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Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors ( nAChR ) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Cotinine; (S)-Cotinine; NIH-10498. CAS No. 486-56-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1178.
Cotinine-d3 N- β-D-Glucuronide
A major metabolite of Nicotine in humans. Carcinogen. Group: Biochemicals. Alternative Names: 1- β -D-Glucopyranuronosyl-3- [ (2S) -1- (methyl-d3) -5-oxo-2-pyrrolidinyl] pyridinium Inner Salt; (Cotinine-d3)-N-glucuronide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: 1-Trideuteromethyl-5-(3-pyridiyl)-2-pyrrolidinone. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Cotinine N-(4-deoxy-4,5-didehydro)-b-D-glucuronide, a remarkable biomedicine employed for investigating nicotine metabolism's impact on human health, embodies this rewritten product description. It serves as a valuable tool to unravel the intricate intricacies of nicotine pharmacokinetics and elimination, shedding light on its potential involvement in multifarious ailments like tobacco-related disorders and drug addiction. Synonyms: N-(b-D-4-Deoxy-4,5-didehydroglucopyranosyl)uronate, cotinium inner salt. CAS No. 146275-15-2. Molecular formula: C16H18N2O6. Mole weight: 334.32.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: N- (ß-D-4-Deoxy-4, 5-dide hydroglucopyranosyl) uronate, Cotinium Inner Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Cotinine-N-a-D-glucuronide (CNG)
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: CNG. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: CNGN-b-D-glucopyranuronosyl-(s)-(-)-cotinium inner salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Cotinine N-β-D-Glucuronide
Cotinine N-β-D-Glucuronide is a major metabolite of Nicotine in humans. Synonyms: 1-β-D-Glucopyranuronosyl-3-[(2S)-1-methyl-5-oxo-2-pyrrolidinyl]pyridinium Inner Salt; Cotinine-N-glucuronide. Grades: > 95%. CAS No. 139427-57-9. Molecular formula: C16H20N2O7. Mole weight: 352.34.
Cotinine-N-b-glucuronide-D3
Cotinine-N-b-glucuronide-D3 is a deuterated variant of Cotinine-N-b-glucuronide. Its utilization lies in the meticulous examination and identification of cotinine, an essential biomarker employed for assessing nicotine exposure. Being a metabolite generated through glucuronidation of cotinine in the liver, this compound greatly contributes to the scientific exploration of areas such as nicotine addiction, the cessation of smoking as well as the evaluation of outcomes pertaining to passive smoking. Molecular formula: C16H17N2O7D3. Mole weight: 355.36.
1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide is a significant metabolite of nicotine. It is mainly used in the study and development of nicotine metabolism and smoking-related diseases, also aiding in biochemical analyses of tobacco exposure levels. Synonyms: trans-3'-Hydroxycotinine-O-glucuronide; (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(3R,5S)-1-methyl-2-oxo-5-pyridin-3-ylpyrrolidin-3-yl]oxyoxane-2-carboxylic acid; N-(trans-3-Hydroxycotinine)-b-D-glucuronide; trans-3'-Hydroxy cotinine N-beta-D-glucuronide; beta-D-Glucopyranosiduronic acid, (3R,5S)-1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl; 3HC-Gluc; 3'-Hydroxycotnine-glucuronide; 132929-88-5 free base; DTXSID40157860; CHEBI:133206; trans-3-hydroxycotinine beta-D-glucuronide; trans-3'-Hydroxy Cotinine O-?-D-Glucuronide; W-201293; 1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium; (3R,5S)-1-methyl-2-oxo-5-(pyridin-3-yl)pyrrolidin-3-yl beta-D-glucopyranosiduronic acid; (2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-(((3R,5S)-1-methyl-2-oxo-5-(pyridin-3-yl)pyrrolidin-3-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid; beta-D-Glucopyranosiduronic acid, 1-methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl, (3R-trans)-. CAS No. 132929-88-5. Molecular formula: C16H20N2O8. Mole weight: 368.34.
