Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Colchicine | 1g Pack Size. Group: Bioactive Small Molecules, Biochemicals. Formula: C22H25NO6. CAS No. 64-86-8. Prepack ID 22115544-1g. Molecular Weight 399.44. See USA prepack pricing. |  |
| Colchicine | Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC 50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 64-86-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-16569. |  |
| Colchicine | Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. Synonyms: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (-)-Colchicine; Colchineos; Colchisol; Colcin; Colsaloid; Condylon; NSC 757. Grades: >98%. CAS No. 64-86-8. Molecular formula: C22H25NO6. Mole weight: 399.44. |  |
| Colchicine | Colchicine is an antimitotic commonly used for doubling chromosomes. Uses: Mutagen. Additional or Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide. Product Category: Inhibitors. Appearance: Off-white to Yellow. CAS No. 64-86-8. Molecular formula: C22H25NO6. Mole weight: 399.44 g/mol. Purity: 0.98. IUPACName: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide. Canonical SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC. Density: 1.277 g/ml. Product ID: ACM64868. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Colchicine | Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standardspharma & vet compounds & metabolitespharma & vet compounds & metabolitesapi standardsbritish pharmacopoeiacovid-19 research and reference materialseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Colchicine. |  |
| Colchicine-d3 | An isotopically labeled an. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Colchicine-d6 | An isotopically labeled an. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Colchicine EP impurity D | Colchicoside is a significantly toxic Colchicine analog with no anti-inflammatory properties. Synonyms: (S)-N-[3-(b-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-[(7S)-3-(b-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; 3-Demethylcolchicine glucoside. Grades: > 95%. CAS No. 477-29-2. Molecular formula: C27H33NO11. Mole weight: 547.55. | |
| Colchicine Impurity 16 | Colchicine Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 186374-94-7. Molecular formula: C27H33NO8. Mole weight: 499.56. Catalog: APB186374947. | |
| Colchicine Impurity 17 | Colchicine Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 152242-11-0. Molecular formula: C16H16BrNO5. Mole weight: 382.21. Catalog: APB152242110. | |
| Colchicine Impurity 2 | Colchicine Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 104158-07-8. Molecular formula: C24H27NO6. Mole weight: 425.48. Catalog: APB104158078. | |
| Colchicine Impurity 8 | Colchicine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 102491-80-5. Molecular formula: C21H23NO6. Mole weight: 385.42. Catalog: APB102491805. | |
| Colchicine Methanethiosulfonate | The methanethiosulfonate derfivative of Colchicine, an an. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Colchicine USP | anti-inflammatory agent, mitosis inhibitor. Grades: USP. CAS No. 64-86-8. Product ID: 1-01052. Molecular formula: C22H25NO5. Mole weight: 399.44. Purity: >98%. Properties: protect from light, moisture. Source : HIGHLY TOXIC LD50 <50 mg/kg POTENTIAL CARCINOGEN. Reference: Merck, 12, 2536; J. Neurochem., 64, 1054, 1995. |  |
| 1-Demethylcolchicine | 1-Demethylcolchicine is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 3464-68-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C21H23NO6, Molecular Weight: 385.41. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2,10-didemethyl-colchicine | 2-Allyl-2,10-didemethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H25NO6. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl 10-Tosyl-10-demethyl Colchicine | 2-Allyl-2-demethyl 10-Tosyl-10-demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine | 2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl-colchicine | 2-Allyl-2-demethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 104158-07-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C24H27NO6. US Biological Life Sciences. | Worldwide |
