Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Cariprazine | Cariprazine is an orally active D2/D3 dopamine receptor antagonist exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. It is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. It has also been used as a potential adjunct in treatment-resistant major depressive disorder. It had lower affinity at human and rat hippocampal 5-HT(1A) receptors (pK(I) 8.59 and 8.34, respectively) and demonstrated low intrinsic efficacy.Cariprazine displayed low affinity at human 5-HT(2A) receptors (pK(I) 7.73) in vitro. It could reduce the rewarding effect of cocaine and attenuated relapse to cocaine seeking with half maximal effective dose values of 0.2, 4.2, and 0.17 mg/kg, respectively. It was developed by Gedeon Richter and received FDA approval on September 17, 2015 and is currently owned by Gedeon Richter and Actavis. It is in phase III clinical trials in patients with schizophrenia and in patients with bipolar disorder. Uses: Cariprazine is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. it has also been used as a potential adjunct in treatment-resistant major depressive disorder. Synonyms: Urea, N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N -diMethyl-; N'-[trans-4-[2-[4-(2,3-Dichloroph |  |
| Cariprazine | Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D 3 ( K i =0.085 nM) and D 2 ( K i =0.49 nM) receptors, and moderate affinity for the 5-HT 1A receptor ( K i =2.6 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RGH-188. CAS No. 839712-12-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14763. |  |
| Cariprazine-[d6] | An isotope labelled of Cariprazine. Cariprazine is an atypical antipsychotic which is used in the treatment of schizophrenia and bipolar mania. Synonyms: N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-di(methyl-d3)-urea. Grade: 95% by HPLC; 98% atom D. CAS No. 1308278-67-2. Molecular formula: C21H26D6Cl2N4O. Mole weight: 433.46. | |
| Cariprazine free base | Cariprazine, also known as RGH-188 and MP-214, is an antipsychotic drug received FDA approval on September 17, 2015. Cariprazine acts as a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder. Cariprazine is approved for schizophrenia and bipolar disorder. It has also been investigated as a potential adjunct in treatment-resistant major depressive disorder. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cariprazine free base; RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214. Product Category: Others. Appearance: Solid powder. CAS No. 839712-12-8. Molecular formula: C21H32Cl2N4O. Mole weight: 427.41. Purity: >98%. IUPACName: 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea. Canonical SMILES: O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C. Product ID: ACM839712128. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cariprazine hydrochloride | Cariprazine hydrochloride is a novel antipsychotic agent candidate that exhibits high affinity for the D 3 ( K i =0.085 nM) and D 2 ( K i =0.49 nM) receptors, and moderate affinity for the 5-HT 1A receptor ( K i =2.6 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RGH188 hydrochloride. CAS No. 1083076-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14763A. | |
| Cariprazine hydrochloride | The hydrochloride salt form of Cariprazine, which is a highly selective inhibitor of Dopamine D3 and D2 receptor so that it might be effective as an antipsychotic agent. It has also been found to have moderate selectivity to serotonin 5-HT(1A) receptors. Uses: Antipsychotic agents. Synonyms: Cariprazine HCl; Vraylar; 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea hydrochloride. Grade: > 98%. CAS No. 1083076-69-0. Molecular formula: C21H33Cl3N4O. Mole weight: 463.87. | |
| Cariprazine Hydrochloride | Cariprazine Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea hydrochloride. CAS No. 1083076-69-0. Molecular formula: C21H32Cl2N4O·HCl. Mole weight: 463.87. Catalog: APB1083076690. |  |
| Cariprazine Impurity 5 | Cariprazine Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: isopropyl ((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate. CAS No. 1231947-90-2. Molecular formula: C22H33Cl2N3O2. Mole weight: 441.19. Catalog: APB1231947902. | |
| Cariprazine Impurity 6 | Cariprazine Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((1r,4r)-4-(3,3-dimethylureido)cyclohexyl)ethyl 4-methylbenzenesulfonate. CAS No. 1698050-46-2. Molecular formula: C18H28N2O4S. Mole weight: 368.18. Catalog: APB1698050462. | |
| Cariprazine Impurity 7 | Cariprazine Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 2-(4-(3,3-dimethylureido)cyclohexylidene)acetate. CAS No. 1698050-47-3. Molecular formula: C13H22N2O3. Mole weight: 254.16. Catalog: APB1698050473. | |
| Cariprazine Impurity 8 | Cariprazine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-1,1-dimethylurea. CAS No. 1698050-40-6. Molecular formula: C11H22N2O2. Mole weight: 214.17. Catalog: APB1698050406. | |
| Cariprazine-[piperazine-d8] | Cariprazine-[piperazine-d8] is a labelled Cariprazine. Cariprazine is an atypical antipsychotic used for the treatment of schizophrenia and bipolar mania. Synonyms: Cariprazine-d8; 3-((1r,4r)-4-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethyl)cyclohexyl)-1,1-dimethylurea; 3,3-dimethyl-1-[(1r,4r)-4-{2-[4-(2,3-dichlorophenyl)(D8)piperazin-1-yl]ethyl}cyclohexyl]urea; N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethyl]cyclohexyl]-N,N-dimethylurea; Cariprazine D8. Grade: 95% by HPLC; 98% atom D. CAS No. 1308278-50-3. Molecular formula: C21H24D8Cl2N4O. Mole weight: 435.46. | |
| Desmethyl cariprazine | Desmethyl cariprazine is an active metabolite of Cariprazine, which is an orally active D2/D3 dopamine receptor antagonist used in the treatment of schizophrenia, bipolar mania and depression. Synonyms: N-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N'-methyl Urea; Urea, N-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N'-methyl-; 1-(trans-4-{2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl}cyclohexyl)-3-methylurea. Grade: ≥95%. CAS No. 839712-15-1. Molecular formula: C20H30Cl2N4O. Mole weight: 413.38. | |
| Didesmethyl cariprazine | Didesmethyl cariprazine is a metabolite of Cariprazine and acts as the predominant circulating active moiety. Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. Synonyms: N-Didesmethyl Cariprazine; N-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]urea; 1-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)urea. CAS No. 839712-25-3. Molecular formula: C19H28Cl2N4O. Mole weight: 399.36. | |
| 1, 3-bis ( (1r, 4R) -4- (2- (4- (2, 3-Dichlorophenyl) piperazin-1-yl) ethyl) cyclohexyl) urea | 1, 3-bis ( (1r, 4R) -4- (2- (4- (2, 3-Dichlorophenyl) piperazin-1-yl) ethyl) cyclohexyl) urea, is an impurity of Cariprazine, an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C37H52Cl4N6O, Molecular Weight: 738.66. US Biological Life Sciences. |  Worldwide |
Our database is helping our users find suppliers everyday.
