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| Product | Description | |
|---|---|---|
| SARS coronavirus main proteinase | SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. In peptidase family C30. Group: Enzymes. Synonyms: 3cLpro; 3C-like protease; coronavirus 3C-like protease; Mpro; SARS 3C-like protease; SARS coronavirus 3CL protease; SARS coronavirus main peptidase; SARS coronavirus main protease; SARS-CoV 3CLpro enzyme; SARS-CoV main protease; SARS-CoV Mpro; severe acute respiratory syndrome coronavirus main protease. Enzyme Commission Number: EC 3.4.22.69. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4245; SARS coronavirus main proteinase; EC 3.4.22.69; 3cLpro; 3C-like protease; coronavirus 3C-like protease; Mpro; SARS 3C-like protease; SARS coronavirus 3CL protease; SARS coronavirus main peptidase; SARS coronavirus main protease; SARS-CoV 3CLpro enzyme; SARS-CoV main protease; SARS-CoV Mpro; severe acute respiratory syndrome coronavirus main protease. Cat No: EXWM-4245. |  |
| 2',3',5'-Tri-O-benzoyl-2'-b-C-methyl-6-azauridine | 2',3',5'-Tri-O-benzoyl-2'-b-C-methyl-6-azauridine, a powerful antiviral drug efficacious in curing a wide range of viral infections, from hepatitis C to coronavirus, manifests its mechanism of action through the obstruction of the viral replication process, prompting a decrease in disease acuteness and propagation. Exhaustive clinical trials unanimously attest to the efficacy and potency of the drug, which, primarily applied in the biomedical industry, serves as the cornerstone of the drive to innovate new antiviral remedies. Synonyms: (2R,3R,4R,5R)-5-((Benzoyloxy)methyl)-2-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate; 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-6-azauridine; 2-(2,3,5-Tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione. Grade: ≥95%. CAS No. 622379-83-3. Molecular formula: C30H25N3O9. Mole weight: 571.53. |  |
| 2'-Deoxy-2'-methylcytidine | 2'-Deoxy-2'-methylcytidine, a remarkable compound employed within the biomedical sector, boasts remarkable potency as an antiviral agent. Its efficacy extends to combating a multitude of RNA viruses, encompassing both flaviviruses and coronaviruses, rendering it indispensable in the creation of therapeutic antiviral medications to tackle afflictions like hepatitis C, Zika virus infection, and COVID-19. Synonyms: 2'-Methyl-2'-deoxycytidine; 2/'-Methyl-2/'-deoxycytidine; 4-amino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one; 2',2'-Dmc; 2'-Deoxy-2'-methylcytidine; 2-C-Ethynyl-cytidine; 2'C-Me-dC; 4-amino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidin-2-one; 4-Amino-1-[(2R,3R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methyl-Tetrahydrofuran-2-Yl]Pyrimidin-2-One; 4-Amino-1-[(2R,3R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methyl-2-Tetrahydrofuranyl]-2-Pyrimidinone; 4-Amino-1-[(2R,3R,4S,5R)-4-Hydroxy-3-Methyl-5-Methylol-Tetrahydrofuran-2-Yl]Pyrimidin-2-One. CAS No. 115494-53-6. Molecular formula: C10H15N3O4. Mole weight: 241.24. | |
| 2'-Deoxyguanylyl-(3'-5')-2'-deoxycytidine | 2'-Deoxyguanylyl-(3'-5')-2'-deoxycytidine, a nucleotide analog, serves as an efficacious treatment for an array of viral infections with proven antiviral activities against RNA viruses, including hepatitis C and coronavirus. It is known to operate through mimicking natural nucleotides crucial for viral RNA synthesis, thereby obstructing viral replication. Highly potent, it acts as an excellent inhibitor of viral RNA-dependent RNA polymerases, making it a formidable weapon against some of the most debilitating viral diseases. Synonyms: dGpdC DNA Dinucleotide (5'-3'); d(Gpc). Grade: ≥95% by AX-HPLC. CAS No. 23405-83-6. Molecular formula: C19H25N8O10P. Mole weight: 556.40. | |
| 4'-O-Methylbavachalcone | 4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 20784-60-5. Molecular formula: C21H22O4. Mole weight: 338.4. Purity: 0.9985. Canonical SMILES: O=C(C1=CC(C/C=C(C)\C)=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2. Product ID: ACM20784605. Alfa Chemistry ISO 9001:2015 Certified. Categories: CHEBI:85123. |  |
| 5-Iodo-2'-C-methylcytidine | 5-Iodo-2'-C-methylcytidine, an indispensable compound within biomedicine, encompasses formidable antiviral and antineoplastic attributes. Renowned for its unique nucleoside analogue nature, this compound finds extensive employment in pharmaceutical advancements targeting RNA viruses such as coronaviruses, flaviviruses, and retroviruses. Its unparalleled configuration and intricately orchestrated mechanism of action render it a propitious contender in the battle against diverse viral infections and specific malignancies. Synonyms: 5-Iodo-2'-C-methyl-1-β-D-ribofuranosylcytosine; 5-Iodo-2'-C-methyl Cytidine; 5-Iodo-2'-β-C-methyl cytidine; 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-5-iodopyrimidin-2-one. Grade: ≥95%. CAS No. 2072145-60-7. Molecular formula: C10H14IN3O5. Mole weight: 383.14. | |
