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Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase ( IC 50 =65 nM) by binding to the allosteric site on the regulatory subunit [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 123318-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-A0005.
Clofarabine
Clofarabine. Group: Biochemicals. Grades: Purified. CAS No. 123318-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. Synonyms: 6-Amino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine; CAFdA; 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside; C1-F-Ara-A; Clofarex; 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine; Clolar; Evoltra; 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine. Grade: ≥95%. CAS No. 123318-82-1. Molecular formula: C10H11ClFN5O3. Mole weight: 303.68.
Clofarabine-[13C,15N3]
Clofarabine-[13C,15N3] is the labeled analogue of Clofarabine. Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α. Synonyms: (2R,3R,4S,5R)-5-(6-(amino-15N)-2-chloro-9H-purin-9-yl-2-13C-1,3-15N2)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol; 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine-13C1, 15N3; Clofarabine-13C-15N3; Clofarabine-13C1,15N3. Grade: >95%. Molecular formula: C9[13C]H11ClFN2[15N]3O3. Mole weight: 307.65.
ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic. Group: Biochemicals. Alternative Names: 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; Clolar. Grades: Highly Purified. CAS No. 123318-82-1. Pack Sizes: 10mg. US Biological Life Sciences.
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Clofarabine-5'-monophosphate
Clofarabine-5'-monophosphate is a prodrug form of clofarabine, an anti-cancer agent used to treat pediatric acute lymphoblastic leukemia and adult refractory or relapsed acute myeloid leukemia. It quickly converts into clofarabine-5'-triphosphate, which inhibits DNA synthesis and induces apoptosis in cancer cells. Grade: ≥ 95% by HPLC. CAS No. 134646-42-7. Molecular formula: C10H12ClFN5O6P (free acid). Mole weight: 383.66 (free acid).
Clofarabine 5'-monophosphate triethyammonium salt
Clofarabine 5'-monophosphate triethyammonium salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences.
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Clofarabine-5'-triphosphate
Clofarabine-5'-triphosphate is an inhibitor of human ribonucleotide reductase that alter the quaternary structure of its large subunit. It has an anticancer activity. Uses: Clofarabine-5'-triphosphate is an inhibitor of human ribonucleotide reductase. Grade: ≥ 95% by HPLC. CAS No. 167620-89-5. Molecular formula: C10H14ClFN5O12P3 (free acid). Mole weight: 543.62 (free acid).
Clofarabine 5'-triphosphate triethyammonium salt
Clofarabine 5'-triphosphate triethyammonium salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences.
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Clofarabine Impurity 9
Clofarabine Impurity 9 is an impurity of Clofarabine, which is a purine analogue and antineoplastic agent used in the therapy of acute lymphoblastic leukemia (ALL) in children. Synonyms: (3R,4R,5S,6S)-6-((2-chloro-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)-5-fluorotetrahydro-2H-pyran-3,4-diol; (3R,4R,5S,6S)-6-[[2-chloro-9-[(2R,3S,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]-5-fluoro-tetrahydropyran-3,4-diol. Molecular formula: C15H18ClF2N5O6. Mole weight: 437.78.
Clofarabine intermediate(I)
Clofarabine intermediate(I). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3,5-tri-o-benzoyl-beta-d-ribose;[4-(Benzoyloxy)-2-(benzoyloxymethyl)-5-hydroxyoxolan-3-yl] benzoate;beta-d-ribofuranose 2,3,5-tribenzoate;β-D-Ribofuranose, 2,3,5-tribenzoate;Clofarabine intermediate (I);SS-D-RIBOFURANOSE, 2,3,5-TRIBENZOATE;2,3,5-TRI-O-. Product Category: Heterocyclic Organic Compound. Appearance: Yellow solid. CAS No. 67525-66-0. Molecular formula: C26H22O8. Mole weight: 462.45. Purity: 0.98. IUPACName: [4-(benzoyloxy)-2-(benzoyloxymethyl)-5-hydroxyoxolan-3-yl] benzoate. Canonical SMILES: C1=CC=C(C=C1)C(=O)OCC2C(C(C(O2)O)OC(=O)C3=CC=CC=C3)OC(=O)C4=CC=CC=C4. Density: 1.37 g/cm³. ECNumber: 614-075-8. Product ID: ACM67525660. Alfa Chemistry ISO 9001:2015 Certified.
Clofarabine Phosphoramidite
Clofarabine Phosphoramidite is a modified phosphoramidite derived from the chemotherapeutic agent clofarabine, a purine nucleoside analog. In this compound, the ribose sugar is substituted with a 2'-fluoro and 2-chloro group, and the base is a chlorinated adenine analog. The sugar moiety features a 3'-cyanoethyl (CE) phosphoramidite group, enabling its incorporation into oligonucleotides during automated synthesis. This modification is used to synthesize oligonucleotides with enhanced stability, resistance to nuclease degradation, and potential therapeutic properties. Clofarabine phosphoramidite is particularly valuable in creating DNA or RNA analogs for research into cancer therapeutics and nucleic acid-based drug development. Synonyms: 2-Chloro-2'-deoxy-2'-fluoro-rA(dmf) Phosphoramidite; 2-Chloro-2'-deoxy-2'-fluoro-rA(dmf) 3'-CED phosphoramidite. Grade: ≥97%. Molecular formula: C43H51ClFN8O6P. Mole weight: 861.35.
Clofarabine Triphosphate-13C,15N3 Triethylamine Salt
Clofarabine Triphosphate-13C,15N3 Triethylamine Salt is intended for use as an internal standard for the quantification of Clofarabine Triphophate Triethylamine Salt, which is a metabolite impurity of Clofarabine. Molecular formula: C9[13C]H14ClFN2[15N]3O12P3 xC6H15N. Mole weight: 547.59.
