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| Product | Description | |
|---|---|---|
| Casein kinase 1δ-IN-4 | Casein kinase 1δ-IN-4 (compound 567) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-4 has the potential for the research of Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851168-98-4. Pack Sizes: 10 mg. Product ID: HY-153747. |  |
| Casein kinase 1δ-IN-7 | Casein kinase 1δ-IN-7 (compound 497) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-7 can be used in the study of neurodegenerative disorders such as Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 764694-25-9. Pack Sizes: 10 mg. Product ID: HY-156662. | |
| Casein Kinase Iδ rat, Recombinant | The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription. C-terminal truncated, n-terminal his-tag/s-tag, > 90% (sds-page), recombinant, expressed in e. coli, solution. Group: Enzymes. Synonyms: Casein Kinase Iδ; Casein Kinase I; CK-Iδ; CK-I; Non-specific serine/threonine protein kinase; Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine (threonine) protein kinase; Serine-specific protein kinase; Serine/t. Purity: > 90% (SDS-PAGE). CK-I&delta. Mole weight: mol wt 41.8 kDa. Activity: 1,000-3,000 units/mg protein. Stability: -20°C. Form: solution. Source: E. coli. Species: Rat. Casein Kinase Iδ; Casein Kinase I; CK-Iδ; CK-I; Non-specific serine/threonine protein kinase; Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine (threonine) protein kinase; Serine-specific protein kinase; Serine/threonine protein kinase; Threonine-specific protein kinase. Cat No: NATE-0140. |  |
| Casein Kinase II from Human, Recombinant | The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. Casein kinase ii (ck2) is a constitutively active serine/threonine protein kinase composed of two 44 kda catalytic α-subunits and two 26 kda regulatory β-subunits in an α2β2 configuration to form stable heterotetramers. ck2 holoenzyme undergoes autophosphorylation at two serine residues (s2/s3) of its β-subunit. recen... ck2 is able to phosphorylate, under special circumstances, tyrosyl residues in proteins. ck2 is implicated in a variety of cellular functions. Group: Enzymes. Synonyms: EC 2.7.11.1; Casein Kinase II; CK2; CK II; Casein Kinase 2. CAS No. 9026-43-1. CK. Mole weight: a-subunit (45 kDa), b-subunit (25 kDa). The apparent molecular weight of the a-subunit estimated by SDS-PAGE is about 42 kDa. Activity: 859,000 units/mg. Storage: at -80°C. Avoid repeated freeze/thaw cycles. Form: 350 mM NaCl, 20 mM Tris-HCl (pH 7.5 25°C), 1 mM Na2EDTA, 2 mM DTT and 0.1% Triton X-100. Source: E. coli. Species: Human. EC 2.7.11.1; Casein Kinase II; CK2; CK II; Casein Kinase 2. Cat No: NATE-1271. | |
| Casein Kinase II Inhibitor VIII (4- (2- (4-Methoxybenzamido) thiazol-5-yl) benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII) | A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50=32 and 46nM against CK2a and CK2a', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50=2.6, 1.6, and 2.4uM, in A549, HCT116, and MCF-7 cultures, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Casein Kinase II Inhibitor XII, TBBz (4, 5, 6, 7-Tetra bromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) | A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at 25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. CAS No:577779-57-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 577779-57-8. Pack Sizes: 20mg. Molecular Formula: C?H?Br?N?, Primary Target: CK2. US Biological Life Sciences. | Worldwide |
| Casein Kinase I Inhibitor III, PF-4800567 (CKI Inhibitor III, PF-4800567)(3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl) | A cell-permeable pyrazolopyrimidinyl amino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKle with ~22-fold greater potency over CKld (IC50=32 and 711nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1uM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKle cells over CKld-transfected cells (IC50=0.13 and 2.65uM, respectively), and PER2 degradation in COS7-GFP-PER2-CKle cells. Unlike Casein Kinase I Inhibitor II, PF-670462, PF-4800567 exerts only marginal effect on circadian clock under similar conditions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Casein Kinase Substrates 3 | Casein Kinase Substrates 3 is a substrate of casein kinase. Synonyms: Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala; L-arginyl-L-arginyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-methionyl-L-seryl-L-isoleucyl-L-threonyl-L-alanine; Casein Kinase I substrate. Grades: ≥95% by HPLC. CAS No. 154444-97-0. Molecular formula: C85H139N27O35S. Mole weight: 2131.24. |  |
| Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| 10Z-Hymenialdisine | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. | Worldwide |