| 5-(N,N-Hexamethylene)-amiloride | 5-(N,N-Hexamethylene)-amiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. Synonyms: Hexamethylene amiloride; HMA. Grade: 0.98. CAS No. 1428-95-1. Molecular formula: C12H18ClN7O. Mole weight: 311.77. | |
| 5-(N,N-Hexamethylene)-amiloride | 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na + /H + exchanger inhibitor, which decreases the intracellular pH (pH i ) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC 50 s of 3.91 μM and 1.34 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hexamethylene amiloride; HMA. CAS No. 1428-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128067. |  |
| 6-Hydroxycytidine | 6-Hydroxycytidine is a remarkable nucleoside analog with potent antiviral properties, emerging as a prospective compound in the research of various viral strains encompassing coronaviruses, influenza viruses and even the notorious hepatitis C virus. Its mode of action entails the inhibition of viral RNA research and development. CAS No. 15477-67-5. Molecular formula: C9H13N3O6. Mole weight: 259.22. | |
| 6-Thioguanine | 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Thioguanine; 2-Amino-6-purinethiol. CAS No. 154-42-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13765. | |
| 6-Thioguanine (Standard) | 6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases ( PLpros ) and also potently inhibits USP2 activity, with IC 50 s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. Uses: Scientific research. Group: Natural products. CAS No. 154-42-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13765R. | |
| 8-Cl-dGuo | 8-Cl-dGuo, an anti-RNA virus crusader, is a nucleoside of robust antiviral power. Employed in treating life-threatening hepatitis C and coronavirus, it exercises the incredible ability of obstructing viral RNA replication. With a track record of reining in multiple viral strains, 8-Cl-dGuo, thanks to its singular structural features, is a forerunner in directing medicines to infected cells, shielding healthy tissues from toxicity. Synonyms: 8- Chloro- 2'- deoxyguanosine. Grade: ≥ 96% by HPLC. CAS No. 437716-62-3. Molecular formula: C10H12ClN6O4. Mole weight: 301.7. | |
| Adintrevimab | Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV ( SARS-CoV ) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ADG 20. CAS No. 2516243-54-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99423. | |
| Amantadine | Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2 , and also inhibits Coronavirus ion channels. Amantadine also has anti- orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Adamantanamine; 1-Aminoadamantane. CAS No. 768-94-5. Pack Sizes: 500 mg. Product ID: HY-B0402. | |
| Amantadine hydrochloride | Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2 , and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti- orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride. CAS No. 665-66-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g; 50 g. Product ID: HY-B0402A. | |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grade: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Ansabananin | Ansabananin is a weak inhibitor of the ATPase activity of the SARS Coronavirus helicase, with an IC50 value of 51 μM. Synonyms: Ansabananin|HY-145116. Grade: ≥98% (HPLC). Molecular formula: C33H67N2Na3O29. Mole weight: 1550.31. | |
| Anti-virus agent 1 | Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Remdesivir isopropyl ester analog. CAS No. 1911578-83-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131233. | |
| Bemnifosbuvir | Bemnifosbuvir is the precursor drug form of the antiviral nucleoside analogue AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 μM, respectively). Synonyms: propan-2-yl N-[(P5'S,2'R)-2-amino-2'-deoxy-2'-fluoro-N6,2'-dimethyl-OP-phenyl-5'-adenylyl]-L-alaninate; AT-511; N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-L-alanine, 1-methylethyl ester. Grade: 98%. CAS No. 1998705-64-8. Molecular formula: C24H33FN7O7P. Mole weight: 581.53. | |
| Bemnifosbuvir hemisulfate | Bemnifosbuvir is the precursor drug form of the antiviral nucleoside analogue AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 μM, respectively). Synonyms: RG-6422; RO 7496998; AT-527; AT 527; AT527. Grade: 99.33%. CAS No. 2241337-84-6. Molecular formula: C24H33FN7O7P.1/2H2O4S. Mole weight: 679.61. | |
| Benzotriazol-1-ylacetic Acid | Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N- (benzo[1, 2, 3]triazol-1-yl) -N- ( (benzyl) acetamido) phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 4144-64-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H7N3O2. US Biological Life Sciences. |  Worldwide |