(2S)-trans-4-Cotininecarboxylic Acid
(2S)-trans-4-Cotininecarboxylic Acid is used as hapten clustering as strategy to enhance vaccines against drugs of abuse as reagent/reactant. Group: Biochemicals. Grades: Highly Purified. CAS No. 33224-01-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C11H12N2O3, Molecular Weight: 220.22. US Biological Life Sciences.
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3,3-Dibromo Cotinine
3,3-Dibromo Cotinine is a derivative of Cotinine, which is currently being used to treat depression, PTSD, schizophrenia, Alzheimer's disease and Parkinson's disease. Synonyms: (S)-3,3-Dibromo-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone; 3,3-Dibromocotinine. Grades: ≥90%. CAS No. 74093-56-4. Molecular formula: C10H10Br2N2O. Mole weight: 334.01.
A metabolite of both nicotine and cotinine. Group: Biochemicals. Alternative Names: cis-3-Hydroxycotinine. Grades: Highly Purified. CAS No. 37096-14-3. Pack Sizes: 5mg. US Biological Life Sciences.
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cis-3'-Hydroxy cotinine
cis-3'-Hydroxy cotinine. Group: Biochemicals. Alternative Names: (3S,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone; (3S-cis)-3-Hydroxycotinine. Grades: Highly Purified. CAS No. 37096-14-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C10H12N2O2. US Biological Life Sciences.
Worldwide
(-)-Cotinine
(-)-Cotinine. Group: Biochemicals. Grades: Purified. CAS No. 486-56-6. Pack Sizes: 50mg. US Biological Life Sciences.
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(+/-)-Cotinine-d3
Heterocyclic Organic Compound. CAS No. 110952-70-0. Molecular formula: C10H9D3N2O. Mole weight: 179.23. Purity: 98 atom % D. Catalog: ACM110952700.
Dibromo Cotinine Hydrobromide Perbromide
Dibromo Cotinine Hydrobromide Perbromide is a derivative of Cotinine, which is currently being used to treat depression, PTSD, schizophrenia, Alzheimer's disease and Parkinson's disease. Synonyms: 3,5-Dibromo-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone mono(hydrogen tribromide). Molecular formula: C10H11Br5N2O. Mole weight: 574.73.
N-(4-Methoxybenzyl)cotinine
Solubility: Chloroform, Dichloromethane, Methanol. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A derivative of cis-3'-Hydroxy Cotinine. Carcinogen. Group: Biochemicals. Alternative Names: rac cis-3-Hydroxy-1-methyl-2-pyrrolidinone-5-(3-pyridinyl)carboxylic Acid Methyl Ester; rel-5-[(2R,4R)-4-Hydroxy-1-methyl-5-oxo-2-pyrrolidinyl]-3-pyridinecarboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 1217778-14-7. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
rac cotinine
rac cotinine. Group: Biochemicals. Alternative Names: 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; (+/-)-Cotinine. Grades: Highly Purified. CAS No. 15569-85-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C10H12N2O. US Biological Life Sciences.
Worldwide
rac-Cotinine
A major metabolite of Nicotine in humans. Carcinogen. Group: Biochemicals. Alternative Names: 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; (+/-)-Cotinine. Grades: Highly Purified. CAS No. 15569-85-4. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
rac-Cotinine-13C,d3
A labeled major metabolite of nicotine in humans. Carcinogen. Group: Biochemicals. Alternative Names: (+/-)-1-(Methyl-13C,d3)-5-(2-pyridinyl)-2-pyrrolidinone; (+/-)-Cotinine-13C,d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
rac-Cotinine-d3. see C725005
A labelled major metabolite of Nicotine in humans. Carcinogen. Group: Biochemicals. Alternative Names: (+/-)-1-(Methyl-d3)-5-(2-pyridinyl)-2-pyrrolidinone; (+/-)-Cotinine-d3. Grades: Highly Purified. CAS No. 110952-70-0. Pack Sizes: 10mg. US Biological Life Sciences.