| 10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 4,5,6,7-Tetrabromobenzimidazole | ,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2. Synonyms: Casein Kinase II Inhibitor XII; TBBz; 4,5,6,7-tetrabromo-1H-benzimidazole. Grades: ≥98%. CAS No. 577779-57-8. Molecular formula: C7H2Br4N2. Mole weight: 433.7. | |
| a-3 Hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. Group: Inhibitors. Alternative Names: A3, Hydrochloride, A3 hydrochloride, IN1547, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl, A-3HYDROCHLORIDE, A1980_SIGMA, SCHEMBL3503907, CHEMBL1255867, CTK7E9088, OR0890T, MolPort-001-756-823, CCG-222331, LP01027, NCGC00094317-01, 3B3-053691, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulphonamide hydrochloride, N-(2-AMINOETHYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE, 78957-85-4. CAS No. 78957-85-4. Molecular formula: C12H14Cl2N2O2S. Mole weight: 321.22. Purity: 0.96. IUPACName: N-(2-aminoethyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride. Catalog: ACM78957854. |  |
| A-3 hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA ( K i =4.3 μM), casein kinase II ( K i =5.1 μM) and myosin light chain kinase (MLCK) ( K i =7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with K i values of 47 μM and 80 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 78957-85-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125957. | |
| AMG-548 | AMG-548, an orally active and selective p38α inhibitor ( K i=0.5 nM), shows slightly selective over p38β ( K i=36 nM) and >1000 fold selective against p38γ and p38&delta. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα ( IC 50 =3 nM) [1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864249-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642. | |
| AMG-548 dihydrochloride | AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i=0.5 nM), shows slightly selective over p38β ( K i=36 nM) and >1000 fold selective against p38γ and p38&delta. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα ( IC 50 =3 nM) [1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2518299-32-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642B. | |
| β-adrenergic-receptor kinase | Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase). Group: Enzymes. Synonyms: ATP:β-adrenergic-receptor phosphotransferase; [β-adrenergic-receptor] kinase; β-adrenergic receptor-specific kinase; β-AR kinase; β-ARK; β-ARK 1; β-ARK 2; β. Enzyme Commission Number: EC 2.7.11.15. CAS No. 102925-39-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3134; β-adrenergic-receptor kinase; EC 2.7.11.15; 102925-39-3; ATP:β-adrenergic-receptor phosphotransferase; [β-adrenergic-receptor] kinase; β-adrenergic receptor-specific kinase; β-AR kinase; β-ARK; β-ARK 1; β-ARK 2; β-receptor kinase; GRK2; GRK3; β-adrenergic-receptor kinase (phosphorylating); β2ARK; βARK1; β-adrenoceptor kinase; β-adrenoceptor kinase 1; β-adrenoceptor kinase 2; ADRBK1; BARK1; adrenergic receptor kinase; STK15. Cat No: EXWM-3134. | |
| BTX-A51 | BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis , and has potent anti-leukemic activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Casein Kinase inhibitor A51. CAS No. 2079068-74-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123954. | |
| CAY10577 | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10577 inhibits CK2 with an IC50 value of 0.8 μM. Synonyms: CAY 10577; CAY-10577. Grades: ≥95%. CAS No. 300675-28-9. Molecular formula: C10H5Cl2NO3. Mole weight: 258.1. | |
| CAY10578 | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10578 is a potent inhibitor of CK2 with IC50 value of 0.3 μM. It is ATP competitive and displays Ki value of 0.2 μM. Synonyms: CAY 10578; CAY-10578. Grades: ≥95%. CAS No. 19231-60-8. Molecular formula: C10H3I4NO4. Mole weight: 708.8. | |
| CKI-7 free base | CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC 50 of 6 μM and a K i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK , ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120615-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133028. | |
| CX 4945 hydrochloride | CX 4945 hydrochloride is an orally bioactive and ATP-competitive casein kinase 2 (CK2) inhibitor. CX 4945 inhibits proliferation and migration in a panel of cancer cell lines which overexpresses CK2. Uses: Antitumor agent. Synonyms: CX 4945 hydrochloride; CX-4945 hydrochloride; CX4945 hydrochloride; Silmitasertib HCl; Silmitasertib hydrochloride. Grades: 98%. CAS No. 2108312-01-0. Molecular formula: C19H12ClN3O2.HCl. Mole weight: 386.23. | |
| D4476 | D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1). Synonyms: Casein Kinase I Inhibitor; D 4476; D-4476. Grades: >98%. CAS No. 301836-43-1. Molecular formula: C23H18N4O3. Mole weight: 398.41. | |