| 2-Demethyl colchicine | 2-Demethyl colchicine. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; O2-Demethylcolchicine; (-)-2-Demethylcolchicine. Grades: Highly Purified. CAS No. 102491-80-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H23NO6. US Biological Life Sciences. | Worldwide |
| 2-Demethyl Colchicine | 2-Demethyl Colchicine is a metabolite of Colchicine. It has shown anti-tumor activity. Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; O2-Demethylcolchicine; (-)-2-Demethylcolchicine; NSC 180533. Grades: > 95%. CAS No. 102491-80-5. Molecular formula: C21H23NO6. Mole weight: 385.41. | |
| 2-Demethyl Colchicine 2-O-Sulfate | 2-Demethyl Colchicine 2-O-Sulfate is the sulfate analogue of the 2-O-desmethyl metabolite of Colchicine. Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-2-sulfooxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide. Grades: > 95%. CAS No. 1391052-56-4. Molecular formula: C21H23NO9S. Mole weight: 465.47. | |
| 2-Demethylcolchicine-d3 | A labeled metabolite of Colchicine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Colchicine | A metabolite of Colchicine. Has shown anti-tumor activity. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide; O3-Demethylcolchicine; 3-Demethyl-(-)-colchicine; 3-Demethylcolchicine; 3-Desmethylcolchicine; O3-Demethylcolchicine. Grades: Highly Purified. CAS No. 7336-33-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Colchicine | Cas No. 7336-33-6. | |
| 3-Demethyl colchicine 3-O-b-D-glucuronide | 3-Demethyl colchicine 3-O-b-D-glucuronide is a potent medicinal compound used in the biomedical industry for its anti-inflammatory and antimitotic properties. It plays a crucial role in studying gout and acute flares by inhibiting microtubule polymerization and reducing neutrophil infiltration. Synonyms: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-3-yl b-D-glucopyranosiduronic acid. CAS No. 913079-71-7. Molecular formula: C27H31NO12. Mole weight: 561.53. | |
| 3-Demethyl Colchicine Glucuronide | Grades: > 95%. CAS No. 477-27-2. Molecular formula: C27H31NO12. Mole weight: 561.55. | |
| 3-Demethylthiocolchicine | 3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 87424-25-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W355463. | |
| 3-Demethyl thiocolchicine | 3-Demethyl thiocolchicine. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 2-Demethylthio-colchicine; 3-De methyl thiocolchicine. Grades: Highly Purified. CAS No. 87424-25-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H23NO5S. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Thiocolchicine | 3-Demethyl Thiocolchicine is a Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent. Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 2-Demethylthio-colchicine; 3-Demethylthiocolchicine; 3-Desmethylthiocolchicine; 3-O-Demethylthiocolchicine; NSC 361792. Grades: > 95%. CAS No. 87424-25-7. Molecular formula: C21H23NO5S. Mole weight: 401.48. | |
| 3-Demethyl Thiocolchicine-d3 | A Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-d3; 2-Demethylthio-colchicine-d3; 3-Demethylthiocolchicine-d3; 3-Des methyl thiocolchicine-d3; 3-O-Demethylthiocolchicine-d3; NSC 361792-d3. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 3-Desmethylthiocolchicine-3-O-D-glucuronide | 3-Desmethylthiocolchicine-3-O-D-glucuronide, an intriguing and efficacious biomedicine, has garnered considerable attention due to its multifaceted therapeutic implications. Originating as an active metabolite of colchicine, a renowned remedy for gout and familial Mediterranean fever, this potent glucuronide derivative showcases substantial anti-inflammatory and anti-mitotic properties, offering a beacon of hope for therapeutic interventions. Synonyms: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl b-D-glucopyranosiduronic acid Thiocolchicoside glucuronide. CAS No. 819802-34-1. Molecular formula: C27H31NO11S. Mole weight: 577.60. | |
