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| Product | Description | |
|---|---|---|
| Camptothecin | Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC 50 of 679 nM [1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Campathecin; (S)-(+)-Camptothecin; CPT. CAS No. 7689-3-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-16560. |  |
| Camptothecin | Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells. Group: Inhibitors. Alternative Names: (S)-(+)-Camptothecin. CAS No. 7689-3-4. Mole weight: 348.4. Purity: 98%+. Catalog: ACM7689034. |  |
| Camptothecin | Camptothecin. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; Camptothecine. Grades: Highly Purified. CAS No. 7689-3-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O4. US Biological Life Sciences. |  Worldwide |
| Camptothecin | Camptothecin - Product ID: NST-10-81. Category: Alkaloids. Purity: 98%. Test method: HPLC. CAS No. 7689-3-4. Pack Sizes: 1g, 2g, 5g, 10g. Appearance: Yellow to brown Powder. Molecular formula: C20H16N2O4. Mole weight: 348.35. Storage: +2 +8 °C. |  |
| Camptothecin-20(S)-O-propionate | Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-&Lota; inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Camptothecin-20-O-propionate. CAS No. 194414-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114668. | |
| Camptothecin sodium | An alkaloid topoisomerase I (topo I) inhibitor with anticancer properties. It is isolated from camptotheca acuminata, a deciduous tree or nothapodytes foetida. Synonyms: 20(S)-Camptothecin Sodium Salt; Camptothecine Sodium; NSC 100880; Sodium Camptothecin; (αS)-α-ethyl-9,11-Dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt; 21,22-Secocamptothecin-21-oic Acid Monosodium Salt. Grades: ≥95%. CAS No. 25387-67-1. Molecular formula: C20H17N2NaO5. Mole weight: 388.35. |  |
| 10-Hydroxy-11-methoxycamptothecin | 10-Hydroxy-11-methoxycamptothecin can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H18N2O6, Molecular Weight: 394.38. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy-11-methoxycamptothecin-d3 | 10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H15D3N2O6, Molecular Weight: 397.4. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin | 10-Hydroxy-9-[ (dimethylamino)methyl]-5-ethoxy- (20S, 5RS)-camptothecin is an impurity of Topotecan (T542500), a chemotherapy agent that is a topoisomerase 1 inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-12-ethoxy-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione. Grades: Highly Purified. CAS No. 504413-76-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin | A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124. Grades: Highly Purified. CAS No. 19685-09-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin 9,9-Methylene Dimer | 10-Hydroxy Camptothecin 9,9-Methylene Dimer, is a 10-Hydroxy Camptothecin (H875000) impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-?Hydroxycamptothecin Acetate | 10-?Hydroxycamptothecin Acetate is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 951770-22-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H18N2O6, Molecular Weight: 406.39. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin-d5 | A labeled Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-(Ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin-d5; Hydroxycamptothecin-d5; NSC 107124-d5. Grades: Highly Purified. CAS No. 1330277-66-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-Nitrocamptothecin | 10-Nitrocamptothecin is a Camptothecin (C175150) derivative used in the treatment of cancers. Used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 104195-61-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H15N3O6, Molecular Weight: 393.35. US Biological Life Sciences. | Worldwide |
| 10-Nitro Camptothecin | Formula: Group: Biochemicals. Grades: Plant Grade. CAS No. 104195-61-1. Pack Sizes: 20mg. US Biological Life Sciences. | Worldwide |
| 11-Ethyl camptothecin | 11-Ethyl camptothecin. Group: Biochemicals. Alternative Names: (4S)-4, 8-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 185807-29-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H20N2O4. US Biological Life Sciences. | Worldwide |
| 11-Methoxycamptothecin | 11-Methoxycamptothecin can be used in biological study of where new indole glucosides which are biosynthetic intermediates of camptothecin isolated from fruit of Camptotheca acuminata showed weak cytotoxicity against human cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 70906-25-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C21H18N2O5, Molecular Weight: 378.38. US Biological Life Sciences. | Worldwide |
