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| Product | Description | |
|---|---|---|
| Combretastatin | Combretastatin is a dihydrostilbenoid that found in Combretum caffrum. Members of the combretastatin family shows varying ability to cause vascular disruption in tumors. Combretastatin can bind to the β-subunit of tubulin. It is a tubulin polymerisation inhibitor and can be used for the treatment of tumor. Uses: Tumor. Synonyms: COMBRETASTATIN;(R)-(-)-Combretastatin;(R)-3-Hydroxy-4-methoxy-α-(3,4,5-trimethoxyphenyl)benzeneethanol;2-Methoxy-5-[(βR)-β-hydroxy-3,4,5-trimethoxyphenethyl]phenol;5-[(R)-2-Hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol. Grades: 95%. CAS No. 82855-09-2. Molecular formula: C18H22O6. Mole weight: 337.37. |  |
| Combretastatin A-1 | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 109971-63-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121993. |  |
| Combretastatin A1 phosphate | Combretastatin A1 phosphate (Oxi4503; CA1P; Combretastatin A1 diphosphate) is a potent vascular disruptive agent. Combretastatin A1 phosphate exerts anti-angiogenic effects on tumors. Combretastatin A1 phosphate has the potential for the research of pancreatic neuroendocrine tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Oxi4503; CA1P; Combretastatin A1 diphosphate. CAS No. 288847-35-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16147. | |
| Combretastatin A4 | Combretastatin A4. Group: Biochemicals. Grades: Purified. CAS No. 117048-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Combretastatin A4 | Combretastatin A4 is a microtubule -targeting agent that binds β-tubulin with K d of 0.4 μM. Uses: Scientific research. Group: Natural products. Alternative Names: CRC 87-09. CAS No. 117048-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2146. | |
| Combretastatin A4 phosphate disodium salt | Combretastatin A4 phosphate disodium salt. Group: Biochemicals. Alternative Names: 2-Methoxy-5-[ (1Z) -2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol 1-(dihydrogen phosphate) sodium salt; CA 4P. Grades: Highly Purified. CAS No. 168555-66-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H19Na2O8P. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 Phosphate, Disodium Salt (CA 4P) | Phosphorylated, Combretastatin a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Indu. Group: Biochemicals. Alternative Names: CA 4P. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Combretastatin A-4 ( (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4) | Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Inducer. Group: Biochemicals. Alternative Names: (Z) -2-Methoxy-5-[2- (3, 4, 5-trimethoxyphenyl) ethenyl]phenol, 3,4,5-Trimethoxy-3-hydroxy-4-methoxy-(Z)-stilbene, CS-A4. Grades: Highly Purified. CAS No. 117048-59-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Combretastatin b-3 | Heterocyclic Organic Compound. CAS No. 116518-76-4. Catalog: ACM116518764. |  |
| Combretastatin d1 | Heterocyclic Organic Compound. CAS No. 117709-78-1. Molecular formula: C18H16O5. Mole weight: 312.32. Density: 1.305. Catalog: ACM117709781. | |
| Combretastatin d2 | Heterocyclic Organic Compound. CAS No. 126191-23-9. Molecular formula: C18H16O4. Mole weight: 296.32. Density: 1.22. Catalog: ACM126191239. | |
| 1,2-Benzenediol,3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]- | Heterocyclic Organic Compound. Alternative Names: COMBRETASTATIN A1;(Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol;Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol );(Z)-3,4,4',5-Tetramethoxy-2',3'-dihydroxystilbene;(Z)-3',4,4',5'-Tetramethoxystilbene-2,3-dio. CAS No. 109971-63-3. Molecular formula: C18H20O6. Mole weight: 332.3478. Purity: 0.96. IUPACName: 3-methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol. Density: 1.251 g/cm³. Catalog: ACM109971633. | |
| 3-Bromo-4-methoxyaniline | 3-Bromo-4-methoxyaniline is an intermediate used to prepare triazole analogs of combretastatin A-4 as cytotoxic agents and inhibitors of tubulin. It is also used in the synthesis of (1, 2, 4-oxadiazolyl) biphenylcarbonyltetra hydrospiro [furo] indolepiperidine (SB-224289) as selective 5-HT1B receptor inverse agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 19056-41-8. Pack Sizes: 500mg, 1g. Molecular Formula: C7H8BrNO, Molecular Weight: 202.05. US Biological Life Sciences. | Worldwide |
