Casein Kinase Suppliers USA
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Product | Description | |
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Casein Kinase II Inhibitor VIII Quick inquiry Where to buy Suppliers range | The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 354.38. Catalog: IAR42415282. Assay: ≥99% (HPLC). | |
Casein Kinase II Inhibitor VIII (4- (2- (4-Methoxybenzamido) thiazol-5-yl) benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII) Quick inquiry Where to buy Suppliers range | A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50=32 and 46nM against CK2a and CK2a', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50=2.6, 1.6, and 2.4uM, in A549, HCT116, and MCF-7 cultures, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Casein Kinase II Inhibitor XII, TBBz (4, 5, 6, 7-Tetra bromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) Quick inquiry Where to buy Suppliers range | A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at 25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. CAS No:577779-57-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 577779-57-8. Pack Sizes: 20mg. Molecular Formula: C?H?Br?N?, Primary Target: CK2. US Biological Life Sciences. | Worldwide |
Casein Kinase I Inhibitor III, PF-4800567 Quick inquiry Where to buy Suppliers range | The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 359.81. Catalog: IAR42415280. Assay: ≥99% (HPLC). | |
Casein Kinase I Inhibitor III, PF-4800567 (CKI Inhibitor III, PF-4800567)(3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolopyrimidinyl amino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKle with ~22-fold greater potency over CKld (IC50=32 and 711nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1uM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKle cells over CKld-transfected cells (IC50=0.13 and 2.65uM, respectively), and PER2 degradation in COS7-GFP-PER2-CKle cells. Unlike Casein Kinase I Inhibitor II, PF-670462, PF-4800567 exerts only marginal effect on circadian clock under similar conditions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 Quick inquiry Where to buy Suppliers range | The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 10MG. Mole weight: 316.81. Catalog: IAR42415281. Assay: ≥98% (HPLC). | |
Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Casein kinase I isoform alpha (26-34) Quick inquiry Where to buy Suppliers range | Casein kinase I isoform alpha. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-198. | |
Casein Kinase Substrates 3 Quick inquiry Where to buy Suppliers range | Casein Kinase Substrates 3 is a substrate of casein kinase. Synonyms: Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala; L-arginyl-L-arginyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-methionyl-L-seryl-L-isoleucyl-L-threonyl-L-alanine; Casein Kinase I substrate. Grades: ≥95% by HPLC. CAS No. 154444-97-0. Molecular formula: C85H139N27O35S. Mole weight: 2131.24. | |
Casein Kinase Substrates 3 Quick inquiry Where to buy Suppliers range | Casein Kinase Substrates 3 is a substrate of casein kinase. Uses: Peptide Inhibitors. CAS No. 154444-97-0. Product ID: R1271. | |
InSolution Casein Kinase II Inhibitor I Quick inquiry Where to buy Suppliers range | The Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 434.71. Catalog: IAR42415276. | |
InSolution Casein Kinase I Inhibitor, D4476 Quick inquiry Where to buy Suppliers range | The Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 398.41. Catalog: IAR42415275. Assay: ≥95% (LC/MS). | |
Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) Quick inquiry Where to buy Suppliers range | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) Quick inquiry Where to buy Suppliers range | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
Casein from milk, suitable for substrate for protein kinase (after dephosphorylation) Quick inquiry Where to buy Suppliers range | In milk, casein exists as a calcium salt, forming micellar particles surrounded by soluble kappa-casein. The casein component of milk is relatively thermally stable and can withstand temperatures of 62-71°C, while the whey protein component denatures at this temperature. Casein is digested slowly in organisms and coagulates in the stomach, resulting in anti-catabolic properties of casein. Casein is a large, firm, dense curd that is extremely difficult to digest. There are four different types of casein, each with a different genetic variation. They are α-s1 casein, α-s2 casein, β-casein and κ-casein, respectively. Uses: ·Nutritional supplements ·Raw material of food ·Paint, wood glue, plastic fiber ·Dentist Materials. Group: Animal Hydrocolloids. CAS No. 9000-71-9. Molecular Weight: 2061.96 g/mol. Boiling Point: 280 °C (dec.) (lit.). Flash Point: ≥70 %. Purity: 1.26 g/cm3. Density: H2O: insoluble, forms a cloudy suspension. | |
10Z-Hymenialdisine Quick inquiry Where to buy Suppliers range | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. | Worldwide |
10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) Quick inquiry Where to buy Suppliers range | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