| 11-Methoxycamptothecin-d3 | 11-Methoxycamptothecin-d3 is a labelled version of 11-Methoxycamptothecin (M261388) which can be used in biological study of where new indole glucosides which are biosynthetic intermediates of camptothecin isolated from fruit of Camptotheca acuminata showed weak cytotoxicity against human cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C21H15D3N2O5, Molecular Weight: 381.4. US Biological Life Sciences. | Worldwide |
| 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
| 20r-Camptothecin | Heterocyclic Organic Compound. Alternative Names: (R)-(-)-Camptothecin; (R)-(-)-Camptothecine; (R)-4-Ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (R)-Camptothecin; 20R-Camptothecin; (4R)-4β -Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. CAS No. 110351-92-3. Molecular formula: C20H16N2O4. Mole weight: 348.35204. Catalog: ACM110351923. | |
| 7-Ethyl-10-Hydroxy-Camptothecin | 7-Ethyl-10-Hydroxy-Camptothecin. Group: Biochemicals. Alternative Names: 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin. Grades: Plant Grade. CAS No. 86639-52-3. Pack Sizes: 20mg. Molecular Formula: C22H20N2O5, Molecular Weight: 392.405. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-hydroxylcamptothecin | Other Alkaloids. Alternative Names: Camptothecin impurity 7. CAS No. 119577-28-5. Mole weight: 392.4. Purity: 95%+. Catalog: ACM119577285. | |
| 7-Ethyl-10-Methoxy Camptothecin | 7-Ethyl-10-Methoxy Camptothecin. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4,11-diethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS No. 86639-53-4. Molecular Formula: C23H22N2O5. Mole Weight: 406.43. Catalog: APB86639534. |  |
| 7-Ethylcamptothecin | 7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminata , is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models [1]. Uses: Scientific research. Group: Natural products. CAS No. 78287-27-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-N2108. | |
| 7-Ethyl Camptothecin | An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; 7-Ethyl-20(S)-camptothecin; SN 22. Grades: Highly Purified. CAS No. 78287-27-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-Ethyl Camptothecin | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Synonyms: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. Grades: >98%. CAS No. 78287-27-1. Molecular formula: C22H20N2O4. Mole weight: 376.42. | |
| 7-Ethyl-d3-camptothecin | An anticancer drug, showed strong activity against various murine tumors. A Labeled camptothecin(CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 7-Ethyl-d3-20(S)-camptothecin; SN 22-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Methyl Camptothecin. | Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin. Grades: Highly Purified. CAS No. 78287-26-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 9-Aminocamptothecin | 9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 9-Amino-20(S)-camptothecin; 9-Amino-CPT. CAS No. 91421-43-1. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100309. | |
| 9-Aminocamptothecin | 9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. Group: Inhibitors. Alternative Names: 9-Amino-20-(S)-camptothecin. CAS No. 91421-43-1. Molecular formula: C20H17N3O4. Mole weight: 363.37. Appearance: Powder. Purity: 0.98. IUPACName: (19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3, 13-diazapentacyclo[11.8.0.02, 11.04, 9.015, 20]henicosa-1(21), 2, 4, 6, 8, 10, 15(20)-heptaene-14, 18-dione. Canonical SMILES: CC[C@@]1 (C2=C (COC1=O)C (=O)N3CC4=CC5=C (C=CC=C5N=C4C3=C2)N)O. Density: 1.55±0.1 g/ml. Catalog: ACM91421431. | |
| 9-Amino Camptothecin Carboxylate Sodium Salt | 9-Amino Camptothecin Carboxylate Sodium Salt. Group: Biochemicals. Alternative Names: (S)-1-Amino-α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Sodium Salt. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C20H18N3NaO5, Molecular Weight: 403.36. US Biological Life Sciences. | Worldwide |
| 9-Hydroxymethyl-10-hydroxy Camptothecin | 9-Hydroxymethyl-10-hydroxy Camptothecin, is a metabolite of Camptothecin (C175150), which is a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: p(S)-4-Ethyl-4, 9-dihydroxy-10-(hydroxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 175613-38-4. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 9-Propoxymethyl-10-hydroxy Camptothecin | 9-Propoxymethyl-10-hydroxy Camptothecin, is a substituted derivative of Camptothecin (C175150), which is a topoisomerase inhibitor used for the treatment of human cancers. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-10-(propoxymethyl)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1379512-11-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (R)-7-Ethyl-10-Hydroxy Camptothecin | R-Enantiomer of SN-38. Used for making the bioconjugates and bifunctional isocyanate cross linking reagents. Synonyms: (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione. Grades: > 95%. CAS No. 647852-82-2. Molecular formula: C22H20N2O5. Mole weight: 392.42. | |
