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2-[7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene]aceticAcid Methyl Ester is an imidazodiaepine derivative and an impurity of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 59468-40-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H14ClFN2O2. US Biological Life Sciences.
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3-Chloro-5-fluorophenylaceticacid
3-Chloro-5-fluorophenylaceticacid. Group: Biochemicals. Grades: Highly Purified. CAS No. 202001-00-1. Pack Sizes: 250g, 500g, 1kg, 2kg, 5kg. Molecular Formula: C8H6ClFO2. US Biological Life Sciences.
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BMS711939
BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPAR&alpha. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation. Uses: Bms711939 was chosen for further preclinical evaluation. Synonyms: BMS-711939; BMS 711939; BMS711939. Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; 2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]aceticacid. Grades: >98 %. CAS No. 1000998-62-8. Molecular formula: C22H20ClFN2O6. Mole weight: 462.86.
Lumiracoxib
Selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory. Group: Biochemicals. Alternative Names: 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneaceticAcid; 2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]aceticAcid; CGS 35189; COX 189; Prexige. Grades: Highly Purified. CAS No. 220991-20-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Vidupiprant
Vidupiprant / AMG853 is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC50s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment. Group: Fluorinated apis. Alternative Names: AMG853. CAS No. 1169483-24-2. Molecular formula: C28H27Cl2FN2O6S. Mole weight: 609.49. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 2-[4-[4- (tert-butylcarbamoyl) -2-[ (2-chloro-4-cyclopropylphenyl) sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]aceticacid. Catalog: OFC1169483242.
Zenarestat
Zenarestat is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract. It was developed by Fujisawa Pharmaceutical Co Ltd and was terminated in clinic phase 3 trials. Uses: Zenarestat was investigated as a treatment of diabetic neuropathy and cataract. Synonyms: FR 74366; FR74366 FR-74366; CI-1014; FK-366; CI1014; FK366; FK 366; FK-366; Zenarestat;2-[3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxoquinazolin-1-yl]aceticacid;FR74366;3-(2-Fluoro-4-bromobenzyl)-7-chloro-2,4(1H,3H)-dioxoquinazoline-1-aceticacid;3-[(4-Bromo-2-fluorophenyl)methyl]-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineaceticacid. Grades: 95%. CAS No. 112733-06-9. Molecular formula: C17H11BrClFN2O4. Mole weight: 441.64.
Intermediate in the preparation of Flucloxacillin (F419200) and its derivatives. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Flucloxacillin sodium Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4S)-2-(carboxy(3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)methyl)-3-(2-(3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)acetyl)-5,5-dimethylthiazolidine-4-carboxylic acid. Molecular Formula: C32H27Cl2F2N5O9S. Mole Weight: 766.55. Catalog: APB06052.
RO-0335
RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Group: Inhibitors. Alternative Names: RO0335; RO-0335; RO 0335. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Appearance: Solid powder. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C (NC1=CC=C (S (=O) (N)=O)C=C1Cl)CC2=CC=C (Br)C (OC3=CC (C#N)=CC (Cl)=C3)=C2F. Catalog: ACM867365762.
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