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| Product | Description | |
|---|---|---|
| Borrelidin (Treponemycin, U 78548, C2989) | Macrolide antibiotic. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50=0.8nM). Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Antimalarial. Group: Biochemicals. Grades: Highly Purified. CAS No. 7184-60-3. Pack Sizes: 500ug, 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
| ATN-161 trifluoroacetate salt | ATN-161 trifluoroacetate salt is a beta integrin antagonist with antitumor activity. It is a five -amino-acid peptide derived from the synergy region of fibronectin. It inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. Synonyms: ATN-161 TFA salt; ATN 161 TFA salt; ATN161 TFA salt. Grades: >98%. CAS No. 904763-27-5. Molecular formula: C25H36F3N9O10S. Mole weight: 711.67. |  |
| Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989) | Borrelidin is an unusual nitrile containing metabolite isolated from Streptomyces. Originally discovered as active against against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery displaying activity against drug-resistant Plasmodia. Group: Biochemicals. Alternative Names: Treponemycin, Antibiotic U 78548, Antibiotic C2989. Grades: Highly Purified. CAS No. 7184-60-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium salt | The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Grades: ≥98%. Molecular formula: C6H12O21P5ยท5Na. Mole weight: 689.96. | |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Synonyms: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. | |
| MPT0B098 | MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values ranging from 70 to 150 nmol/L. MPT0B098 arrests cells in the G2-M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. Distinguished from other microtubule inhibitors, MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA. The mechanism of causing unstable of HIF-1α mRNA by MPT0B098 is through decreasing RNA-binding protein, HuR, translocation from the nucleus to the cytoplasm. Notably, MPT0B098 effectively suppresses tumor growth and microvessel density of tumor specimens in vivo. Taken together, our results provide a novel mechanism of inhibiting HIF-1α of a microtubule inhibitor MPT0B098. MPT0B098 is a promising anticancer drug candidate with potential for the treatment of human malignancies. Synonyms: MPT 0B098; MPT-0B098; 1-(4-methoxyphenylsulfonyl)-7-(pyridin-4-yl)indoline. CAS No. 1254363-89-7. Molecular formula: C20H18N2O3S. Mole weight: 366.43. | |
| Niobium Zirconium Alloy Capillary | Niobium Zirconium Alloy Capillary. Group: Magnetic nanoparticles. Alternative Names: Nb-1Zr Capillary, Nb1Zr Capillary, Niobium Zirconium Alloy Capillary Tube. |  |
| Sulochrin | Sulochrin is a fungal metabolite isolated from a number of Aspergillus and Penicillium sp. An anti-angiogenic agent it inhibits vascular endothelial growth factor (VEGF) leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells. Sulochrin also inhibits eosinophil activation and chemotaxis. Group: Biochemicals. Grades: Highly Purified. CAS No. 519-57-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tantalum Capillary | Tantalum Capillary. Group: Magnetic nanoparticles. Alternative Names: Ta Capillary, Tantalum Capillary, Tantalum Tubing, , Tantalum Tube, Tantalum Pipe, Ta Tubing, Ta Tube, Ta Pipe. | |
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