| rac-4,11-Diethyl-9-hydroxycamptothecin | Synonyms: 1H-Pyrano[3',?4':6,?7]?indolizino[1,?2-b]?quinoline-3,?14(4H,?12H)?-dione, 4,?11-diethyl-4,?9-dihydroxy-; (rac)-7-Ethyl-10-Hydroxy Camptothecin. Grades: >95%. CAS No. 130144-34-2. Molecular formula: C22H20N2O5. Mole weight: 392.411. | |
| Rubitecan ((4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3, 4:6, 7]indolizinol[1, 2-b]quinoline-3, . 14(4H,-12H)-dione, 9-Nitrocamptothecin, 9-NC, Orathecin) | Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3, 4:6, 7]indolizinol[1, 2-b]quinoline-3, 14(4H, -12H)-dione; 9-Nitrocamptothecin; 9-NC; Orathecin. Grades: Highly Purified. CAS No. 91421-42-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| S)-(+)-Camptothecin | 100mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Biochemicals. Formula: C20H16N2O4. CAS No. 7689-3-4. Prepack ID 48231379-100mg. Molecular Weight 348.35. See USA prepack pricing. |  |
| (S)-(+)-Camptothecin 99+% | (S)-(+)-Camptothecin 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| (S)-(+)-Camptothecin ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione) | Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3, 4:6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Sodium Camptothecin | Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 25387-67-1. Pack Sizes: 10 mg; 25 mg. Product ID: HY-N8533. | |
| 11-Desethyl Irinotecan | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 11-Desethyl Irinotecan-d10 | 11-Desethyl Irinotecan-d10. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid-d10; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.-d10; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin-d10. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C31H24D10N4O6, Molecular Weight: 568.69. US Biological Life Sciences. | Worldwide |
| 1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile | Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 58610-63-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1-(2-Amino-5-hydroxyphenyl)propan-1-one | 1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 35364-15-9. Pack Sizes: 250mg, 2.5g. Molecular Formula: C9H11NO2. US Biological Life Sciences. | Worldwide |
| 1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione | 1',4',7',8'-Tetrahydro-4'-hydroxy-4'-methylspiro[1,3-dioxolane-2,6'(10'H)-[3H]pyrano[3,4-f]indolizine]-3',10'-dione is a key intermediate in the synthesis of camptothecin (C175150) analogues. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H15NO6. US Biological Life Sciences. | Worldwide |
| 1,4-Dichloro-2-butyne | 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents. Group: Biochemicals. Alternative Names: 1,4-Dichloro-2-butyne; 1,4-Dichlorobutyne; Bis (chloromethyl) acetylene; NSC 30603. Grades: Highly Purified. CAS No. 821-10-3. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-9-nitro- | Heterocyclic Organic Compound. Alternative Names: RUBETICAN;9-NITRO-CPT;CAMPTOTHECIN, 9-NITRO-20(S)-. CAS No. 104195-61-1. Molecular formula: C20H15N3O6. Mole weight: 393.35. Purity: 0.96. IUPACName: RUBITECAN. Canonical SMILES: CCC1 (C2=C (COC1=O)C (=O)N3CC4=C (C3=C2)N=C5C=CC=C (C5=C4)N)O. Density: 1.63 g/cm³. Catalog: ACM104195611. | |
| 2',3'-Dihydro-7'-methyl-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-6'-carbonitrile | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 58610-64-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 2,3-Quinolinedimethanol | 2,3-Quinolinedimethanol is a reactant used in the synthesis of camptothecin (C175150), an ntitumor alkaloid which binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 57032-14-1. Pack Sizes: 100mg, 1g. Molecular Formula: C11H11NO2, Molecular Weight: 189.21. US Biological Life Sciences. | Worldwide |
| 2,5-Anhydro-3-deoxy-6-O-DMT-D-ribo-hexonic acid methyl ester | 2,5-Anhydro-3-deoxy-6-O-DMT-D-ribo-hexonic acid methyl ester has garnered attention as a valuable synthetic precursor utilized within the biomedical industry, facilitating the creation of a broad range of pharmacological substances. Notably, its involvement in the production of camptothecin analogs and other anti-cancer agents has been documented, underscoring its remarkable potential as a building block in the design of powerful pharmaceuticals. CAS No. 184296-62-6. Molecular formula: C28H30O7. Mole weight: 478.53. | |
