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| Product | Description | |
|---|---|---|
| Cobicistat | Cobicistat. Group: Biochemicals. Grades: Highly Purified. CAS No. 1004316-88-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Cobicistat | Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC 50 s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9350. CAS No. 1004316-88-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10493. |  |
| Cobicistat | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grades: 0.99. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028. |  |
| Cobicistat Impurity ((2S)-2-Amino-4-Meorpholine-4-yl-Butanoic Acid) | Cobicistat Impurity serves as an impurity for the drug Cobicistat, which is frequently prescribed to treat human immunodeficiency virus (HIV) infection. Synonyms: 2-Amino-4-morpholinobutanoic acid; 2-amino-4-(morpholin-4-yl)butanoic acid; 770684-35-0; 2-amino-4-morpholin-4-ylbutanoic acid; (2S) -2-Amino-4-morpholinebutanoicAcidDi hydrochloride ; 854893-19-9; SCHEMBL1889261; 2-Amino-4-morpholinobutanoicacid; MFCD07786927; AKOS000212411; BS-9757; 2-Amino-4-(mopholin-4-yl) butanoic acid; EN300-91881. Grades: > 95%. CAS No. 854893-19-9. Molecular formula: C8H16N2O3. Mole weight: 188.23. | |
| Cobicistat Impurity HCl | α,α-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride is a Cobicistat impurity. Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir as a pharmacoenhancer, significantly increasing their plasma concentrations. Synonyms: α,α-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride. Grades: > 95%. Molecular formula: C8H15ClN2OS. Mole weight: 222.74. | |
| Hydroxy Cobicistat | Hydroxy Cobicistat is an impurity in commercial preparation of Cobicistat. Synonyms: (S)-2- ( (hydroxy ( ( (2- (2-hydroxypropan-2-yl)thiazol-4-yl)methyl) (methyl)amino)methylene)amino)-N- ( (2R, 5R)-5- ( (hydroxy (thiazol-5-ylmethoxy)methylene)amino)-1, 6-diphenylhexan-2-yl)-4-morpholinobutanimidic acid. Grades: > 95%. CAS No. 1051463-40-1. Molecular formula: C40H53N7O6S2. Mole weight: 792.02. | |
| GS-7340 fumarate | Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate; TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing Elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil fumarate to elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide fumarate, the results showed the prodrug to be non inferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. Synonyms: GS-7340 fumarate; GS 7340 fumarate; GS7340 fumarate; (S)-isopropyl 2- ( ( (S)- ( ( ( (R)-1- (6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (phenoxy)phosphoryl)amino)propanoate fumarate; TAF; GS734; GS-734; GS 7340; Tenofovir alafenamide fumarate; trade name: Genvoya. Grades: >98%. CAS No. 379270-38-9. Molecular formula: C25H33N6O9P. Mole weight: 592.54. | |
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