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Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Alternative Names: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol. Grades: Highly Purified. CAS No. 842133-18-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Canagliflozin
Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC 50 s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ 28431754. CAS No. 842133-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10451.
Canagliflozin
Canagliflozin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene. Product Category: Thiophenes. Appearance: White to Pale Yellow Solid. CAS No. 842133-18-0. Molecular formula: C24H25FO5S. Mole weight: 444.52. Purity: 95%+. Product ID: ACM842133180. Alfa Chemistry ISO 9001:2015 Certified.
Canagliflozin 2-Glucuronide
Canagliflozin 2-glucuronide is a derivative of Canagliflozin. Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion. Synonyms: Canagliflozin 2-Glucuronide; 2648415-15-8. Grades: 96%. Molecular formula: C30H33FO11S. Mole weight: 620.64.
Canagliflozin 3-Glucuronide
Canagliflozin 3-glucuronide is a derivative of Canagliflozin. Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion. Grades: 96%. Molecular formula: C30H33FO11S. Mole weight: 620.64.
Canagliflozin alpha-Isomer Impurity
epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1R)-1,5-Anhydro-1-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-D-glucitol; epi-Canagliflozin; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1R)-; (1R)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2R,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; Canagliflozin alpha-Isomer; Canagliflozin α-isomer. Grades: ≥95%. CAS No. 1589590-87-3. Molecular formula: C24H25FO5S. Mole weight: 444.53.
Canagliflozin Defluoro Impurity
Defluoro-Canagliflozin is an impurity of Canagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: Canagliflozin Impurity A; Canagliflozin Desfluoro Impurity; D-Glucitol, 1,?5-anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-, (1S)?-; (1S)-1,?5-Anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-D-glucitol; Desfluoro Canagliflozin; (2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(4-methyl-3-((5-phenylthiophen-2-yl)methyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol. Grades: ≥95%. CAS No. 842133-16-8. Molecular formula: C24H26O5S. Mole weight: 426.54.
Canagliflozin Furanose Form (Mixture of Anomers)
Canagliflozin Furanose Form (Mixture of Anomers) is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Galactitol, 1,4-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; Canagliflozin-10; Canagliflozin Impurity 17; (2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol. CAS No. 2161394-94-9. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin hemihydrate is a highly potent and selective inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. It is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes. Uses: The potential treatment of type 2 diabetes. Synonyms: (3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate; JNJ 28431754; JNJ-28431754; JNJ28431754; TA 7284; TA-7284; TA7284; JNJ-24831754-ZAE; JNJ-28431754-AAA; Canagliflozin hemihydrate; brand name: Invokana Sulisent. Grades: >98%. CAS No. 928672-86-0. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin hemihydrate
Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC 50 s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ 28431754 hemihydrate. CAS No. 928672-86-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-I0383.
Canagliflozin Impurity 14
Canagliflozin Impurity 14 is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(3-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-; (2S,3R,4R,5S,6R)-2-(3-((5-(3-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 842133-17-9. Molecular formula: C24H25FO5S. Mole weight: 444.52.
Canagliflozin Impurity 20
Canagliflozin Impurity 20. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol. CAS No. 1672658-93-3. Molecular formula: C24H25FO6S. Mole weight: 460.52. Catalog: APB1672658933.
Canagliflozin impurity 25
Canagliflozin impurity 25. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1071929-08-2. Molecular formula: C18H12FIOS. Mole weight: 422.26. Catalog: APB1071929082.
Canagliflozin Impurity 52
Canagliflozin Impurity 52. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene. CAS No. 1030825-20-7. Molecular formula: C18H14BrFS. Mole weight: 361.27. Catalog: APB1030825207.
Canagliflozin Impurity B
Canagliflozin Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1132832-75-7. Molecular formula: C18H12BrFOS. Mole weight: 375.25. Catalog: APB1132832757.
Canagliflozin Monoacetyl Impurity
Canagliflozin Monoacetyl Impurity is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: ((2R,3S,4R,5R,6S)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl acetate; Canagliflozin impurity 03. CAS No. 2146135-87-5. Molecular formula: C26H27FO6S. Mole weight: 486.55.
Canagliflozin Related Impurity 10
an impurity of Canagliflozin. Synonyms: β-D-Glucopyranose, 1-C-[3-[[5-(4-fluorophenyl)?-2-thienyl]?methyl]?-4-methylphenyl]?-. Grades: > 95%. CAS No. 1799552-91-2. Molecular formula: C24H25FO6S. Mole weight: 460.53.
Canagliflozin Related Impurity 14
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. Synonyms: Thiophene, 2-(4-fluorophenyl)?-. Grades: > 95%. CAS No. 58861-48-6. Molecular formula: C10H7FS. Mole weight: 178.23.
Canagliflozin Related Impurity 8
A lactone (cyclic ester) of D-gluconic acid used as a used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. Synonyms: 1,2,3,4,5-Pentahydroxycaproic acid δ-lactone; D-(+)-Gluconic acid d-lactone; d-Gluconolactone; D-(+)-Dextronic acid d-lactone. Grades: > 95%. CAS No. 90-80-2. Molecular formula: C6H10O6. Mole weight: 178.14.
Canagliflozin Ring Opening Impurity is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: (2S,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)hexane-1,2,3,4,5,6-hexaol; D-Glucitol, 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; 1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol. Molecular formula: C24H27FO6S. Mole weight: 462.53.