| 9-Thiomethyl Thiocolchicine | Thiocolchicine derivative. Group: Biochemicals. Alternative Names: N-[ (7S) -5, 6, 7, 9-Tetrahydro-1, 2, 3-trimethoxy-10- (methylthio) -9- (thiomethyl) benzo[a]heptalen-7-yl]acetamide; 10-Thio-9-thiomethyl-colchicine. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| β-Lumi (-)-Colchicine | An analog of Colchicine, beta-lumicolchicine, does not bind tubulin or disrupt microtubules. Group: Biochemicals. Alternative Names: N- [ (7S, 7bR, 10aS) -5, 6, 7, 7b, 8, 10a-Hexahydro-1, 2, 3, 9-tetramethoxy-8-oxobenzo [a]cyclopenta [3, 4]cyclobuta [1, 2-c]cyclohepten-7-yl]acetamide; β-Lumicolchicine. Grades: Highly Purified. CAS No. 6901-13-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| iso-Colchicine-d3 | An isotopically labeled an. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-Deacetyl-N-formyl Colchicine | Cas No. 7411-12-3. | |
| N-Deacetyl-N-formyl Colchicine | Colchicine derivative. A new alkaloid from Gloriosa superba. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]formamide; Gloriosine; N-Deacetyl-N-formylcolchicine; N-Formyl-N-deacetylcolchicine; N-Formyl-N-desacetylcolchicine; N-Formyl deacetyl colchicine; NSC 403142. Grades: Highly Purified. CAS No. 7411-12-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (R)-Colchicine | The R-enantiomer of Colchicine. An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Group: Biochemicals. Alternative Names: (R)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (+)-Colchicine. Grades: Highly Purified. CAS No. 75520-89-7. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| (R)-N-Deacetyl colchicine | (R)-N-Deacetyl colchicine. Group: Biochemicals. Alternative Names: (7R)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (+)-7-Deacetylcolchicine. Grades: Highly Purified. CAS No. 102419-91-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H23NO5. US Biological Life Sciences. | Worldwide |
| (R)-N-Deacetyl Colchicine d-10-Camphorsulfonate | (R)-Colchicine intermediate. Group: Biochemicals. Alternative Names: (+)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one d-10-Camphorsulfonate. Grades: Highly Purified. CAS No. 102419-97-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (r/s)-Colchicine | (r/s)-Colchicine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; (+/-)-Colchicine. Product Category: Heterocyclic Organic Compound. CAS No. 209810-38-8. Molecular formula: C22H25NO6. Mole weight: 399.44. Purity: 0.96. IUPACName: N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide. Product ID: ACM209810388. Alfa Chemistry ISO 9001:2015 Certified. | |
| (R/S)-Colchicine | Racemic Colchicine. Group: Biochemicals. Alternative Names: N-[5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; (+/-)-Colchicine. Grades: Highly Purified. CAS No. 209810-38-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (R/S)-N-Deacetyl Colchicine | Colchicine intermediate. Group: Biochemicals. Alternative Names: 7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (+/-)-7-Deacetylcolchicine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (R/S)-N-Deacetyl Colchicine d-10-Camphorsulfonate | Colchicine intermediate. Group: Biochemicals. Alternative Names: (+/-)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one d-10-Camphorsulfonate. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (S)-N-Deacetyl colchicine | (S)-N-Deacetyl colchicine. Group: Biochemicals. Alternative Names: (7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (-)-7-Deacetylcolchicine; NSC 201400. Grades: Highly Purified. CAS No. 3476-50-4. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H23NO5. US Biological Life Sciences. | Worldwide |
| (S)-N-Deacetyl Colchicine | (7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (-)-7-Deacetylcolchicine. antimitotic. CAS No. 3476-50-4. Product ID: 1-01631. Molecular formula: C20H23NO5. Mole weight: 357.41. | |
| (S)-N-Deacetyl Colchicine | (7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (-)-7-Deacetylcolchicine. CAS No. 3476-50-4. Product ID: 1-01718. Molecular formula: C20H23NO5. Mole weight: 357.41. Purity: 0.98. Reference: antimitotic. | |
| (S)-N-Deacetyl colchicine d-10-camphorsulfonate | (S)-N-Deacetyl colchicine d-10-camphorsulfonate. Group: Biochemicals. Alternative Names: (-)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one d-10-camphorsulfonate. Grades: Highly Purified. CAS No. 102419-98-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C30H40N2O8S. US Biological Life Sciences. | Worldwide |
