack Sizes: 1g, 2g, 5g, 10g. Appearance: Yellow to brown Powder. Molecular formula: C20H16N2O4. Mole weight: 348.35. Storage: +2 +8 °C. | |
Camptothecin sodium Quick inquiry Where to buy Suppliers range | An alkaloid topoisomerase I (topo I) inhibitor with anticancer properties. It is isolated from camptotheca acuminata, a deciduous tree or nothapodytes foetida. Synonyms: 20(S)-Camptothecin Sodium Salt; Camptothecine Sodium; NSC 100880; Sodium Camptothecin; (αS)-α-ethyl-9,11-Dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt; 21,22-Secocamptothecin-21-oic Acid Monosodium Salt. Grades: ≥95%. CAS No. 25387-67-1. Molecular formula: C20H17N2NaO5. Mole weight: 388.35. | |
10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin is an impurity of Topotecan (T542500), a chemotherapy agent that is a topoisomerase 1 inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-12-ethoxy-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione. Grades: Highly Purified. CAS No. 504413-76-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: (S)-10-Hydroxycamptothecin, SKF-S-104961, Hydroxycamptothecin, (+)-10-Hydroxycamptothecin, (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-, 10-Hydroxycamptothecine, Camptothecine, 10-hydroxy- (8CI), Topotecan related, 10-Hydroxycamptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-, NSC 107124, ChEMBL 273862. CAS No. 19685-09-7. Pack Sizes: 1MG. IUPAC Name: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Molecular formula: C20H16N2O5. Mole weight: 364.35. Catalog: APS19685097A. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5cc (O)ccc5nc34)C2=O. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124. Grades: Highly Purified. CAS No. 19685-09-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin 9,9-Methylene Dimer Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin 9,9-Methylene Dimer, is a 10-Hydroxy Camptothecin (H875000) impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin-d5 Quick inquiry Where to buy Suppliers range | A labeled Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-(Ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin-d5; Hydroxycamptothecin-d5; NSC 107124-d5. Grades: Highly Purified. CAS No. 1330277-66-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy Camptothecin-d5 Quick inquiry Where to buy Suppliers range | 10-Hydroxy Camptothecin-d5. Uses: For analytical and research use. Group: Chiral Molecules. Pack Sizes: 1MG. Catalog: APS014140. Format: Neat. Product Type: Stable Isotope Labelled. Shipping: Room Temperature. | |
10-Nitro Camptothecin Quick inquiry Where to buy Suppliers range | Formula: Group: Biochemicals. Grades: Plant Grade. CAS No. 104195-61-1. Pack Sizes: 20mg. US Biological Life Sciences. | Worldwide |
11-Ethyl camptothecin Quick inquiry Where to buy Suppliers range | 11-Ethyl camptothecin. Group: Biochemicals. Alternative Names: (4S)-4, 8-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 185807-29-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H20N2O4. US Biological Life Sciences. | Worldwide |
20r-Camptothecin Quick inquiry Where to buy Suppliers range | 20r-Camptothecin. Group: Heterocyclic Organic Compound. Alternative Names: (R)-(-)-Camptothecin;(R)-(-)-Camptothecine;(R)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(R)-Camptothecin;20R-Camptothecin;(4R)-4β-Ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 110351-92-3. Molecular formula: C20H16N2O4. Mole weight: 348.35204. | |
7-Ethyl-10-Hydroxy-Camptothecin Quick inquiry Where to buy Suppliers range | 7-Ethyl-10-Hydroxy-Camptothecin. Group: Biochemicals. Alternative Names: 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin. Grades: Plant Grade. CAS No. 86639-52-3. Pack Sizes: 20mg. Molecular Formula: C22H20N2O5, Molecular Weight: 392.405. US Biological Life Sciences. | Worldwide |
7-Ethyl Camptothecin Quick inquiry Where to buy Suppliers range | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Synonyms: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. Grades: >98%. CAS No. 78287-27-1. Molecular formula: C22H20N2O4. Mole weight: 376.42. | |
7-Ethyl Camptothecin Quick inquiry Where to buy Suppliers range | An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; 7-Ethyl-20(S)-camptothecin; SN 22. Grades: Highly Purified. CAS No. 78287-27-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
7-Ethyl-d3-camptothecin Quick inquiry Where to buy Suppliers range | An anticancer drug, showed strong activity against various murine tumors. A Labeled camptothecin(CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 7-Ethyl-d3-20(S)-camptothecin; SN 22-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Methyl Camptothecin. Quick inquiry Where to buy Suppliers range | Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin. Grades: Highly Purified. CAS No. 78287-26-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
9-Amino Camptothecin Carboxylate Sodium Salt Quick inquiry Where to buy Suppliers range | 9-Amino Camptothecin Carboxylate Sodium Salt. Group: Biochemicals. Alternative Names: (S)-1-Amino-α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Sodium Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C20H18N3NaO5, Molecular Weight: 403.36. US Biological Life Sciences. | Worldwide |
9-Hydroxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Hydroxymethyl-10-hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(hydroxymethyl)-, (S)- (9CI). CAS No. 175613-38-4. Pack Sizes: 1MG. Molecular formula: C21H18N2O6. Mole weight: 394.38. Catalog: APS175613384. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5c (CO)c (O)ccc5nc34)C2=O. Format: Neat. Shipping: Room Temperature. | |