A derivative of trans-3'-Hydroxy Cotinine. Carcinogen. Group: Biochemicals. Alternative Names: rac trans-3-Hydroxy-1-methyl-2-pyrrolidinone-5-(3-pyridinyl)carboxylic Acid Methyl Ester; rel-5-[(2R,4S)-4-Hydroxy-1-methyl-5-oxo-2-pyrrolidinyl]-3-pyridinecarboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 1217641-50-3. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
rac trans-3'-Hydroxy Cotinine-3-carboxylic Acid (Mixture of Diastereomers)
A derivative of trans-3'-Hydroxy Cotinine. Carcinogen. Group: Biochemicals. Alternative Names: rac trans-3-Hydroxy-1-methyl-2-pyrrolidinone-5-(3-pyridinyl)carboxylic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
rac trans-4-cotinine carboxylic acid
rac trans-4-cotinine carboxylic acid. Group: Biochemicals. Alternative Names: (2R,3R)-rel-1-methyl-5-oxo-2-(3-pyridinyl)-3-pyrrolidinecarboxylic acid; (+/-)-trans-4-Cotininecarboxylic acid. Grades: Highly Purified. CAS No. 161171-06-8. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C11H12N2O3. US Biological Life Sciences.
Worldwide
rac trans-4-Cotinine Carboxylic Acid Methyl Ester
Cotinine derivative. A chemokine receptor. Group: Biochemicals. Alternative Names: (2R,3R)-rel-1-Methyl-5-oxo-2-(3-pyridinyl)-3-pyrrolidinecarboxylic Acid Methyl Ester; trans-1-Methyl-5-oxo-2-(3-pyridinyl)-3-pyrrolidinecarboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 135028-97-6. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
R-(+)-Cotinine
R-(+)-Cotinine. Group: Biochemicals. Alternative Names: (5R)-(+)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone; (+)-Cotinine; (R)-Cotinine. Grades: Highly Purified. CAS No. 32162-64-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C10H12N2O. US Biological Life Sciences.
This is the unnatural isomer of Cotinine. Group: Biochemicals. Alternative Names: (5R)-(+)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone. Grades: Highly Purified. CAS No. 32162-64-4. Pack Sizes: 10mg. US Biological Life Sciences.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: CNGN-ß-D-glucopyranuronosyl-(r,s)-(-)-cotinium, Methyl-d3 inner salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
(R,S)-Cotinine N-Oxide-methyl-d3
An isotopically labeled metabolite of nicotine in humans. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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(R,S)-Norcotinine
(R,S)-Norcotinine is a metabolite of (+/-)-Cotinine. Synonyms: 5-(3-Pyridinyl)-2-pyrrolidinone; (+/-)-Demethylcotinine; (+/-)-Norcotinine. Grades: > 95%. CAS No. 17708-87-1. Molecular formula: C9H10N2O. Mole weight: 162.19.
A metabolite of nicotine in humans. Used for internal standardization for routine biomonitoring of nicotine metabolites. Group: Biochemicals. Alternative Names: 1-methyl-5-(2-pyridyl)-2-pyrrolidinone. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
S-(-)-Cotinine
S-(-)-Cotinine. Group: Biochemicals. Alternative Names: (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; (S)-(-)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone; (-)-Cotinine. Grades: Highly Purified. CAS No. 486-56-6. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C10H12N2O. US Biological Life Sciences.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: (5S)-(-)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone. Grades: Highly Purified. CAS No. 486-56-6. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
(S)-Cotinine N-Oxide
A major metabolite of nicotine in human. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
(S)-Cotinine N-Oxide
(S)-Cotinine N-Oxide is a major metabolite of Nicotine in humans. Synonyms: (5S)-1-Methyl-5-(1-oxido-3-pyridinyl)-2-pyrrolidinone; (-)-Cotinine N-oxide; 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone N-Oxide. Grades: > 95%. CAS No. 36508-80-2. Molecular formula: C10H12N2O2. Mole weight: 192.21.