| Thiocolchicine | A muscle relaxant. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 10-Thio-colchicine; 10-Demethoxy-10- (methylthio) colchicine; NSC 186301. Grades: Highly Purified. CAS No. 2730-71-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Thiocolchicine | Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization ( IC 50 =2.5 μM) and competitively binds to tubulin with a K i of 0.7 μM. Thiocolchicine induces cell apoptosis [1] [2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. Uses: Scientific research. Group: Signaling pathways. CAS No. 2730-71-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116852. | |
| Thiocolchicine | Thiocolchicine is a potent tubulin polymerization and microtubule assembly inhibitor, a axonal cytoskeleton modulator and apoptosis inducer. Structurally, thiocolchicine is a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety. Thiocolchicine was shown to bind with high affinity to the colchicine site on tubulin. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors. Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 10-Thio-colchicine; 10-Demethoxy-10-(methylthio)colchicine; NSC 186301. Grades: 98%. CAS No. 2730-71-4. Molecular formula: C22H25NO5S. Mole weight: 415.50. | |
| 2,2,2-Trifluoro-N-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)acetamide | 2,2,2-Trifluoro-N-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)acetamide is an intermediate in the facile conversion of natural colchicine into (±)-congeners and (+)-enantiomers. Group: Biochemicals. Grades: Highly Purified. CAS No. 102491-72-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H22F3NO6. US Biological Life Sciences. | Worldwide |
| 2-?Fluoro-?3-? (hydroxymethyl) ?benzoic Acid | 2-?Fluoro-?3-? (hydroxymethyl) ?benzoic Acid is a reagent used in the preparation of novel colchicine-derived immunosuppressants. Group: Biochemicals. Grades: Highly Purified. CAS No. 481075-37-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H7FO3, Molecular Weight: 170.14. US Biological Life Sciences. | Worldwide |
| 2-Methoxy 17 β-Estradiol-16,16,17-d3 | A natural metabolite of 17 β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. Group: Biochemicals. Alternative Names: (17 β)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol-16,16,17-d3; 2-Hydroxyestradiol-16,16,17-d3 2-Methyl Ether; 2-Methoxyestra-1,3,5(10)-triene-3,17-diol-16,16,17-d3; NSC 659853-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Methoxy-d3 17 β-Estradiol | A natural metabolite of 17 β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. Group: Biochemicals. Alternative Names: (17 β)-2-Methoxy-d3-estra-1,3,5(10)-triene-3,17-diol; 2-Hydroxyestradiol 2-Methyl-d3 Ether; 2-Methoxy-d3-estra-1,3,5(10)-triene-3,17 β-diol; 2-Methoxy-d3-estradiol; NSC 659853-d3; Panzem-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| ABT-751 | ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis , thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E7010. CAS No. 141430-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13270. | |
| Adipic acid monoethyl ester | Adipic acid monoethyl ester (CAS# 626-86-8) is used in the selection of streptavidin binder from DNA-encoded chemical library. Reagent in the synthetic preparation of colchicine-SAHA hybrids as antitumor agents. Synonyms: 6-ethoxy-6-oxohexanoic acid. Grades: 95 %. CAS No. 626-86-8. Molecular formula: C8H14O4. Mole weight: 174.19. | |
| Colcemid | Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer and thrombopoietic agent.Source:Semi-synthetic from colchicine: Group: Biochemicals. Grades: Highly Purified. CAS No. 477-30-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H25NO5, Method for Determining. US Biological Life Sciences. | Worldwide |
| Colchiceine | A metabolite of Colchicine. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; O10-Demethylcolchicine; NSC 33411. Grades: Highly Purified. CAS No. 477-27-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Colchiceine-d3 (N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide) | Labeled derivative of Colchicine. Group: Biochemicals. Alternative Names: N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Combretastatin A-1 | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 109971-63-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121993. | |
| Crolibulin | Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis. Synonyms: EPC2407; EPC 2407; EPC-2407; (R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile. CAS No. 1000852-17-4. Molecular formula: C18H17BrN4O3. Mole weight: 417.263. | |
| Demecolcine | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. Alternative Names: Deacetyl-N-methylcolchicine, Demecolcin, Colchicine, N-deacetyl-N-methyl-, (-)-, Demecolcine, Santavy's substance F, NSC 3096, Omaine,Colcemid, N-Methyl-N-deacetylcolchicine, N-Methyl-N-desacetylcolchicine, Omain, N-Methyltri-O-methylcolchicinic acid, Desacetylmethylcolchicine, C 12669, Colchicine, N-deacetyl-N-methyl- , Deacetylmethylcolchicine, (-)-Colchamine, N-Deacetyl-N-methylcolchicine, Alkaloid H 3, from Colchicum antumnale, Desmecolcine, Reichstein's F, Ciba 12669A, Kolchamin, (-)-Demecolcine, Colchamin, Colchamine , N-Desacetyl-N-methylcolchicine, Substance F, Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-. | |
| EHT-6706 | EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell monolayers and inhibits endothelial cell migration. Genome-wide transcriptomic analysis of EHT 6706 effects on human endothelial cells shows that the antiangiogenic activity elicits gene deregulations of antiangiogenic pathways. These findings indicate that EHT 6706 is a promising tubulin-binding compound with potentially broad clinical antitumor efficacy. Synonyms: EHT6706; EHT 6706; EHT-6706. CAS No. 1351592-10-3. Molecular formula: C21H24N2O4. Mole weight: 368.43. | |
| EHT-6706 dihydrochloride | EHT-6706 can target the colchicine-binding site to inhibit tubulin polymerization as a tubulin polymerisation inhibitor. It is under the development of Diaxonhit. EHT 6706 also is a vascular-disrupting agent. It can prevent endothelial cell tube formation and disrupt pre-established vessels, change the permeability of endothelial cell monolayers and inhibit endothelial cell migration. In Jul 2013, preclincal development for treatment of cancer was ongoing in the USA. Uses: Cancer. Synonyms: EHT-6706 dihydrochloride; EHT 6706 dihydrochloride; EHT6706 dihydrochloride; 7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine dihydrochloride. Grades: 98%. CAS No. 1351592-09-0. Molecular formula: C21H26Cl2N2O4. Mole weight: 441.35. | |
| ELR510444 | ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site. ELR510444 is not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines, suggesting that it circumvents both clinically relevant mechanisms of drug resistance to this class of agents. ELR510444 also shows potent antitumor activity in the MDA-MB-231 xenograft model with at least a 2-fold therapeutic window. Synonyms: ELR510444; ELR-510444; ELR 510444. Grades: >98%. CAS No. 1233948-35-0. Molecular formula: C19H16N2O2S2. Mole weight: 368.47. | |
| Ferulenol | Prenylated 4-hydroxycoumarin. Anti-tumor compound. Cytotoxic. Stimulator of tubulin polymerisation in vitro. Inhibitor of colchicine binding to tubulin. Antitubercular antibiotic with potent antibacterial activity. Anti-coagulant, pro-haemorrhagic compound with higher activity than warfarin. Shows hepatocyte toxicity. Disrupts mitochondrial membrane potential. Source:Ferula communis. Group: Biochemicals. Grades: Highly Purified. CAS No. 6805-34-1. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C24H30O3. US Biological Life Sciences. | Worldwide |
| Hatomarubigin A | It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-1,7,12(2H)-trione,3,4-dihydro-6-hydroxy-8-methoxy-3-methyl-, (S)-. CAS No. 139562-86-0. Molecular formula: C20H16O5. Mole weight: 336.34. | |
| Hatomarubigin B | It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-1,7,12(2H)-trione,3,4-dihydro-11-hydroxy-8-methoxy-3-methyl-, (S)-. CAS No. 139501-91-0. Molecular formula: C20H16O5. Mole weight: 336.34. | |
| Hatomarubigin C | It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-7,12-dione,1,2,3,4-tetrahydro-1,11-dihydroxy-8-methoxy-3-methyl-, (1S-cis)-; (1S)-1β,11-Dihydroxy-3β-methyl-8-methoxy-1,2,3,4-tetrahydrobenz[a]anthracene-7,12-dione. CAS No. 139501-92-1. Molecular formula: C20H18O5. Mole weight: 338.35. | |
Our database is helping our users find suppliers everyday.