9-Hydroxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Hydroxymethyl-10-hydroxy Camptothecin, is a metabolite of Camptothecin (C175150), which is a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: p(S)-4-Ethyl-4, 9-dihydroxy-10-(hydroxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 175613-38-4. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
9-Propoxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Propoxymethyl-10-hydroxy Camptothecin. Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. CAS No. 1379512-11-4. Pack Sizes: 5MG. Molecular formula: C24H24N2O6. Mole weight: 436.46. Catalog: APS1379512114. SMILES: CCCOCc1c (O)ccc2nc3C4=CC5=C (COC (=O)[C@]5 (O)CC)C (=O)N4Cc3cc12. Format: Neat. Shipping: Room Temperature. | |
9-Propoxymethyl-10-hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | 9-Propoxymethyl-10-hydroxy Camptothecin, is a substituted derivative of Camptothecin (C175150), which is a topoisomerase inhibitor used for the treatment of human cancers. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-10-(propoxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1379512-11-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
(R)-7-Ethyl-10-Hydroxy Camptothecin Quick inquiry Where to buy Suppliers range | R-Enantiomer of SN-38. Used for making the bioconjugates and bifunctional isocyanate cross linking reagents. Synonyms: (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione. Grades: > 95%. CAS No. 647852-82-2. Molecular formula: C22H20N2O5. Mole weight: 392.42. | |
S)-(+)-Camptothecin Quick inquiry Where to buy Suppliers range | 100mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Biochemicals. Formula: C20H16N2O4. CAS No. 7689-3-4. Prepack ID 48231379-100mg. Molecular Weight 348.35. See USA prepack pricing. | |
(S)-(+)-Camptothecin 99+% Quick inquiry Where to buy Suppliers range | (S)-(+)-Camptothecin 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
(S)-(+)-Camptothecin ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione) Quick inquiry Where to buy Suppliers range | Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
10-Hydroxy-11-methoxycamptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H18N2O6, Molecular Weight: 394.38. US Biological Life Sciences. | Worldwide |
10-Hydroxy-11-methoxycamptothecin-d3 Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H15D3N2O6, Molecular Weight: 397.4. US Biological Life Sciences. | Worldwide |
10-?Hydroxycamptothecin Acetate Quick inquiry Where to buy Suppliers range | 10-?Hydroxycamptothecin Acetate is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 951770-22-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H18N2O6, Molecular Weight: 406.39. US Biological Life Sciences. | Worldwide |
10-Nitrocamptothecin Quick inquiry Where to buy Suppliers range | 10-Nitrocamptothecin is a Camptothecin (C175150) derivative used in the treatment of cancers. Used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 104195-61-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H15N3O6, Molecular Weight: 393.35. US Biological Life Sciences. | Worldwide |
11-Desethyl Irinotecan Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates; Impurity Standards. Alternative Names: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)-, 10-[4-(1-Piperidino)-1-piperidinocarbonyloxy]camptothecin, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv., 11-Desethyl irinotecan, (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate,[1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (4S)-4-Ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate. CAS No. 103816-16-6. Molecular formula: C31H34N4O6. Mole weight: 558.62. Catalog: APS103816166. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (Cc4cc5cc (OC (=O)N6CCC (CC6)N7CCCCC7)ccc5nc34)C2=O. Format: Neat. Product Type: Impurity. | |
11-Desethyl Irinotecan Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
11-Desethyl Irinotecan-d10 Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan-d10. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid-d10; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.-d10; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin-d10. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C31H24D10N4O6, Molecular Weight: 568.69. US Biological Life Sciences. | Worldwide |
11-Methoxycamptothecin Quick inquiry Where to buy Suppliers range | 11-Methoxycamptothecin can be used in biological study of where new indole glucosides which are biosynthetic intermediates of camptothecin isolated from fruit of Camptotheca acuminata showed weak cytotoxicity against human cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 70906-25-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C21H18N2O5, Molecular Weight: 378.38. US Biological Life Sciences. | Worldwide |
11-Methoxycamptothecin-d3 Quick inquiry Where to buy Suppliers range | 11-Methoxycamptothecin-d3 is a labelled version of 11-Methoxycamptothecin (M261388) which can be used in biological study of where new indole glucosides which are biosynthetic intermediates of camptothecin isolated from fruit of Camptotheca acuminata showed weak cytotoxicity against human cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C21H15D3N2O5, Molecular Weight: 381.4. US Biological Life Sciences. | Worldwide |