Canagliflozin Tetraacetate
Canagliflozin Tetraacetate is an intermediate in the synthesis of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-Tetraacetate; Canagliflozin impurity 05; Tetra Acetyl Canagliflozin. Grades: 98%. CAS No. 866607-35-4. Molecular formula: C32H33FO9S. Mole weight: 612.66.
1,4-Anhydro-1,5-dihydroxy Canagliflozin
1,4-Anhydro-1,5-dihydroxy Canagliflozin is an impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H25FO5S, Molecular Weight: 444.52. US Biological Life Sciences.
Worldwide
1-Methoxy Canagliflozin
1-Methoxy Canagliflozin is an impurity in the synthesis of the drug Canagliflozin (C175190). Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1358581-37-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H27FO6S, Molecular Weight: 474.54. US Biological Life Sciences.
Worldwide
(1R)-1,5-Dihydroxy Canagliflozin
(1R)-1,5-Dihydroxy Canagliflozin is an impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H27FO6S, Molecular Weight: 462.53. US Biological Life Sciences.
Worldwide
2-Methoxy Canagliflozin
2-Methoxy Canagliflozin is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Methyl 1-C-[3-[[5-(4-Fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-α-D-glucopyranoside; 2-Methoxytetrahydro-2H-pyran-3,4,5-triol, (2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl); Canagliflozin impurity 10. CAS No. 1358581-37-9. Molecular formula: C25H27FO6S. Mole weight: 474.54.
epi-Canagliflozin
epi-Canagliflozin. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS001676. Format: Neat.
1,2:3,4:5,6-Tri-O-isopropylidene-D-gluconate
1,2:3,4:5,6-Tri-O-isopropylidene-D-gluconate, a crucial synthetic intermediate for various drugs including dapagliflozin, empagliflozin, and canagliflozin, among others, has gained significant spotlight in the pharmaceutical industry for its role in treating type 2 diabetes. Its usage as an intermediary has created a promising avenue for medical synthesis and research, thereby augmenting the application of this compound in diverse fields. CAS No. 52492-60-1. Molecular formula: C15H24O7. Mole weight: 316.35.
2-(4-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Canagliflozin Impurity 27; Thiophene, 2-[(4-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)-. CAS No. 2265214-89-7. Molecular formula: C18H14BrFS. Mole weight: 361.27.
2- (4-Fluorophenyl) -5-[ (5-iodo-2-methylphenyl) methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 898566-17-1. Pack Sizes: 250mg, 500mg. Molecular Formula: C18H14FIS, Molecular Weight: 408.27. US Biological Life Sciences.
Worldwide
2-(4-Fluorophenyl)-thiophene
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 58861-48-6. Pack Sizes: 250mg, 1g. Molecular Formula: C10H7FS, Molecular Weight: 178.23. US Biological Life Sciences.
2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene is an intermediate in the preparation of Canagliflozin which is a sodium-dependent glucose co-transporter 2 inhibitor used in the treatment of type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1132832-75-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C18H12BrFOS. US Biological Life Sciences.
2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene; Thiophene, 2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)-; Canagliflozin Impurity 29. CAS No. 1030825-20-7. Molecular formula: C18H14BrFS. Mole weight: 361.27.
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Group: Biochemicals. Grades: Highly Purified. CAS No. 1030825-20-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H14BrFS. US Biological Life Sciences.
(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl) (hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Tetrahydro-2H-pyran-3,4,5-triol, (2S,3R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)(hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl); Canagliflozin impurity 08. CAS No. 1951467-29-0. Molecular formula: C24H25FO6S. Mole weight: 460.52.
(2S, 3R, 4R, 5S, 6R) -2- (3- ( (5- (4-Fluorophenyl) thiophen-2-yl) (hydroxy) methyl) -4-methylphenyl) -6- (hydroxymethyl) tetrahydro-2H-pyran-3, 4, 5-triol is an impurity of Canagliflozin (C175190), a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1951467-29-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H25FO6S, Molecular Weight: 460.52. US Biological Life Sciences.
Worldwide
3-(4-Fluorophenyl)thiophene
3-(4-Fluorophenyl)thiophene is an impurity of Canagliflozin (C175190), a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. CAS No. 119492-73-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H7FS, Molecular Weight: 178.23. US Biological Life Sciences.
Worldwide
3-(4-Fluorophenyl)-Thiophene
An impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Synonyms: 3-(4-fluorophenyl)thiophene; 119492-73-8; 3-(4-Fluoro-phenyl)-thiophene3-(4-Fluorophenyl)-Thiophene; SCHEMBL1046660. Grades: > 95%. CAS No. 119492-73-8. Molecular formula: C10H7FS. Mole weight: 178.23.
3-(4-Fluorophenyl)thiophene-d4
3-(4-Fluorophenyl)thiophene-d4 is labelled 3-(4-Fluorophenyl)thiophene (F596255) which is an impurity of Canagliflozin (C175190), a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H3D4FS, Molecular Weight: 182.25. US Biological Life Sciences.
Worldwide
Empagliflozin R-Furanose
Empagliflozin R-Furanose is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: Canagliflozine Furanose Impurity; (2R,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol; (3R,4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol. CAS No. 1620758-31-7. Molecular formula: C23H27ClO7. Mole weight: 450.91.
(R)-Cangliflozin Furanose Impurity is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: (2S,3R,4R,5S)-2-((R)-1,2-Dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol. Molecular formula: C24H25FO5S. Mole weight: 444.52.
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