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| Product | Description | |
|---|---|---|
| 2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-dimethyl-2-propenamide | 2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-dimethyl-2-propenamide is an impurity of Entacapone, which is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-dimethyl-; N,N-Dimethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide; 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-dimethylacrylamide. Grade: 95%. CAS No. 116314-66-0. Molecular formula: C12H11N3O5. Mole weight: 277.23. |  |
| 3,5-Dinitrocatechol | 3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC 50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OR-486; 3,5-Dinitropyrocatechol. CAS No. 7659-29-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100959. |  |
| 3-Mercaptotyramine, Hydrochloride | 3-Mercaptotyramine, the mercapto analog of dopamine, irreversibly inhibits the enzyme, catechol-O-methyltransferase, presumably by the formation of an SS bridge to a reactive mercapto group in the reactive site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 3-O-Methyldopa | 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA. CAS No. 300-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-113468A. | |
| catechol O-methyltransferase | The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. Group: Enzymes. Synonyms: COMT I COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase. Enzyme Commission Number: EC 2.1.1.6. CAS No. 9012-25-3. COMT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1961; catechol O-methyltransferase; EC 2.1.1.6; 9012-25-3; COMT I COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase. Cat No: EXWM-1961. |  |
| Entacapone | Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC 50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC 50 s>50 μM). Entacapone can be used for the research of Parkinson's disease [1]. Entacapone serves as a inhibitor of FTO demethylation with an IC 50 of 3.5 μM, can be used for the research of metabolic disorders [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130929-57-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14280. | |
| Entacapone | Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) (IC50 = 151 nM), commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-; Comtan; HSDB 8251; HSDB-8251; HSDB8251; OR-611; OR 611; OR611; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-; (E)-Entacapone; Comtess; Entacom; Parkicapone. Grade: >98%. CAS No. 130929-57-6. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| Entacapone 3-b-D-glucuronide | Entacapone 3-b-D-glucuronide is a metabolite of Entacapone, which is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) used in combination with other medications for the treatment of Parkinson's disease. Synonyms: β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl; 5-[(1E)-2-Cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl β-D-glucopyranosiduronic acid; β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl; β-D-Glucopyranosiduronic acid, 5-[2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl, (E)-; Entacapone 3-β-D-glucuronide. Grade: ≥95%. CAS No. 158069-75-1. Molecular formula: C20H23N3O11. Mole weight: 481.41. | |
| Flopropione | Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor [1] [2]. Flopropione also as an antispasmodic agent [3]. Uses: Scientific research. Group: Natural products. CAS No. 2295-58-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-100562. | |
| Native Porcine Catechol-O-methyl Transferase | Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In Humans, catechol-O-methyltransferase protein is encoded by the COMT gene. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Group: Enzymes. Synonyms: catechol O-methyltransferase; COMT; COMT I; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase; EC 2.1.1.6; 9012-25-3; Py. Enzyme Commission Number: EC 2.1.1.6. CAS No. 9012-25-3. COMT. Activity: > 150 units/mg protein. Form: Lyophilized powder containing phosphate buffer and dithiothreitol. Source: Porcine liver. Species: Porcine. catechol O-methyltransferase; COMT; COMT I; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase; EC 2.1.1.6; 9012-25-3; Pyrocatechol-O-methyl Transferase; S-Adenosyl-L-methionine:catechol O-methyltransferase. Cat No: NATE-0148. | |
| Nebicapone | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIA 3-202. CAS No. 274925-86-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106405. | |
| Nitecapone | Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OR-462. CAS No. 116313-94-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-106842. | |
| Opicapone | Opicapone (BIA 9-1067) is a potent third-generation catechol-O-methyltransferase ( COMT ) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC 50 of 98 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIA 9-1067. CAS No. 923287-50-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14896. | |
| Opicapone | Opicapone, is used for the synthesis of novel nitrocatechol-substituted heterocycles, having the ability to inhibit catechol-O-methyltransferase (COMT), used for the treatment of Parkinson`s diseases. Alternative Names: 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol;BIA9-1067;1,2-Benzenediol,5-[3-(2,5-dichloro-4,6-dimetChemicalbookhyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-;2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine1-oxide. CAS No. 923287-50-7. Product ID: API923287507. Molecular formula: C15H10Cl2N4O6. Mole weight: 413.17. SMILES: CC1=C(C(=[N+](C(=C1Cl)C)[O-])Cl)C2=NOC(=N2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-]. Appearance: Powder. Category: APIs for Parkinson's Disease. |  |
| S-(5'-Adenosyl)-L-methionine Chloride Dihydrochloride | S-(5?-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine- β-synthase (CBS).S-(5?-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles. Group: Biochemicals. Alternative Names: 5'- [ [ (3S) -3-Amino-3-carboxypropyl] methylsulfonio] -5'-deoxya. Grades: Purified. CAS No. 86867-01-8. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C15H23ClN6O5S·2HCl, Molecular Weight: 507.82. US Biological Life Sciences. | Worldwide |
| Tolcapone ( (3, 4-Dihydroxy-5-nitro-phenyl) (4-methylphenyl) methanone, Ro-40-7592, Tasmar) | Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian. Group: Biochemicals. Alternative Names: (3, 4-Dihydroxy-5-nitro-phenyl) (4-methylphenyl) methanone; Ro-40-7592; Tasmar. Grades: Highly Purified. CAS No. 134308-13-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Tolcapone-d4 | Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian. Group: Biochemicals. Alternative Names: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl-d4)methanone; Ro-40-7592-d4; Tasmar-d4. Grades: Highly Purified. CAS No. 1246816-93-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tolcapone-[d4] | Tolcapone-[d4] is the labelled analogue of Tolcapone. Tolcapone is a nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase. It can be used to treat Parkinson's disease. Synonyms: Tolcapone D4; (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl-d4)methanone. Grade: 95% by HPLC; 98% atom D. CAS No. 1246816-93-2. Molecular formula: C14H7D4NO5. Mole weight: 277.27. | |
| Tolcapone-[d7] | An isotope labelled form of Tolcapone. Tolcapone is a nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase. It can be used to treat Parkinson's disease. Synonyms: Tolcapone-d7; 5-[4-(D3)methyl(D4)benzoyl]-3-nitrobenzene-1,2-diol. Grade: 95% by HPLC; 98% atom D. CAS No. 2749285-04-7. Molecular formula: C14H4D7NO5. Mole weight: 280.28. | |
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