| Daidzein Diglucuronide | Daidzein Diglucuronide is a metabolite of Daidzein (D103500) which is an inactive analog of Genistein (G350000). Genistein blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 335591-27-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C27H26O16. US Biological Life Sciences. | Worldwide |
| DMAT | DMAT is a potent and specific CK2 inhibitor. It also displays submicromolar IC50 values with almost all of the other kinases with special reference to PKD1, PIM3 and PIM1. Synonyms: Casein kinase II Inhibitor; CK2 Inhibitor. Grades: >98%. CAS No. 749234-11-5. Molecular formula: C9H7Br4N3. Mole weight: 476.79. | |
| DMAT | DMAT is a potent and specific CK2 inhibitor with an IC 50 value of 130 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CK2 Inhibitor; Casein kinase II Inhibitor. CAS No. 749234-11-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15535. | |
| Emodin | Emodin (Frangula emodin), an anthraquinone derivative, is an anti- SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction [1]. Emodin inhibits casein kinase-2 ( CK2 ). Anti-inflammatory and anticancer effects [2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC 50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Frangula emodin. CAS No. 518-82-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-14393. | |
| Emodin | Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Inhibitors. Alternative Names: 1,3,8-trihydroxy-6-methylanthraqunone. CAS No. 518-82-1. Molecular formula: C15H10O5. Mole weight: 270.24. Appearance: Powder. Purity: 0.98. IUPACName: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione. Canonical SMILES: CC1=CC2=C (C (=C1)O)C (=O)C3=C (C2=O)C=C (C=C3O)O. Density: 1.33 g/ml. Catalog: ACM518821-1. | |
| Emodin-d4 | Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Group: Inhibitors. Alternative Names: Emodin-d4;1,3,8-Trihydroxy-6-Methyl-9,10-anthracenedione-d4;1,6,8-Trihydroxy-3-Methylanthraquinone-d4;4,5,7-Trihydroxy-2-Methyl- anthraquinone-d4;Archin-d4;EModol-d4;Frangula EModin-d4;Frangulic Acid-d4. CAS No. 132796-52-2. Molecular formula: C15H10O5. Mole weight: 270.2369. Appearance: Brownish Solid. Purity: 0.96. IUPACName: 1,3,6,8-tetradeuterio-2,4,5-trihydroxy-7-methylanthracene-9,10-dione. Canonical SMILES: O=C1C2=C (O)C ([2H])=C (C)C ([2H])=C2C (C3=C ([2H])C (O)=C ([2H])C (O)=C31)=O. Catalog: ACM132796522. | |
| Epiblastin A | Epiblastin A is a Casein Kinase 1 (CK1) inhibitor. Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). Group: Inhibitors. Alternative Names: Epiblastin A; AUE. CAS No. 16470-02-3. Molecular formula: C12H10ClN7. Mole weight: 287.71. Appearance: Solid powder. Purity: >98%. IUPACName: 6-(3-Chloro-phenyl)-pteridine-2,4,7-triamine. Canonical SMILES: NC1=NC (N)=C2N=C (C3=CC=CC (Cl)=C3)C (N)=NC2=N1. Catalog: ACM16470023. | |
| H 89 2HCl | H 89 2HCl is a cell permeable and potent PKA inhibitor with Ki of 48 nM in a cell-free assay, wihich is 10-fold selective for PKA than PKG, 500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. Synonyms: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 130964-39-5. Molecular formula: C20H20BrN3O2S·2HCl. Mole weight: 519.28. | |
| H-89 dihydrochloride (N-5-isoquinolinesulfonamid e . 2HCl) | Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H20BrN3O2S. 2HCl, Molecular Weight: 519.3. US Biological Life Sciences. | Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| H-9 dihydrochloride | H-9 dihydrochloride is a protein kinase inhibitor. It inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM). H-9 hydrochloride reduces the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and inhibits PKA-mediated phosphorylation in a rat seizure model. Synonyms: H-9 dihydrochloride; H 9 dihydrochloride; H9 dihydrochloride; N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 116700-36-8. Molecular formula: C11H13N3O2S.2HCl. Mole weight: 324.22. | |
| Hematein | Hematein is a oxidation product of hematoxylin acted as a dye [1]. Hematein is an allosteric casein kinase II inhibitor with an IC 50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 475-25-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-119751. | |
| Hematein | Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Group: Inhibitors. CAS No. 475-25-2. Molecular formula: C16H12O6. Mole weight: 300.26. Purity: 0.749. Catalog: ACM475252. | |
| KL001 | KL001 is a small molecule that specifically interacts with cryptochrome (CRY), blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Uses: Cryptochrome protein (cry) stabilizer. Synonyms: KL 001; KL-001; N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide. Grades: ≥98%. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. | |
| λ Protein phosphatase | λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn 2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 401941-75-1. Pack Sizes: 10 KU. Product ID: HY-E70373. | |
