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| Product | Description | |
|---|---|---|
| cGAMP | cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12512. |  |
| cGAMP sodium salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| 2',2'-cGAMP | Grades: > 95%. Molecular formula: C20H30N12O13P2. Mole weight: 708.49. |  |
| 22-cGAMP | Cas No. 1465774-27-9. | |
| 2',3'-cGAMP | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP. CAS No. 1441190-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100564. | |
| 2',3'-cGAMP sodium | 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2'-3'-cyclic GMP-AMP sodium. CAS No. 2734858-36-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100564A. | |
| 2?,3?-cGAMP sodium salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| 2',3'-cGAMP sodium salt | 2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-&beta. 2',3'-cGAMP is an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. Synonyms: Cyclic [G(2',5')pA(3',5')p] sodium; cyclic GMP-AMP sodium; 2',3'-cyclic GMP-AMP sodium; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt. Grades: 95%. CAS No. 2734858-36-5. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.38. | |
| 3'3'-cGAMP | Cas No. 849214-04-6. | |
| c[8-AET-G(2',5')pA(3',5')p] | c[8-AET-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which is used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. c[G(2',5')pA(3',5')p] is the metazoan second messenger produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. Synonyms: Cyclic (8- (2- aminoethylthio)guanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H29N11O13P2S (free acid). Mole weight: 749.6 (free acid). | |
| c[8-Br-G(2',5')pA(3',5')p] | c[8-Br-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger, which can be used for binding studies and as precursor for further modifications with spacers or labels. c[G(2',5')pA(3',5')p] is the metazoan second messenger produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. Synonyms: Cyclic (8- bromoguanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H23BrN10O13P2 (free acid). Mole weight: 753.3 (free acid). | |
| c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grades: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
| Cyclic di-GMP sodium salt | Cyclic di-GMP is a second messenger in bacteria, which is involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. Cyclic di-GMP induces expression of IFN-β mRNA in vitro (EC50 = 537.8 nM) but less potently than 2'3'-cGAMP, 3'2'-cGAMP, 3'3'-cGAMP, and 2'2'-cGAMP. Synonyms: c-di-GMP; Cyclic diguanylate; 3',5'-Cyclic diguanylic acid. Grades: ≥95%. CAS No. 2222132-40-1. Molecular formula: C20H22N10Na2O14P2. Mole weight: 734.37. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| cyclic GMP-AMP synthase | Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. Group: Enzymes. Synonyms: cGAMP synthase; cGAS. Enzyme Commission Number: EC 2.7.7.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3299; cyclic GMP-AMP synthase; EC 2.7.7.86; cGAMP synthase; cGAS. Cat No: EXWM-3299. |  |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
| Cyclic Guanosine-(2',5')-monophosphate-adenosine-(3'',5'')-monophosphate Di-ammonium Salt | Cyclic Guanosine-(2',5')-monophosphate-adenosine-(3'',5'')-monophosphate Di-ammonium Salt is a non-symmetrical, mixed phosphodiester link dimeric nucleotide. It is a natural substrate for the immune adaptor protein STING. Synonyms: 2',3'-cGAMP. Molecular formula: C20H22N10O13P2 2(NH4). Mole weight: 672.40. | |
| pApG | pApG is a metabolite of 3'3'-cGAMP, the bacterial second messenger, which is generated by specific PDEs in Vibrio cholerae. pApG does not bind to the c-diGMP-I riboswitch. Synonyms: 5'- Phosphoadenylyl- (3' -≥ 5')- guanosine, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 5064-50-6. Molecular formula: C20H26N10O14P2. Mole weight: 692.4. | |
| pG(2',5')pA | pG(2',5')pA is a potential metabolite of 2'3'-cGAMP, the metazoan cyclic dinucleotide second messenger. Synonyms: 5'- Phosphoguanylyl- (2' -≥ 5')- adenosine, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 55779-55-0. Molecular formula: C20H26N10O14P2. Mole weight: 692.4. | |
| pGpA | A STING agonist negative control (pGpA). Synonyms: 3'5'-pGpA sodium salt; 3'3'-cGAMP Control. CAS No. 20137-01-3. Molecular formula: C20H23N10O14P2.3Na. Mole weight: 758.38. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SR-717 lithium; SR 717 lithium; SR717 lithium. Product Category: Agonists. Appearance: Solid powder. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. Purity: >98%. IUPACName: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate. Canonical SMILES: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]. Product ID: ACM2375421091. Alfa Chemistry ISO 9001:2015 Certified. |  |
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