1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile Quick inquiry Where to buy Suppliers range | Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 58610-63-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
1-(2-Amino-5-hydroxyphenyl)propan-1-one Quick inquiry Where to buy Suppliers range | 1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 35364-15-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C9H11NO2. US Biological Life Sciences. | Worldwide |
1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione Quick inquiry Where to buy Suppliers range | 1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione is a key intermediate in the synthesis of camptothecin (C175150) analogues. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H15NO6. US Biological Life Sciences. | Worldwide |
1,4-Dichloro-2-butyne Quick inquiry Where to buy Suppliers range | 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents. Group: Biochemicals. Alternative Names: 1,4-Dichloro-2-butyne; 1,4-Dichlorobutyne; Bis (chloromethyl) acetylene; NSC 30603. Grades: Highly Purified. CAS No. 821-10-3. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin Quick inquiry Where to buy Suppliers range | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
2',3'-Dihydro-7'-methyl-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-6'-carbonitrile Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 58610-64-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
2,3-Quinolinedimethanol Quick inquiry Where to buy Suppliers range | 2,3-Quinolinedimethanol is a reactant used in the synthesis of camptothecin (C175150), an ntitumor alkaloid which binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 57032-14-1. Pack Sizes: 100mg, 1g. Molecular Formula: C11H11NO2, Molecular Weight: 189.21. US Biological Life Sciences. | Worldwide |
2,5-Anhydro-3-deoxy-6-O-DMT-D-ribo-hexonic acid methyl ester Quick inquiry Where to buy Suppliers range | 2,5-Anhydro-3-deoxy-6-O-DMT-D-ribo-hexonic acid methyl ester has garnered attention as a valuable synthetic precursor utilized within the biomedical industry, facilitating the creation of a broad range of pharmacological substances. Notably, its involvement in the production of camptothecin analogs and other anti-cancer agents has been documented, underscoring its remarkable potential as a building block in the design of powerful pharmaceuticals. CAS No. 184296-62-6. Molecular formula: C28H30O7. Mole weight: 478.53. | |
2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide Quick inquiry Where to buy Suppliers range | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
2-Propionyl-4-methoxyaniline Quick inquiry Where to buy Suppliers range | 2-Propionyl-4-methoxyaniline is an intermediate in the synthesis of camptothecin-family alkaloids. Group: Biochemicals. Grades: Highly Purified. CAS No. 60997-56-0. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H13NO2. US Biological Life Sciences. | Worldwide |
4-[(Carbobenzoxyamino)methyl]benzoic acid Quick inquiry Where to buy Suppliers range | 4-[(Carbobenzoxyamino)methyl]benzoic acid is an intermediate used in the preparation of paclitaxel-camptothecin conjugates with antitumor properties. Synonyms: Z-(4)Ambz-OH; Z-HN-CH2-Ph(4)-COOH; 4- ( ([ (Benzyloxy) carbonyl]amino) methyl) benzoic Acid. Grades: 95%. CAS No. 58933-52-1. Molecular formula: C16H15NO4. Mole weight: 285.30. | |
4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5 Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin and Homocamptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (±)-4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
4'-Ethyl-7',8'-dihydro-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5 Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (±)-4'-ethyl-7',8'-dihydro-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
(4S)-10-(Ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione Quick inquiry Where to buy Suppliers range | (4S)-10-(Ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Alternative Names: (S)-10-(ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 123949-01-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(4S)-4, 9-Bis(acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione Quick inquiry Where to buy Suppliers range | (4S)-4, 9-Bis(acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1304788-27-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5 Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione Quick inquiry Where to buy Suppliers range | (4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1304788-26-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
5-Hydroxy Topotecan-d6 Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan-d6. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione-d6; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin-d6. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H17D6N3O6, Molecular Weight: 443.48. US Biological Life Sciences. | Worldwide |
5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | 5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers). Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. Alternative Names: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-, (4S)-, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin. CAS No. 504413-73-4. Molecular formula: C23H23N3O6. Mole weight: 437.45. Catalog: APS504413734. SMILES: CC[C@@]1 (O)C (=O)OCC2=C1C=C3N (C (O)c4cc5c (CN (C)C)c (O)ccc5nc34)C2=O. Format: Neat. | |