| low-density-lipoprotein receptor kinase | Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP. Group: Enzymes. Synonyms: ATP:low-density-lipoprotein-L-serine O-phosphotransferase; LDL receptor kinase; [low-density-lipoprotein] kinase; low-density lipoprotein kinase; low-density-lipoprotein receptor kinase (phosphorylating); STK7. Enzyme Commission Number: EC 2.7.11.29. CAS No. 107445-00-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3149; low-density-lipoprotein receptor kinase; EC 2.7.11.29; 107445-00-1; ATP:low-density-lipoprotein-L-serine O-phosphotransferase; LDL receptor kinase; [low-density-lipoprotein] kinase; low-density lipoprotein kinase; low-density-lipoprotein receptor kinase (phosphorylating); STK7. Cat No: EXWM-3149. | |
| N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases. Group: Biochemicals. Alternative Names: CKI-7 Dihydrochloride. Grades: Highly Purified. CAS No. 1177141-67-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| NSC 210902 | NSC 210902 is an ATP-competitive inhibitor of casein kinase 2 (CK2). It inhibits CK2 which is increased in tumor tissues, suppressing the proliferation of cancer cells. Synonyms: 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid. Grades: ≥95%. CAS No. 51726-83-1. Molecular formula: C14H9NO3. Mole weight: 239.2. | |
| PF 4800567 | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
| PF 4800567 hydrochloride | PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ respectively). Synonyms: PF 4800567 hydrochloride; PF-4800567 hydrochloride; PF4800567 hydrochloride; 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 1391052-28-0. Molecular formula: C17H18ClN5O2.HCl. Mole weight: 396.27. | |
| PF-4800567 Hydrochloride | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF 5006739 | PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhythm phase-delaying effects in vivo. Synonyms: PF 5006739; PF5006739; PF-5006739; 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-Pyrimidinamine; 4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine. Grades: ≥98% by HPLC. CAS No. 1293395-67-1. Molecular formula: C22H22FN7O. Mole weight: 419.46. | |
| PF-670462 dihydrochloride | PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase ( CK1ε and CK1δ ) , with IC 50 s of 7.7 nM and 14 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 950912-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15490. | |
| polo kinase | The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. Group: Enzymes. Synonyms: Cdc5; Cdc5p; Plk; PLK; Plk1; Plo1; POLO kinase; polo serine-threonine kinase; polo-like kinase; polo-like kinase 1; serine/threonine-specific Drosophila kinase polo; STK21. Enzyme Commission Number: EC 2.7.11.21. CAS No. 149433-93-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3141; polo kinase; EC 2.7.11.21; 149433-93-2; Cdc5; Cdc5p; Plk; PLK; Plk1; Plo1; POLO kinase; polo serine-threonine kinase; polo-like kinase; polo-like kinase 1; serine/threonine-specific Drosophila kinase polo; STK21. Cat No: EXWM-3141. | |
| Protein Kinase Inhibitor CKI-7 (PKI) (N-(2-aminoethyl)-5-chloro-isoquinoline-8-sulfonamide) | A potent inhibitor against casein kinase 1 with respect to ATP. Exhibits a much weaker effect on casein kinase 2 and other protein kinases. Group: Biochemicals. Alternative Names: N-(2-aminoethyl)-5-chloro-isoquinoline-8-sulfonamide. Grades: Molecular Biology Grade. CAS No. 120615-25-0. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| protein-serine/threonine phosphatase | A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase). Group: Enzymes. Synonyms: phosphoprotein phosphatase (ambiguous); protein phosphatase-1; protein phosphatase-2A; protein phosp. Enzyme Commission Number: EC 3.1.3.16. CAS No. 9025-75-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3618; protein-serine/threonine phosphatase; EC 3.1.3.16; 9025-75-6; phosphoprotein phosphatase (ambiguous); protein phosphatase-1; protein phosphatase-2A; protein phosphatase-2B; protein phosphatase-2C; protein D phosphatase; phosphospectrin phosphatase; casein phosphatase; Aspergillus awamori acid protein phosphatase; calcineurin; phosphatase 2A; phosphatase 2B; phosphatase II; phosphatase IB; phosphatase C-II; polycation modulated (PCM-) phosphatase; phosphopyruvate dehydrogenase phosphatase; phosphatase SP; branched-chain α-keto acid dehydrogenase phosphatase; BCKDH phosphatase; 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase; HMG-CoA reductase phosphatase; phosph | |
| rhodopsin kinase | Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the β-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, β-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase). Group: Enzymes. Synonyms: cone opsin kinase; G-protein-coupled receptor kinase 1; GPCR kinase 1; GRK1; GRK7; opsin kinase; opsin kinase (phosphorylating); rhodopsin kinase (phosphorylating); RK; STK14. Enzyme Commission Number: EC 2.7.11.14. CAS No. 54004-64-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3133; rhodopsin kinase; EC 2.7.11.14; 54004-64-7; cone opsin kinase; G-protein-coupled receptor kinase 1; GPCR kinase 1; GRK1; GRK7; opsin kinase; opsin kinase (phosphorylating); rhodopsin kinase (phosphorylating); RK; STK14. Cat No: EXWM-3133. | |
| [RNA-polymerase]-subunit kinase | The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone. Group: Enzymes. Synonyms: CTD kinase; STK9. Enzyme Commission Number: EC 2.7.11.23. CAS No. 122097-00-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3143; [RNA-polymerase]-subunit kinase; EC 2.7.11.23; 122097-00-1; CTD kinase; STK9. Cat No: EXWM-3143. | |
| (R)-Perharidine 1 | Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 1133437-80-5. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Alternative Names: Butanoic Acid Sodium Salt; Butyric acid Sodium Salt; Adimix; Butyrate Sodium; Gustor XXI B 70; Sodium Butanoate. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 250g, 500g, 1Kg. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate, 1M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| (S)-Perharidine 1 | Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and DYRK1A inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 1133437-81-6. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| SR-3029 | SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines. Group: Inhibitors. Alternative Names: SR-3029; SR 3029; SR3029. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.46. Appearance: Solid powder. Purity: >98%. IUPACName: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine. Canonical SMILES: FC1=CC (N2C=NC3=C (NCC4=NC5=CC=C (F)C (F)=C5N4)N=C (N6CCOCC6)N=C23)=CC=C1. Catalog: ACM1454585068. | |
| TBB | TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC 50 of 0.15 μM for rat liver CK2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 231634; Casein Kinase II Inhibitor I. CAS No. 17374-26-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14394. | |
| TBCA | TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC 50 of 110 nM and a K i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934358-00-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110052. | |
| TBCA | TBCA is a potent CK2 inhibitor. TBCA inhibits CK2 five times more efficiently than TBB without having any comparable effect on DYRK1 a (IC50 24.5 microM) or on a panel of 28 protein kinases. The usefulness of TBCA for cellular studies has been validated by showing that it reduces the viability of Jurkat cells more efficiently than TBB through enhancement of apoptosis. Synonyms: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic Acid; Casein Kinase II Inhibitor III; (2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid; Tetrabromocinnamic acid. Grades: ≥98%. CAS No. 934358-00-6. Molecular formula: C9H4Br4O2. Mole weight: 463.74. | |
| Tmcb | TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively. Group: Inhibitors. Alternative Names: CHEMBL1233807, SureCN1759230, ABP000318, [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, 905105-89-7, K66. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: C11H9Br4N3O2. Purity: >98 %. IUPACName: 2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid. Canonical SMILES: CN (C)C1=NC2=C (N1CC (=O)O)C (=C (C (=C2Br)Br)Br)Br. Catalog: ACM905105897. | |
| TMCB | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). Synonyms: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid. Grades: ≥98% by HPLC. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: 534.82. | |
| tropomyosin kinase | The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein. Group: Enzymes. Synonyms: tropomyosin kinase (phosphorylating); STK. Enzyme Commission Number: EC 2.7.11.28. CAS No. 90804-56-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3148; tropomyosin kinase; EC 2.7.11.28; 90804-56-1; tropomyosin kinase (phosphorylating); STK. Cat No: EXWM-3148. | |
| TTP 22 | Potent and ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki=40 nM). Synonyms: TTP22; TTP-22. Grades: >98%. CAS No. 329907-28-0. Molecular formula: C16H14N2O2S2. Mole weight: 330.42. | |
| Umbralisib | Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202; RP5264. CAS No. 1532533-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279. | |
| Umbralisib hydrochloride | Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202 hydrochloride; RP5264 hydrochloride. CAS No. 1532533-78-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279C. | |
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