4,5,6,7-Tetrabromobenzimidazole Quick inquiry Where to buy Suppliers range | ,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2. Synonyms: Casein Kinase II Inhibitor XII; TBBz; 4,5,6,7-tetrabromo-1H-benzimidazole. Grades: ≥98%. CAS No. 577779-57-8. Molecular formula: C7H2Br4N2. Mole weight: 433.7. | |
Casein solution derived from milk Quick inquiry Where to buy Suppliers range | In milk, casein exists as a calcium salt, forming micellar particles surrounded by soluble kappa-casein. The casein component of milk is relatively thermally stable and can withstand temperatures of 62-71°C, while the whey protein component denatures at this temperature. Casein is digested slowly in organisms and coagulates in the stomach, resulting in anti-catabolic properties of casein. Casein is a large, firm, dense curd that is extremely difficult to digest. There are four different types of casein, each with a different genetic variation. They are α-s1 casein, α-s2 casein, β-casein and κ-casein, respectively. Uses: ·Determination of protease activity in ground beef and its effect on bacteriocins ·As a non-specific substrate to measure the activity of protein phosphatase 2C (PP2C) fusions ·Sodium dodecyl sulfate (SDS)-polyacrylamide gel for casein profiling ·Casein solutions in cow's milk have been used as substrates for cyclic adenylate-dependent protein kinases. Group: Animal Hydrocolloids. CAS No. 9000-71-9. Molecular Weight: 2061.96 g/mol. Boiling Point: 280 °C (dec.) (lit.). Flash Point: ≥70 %. Purity: 1.26 g/cm3. Density: H2O: insoluble, forms a cloudy suspension. | |
CAY10577 Quick inquiry Where to buy Suppliers range | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10577 inhibits CK2 with an IC50 value of 0.8 μM. Synonyms: CAY 10577; CAY-10577. Grades: ≥95%. CAS No. 300675-28-9. Molecular formula: C10H5Cl2NO3. Mole weight: 258.1. | |
CAY10578 Quick inquiry Where to buy Suppliers range | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10578 is a potent inhibitor of CK2 with IC50 value of 0.3 μM. It is ATP competitive and displays Ki value of 0.2 μM. Synonyms: CAY 10578; CAY-10578. Grades: ≥95%. CAS No. 19231-60-8. Molecular formula: C10H3I4NO4. Mole weight: 708.8. | |
CX 4945 hydrochloride Quick inquiry Where to buy Suppliers range | CX 4945 hydrochloride is an orally bioactive and ATP-competitive casein kinase 2 (CK2) inhibitor. CX 4945 inhibits proliferation and migration in a panel of cancer cell lines which overexpresses CK2. Uses: Antitumor agent. Synonyms: CX 4945 hydrochloride; CX-4945 hydrochloride; CX4945 hydrochloride; Silmitasertib HCl; Silmitasertib hydrochloride. Grades: 98%. CAS No. 2108312-01-0. Molecular formula: C19H12ClN3O2.HCl. Mole weight: 386.23. | |
D4476 Quick inquiry Where to buy Suppliers range | D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1). Synonyms: Casein Kinase I Inhibitor; D 4476; D-4476. Grades: >98%. CAS No. 301836-43-1. Molecular formula: C23H18N4O3. Mole weight: 398.41. | |
Daidzein Diglucuronide Quick inquiry Where to buy Suppliers range | Daidzein Diglucuronide is a metabolite of Daidzein (D103500) which is an inactive analog of Genistein (G350000). Genistein blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 335591-27-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C27H26O16. US Biological Life Sciences. | Worldwide |
DMAT Quick inquiry Where to buy Suppliers range | DMAT is a potent and specific CK2 inhibitor. It also displays submicromolar IC50 values with almost all of the other kinases with special reference to PKD1, PIM3 and PIM1. Synonyms: Casein kinase II Inhibitor; CK2 Inhibitor. Grades: >98%. CAS No. 749234-11-5. Molecular formula: C9H7Br4N3. Mole weight: 476.79. | |
Emodin Quick inquiry Where to buy Suppliers range | Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Biobased Products. Alternative Names: 1,3,8-trihydroxy-6-methylanthraqunone. Grades: 98%. CAS No. 518-82-1. Product ID: BBC518821. Molecular formula: C15H10O5. Mole weight: 270.24. IUPAC Name: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione. Appearance: Powder. Density: 1.33 g/ml. SMILES: CC1=CC2=C (C (=C1)O)C (=O)C3=C (C2=O)C=C (C=C3O)O. | |
H 89 2HCl Quick inquiry Where to buy Suppliers range | H 89 2HCl is a cell permeable and potent PKA inhibitor with Ki of 48 nM in a cell-free assay, wihich is 10-fold selective for PKA than PKG, 500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. Synonyms: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 130964-39-5. Molecular formula: C20H20BrN3O2S·2HCl. Mole weight: 519.28. | |
H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) Quick inquiry Where to buy Suppliers range | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) Quick inquiry Where to buy Suppliers range | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
