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| Product | Description | |
|---|---|---|
| Combretastatin | Combretastatin is a dihydrostilbenoid that found in Combretum caffrum. Members of the combretastatin family shows varying ability to cause vascular disruption in tumors. Combretastatin can bind to the β-subunit of tubulin. It is a tubulin polymerisation inhibitor and can be used for the treatment of tumor. Uses: Tumor. Synonyms: COMBRETASTATIN; (R)-(-)-Combretastatin; (R)-3-Hydroxy-4-methoxy-α-(3,4,5-trimethoxyphenyl)benzeneethanol; 2-Methoxy-5-[(βR)-β-hydroxy-3,4,5-trimethoxyphenethyl]phenol; 5-[(R)-2-Hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol. Grade: 95%. CAS No. 82855-09-2. Molecular formula: C18H22O6. Mole weight: 337.37. |  |
| Combretastatin A-1 | Combretastatin A1 is a cis-stilbene originally isolated from C. caffrum that inhibits microtubule assembly (ID50 = 2 μM) by binding to the colchicine binding site on β-tubulin. It inhibits proliferation of hepatocellular carcinoma (IC50s = 9.2-728.2 nM) and other carcinoma cell lines (IC50s = 12.2-2,247 nM). Combretastatin A1 increases apoptosis of HepG2 cells in a GSK3β-dependent manner by decreasing the levels of MCL-1 and β-catenin. Synonyms: Combretastatin A1; NSC-600032; (Z)-3-(3,4,5-trimethoxystyryl)-6-methoxybenzene-1,2-diol. Grade: 95%. CAS No. 109971-63-3. Molecular formula: C18H20O6. Mole weight: 332.35. | |
| Combretastatin A-1 | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 109971-63-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121993. |  |
| Combretastatin A1 phosphate | Combretastatin A1 phosphate (Oxi4503; CA1P; Combretastatin A1 diphosphate) is a potent vascular disruptive agent. Combretastatin A1 phosphate exerts anti-angiogenic effects on tumors. Combretastatin A1 phosphate has the potential for the research of pancreatic neuroendocrine tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Oxi4503; CA1P; Combretastatin A1 diphosphate. CAS No. 288847-35-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16147. | |
| Combretastatin A4 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. |  |
| Combretastatin A4 | Combretastatin A4. Group: Biochemicals. Grades: Purified. CAS No. 117048-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Combretastatin A4 | Combretastatin A4 is a microtubule -targeting agent that binds β-tubulin with K d of 0.4 μM. Uses: Scientific research. Group: Natural products. Alternative Names: CRC 87-09. CAS No. 117048-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2146. | |
| Combretastatin A4 | Combretastatin A4 is a stilbenoid isolated from Combretum caffrum. Combretastatin A4 was shown to inhibit tubulin polymerization (IC50 = 2.2 μM). It has demonstrable antineoplastic activity. Uses: Antineoplastic agents, phytogenic. Synonyms: 1-(3,4,5-trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene. Grade: ≥95%. CAS No. 117048-59-6. Molecular formula: C18H20O5. Mole weight: 316.35. | |
| Combretastatin A4 phosphate disodium salt | Combretastatin A4 phosphate disodium salt. Group: Biochemicals. Alternative Names: 2-Methoxy-5-[ (1Z) -2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol 1-(dihydrogen phosphate) sodium salt; CA 4P. Grades: Highly Purified. CAS No. 168555-66-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H19Na2O8P. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 Phosphate, Disodium Salt (CA 4P) | Phosphorylated, Combretastatin a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Indu. Group: Biochemicals. Alternative Names: CA 4P. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 ( (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4) | Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Inducer. Group: Biochemicals. Alternative Names: (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4. Grades: Highly Purified. CAS No. 117048-59-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4-methoxyaniline | 3-Bromo-4-methoxyaniline is an intermediate used to prepare triazole analogs of combretastatin A-4 as cytotoxic agents and inhibitors of tubulin. It is also used in the synthesis of (1, 2, 4-oxadiazolyl) biphenylcarbonyltetra hydrospiro [furo] indolepiperidine (SB-224289) as selective 5-HT1B receptor inverse agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 19056-41-8. Pack Sizes: 500mg, 1g. Molecular Formula: C7H8BrNO, Molecular Weight: 202.05. US Biological Life Sciences. | Worldwide |
| 3-Methoxycatechol | 3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934-00-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 25 g. Product ID: HY-W116576. | |
| Fosbretabulin | Fosbretabulin, also called as CA4P, has antitumor activity against anaplastic thyroid cancer (ATC) cell lines. Fosbretabulin, a novel water-soluble vascular-disrupting agent, is a phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum). Synonyms: [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate; 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene; CA4DP; combretastatin A-4; 168555-66-6 (fosbretabulin disodium); 82855-09-2 (combretastatin); 117048 -59-6 (combretastatin A4). Grade: >98%. CAS No. 222030-63-9. Molecular formula: C18H21O8P. Mole weight: 396.33. | |
| Fosbretabulin disodium | Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3]. Uses: Scientific research. Group: Natural products. Alternative Names: CA 4DP; CA 4P; Combretastatin A4 disodium phosphate. CAS No. 168555-66-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17449. | |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Synonyms: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. | |
| Nitrilotriacetic acid | Nitrilotriacetic acid (NTA) is the aminopolycarboxylic acid with the formula N(CH2CO2H)3. It is a colourless solid that is used as a chelating agent, which forms coordination compounds with metal ions (chelates) such as Ca2+, Cu2+, and Fe3+. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Triglycollamic Acid;Nitrilotriacetic Acid;N,N-Bis(carb;Glycine, N,N-bis(carboxymethyl)-;combretastatin A2. Product Category: Heterocyclic Organic Compound. Appearance: White powder. CAS No. 139-13-9. Molecular formula: C6H9NO6. Mole weight: 191.14. Density: 1.61 g/cm³. ECNumber: 205-355-7. Product ID: ACM139139. Alfa Chemistry ISO 9001:2015 Certified. |  |
| (Z)-5-(3-Hydroxy-4-methoxystyryl)-2,3-dimethoxyphenol | (Z)-5-(3-Hydroxy-4-methoxystyryl)-2,3-dimethoxyphenol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: combretastatins A-3; Combretastatin A3. Product Category: Heterocyclic Organic Compound. CAS No. 111394-45-7. Molecular formula: C17H18O5. Mole weight: 302.32. Purity: 0.96. IUPACName: 5-[(Z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-2,3-dimethoxyphenol. Density: 1.251g/cm³. Product ID: ACM111394457. Alfa Chemistry ISO 9001:2015 Certified. | |
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