5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 66917-18-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: 6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester; NSC 633170. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
9-Aminocamptothecin Quick inquiry Where to buy Suppliers range | 9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. Group: Biobased Products. Alternative Names: 9-Amino-20-(S)-camptothecin. Grades: 98%. CAS No. 91421-43-1. Product ID: BBC91421431. Molecular formula: C20H17N3O4. Mole weight: 363.37. IUPAC Name: (19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3, 13-diazapentacyclo[11.8.0.02, 11.04, 9.015, 20]henicosa-1(21), 2, 4, 6, 8, 10, 15(20)-heptaene-14, 18-dione. Appearance: Powder. Density: 1.55±0.1 g/ml. SMILES: CC[C@@]1 (C2=C (COC1=O)C (=O)N3CC4=CC5=C (C=CC=C5N=C4C3=C2)N)O. | |
Ac-DMQD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord. Synonyms: Ac-Asp-Met-Gln-Asp-CHO; Caspase-3 Inhibitor. Grades: ≥95%. Molecular formula: C20H31N5O10S·xCF3COOH. Mole weight: 533.6. | |
Adsorbent Resin for Natural product extraction,MC:52-62% Quick inquiry Where to buy Suppliers range | Adsorbent Resin for Natural product extraction,MC:52-62%. Uses: ·Ginkgo flavonoids adsorption extraction ·Adsorption and extraction of flavonoids from seabuckthorn leaves ·Extraction and separation of camptothecin, etc. Group: Adsorbent Resin. | |
BAY 56-3722 Quick inquiry Where to buy Suppliers range | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
BAY 56-3722 hydrochloride Quick inquiry Where to buy Suppliers range | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
CHIR-124 Quick inquiry Where to buy Suppliers range | CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons. Synonyms: CHIR-124; CHIR 124; CHIR124. Grades: 0.98. CAS No. 405168-58-3. Molecular formula: C23H22ClN5O. Mole weight: 419.913. | |
CKD 602 Quick inquiry Where to buy Suppliers range | CKD-602 is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Synonyms: (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione phosphate; Belotecan hydrochloride. Grades: ≥98% by HPLC. CAS No. 213819-48-8. Molecular formula: C25H27N3O4·H3PO4. Mole weight: 531.49. | |
Diflomotecan Quick inquiry Where to buy Suppliers range | Diflomotecan is an E-ring modified camptothecin analogue, which possesses greater lactone stability in plasma compared with other topoisomerase I inhibitors. Diflomotecan is also a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced plasma stability and superior preclinical anti-tumour activity as compared to the established camptothecins, irinotecan and topotecan. Diflomotecan was the first homocamptothecin to enter clinical studies. Phase I data are summarized for both the intravenous and oral schedules. The toxicity is primarily haematological while no severe gastrointestinal toxicity has been observed in contrast to other topoisomerase I inhibitors. Diflomotecan has a high oral bioavailability (72 - 95%) and the oral day 1 - 5 every 3 weeks regimen is recommended for Phase II testing because it is relatively well tolerated, convenient and mimics protracted exposure. Synonyms: BN 80915; 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-, (5R)-; (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione; (R)-5-Ethyl-9, 10-difluoro-5-hydroxy-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. Grades: ≥95%. CAS No. 220997-97-7. Molecular formula: C21H16F2N2O4. Mole weight: 398.36. | |
Elomotecan Quick inquiry Where to buy Suppliers range | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G(0)-G(1) synchronized). In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Altogether, these data strongly support the clinical development of BN80927. Synonyms: BN-80927; BN80927; BN 80927; R-1559; R1559; R 1559; (R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-((4-methylpiperidin-1-yl)methyl)-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. CAS No. 220998-10-7. Molecular formula: C29H32ClN3O4. Mole weight: 522.04. | |
Etirinotecan pegol Quick inquiry Where to buy Suppliers range | Etirinotecan pegol, also know as pegylated irinotecan, NKTR102, is a formulation of polyethylene glycol (PEG)-encapsulated irinotecan with antineoplastic activity. The prodrug irinotecan, a semisynthetic derivative of camptothecin, is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, 7-ethyl-10-hydroxy-camptothecin inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. Pegylation provides improved drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile. Synonyms: NKTR102; NKTR 102; NKTR-102; pegylated irinotecan NKTR 102; Etirinotecan pegol. CAS No. 1193151-09-5. Molecular formula: C161H196Cl4N20O40. Mole weight: 3193.24. | |
GENZ-644282 Quick inquiry Where to buy Suppliers range | Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Synonyms: GENZ-644282; GENZ644282; GENZ 644282. CAS No. 529488-28-6. Molecular formula: C24H22F3N3O7. Mole weight: 521.44. | |
Gimatecan Quick inquiry Where to buy Suppliers range | Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF). Synonyms: ST1481; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-; 7-t-Butoxyiminomethylcamptothecin; (4S)-11-((E)-((1,1-DImethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione; NSC793724. Grades: ≥98%. CAS No. 292618-32-7. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) Quick inquiry Where to buy Suppliers range | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |