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| Product | Description | |
|---|---|---|
| COX-2 Inhibitor I | An inhibitor of COX-2. Synonyms: Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate; LM-1685; LM 1685; LM1685. CAS No. 416901-58-1. Molecular formula: C18H16ClNO4S. Mole weight: 377.8. |  |
| COX-2 Inhibitor I - CAS 416901-58-1 | The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. |  |
| COX-2 Inhibitor I - CAS 416901-58-1 | The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 416901-58-1. Pack Sizes: 5MG. Mole weight: 377.84. Catalog: AP416901581. Assay: ?97% (HPLC). | |
| COX-2 Inhibitor II | A selective inhibitor of COX-2. Synonyms: SC-791; IN1371; 181696-33-3; 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide; SCHEMBL214781. CAS No. 181696-33-3. Molecular formula: C16H12F2N2O3S. Mole weight: 350.34. | |
| COX-2 Inhibitor II - CAS 181696-33-3 | The COX-2 Inhibitor II, also referenced under CAS 181696-33-3, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. | |
| COX-2 Inhibitor V, FK3311 | COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID. Group: Biochemicals. Grades: Highly Purified. CAS No. 116686-15-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H13F2NO4S, Molecular Weight: 341.33. US Biological Life Sciences. |  Worldwide |
| COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 | The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. | |
| 1,1,2-Triethoxyethane | 1,1,2-Triethoxyethane is an intermediate used to synthesize pyrazolopyrimidine derivatives as COX-2 selective inhibitors. It is also used to prepare [ (1, 2, 4-oxadiazolylphenoxy) alkyl]isoxazoles as antiviral agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 4819-77-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H18O3, Molecular Weight: 162.229999999999. US Biological Life Sciences. | Worldwide |
| 1-(4-Ethoxyphenyl)-3-methyl-4-hexen-1-one | 1-(4-Ethoxyphenyl)-3-methyl-4-hexen-1-one is an intermediate in synthesizing Apricoxib (A729850), which is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 1337994-12-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C15H20O2, Molecular Weight: 232.32. US Biological Life Sciences. | Worldwide |
| 1-(6-Methyl-1-oxido-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: Etoricoxib YY. Grade: ≥95%. CAS No. 1027162-35-1. Molecular formula: C15H15NO4S. Mole weight: 305.35. | |
| 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 3-[2-(4-(methylthio)phenyl)acetyl](6-methyl)pyridine; Ethanone, 1-(6-ethyl-3-yridinyl)-2-4-(methylthio)henyl]-; Etoricoxib Impurity P. Grade: ≥95%. CAS No. 221615-72-1. Molecular formula: C15H15NOS. Mole weight: 257.35. | |
| 1-Bromo-3,5-difluorobenzene | 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents. Group: Biochemicals. Alternative Names: 1,3-Difluoro-5-bromobenzene; 1-Bromo-3,5-difluorobenzene; 3,5-Difluoro-1-bromobenzene; 3,5-Difluorobromobenzene; 3,5-Difluorophenyl Bromide; 5-Bromo-1,3-difluorobenzene. Grades: Highly Purified. CAS No. 461-96-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 2-(4-Methanesulfonylphenyl)-1-pyridin-3-ylethanone | 2-(4-Methanesulfonylphenyl)-1-pyridin-3-ylethanone is an intermediate in synthesizing Desmethyl Etoricoxib (D296895), which is an impurity of Etoricoxib (E934100), a specific inhibitor of COX-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 40061-50-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C14H13NO3S. US Biological Life Sciences. | Worldwide |
| 2,5-Dimethylcelecoxib | 2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 457639-26-8. Pack Sizes: 1 mg. Product ID: HY-W010995. |  |
| 2,5-Dimethyl Celecoxib | A non-cyclooxygenase-2 inhibitor analog of Celecoxib. The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib. Group: Biochemicals. Alternative Names: 4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; DMC. Grades: Highly Purified. CAS No. 457639-26-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 15307-93-4. Molecular formula: C13H12N2OS. Mole weight: 238.11. Purity: 0.9971. Canonical SMILES: ClC1=C(NC2=CC=CC=C2)C(Cl)=CC=C1. Product ID: ACM15307934. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2,6-Dichloro-N-phenylaniline. |  |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti- Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,6-Dichloro-N-phenylaniline. CAS No. 15307-93-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W012126. | |
| 2-(6-Methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine; Etoricoxib C; 2,3'-Bipyridine, 6'-methyl-3-[4-(methylsulfonyl)phenyl]-. Grade: ≥95%. CAS No. 1350206-14-2. Molecular formula: C18H16N2O2S. Mole weight: 324.40. | |
| 2-Amino-3-Benzoyl-α-(Methylthio)benzeneacetamide | An impurity of Nepafenac, a COX-2 inhibitor used as an anti-inflammatory agent. Synonyms: 2-Amino-3-benzoyl-alpha-(methylthio)benzeneacetamide; 2-Amino-3-benzoyl-a-methylthio-phenylacetamide; Nepafenac Impurity B. Grade: 95%. CAS No. 78281-61-5. Molecular formula: C16H16N2O2S. Mole weight: 300.37. | |
| 2-Aminobenzophenone | 2-Aminobenzophenone is a derivative of Benzophenone, which is used in the manufacturing of antihistamines, hypnotics, insecticides. 2-Aminobenzophenone was shown to exhibit modulation activity of GABAA receptor-mediated currents in isolated purkinje neurons. 2-Aminobenzophenone is also an impurity of Nepafenac, a COX-2 inhibitor used as an anti-inflammatory agent. Synonyms: 2-Benzoylaniline; o-Benzoylaniline; o-Aminobenzophenone; Nepafenac Impurity A. Grade: 95%. CAS No. 2835-77-0. Molecular formula: C13H11NO. Mole weight: 197.23. | |
| 2-(Bromoacetyl)-6-methoxynaphthalene | 2-(Bromoacetyl)-6-methoxynaphthalene is used in the preparation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 10262-65-4. Pack Sizes: 100mg, 1g. Molecular Formula: C13H11BrO2, Molecular Weight: 279.13. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3-(phenylamino)-2-propenal | 2-Chloro-3-(phenylamino)-2-propenal is an intermediate in the synthesis of 3-Amino-2-chloro-propenal (A604190). 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 131139-84-9. Pack Sizes: 1g, 2.5g. Molecular Formula: C9H8ClNO, Molecular Weight: 181.62. US Biological Life Sciences. | Worldwide |
| 2-Methoxyacetic Acid-d3 | Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl (alkyloxy) [ (methylsulfonyl) phenyl]furanones as COX-2 inhibitors. Group: Biochemicals. Alternative Names: 2-Methoxyacetic Acid-d3; Methoxyacetic Acid-d3; Methoxyethanoic Acid-d3; NSC 7300-d3; Methoxyacetic Acid-d3. Grades: Highly Purified. CAS No. 345910-00-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Methoxyacetic Acid-[d3] | 2-Methoxyacetic Acid-[d3] is the labelled analogue of 2-Methoxyacetic Acid, which is a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors. Synonyms: 2-Methoxyacetic Acid D3; Methoxyacetic Acid-d3; Methoxyethanoic Acid-d3; NSC 7300-d3. Grade: ≥98%; ≥98% atom D. CAS No. 345910-00-1. Molecular formula: C3H3D3O3. Mole weight: 93.10. | |
| 2-Methyl-1-[4- (methylsulfonyl) phenyl]-2-propen-1-one | Used in the preparation of DFP analog as potent COX-2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 516453-68-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Methyl-5- (3- (4- (methylsulfonyl) phenyl) furan-2-yl) pyridine | 2-Methyl-5- (3- (4- (methylsulfonyl) phenyl) furan-2-yl) pyridine is a byproduct from the preparation of methyl sulfonyl phenyl bipyridine, a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 307531-96-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C17H15NO3S, Molecular Weight: 313.37. US Biological Life Sciences. | Worldwide |
| 2-Methyl-Celecoxib | 2-Methyl-Celecoxib is an analog of the anti-inflammatory drug Celecoxib (C251000). Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 170570-09-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H16F3N3O2S, Molecular Weight: 395.4. US Biological Life Sciences. | Worldwide |
| 2-Phenoxyaniline | An impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: 2-phenoxyaniline. Grade: 99 %. CAS No. 2688-84-8. Molecular formula: C12H11NO. Mole weight: 185.22. | |