trans-3-Benzoyloxy cotinine 2,3,4-tri-O-acetyl-N-b-D-glucuronide methyl ester bromide is a potent biomedical compound, emerging as a breakthrough tool in studying nicotine addiction and associated pathological conditions. By exerting a profound antagonistic influence on nicotine receptors, this astounding compound inhibits the indulgence of nicotine. Synonyms: (2S-trans)-3-[4-(Benzoyloxy)-1-methyl-5-oxo-2-pyrrolidinyl]-1-(2,3,4-tri-O-acetyl-6-methyl-b-D-glucopyranuronosyl)-pyridinium bromide. CAS No. 146490-58-6. Molecular formula: C30H33BrN2O12. Mole weight: 693.49.
trans-3-Hydroxy Cotinine
Cas No. 34834-67-8.
trans-3'-Hydroxy cotinine acetate
trans-3'-Hydroxy cotinine acetate. Group: Biochemicals. Alternative Names: (3R-trans)-3-(acetyloxy)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone; (3'R,5'S)-3'-Hydroxy cotinine acetate; Hydroxycotinine acetate. Grades: Highly Purified. CAS No. 111034-55-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C12H14N2O3. US Biological Life Sciences.
Worldwide
trans-3'-Hydroxy Cotinine Benzoate
Cotinine derivative. Carcinogen. Group: Biochemicals. Alternative Names: (3R-trans)-3-(Benzoyloxy)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone. Grades: Highly Purified. CAS No. 146275-16-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
trans-3'-Hydroxy Cotinine-d3 N- β-D-Glucuronide
It is a major labeled metabolite of Nicotine in humans. Group: Biochemicals. Alternative Names: 1- β -D-Glucopyranuronosyl-3- [ (2S, 4R) -4-hydroxy-1- (methyl-d3) -5-oxo-2-pyrrolidinyl] pyridinium. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A major metabolite of nicotine in humans. Group: Biochemicals. Alternative Names: Carboxy Cotinine. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences.
Worldwide
trans-Cotinine Amide
Cotinine derivative. Carcinogen. Group: Biochemicals. Alternative Names: (2R, 3R) -rel-1- methyl -5-oxo-2- (3-pyridinyl) -3-pyrrolidinecarboxamide . Grades: Highly Purified. CAS No. 939437-34-0. Pack Sizes: 10mg. US Biological Life Sciences.
Nicotine-1-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans. Group: Biochemicals. Alternative Names: (1S,2'S)-trans-Nicotine 1'-Oxide. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
(1S,2'S)-Nicotine 1'-Oxide and (1R,2'S)-Nicotine 1'-Oxide Mixture
Nicotine-1-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1-N-oxide (both diastereomers) or cotinine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
(2'S)-Nicotine 1-Oxide
Nicotine-1-N-oxide is a derivative of nicotine found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1-N-oxide has also been identified as metabolites of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 2820-55-5. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Ethyl 4-Oxo-4-(3-pyridyl)butanoate
Precursor of N-substituted cotinine analogues as well as norcotinine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
As a by-product intermediate during the synthesis of rac-trans-3'-Hydroxy Cotinine-d3 O-β-D-Glucuronide, Methyl 2,3,4-Tri-O-isobutyryl-1-O-trichloroacetimidoyl-β-D-glucopyranuronate is a labelled Nicotine metabolite. Carcinogen. Synonyms: (2S,3S,5R,6S)-2-(Methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate). Molecular formula: C21H30Cl3NO10. Mole weight: 562.82.
N-Methyl-g-oxo-3-pyridinebutanamide.
An metabolite of Cotinine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Fisetin
Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. Uses: Antimetastatic/anti-inflammatory. Synonyms: 3,3',4',7-Tetrahydroxyflavone; 5-Desoxyquercetin; Cotinin; Fiestin; Fietin; Fisetholz; Fisitin; Fustel; Fustet; Junger Ustik; NSC 407010; NSC 656275; Superfustel; Superfustel K; Ungarisches Gelbholz; Ventin Sumach; Viset; Zante Fustic; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one. Grades: ≥98%. CAS No. 528-48-3. Molecular formula: C15H10O6. Mole weight: 286.24.
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