| 3-Methoxycatechol | 3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934-00-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 25 g. Product ID: HY-W116576. | |
| Fosbretabulin | Fosbretabulin, also called as CA4P, has antitumor activity against anaplastic thyroid cancer (ATC) cell lines. Fosbretabulin, a novel water-soluble vascular-disrupting agent, is a phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum). Synonyms: [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate; 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene; CA4DP; combretastatin A-4; 168555-66-6 (fosbretabulin disodium); 82855-09-2 (combretastatin); 117048 -59-6 (combretastatin A4). Grades: >98%. CAS No. 222030-63-9. Molecular formula: C18H21O8P. Mole weight: 396.33. | |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Synonyms: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. | |
| Nitrilotriacetic acid | Nitrilotriacetic acid (NTA) is the aminopolycarboxylic acid with the formula N(CH2CO2H)3. It is a colourless solid that is used as a chelating agent, which forms coordination compounds with metal ions (chelates) such as Ca2+, Cu2+, and Fe3+. Group: Heterocyclic organic compound. Alternative Names: Triglycollamic Acid;Nitrilotriacetic Acid;N,N-Bis(carb;Glycine, N,N-bis(carboxymethyl)-;combretastatin A2. CAS No. 139-13-9. Molecular formula: C6H9NO6. Mole weight: 191.14. Appearance: White powder. Density: 1.61 g/cm³. ECNumber: 205-355-7. Catalog: ACM139139. | |
| Ombrabulin | Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. Synonyms: AVE8062; AVE 8062; AC-7700; AC 7700; AC7700; CS-39-L-Ser.HCl; AVE-8062A; AVE-8062; RPR-258062A; RPR 258062A. CAS No. 181816-48-8. Molecular formula: C21H26N2O6. Mole weight: 402.45. | |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Synonyms: OXi4503; OXi 4503; CA1P; tetrasodium [3-methoxy-2-phosphonatooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate. Grades: >98%. CAS No. 288847-35-8. Molecular formula: C18H22O12P2. Mole weight: 492.31. | |
| Phenol,2-methoxy-5-[(1Z)-2-(7-methoxy-1,3-benzodioxol-5-yl)ethenyl]- | Heterocyclic Organic Compound. Alternative Names: (Z)-2-Methoxy-5-(2-(7-Methoxy-Benzo[D][1,3]Dioxol-5-Yl)Vinyl)Phenol;combretastatin A-2;2-Methoxy-5-[(Z)-2-(7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenol. CAS No. 111394-44-6. Molecular formula: C17H16O5. Mole weight: 300.3059. Purity: 0.96. IUPACName: 2-methoxy-5-[(E)-2-(7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenol. Density: 1.304 g/cm³. Catalog: ACM111394446. | |
| STA-9584 | STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P). It is noteworthy that histological analysis revealed that STA-9584 disrupted microvasculature at both the center and periphery of tumors. Compared with CA4P, STA-9584 induced a 73% increase in central necrotic area, 77% decrease in microvasculature, and 7-fold increase in tumor cell apoptosis in the remaining viable rim 24 h post-treatment. Ultrasound imaging confirmed that STA-9584 rapidly and efficiently blocked blood flow in highly perfused tumor regions. Moreover, cardiovascular effects were evaluated in the Langendorff assay and telemetered dogs, and cardiovascular toxicity was not predicted to be dose-limiting. This bioactivity profile distinguishes STA-9584 from the combretastatin class and identifies the compound as a promising new therapeutic VDA candidate. Synonyms: STA 9584; STA9584. CAS No. 906481-23-0. Molecular formula: C28H30ClN3O6. Mole weight: 540.01. | |
| (Z)-5-(3-Hydroxy-4-methoxystyryl)-2,3-dimethoxyphenol | Heterocyclic Organic Compound. Alternative Names: combretastatins A-3; Combretastatin A3. CAS No. 111394-45-7. Molecular formula: C17H18O5. Mole weight: 302.32. Purity: 0.96. IUPACName: 5-[(Z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-2,3-dimethoxyphenol. Density: 1.251g/cm³. Catalog: ACM111394457. | |
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