| 2-Phenylthio-5-propionylphenylacetic Acid | 2-Phenylthio-5-propionylphenylacetic Acid is a useful synthetic intermediate in the synthesis of Zaltoprofen (Z146000); an inhibitor of Cox-1 and Cox-2. Zaltoprofen preferentially inhibits Cox-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 103918-73-6. Pack Sizes: 1g, 10g. Molecular Formula: C17H16O3S. US Biological Life Sciences. | Worldwide |
| 3-[[3-fluoro-5- (tetrahydro-4-methoxy-2H-pyran-4-yl) phenoxy]methyl]-1-[4- (methylsulfonyl) phenyl]-5-phenyl-1H-pyrazole | 3-[[3-fluoro-5- (tetrahydro-4-methoxy-2H-pyran-4-yl) phenoxy]methyl]-1-[4- (methylsulfonyl) phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 and 5-LO. Group: Biochemicals. Grades: Highly Purified. CAS No. 443919-96-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C29H29FN2O5S, Molecular Weight: 536.61. US Biological Life Sciences. | Worldwide |
| 3-Amino-2-chloro-propenal | 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 221615-73-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C3H4ClNO. US Biological Life Sciences. | Worldwide |
| 3-Methoxyacetaminophen | 3-Methoxyacetaminophen is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Uses: A metabolite of acetaminophen. Synonyms: 4-Acetylamino-2-methoxy-phenol; N-(4-Hydroxy-3-methoxy-phenyl)-acetamide; Acetic Acid-(4-hydroxy-3-methoxyanilide); 3-O-methyl-Acetaminophen; Acetamide, N-(4-hydroxy-3-methoxyphenyl)-. Grade: 95%. CAS No. 3251-55-6. Molecular formula: C9H11NO3. Mole weight: 181.19. | |
| 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen | 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-L-Cysteine; PCM-M; 3-[(5-Acetamido-2-Hydroxyphenyl)thio]-N-Acetylalanine; Acetaminophen Mercapturate; N-Acetyl-2-(N-Acetyl-L-Cysteinyl)-4-Aminophenol; S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine; Acetaminophen-2-mercapturate. Grade: 96%. CAS No. 52372-86-8. Molecular formula: C13H16N2O5S. Mole weight: 312.34. | |
| 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 151752-08-8. Pack Sizes: 25 mg; 1 mg; 5 mg; 10 mg. Product ID: HY-N8184. | |
| 4-Hydroxy nimesulide | An impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide; 4-Hydroxynimesulide. Grade: > 95%. CAS No. 109032-22-6. Molecular formula: C13H12N2O6S. Mole weight: 324.31. | |
| 4'-Hydroxy Nimesulide-[d4] | 4'-Hydroxy Nimesulide-[d4] is the labelled analogue of 4'-Hydroxy Nimesulide. 4'-Hydroxy Nimesulide is an impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: 4'-Hydroxy Nimesulide-d4; N-[2-(4-Hydroxyphenoxy-d4)-4-nitrophenyl]methanesulfonamide; 4-Hydroxynimesulide-d4. Grade: > 95%. CAS No. 1329838-26-7. Molecular formula: C13H8D4N2O6S. Mole weight: 328.33. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. | |
| 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfanylphenyl)pyridine | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 3-[4-(Methylthio)phenyl]-5-chloro-6'-methyl-2,3'-bipyridine; Etoricoxib B; 5-chloro-6'-methyl-3-(4-(methylthio)phenyl)-2,3'-bipyridine. Grade: ≥95%. CAS No. 292067-97-1. Molecular formula: C18H15ClN2S. Mole weight: 326.84. | |
| 5-Methoxy-2-mercaptobenzimidazole | Reagent used in the synthesis of COX-2 inhibitors. Group: Biochemicals. Alternative Names: 1,3-Dihydro-5-methoxy-2H-benzimidazole-2-thione; 2-Mercapto-5-methoxy-1H-benzimidazole; 2-Mercapto-5-methoxybenzimidazole; 5-Methoxy-1H-benzimidazole-2-thiol; 5-Methoxy-2-benzimidazolethiol. Grades: Highly Purified. CAS No. 37052-78-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 6-ROX | 6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 6-Carboxy-X-rhodamine. CAS No. 194785-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0053. | |
| 7,3',4'-Trihydroxyisoflavone (3-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, 3-Hydroxydiadzein, THIF, 7,3,4-THIF) | An ATP-competitive inhibitor of Cot and MKK4 that subsequently suppresses UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 485-63-2. Pack Sizes: 25mg, 100mg. US Biological Life Sciences. | Worldwide |