H-9 dihydrochloride Quick inquiry Where to buy Suppliers range | H-9 dihydrochloride is a protein kinase inhibitor. It inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM). H-9 hydrochloride reduces the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and inhibits PKA-mediated phosphorylation in a rat seizure model. Synonyms: H-9 dihydrochloride; H 9 dihydrochloride; H9 dihydrochloride; N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 116700-36-8. Molecular formula: C11H13N3O2S.2HCl. Mole weight: 324.22. | |
KL001 Quick inquiry Where to buy Suppliers range | KL001 is a small molecule that specifically interacts with cryptochrome (CRY), blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Uses: Cryptochrome protein (cry) stabilizer. Synonyms: KL 001; KL-001; N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide. Grades: ≥98%. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. | |
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Quick inquiry Where to buy Suppliers range | Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases. Group: Biochemicals. Alternative Names: CKI-7 Dihydrochloride. Grades: Highly Purified. CAS No. 1177141-67-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
NSC 210902 Quick inquiry Where to buy Suppliers range | NSC 210902 is an ATP-competitive inhibitor of casein kinase 2 (CK2). It inhibits CK2 which is increased in tumor tissues, suppressing the proliferation of cancer cells. Synonyms: 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid. Grades: ≥95%. CAS No. 51726-83-1. Molecular formula: C14H9NO3. Mole weight: 239.2. | |
PF 4800567 Quick inquiry Where to buy Suppliers range | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
PF 4800567 hydrochloride Quick inquiry Where to buy Suppliers range | PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ respectively). Synonyms: PF 4800567 hydrochloride; PF-4800567 hydrochloride; PF4800567 hydrochloride; 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1391052-28-0. Molecular formula: C17H18ClN5O2.HCl. Mole weight: 396.27. | |
PF-4800567 Hydrochloride Quick inquiry Where to buy Suppliers range | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF 5006739 Quick inquiry Where to buy Suppliers range | PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhythm phase-delaying effects in vivo. Synonyms: PF 5006739; PF5006739; PF-5006739; 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-Pyrimidinamine; 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine. Grades: ≥98% by HPLC. CAS No. 1293395-67-1. Molecular formula: C22H22FN7O. Mole weight: 419.46. | |
Protein Kinase Inhibitor CKI-7 (PKI) (N-(2-aminoethyl)-5-chloro-isoquinoline-8-sulfonamide) Quick inquiry Where to buy Suppliers range | A potent inhibitor against casein kinase 1 with respect to ATP. Exhibits a much weaker effect on casein kinase 2 and other protein kinases. Group: Biochemicals. Alternative Names: N-(2-aminoethyl)-5-chloro-isoquinoline-8-sulfonamide. Grades: Molecular Biology Grade. CAS No. 120615-25-0. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
(R)-Perharidine 1 Quick inquiry Where to buy Suppliers range | Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 1133437-80-5. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Sodium Butyrate Quick inquiry Where to buy Suppliers range | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Alternative Names: Butanoic Acid Sodium Salt; Butyric acid Sodium Salt; Adimix; Butyrate Sodium; Gustor XXI B 70; Sodium Butanoate. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 250g, 500g, 1Kg. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) Quick inquiry Where to buy Suppliers range | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
Sodium Butyrate, 1M (Histone Deacetylase Inhibitor) Quick inquiry Where to buy Suppliers range | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
(S)-Perharidine 1 Quick inquiry Where to buy Suppliers range | Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and DYRK1A inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 1133437-81-6. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
TBCA Quick inquiry Where to buy Suppliers range | TBCA is a potent CK2 inhibitor. TBCA inhibits CK2 five times more efficiently than TBB without having any comparable effect on DYRK1 a (IC50 24.5 microM) or on a panel of 28 protein kinases. The usefulness of TBCA for cellular studies has been validated by showing that it reduces the viability of Jurkat cells more efficiently than TBB through enhancement of apoptosis. Synonyms: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic Acid; Casein Kinase II Inhibitor III; (2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid; Tetrabromocinnamic acid. Grades: ≥98%. CAS No. 934358-00-6. Molecular formula: C9H4Br4O2. Mole weight: 463.74. | |
TMCB Quick inquiry Where to buy Suppliers range | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). Synonyms: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid. Grades: ≥98% by HPLC. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: 534.82. | |
TTP 22 Quick inquiry Where to buy Suppliers range | Potent and ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki=40 nM). Synonyms: TTP22; TTP-22. Grades: >98%. CAS No. 329907-28-0. Molecular formula: C16H14N2O2S2. Mole weight: 330.42. |