Clofarabine Triphosphate Triethylamine Salt
Clofarabine Triphosphate Triethylamine Salt is a metabolite of Clofarabine. Synonyms: 2-Chloro-9-[2-deoxy-2-fluoro-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-9H-purin-6-amine Triethylamine Salt. Molecular formula: C10H14ClFN5O12P3 X(C6H15N). Mole weight: 543.62.
1,3,5-Tri-O-benzoyl-2-O-(1H-imidazol-1-ylsulfonyl)-alpha-D-ribofuranose is used in the preparation of clofarabine (nucleoside analog) for cancer treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 97614-42-1. Pack Sizes: 1g, 5g. Molecular Formula: C29H24N2O10S, Molecular Weight: 592.57. US Biological Life Sciences.
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1,3,5-Tri-O-benzoyl-a-D-ribofuranose
It is a reagent for nucleosides and is used in the synthesis of antileukemia drug Clofarabine. Synonyms: a-D-Ribofuranose 1,3,5-tribenzoate; 1,3,5-Tribenzoate-α-D-ribofuranose; 1,3,5-Tribenzoate Ribofuranose; α-D-1,3,5-Tri-O-benzoyl-ribofuranose; (2R,3R,4S,5R)-5-(benzoyloxymethyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate. Grade: ≥98% by HPLC. CAS No. 22224-41-5. Molecular formula: C26H22O8. Mole weight: 462.45.
1,3,5-Tri-O-benzoyl-α-D-ribofuranose
1,3,5-Tri-O-benzoyl-α-D-ribofuranose is a reagent for nucleosides and it is used in the synthesis of antileukemia drug Clofarabine (C586890). 1,3,5-Tri-O-benzoyl-α-D-ribofuranose is a carbohydrate intermediate. Group: Biochemicals. Grades: Highly Purified. CAS No. 22224-41-5. Pack Sizes: 1g, 5g. Molecular Formula: C26H22O8, Molecular Weight: 462.45. US Biological Life Sciences.
Worldwide
2',3'-O-Isopropylideneadenosine
2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 362-75-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W008048.
2-Aminoadenosine
2-Aminoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2096-10-8. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-W011548.
2-Chloro-9-(2-chloro-2-deoxy- β-D-arabinofuranosyl)purin-6-amine is used in the synthetic preparation of impurities and degradants from clofarabine process. Group: Biochemicals. Grades: Highly Purified. CAS No. 111615-20-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C10H11Cl2N5O3, Molecular Weight: 320.13. US Biological Life Sciences.
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2'-Deoxy-2'-fluoro-2-hydroxy-b-D-arabinoadenosine
It is the impurity B of Clofarabine and a DNA and RNA synthetase inhibitor. Synonyms: 2'-Deoxy-2'-fluoro-arabinoisoguanosine; 2-Hydroxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine; 6-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one; 6-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-3,9-dihydro-2H-purin-2-one. Grade: ≥95%. CAS No. 899827-82-8. Molecular formula: C10H12FN5O4. Mole weight: 285.23.
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine
It is the impurity C of Clofarabine and is also an anticancer agent. Synonyms: 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine; 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine; 2'-deoxy-2'-fluoro-arabino-guanosine; 2'-FANA-Gr; 2-Amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1H-purin-6(9H)-one; 2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one; 2'-Fluoro-Arabinoguanosine; NUK-2. Grade: ≥95%. CAS No. 103884-98-6. Molecular formula: C10H12FN5O4. Mole weight: 285.23.
2-Iodoadenosine
2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35109-88-7. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W008552.
It can be used in the synthesis of Clofarabine. Synonyms: 2-Deoxy-2-fluoro-a-D-arabinofuranosyl bromide 3,5-dibenzoate; 2-Deoxy-2-fluoro-α-D-arabinofuranosyl Bromide Dibenzoate; 2-deoxy-2-fluoro-3,5-di-o-benzoyl-alpha-d-arabinofuranosyl bromide; 2-Deoxy-2-fluoro-3-O,5-O-dibenzoyl-alpha-D-arabinofuranosyl bromide; ((2R,3R,4S,5R)-3-(Benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate. Grade: ≥97% by HPLC. CAS No. 97614-44-3. Molecular formula: C19H16BrFO5. Mole weight: 423.24.
3-O-Methyladenosine
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10300-22-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W393243.
(3S,4S,5R)-6-(6-Amino-2-chloro-9H-purin-9-yl)-5-fluorotetrahydro-2H-pyran-3,4-diol is an impurity of Clofarabine, Second generation purine nucleoside analog, antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic. Synonyms: Clofarabine Impurity. Molecular formula: C10H11ClFN5O3. Mole weight: 303.68.
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE. CAS No. 81352-25-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-W097775.
6-Amino-2-chloro-9-(2'-deoxy-2-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine is an intermediate in the synthesis of N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-β-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide which is a clofarabine related compound. Clofarabine is a second generation purine nucleoside analog, and antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic. Synonyms: 2-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. CAS No. 355138-50-0. Molecular formula: C24H19ClFN5O5. Mole weight: 511.89.
6-Amino-2-chloro-9- (2'-deoxy-2'-fluoro-b-D-arabinofuranosyl) purine. Group: Biochemicals. Alternative Names: Clofarabine; 2-Chloro-6-amino-purine-2'-fluoro-2'-deoxy arabinoside. Grades: Highly Purified. CAS No. 123318-82-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C10H11ClFN5O3. US Biological Life Sciences.
Worldwide
8-Bromoadenosine
8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2946-39-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W013195.
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