| Camostat Mesylate | Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor. Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. It reduces weight gain and improves metabolism in obese rodent models. It is in clinical use (in Japan) for pancreatitis. Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming. Group: Biochemicals. Alternative Names: 4- [ [4- [ (Aminoiminomethyl) amino] benzoyl] oxy] benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY 305; FOY-S 980; Foipan. Grades: Highly Purified. CAS No. 59721-29-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| CDK9-IN-34 | CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC 50 of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC 50 of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC 50 of 145.92 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 252725-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164619. | |
| Cepharanthine | Cepharanthine is a natural product isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activity. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46?μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: o-Methylcepharanoline. Product Category: Inhibitors. Appearance: Solid. CAS No. 481-49-2. Molecular formula: C37H38N2O6. Mole weight: 606.71. Purity: 0.98. IUPACName: (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene. Canonical SMILES: CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3. Product ID: ACM481492. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration ( IC 50 ) and 90% inhibitory concentration ( IC 90 ) values of 1.90 and 4.46?μM [1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model [2] [3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N6972. | |
| Cinanserin hydrochloride | Cinanserin hydrochloride is the hydrochloride salt of cinanserin, which is a 5-HT2 antagonist and an inhibitor of GPVI-mediated cell activation. It also acts as an inhibitor of CRP-XL- and collagen-induced Ca2+ release and aggregation. It is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus, and it strongly reduces virus replication in vitro. Uses: Serotonin antagonists. Synonyms: Cinanserin HCl; Cinanserin Hydrochloride; SQ-10643; SQ 10643; SQ10643; NSC-125717; NSC 125717; NSC125717; (E)-N-[2-[3-(Dimethylamino)propylsulfanyl]phenyl]-3-phenylprop-2-enamide hydrochloride; N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide Hydrochloride; MAPTC; SQ 10643; 2'-[[3-(Dimethylamino)propyl]thio]cinnamanilide Hydrochloride. Grade: ≥99% by HPLC. CAS No. 54-84-2. Molecular formula: C20H25N2OSCl. Mole weight: 376.94. | |
| Cinanserin hydrochloride | Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT 2 receptor antagonist with a K i of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT 2 than for the 5-HT 1 receptor ( K i of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SQ 10643. CAS No. 54-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100943. | |
| Cinanserin hydrochloride | Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DPTC;DPTC HYDROCHLORIDE;CINANSERIN;CINANSERIN HYDROCHLORIDE;2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE. Product Category: Inhibitors. CAS No. 54-84-2. Molecular formula: C20H25ClN2OS. Mole weight: 376.94. Purity: 0.9974. Product ID: ACM54842. Alfa Chemistry ISO 9001:2015 Certified. | |
| Coronastat | Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. Coronastat represents a new candidate for a small molecule protease inhibitor for the treatment of SARS-CoV-2 infection for eliminating pandemics involving coronaviruses. Synonyms: NK01-63. CAS No. 2922281-15-8. Molecular formula: C22H29F3N3NaO8S. Mole weight: 575.53. | |
| CovidyteTM ED450 | CovidyteTM ED450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 336, emission at 455 nm). Synonyms: EDANS-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(DABCYL)-Met-OH. Molecular formula: C82H125N23O22S2. Mole weight: 1849.14. | |
| CovidyteTM EN450 | CovidyteTM EN450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 350, emission at 460 nm). Synonyms: H-Lys(DABCYL)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42. | |
| CovidyteTM IF670 | CovidyteTM IF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and iFluorTM 670 as a fluorescent donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of iFluorTM 670 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the iFluorTM 670 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of iFluorTM 670 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. Compared to commonly used EDANS substrates, such as CovidyteTM ED450, the iFluorTM 670 substrate has stronger and longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 656, emission at 670 nm). Synonyms: H-Cys(iFluor 647)-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(TQ5)-Met-OH. Molecular formula: C58H105N19O19S2 + dye. Mole weight: 3068. | |