| 7-(Trifluoromethyl)1H-indole-2,3-dione | An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin. Grades: Highly Purified. CAS No. 391-12-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 7-(Trifluoromethyl)-1H-indole-2,3-dione-d2 | 7-(Trifluoromethyl)1H-indole-2,3-dione-d2 is a labelled 7-(Trifluoromethyl)1H-indole-2,3-dione (T791300), an inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin-d2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Acetaminophen | Acetaminophen is a selective COX-2 inhibitor. It has antipyretic, analgesic, and anti-inflammatory effects. Synonyms: Paracetamol; 4-Acetamidophenol. Grade: > 95 %. CAS No. 103-90-2. Molecular formula: C8H9NO2. Mole weight: 151.16. | |
| Acetaminophen | Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent. [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide. CAS No. 103-90-2. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-66005. | |
| Acetaminophen-cysteine | Acetaminophen-cysteine is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: S-[4-(Acetylamino)phenyl]-L-cysteine; L-Cysteine, S-[4-(acetylamino)phenyl]-. Grade: 95%. CAS No. 64014-06-8. Molecular formula: C11H14N2O3S. Mole weight: 254.30. | |
| Acetaminophen cysteinylglycine | Acetaminophen cysteinylglycine is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: AA-Cys-CG; N-(S-(4-(Acetylamino)phenyl)-L-cysteinyl)glycine; Glycine, N-(S-(4-(acetylamino)phenyl)-L-cysteinyl)-; S-(4-Acetamidophenyl)-L-cysteinylglycine; Glycine, S-[4-(acetylamino)phenyl]-L-cysteinyl-. Grade: 95%. CAS No. 116709-74-1. Molecular formula: C13H17N3O4S. Mole weight: 311.36. | |
| Acetaminophen-[d3] | Acetaminophen-[d3] is the labelled analogue of Acetaminophen, which is a selective COX-2 inhibitor. Acetaminophen is a medication for the treatment of fever and pains. Synonyms: Paracetamol-d3; N-(4-Hydroxyphenyl)acetamide-d3; N-(4-Hydroxyphenyl)acetamide-2,2,2-d3; 4'-Hydroxyacetanilide-d3; 4-Acetamidophenol-d3; N-Acetyl-4-aminophenol-d3; Acetaminophen-d3. Grade: 98% by HPLC; ≥99% atom D. CAS No. 60902-28-5. Molecular formula: C8H6D3NO2. Mole weight: 154.18. | |
| Acetaminophen glucuronide | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) [1] [2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: APAP-glu. CAS No. 16110-10-4. Pack Sizes: 5 mg. Product ID: HY-113083. | |
| Acetaminophen glutathione | Acetaminophen glutathione is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Uses: A metabolite of acetaminophen. Synonyms: L-γ-Glutamyl-S-[5-(acetylamino)-2-hydroxyphenyl]-L-cysteinylglycine; 3-(Glutathion-S-yl)acetaminophen; 3-Glutathionylacetaminophen; Acetaminophen-glutathione Adduct; Acetaminophen Impurity 3; AA-Glutathion; AA-Gsh; N-(S-(5-(Acetylamino)-2-hydroxyphenyl)-N-L-gamma-glutamyl-L-cysteinylglycine. Grade: ≥95%. CAS No. 64889-81-2. Molecular formula: C18H24N4O8S. Mole weight: 456.47. | |
| Acetaminophen Mercapurate Disodium Salt | Acetaminophen Mercapurate Disodium Salt is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: Paracetamol 3-Mercapturate Disodium Salt; 2-Acetamido-3-((5-acetamido-2-hydroxyphenyl)thio)propanoic Acid Disodium Salt; N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-DL-cysteine Disodium Salt; N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-cysteine Disodium Salt. Grade: 98%. Molecular formula: C13H14N2Na2O5S. Mole weight: 356.30. | |
| Acetaminophen (Standard) | Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard). CAS No. 103-90-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-66005R. | |
| Acetylsalicylic Acid-[d4] | Acetylsalicylic Acid-[d4] is the labelled analogue of Acetylsalicylic Acid, which is an antithrombotic, anti-inflammatory, antipyretic analgesic. Acetylsalicylic Acid is an inhibitor of Cox-1 and Cox-2. Synonyms: 2-Acetoxybenzoic-3,4,5,6-d4 Acid; Acetylsalicylic Acid-d4; Acylpyrin-d4; Angettes-d4; Aspro-d4; Aspirin-d4; Acetylsalicylic Acid-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 97781-16-3. Molecular formula: C9H4D4O4. Mole weight: 184.18. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grade: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
| α-Demethylnaproxen | α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23981-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W086896. | |