| 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
| 2-Propionyl-4-methoxyaniline | 2-Propionyl-4-methoxyaniline is an intermediate in the synthesis of camptothecin-family alkaloids. Group: Biochemicals. Grades: Highly Purified. CAS No. 60997-56-0. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H13NO2. US Biological Life Sciences. | Worldwide |
| 4-[(Carbobenzoxyamino)methyl]benzoic acid | 4-[(Carbobenzoxyamino)methyl]benzoic acid is an intermediate used in the preparation of paclitaxel-camptothecin conjugates with antitumor properties. Synonyms: Z-(4)Ambz-OH; Z-HN-CH2-Ph(4)-COOH; 4- ( ([ (Benzyloxy) carbonyl]amino) methyl) benzoic Acid. Grades: 95%. CAS No. 58933-52-1. Molecular formula: C16H15NO4. Mole weight: 285.30. | |
| 4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5 | Used in the preparation of Camptothecin and Homocamptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (±)-4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 4'-Ethyl-7',8'-dihydro-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5 | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (±)-4'-ethyl-7',8'-dihydro-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| (4S)-10-(Ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione | (4S)-10-(Ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Alternative Names: (S)-10-(ethoxymethyl)-4-ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 123949-01-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (4S)-4, 9-Bis(acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione | (4S)-4, 9-Bis(acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1304788-27-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5 | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione | (4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1304788-26-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy Topotecan-d6 | 5-Hydroxy Topotecan-d6. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione-d6; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin-d6. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C23H17D6N3O6, Molecular Weight: 443.48. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 6-Cyano-1,2,3,5-tetrahydro-7-methyl-1,5-dioxo-2-Indolizinecarboxylic Acid Methyl Ester | Intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 66917-18-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester | Used in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents. Group: Biochemicals. Alternative Names: 6'-Cyano-2',3'-dihydro-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic Acid Ethyl Ester; NSC 633170. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ac-DMQD-CHO trifluoroacetate salt | Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord. Synonyms: Ac-Asp-Met-Gln-Asp-CHO; Caspase-3 Inhibitor. Grades: ≥95%. Molecular formula: C20H31N5O10S·xCF3COOH. Mole weight: 533.6. | |
| BAY 56-3722 | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
| BAY 56-3722 hydrochloride | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
| Belotecan | Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CKD-602 free base. CAS No. 256411-32-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-13566. | |
| Belotecan hydrochloride | Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CKD-602. CAS No. 213819-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13566A. | |
| Carboxylesterase 1D from Mouse, Recombinant | Ces1d, also known as carboxylesterase 1D, is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. It is the principle lipase of white adipose tissue fat cake extracts. Partially purified white adipose tissue Ces1d had lipase activity as well as lesser but detectable neutral cholesteryl ester hydrolase activity. The protein shows low catalytic efficiency for hydrolysis of CPT-11, a prodrugs for camptothecin used in cancer therapeutics. Recombinant mouse Ces1d, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Ces1d; Carboxylesterase 3; FAEE synthase; TGH; Ces3. Purity: > 90% by SDS-PAGE. Esterase. Mole weight: 60.9 kDa. Activity: > 80,000 pmol/min/ug. Storage: Store at +4°C for short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. Form: Liquid. Source: Insect cell (Baculovirus) and fused to His-tag at N-terminus. Species: Mouse. Ces1d; Carboxylesterase 3; FAEE synthase; TGH; Ces3; Carboxylesterase 1D. Cat No: NATE-1633. |  |
| CHIR-124 | CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons. Synonyms: CHIR-124; CHIR 124; CHIR124. Grades: 0.98. CAS No. 405168-58-3. Molecular formula: C23H22ClN5O. Mole weight: 419.913. | |
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