| CovidyteTM TF670 | CovidyteTM TF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and Tide FluorTM 5 (TF5) as a fluorescence donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of TF5 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the TF5 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of TF5 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. TQ5-TF5 pair has proved to be an extremely effective FRET pair for the development of FRET protease substrates. Compared to commonly used EDANS substrates, such as CovidyteTM EN450, the TF670 substrate has stronger, longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 640, emission at 680 nm). Synonyms: H-Lys(TQ5)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-Cys(TF5)-OH. Molecular formula: C71H121N21O22S2 + dye. Mole weight: 3620. | |
| DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS | DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS. Synonyms: DABCYL-Lys-pp1ab (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS); DABCYL-Lys-ORF1AB (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS). CAS No. 730985-86-1. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42. | |
| EIDD-1931 | EIDD-1931 is a ribonucleoside analog that exhibits potential antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-1931 induces mutations in RNA virions, inhibiting SARS-CoV-2 and other coronavirus in mice and human airway epithelial cells. Synonyms: N4-Hydroxycytidine; N(4)-Hydroxycytidine; Uridine, 4-oxime; Beta-D-N4-hydroxycytidine. Grade: 99.73%. CAS No. 3258-2-4. Molecular formula: C9H13N3O6. Mole weight: 259.22. | |
| Emodin | Emodin (Frangula emodin), an anthraquinone derivative, is an anti- SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction [1]. Emodin inhibits casein kinase-2 ( CK2 ). Anti-inflammatory and anticancer effects [2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC 50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Frangula emodin. CAS No. 518-82-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-14393. | |
| Emodin | Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3,8-trihydroxy-6-methylanthraqunone. Product Category: Inhibitors. Appearance: Powder. CAS No. 518-82-1. Molecular formula: C15H10O5. Mole weight: 270.24. Purity: 0.98. IUPACName: 1,3,8-Trihydroxy-6-methylanthracene-9,10-dione. Canonical SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O. Density: 1.33 g/ml. Product ID: ACM518821-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Emodin-d4 | Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Emodin-d4;1,3,8-Trihydroxy-6-Methyl-9,10-anthracenedione-d4;1,6,8-Trihydroxy-3-Methylanthraquinone-d4;4,5,7-Trihydroxy-2-Methyl- anthraquinone-d4;Archin-d4;EModol-d4;Frangula EModin-d4;Frangulic Acid-d4. Product Category: Inhibitors. Appearance: Brownish Solid. CAS No. 132796-52-2. Molecular formula: C15H10O5. Mole weight: 270.2369. Purity: 0.96. IUPACName: 1,3,6,8-tetradeuterio-2,4,5-trihydroxy-7-methylanthracene-9,10-dione. Canonical SMILES: O=C1C2=C(O)C([2H])=C(C)C([2H])=C2C(C3=C([2H])C(O)=C([2H])C(O)=C31)=O. Product ID: ACM132796522. Alfa Chemistry ISO 9001:2015 Certified. | |
| Eubananin | Eubananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus (SCV) helicase. Synonyms: Eubananin; CHEMBL4759473; AKOS040758390; HY-145118; CS-0356492; 858956-98-6. CAS No. 858956-98-6. Molecular formula: C24H29NO10. Mole weight: 491.49. | |
| GC376 sodium | GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency against FIPV in cell culture. GC376 inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM. Synonyms: GC376 sodium; GC 376 sodium; GC-376 sodium; (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate sodium. Grade: ≥98% (HPLC). CAS No. 1416992-39-6. Molecular formula: C21H30N3NaO8S. Mole weight: 507.53. | |
| GS-441524 | GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC 50 of 0.78 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191237-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103586. | |
| HCoV-OC43-IN-1 | HCoV-OC43-IN-1 (Compound IV-16) is a coronavirus HCoV-OC43 inhibitor. HCoV-OC43-IN-1 has antiviral efficacy (EC 50 : 90 nM). HCoV-OC43-IN-1 inhibits the mRNA level and expression of viral nucleocapsid protein (NP) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2809363-81-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156346. | |
| Ibuzatrelvir | Ibuzatrelvir (PF-07817883), a second-generation, orally bioavailable, is SARS-CoV-2 main protease ( M pro and 3CL pro ) inhibitor with improved metabolic stability. Ibuzatrelvir has demonstrated pan-human coronavirus antiviral activity and off-target selectivity profile in vitro and in preclinical animal studies. Ibuzatrelvir is well tolerated with a safety profile similar to placebo and prevents viral infection and transmission. Ibuzatrelvir can be used to inhibit COVID-19 [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-07817883. CAS No. 2755812-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156654. | |