| α-Mangostin | It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent. It can inhibit the activity of COX-2, an inhibitor of mutant IDH1 (IDH1-R132H). Synonyms: 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone; α-Mangosten; NSC 139154; NSC 27593; NSC 30552. Grade: >98%. CAS No. 6147-11-1. Molecular formula: C24H26O6. Mole weight: 410.46. | |
| Amfenac-[d5] Sodium Salt | Amfenac-[d5] Sodium Salt is a labelled sodium compound of Amfenac. Amfenac is a COX inhibitor with IC50 of 0.25 and 0.15 μM for COX-1 and COX-2, respectively. Synonyms: 2-Amino-3-(benzoyl-d5)benzeneacetic Acid Sodium Salt. Grade: 95% by HPLC; 98% atom D. Molecular formula: C15H7D5NNaO3. Mole weight: 282.28. | |
| Amfenac Sodium Hydrate | Amfenac Sodium Hydrate is a COX-2 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 61618-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17479A. | |
| Amino Hydroxynimesulide NAC Adduct | Amino Hydroxynimesulide NAC Adduct is an analog of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-Acetyl-S-[2-amino-4-(4-hydroxyphenoxy)-5-[(methylsulfonyl)amino]phenyl]-L-cysteine. Grade: ≥90%. CAS No. 1094566-37-6. Molecular formula: C18H21N3O7S2. Mole weight: 455.50. | |
| Amino Nimesulide NAC Adduct Sodium Salt | Amino Nimesulide NAC Adduct Sodium Salt is an impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-Acetyl-S-[2-amino-5-[(methylsulfonyl)amino]-4-phenoxyphenyl]-L-cysteine Sodium Salt; sodium N-acetyl-S-(2-amino-5-(methylsulfonamido)-4-phenoxyphenyl)-L-cysteinate; L-Cysteine, N-acetyl-S-[2-amino-5-[(methylsulfonyl)amino]-4-phenoxyphenyl]-, sodium salt (1:1). Grade: ≥95%. CAS No. 1798888-56-8. Molecular formula: C18H20N3NaO6S2. Mole weight: 461.49. | |
| APHS | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209125-28-0. Pack Sizes: 1 mg (38.11 mM * 100 μL in Methyl acetate); 5 mg (38.11 mM * 500 μL in Methyl acetate); 10 mg (38.11 mM * 1 mL in Methyl acetate). Product ID: HY-129284. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Aspirin | Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid; ASA. CAS No. 50-78-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14654. | |
| Aspirin (Standard) | Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid(Standard); ASA (Standard). CAS No. 50-78-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-14654R. | |
| Avicularin | Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4. Purity: 0.98. IUPACName: 3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one. Canonical SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(O4)CO)O)O)O)O. Product ID: ACM572305. Alfa Chemistry ISO 9001:2015 Certified. | |
| BMS-347070 | BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer. Synonyms: (3Z)-3-[(4-bromophenyl)-(4-methylsulfonylphenyl)methylidene]oxolan-2-one; BMS-347070; BMS 347070; BMS347070; UNII-0CKM4H090C; 0CKM4H090C; SCHEMBL6882900; SCHEMBL6882905. Grade: >98%. CAS No. 197438-73-6. Molecular formula: C18H15BrO4S. Mole weight: 407.28. | |
| Bromfenac-d4 sodium salt | Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2) with IC50 of 6.6 nM that is selective over COX-1 with IC50 of 210 nM. It inhibits prostaglandin E2 production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs. Bromfenac is a non-steroidal anti-inflammatory agent. Synonyms: Bromfenac-d4. Grade: ≥99% atom D. Molecular formula: C15H7BrD4NO3·Na. Mole weight: 360.17. | |
| Bromfenac sodium | Bromfenac sodium is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91714-93-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888A. | |
| Bromfenac sodium hydrate | Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium hydrate can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bromfenac monosodium salt sesquihydrate. CAS No. 120638-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888B. | |
| Bromfenac Sodium Salt | Bromfenac Sodium Salt is a potent inhibitor of both COX-1 and COX-2. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: AHR 10282R; AHR10282R; AHR-10282R. Grade: > 95%. CAS No. 91714-93-1. Molecular formula: C15H11BrNO3.Na. Mole weight: 356.15. | |
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