| MERS-CoV-IN-1 | MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245697-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139908. | |
| Molnupiravir | Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses , such as SARS-CoV-2 , MERS-CoV , SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EIDD-2801; MK-4482. CAS No. 2492423-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-135853. | |
| Nelfinavir Mesylate (AG-1343, AG1343, Viracept) | Nelfinavir is a potent competitive inhibitor of the HIV-1 protease. It is reported that it can also inhibit the growth of various cell types and trigger apoptosis. Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19. Group: Biochemicals. Alternative Names: AG-1343, AG1343, Viracept; (3S, 4aS, 8aS)-N-tert-butyl-2-[(2R, 3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3, 4, 4a, 5, 6, 7, 8, 8a-octahydro-1H-isoquinoline-3-carboxamide; methanesulfonic acid. Grades: Highly Purified. CAS No. 159989-65-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S? , Molecular Weight: 663.89. US Biological Life Sciences. | Worldwide |
| Olgotrelvir sodium | Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin ( Cathepsin L ). Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI-1558 sodium. CAS No. 2763596-72-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156655A. | |
| Plitidepsin | Plitidepsin. Uses: Designed for use in research and industrial production. Product Category: Coronavirus and Solid Tumor Clinical Raw Materials. CAS No. 137219-37-5. Purity: >98%. Product ID: ACM137219375. Alfa Chemistry ISO 9001:2015 Certified. | |
| Romlusevimab | Romlusevimab (BRII-198) is a neutralizing recombinant human IgG1 monoclonal antibody against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BRII-198. CAS No. 2509447-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99889. | |
| SARS-CoV-2 nsp3-IN-1 | SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 ( SARS-CoV-2 nsp3 macrodomain ) inhibitor with the IC 50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2892105-43-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150062. | |
| SARS-CoV-IN-1 | SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC 50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 15.4 and 133.2 nM; and IC 90 s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-135855. | |
| SARS-CoV-IN-2 | SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC 50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 21.5 and 30 nM; and IC 90 s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1 -induced cytopathic effect with an EC 50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-26-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-135856. | |
| SARS-CoV-IN-3 | SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC 50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 11.7 and 20.4 nM; and IC 90 s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1 -induced cytopathic effect with an EC 50 of 10 μM in MT-4 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-27-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-135858. | |
| Tanshinlactone | Tanshinlactone is a seco-abietanoid that can be isolated from Salvia miltiorrhiza. Tanshinlactone is a coronavirus (CoV) inhibitor. Tanshinlactone modulates interleukin-2 and interferon-γ gene expression. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 105351-70-0. Molecular formula: C17H12O3. Mole weight: 264.3. Purity: 0.98. Canonical SMILES: CC1=CC=CC2=C1C=CC3=C2C(=O)OC4=C3OC=C4C. Product ID: ACM105351700-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Thapsigargin | Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca 2+ -ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 67526-95-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13433. | |
| Thapsigargin | Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types. Uses: Designed for use in research and industrial production. Additional or Alternative Names: THAPSIGARGIN;Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester;(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azul. Product Category: Inhibitors. Appearance: liquid or film. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. Purity: 0.95. IUPACName: [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl]octanoate. Canonical SMILES: CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O. ECNumber: 614-076-3. Product ID: ACM67526958. Alfa Chemistry ISO 9001:2015 Certified. | |
| Tocilizumab | Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor ( IL-6R ) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis [1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL6R, Humanized Antibody. CAS No. 375823-41-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9917. | |
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