Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| COX-2 Inhibitor I | An inhibitor of COX-2. Synonyms: Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate; LM-1685; LM 1685; LM1685. CAS No. 416901-58-1. Molecular formula: C18H16ClNO4S. Mole weight: 377.8. |  |
| COX-2 Inhibitor I - CAS 416901-58-1 | The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. |  |
| COX-2 Inhibitor I - CAS 416901-58-1 | The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 416901-58-1. Pack Sizes: 5MG. Mole weight: 377.84. Catalog: AP416901581. Assay: ?97% (HPLC). | |
| COX-2 Inhibitor II | A selective inhibitor of COX-2. Synonyms: SC-791; IN1371; 181696-33-3; 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide; SCHEMBL214781. CAS No. 181696-33-3. Molecular formula: C16H12F2N2O3S. Mole weight: 350.34. | |
| COX-2 Inhibitor II - CAS 181696-33-3 | The COX-2 Inhibitor II, also referenced under CAS 181696-33-3, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. | |
| COX-2 Inhibitor V, FK3311 | COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID. Group: Biochemicals. Grades: Highly Purified. CAS No. 116686-15-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H13F2NO4S, Molecular Weight: 341.33. US Biological Life Sciences. |  Worldwide |
| COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 | The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. | |
| 1,1,2-Triethoxyethane | 1,1,2-Triethoxyethane is an intermediate used to synthesize pyrazolopyrimidine derivatives as COX-2 selective inhibitors. It is also used to prepare [ (1, 2, 4-oxadiazolylphenoxy) alkyl]isoxazoles as antiviral agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 4819-77-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H18O3, Molecular Weight: 162.229999999999. US Biological Life Sciences. | Worldwide |
| 1-(4-Ethoxyphenyl)-3-methyl-4-hexen-1-one | 1-(4-Ethoxyphenyl)-3-methyl-4-hexen-1-one is an intermediate in synthesizing Apricoxib (A729850), which is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 1337994-12-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C15H20O2, Molecular Weight: 232.32. US Biological Life Sciences. | Worldwide |
| 1-(6-Methyl-1-oxido-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: Etoricoxib YY. Grades: ≥95%. CAS No. 1027162-35-1. Molecular formula: C15H15NO4S. Mole weight: 305.35. | |
| 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 3-[2-(4-(methylthio)phenyl)acetyl](6-methyl)pyridine; Ethanone, 1-(6-ethyl-3-yridinyl)-2-4-(methylthio)henyl]-; Etoricoxib Impurity P. Grades: ≥95%. CAS No. 221615-72-1. Molecular formula: C15H15NOS. Mole weight: 257.35. | |
| 1-Bromo-3,5-difluorobenzene | 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents. Group: Biochemicals. Alternative Names: 1,3-Difluoro-5-bromobenzene; 1-Bromo-3,5-difluorobenzene; 3,5-Difluoro-1-bromobenzene; 3,5-Difluorobromobenzene; 3,5-Difluorophenyl Bromide; 5-Bromo-1,3-difluorobenzene. Grades: Highly Purified. CAS No. 461-96-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 2-(4-Methanesulfonylphenyl)-1-pyridin-3-ylethanone | 2-(4-Methanesulfonylphenyl)-1-pyridin-3-ylethanone is an intermediate in synthesizing Desmethyl Etoricoxib (D296895), which is an impurity of Etoricoxib (E934100), a specific inhibitor of COX-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 40061-50-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C14H13NO3S. US Biological Life Sciences. | Worldwide |
| 2,5-Dimethylcelecoxib | 2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 457639-26-8. Pack Sizes: 1 mg. Product ID: HY-W010995. |  |
| 2,5-Dimethyl Celecoxib | A non-cyclooxygenase-2 inhibitor analog of Celecoxib. The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib. Group: Biochemicals. Alternative Names: 4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; DMC. Grades: Highly Purified. CAS No. 457639-26-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 15307-93-4. Molecular formula: C13H12N2OS. Mole weight: 238.11. Purity: 0.9971. Canonical SMILES: ClC1=C(NC2=CC=CC=C2)C(Cl)=CC=C1. Product ID: ACM15307934. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2,6-Dichloro-N-phenylaniline. |  |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti- Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,6-Dichloro-N-phenylaniline. CAS No. 15307-93-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W012126. | |
| 2-(6-Methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine; Etoricoxib C; 2,3'-Bipyridine, 6'-methyl-3-[4-(methylsulfonyl)phenyl]-. Grades: ≥95%. CAS No. 1350206-14-2. Molecular formula: C18H16N2O2S. Mole weight: 324.40. | |
| 2-(Bromoacetyl)-6-methoxynaphthalene | 2-(Bromoacetyl)-6-methoxynaphthalene is used in the preparation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 10262-65-4. Pack Sizes: 100mg, 1g. Molecular Formula: C13H11BrO2, Molecular Weight: 279.13. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3-(phenylamino)-2-propenal | 2-Chloro-3-(phenylamino)-2-propenal is an intermediate in the synthesis of 3-Amino-2-chloro-propenal (A604190). 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 131139-84-9. Pack Sizes: 1g, 2.5g. Molecular Formula: C9H8ClNO, Molecular Weight: 181.62. US Biological Life Sciences. | Worldwide |
| 2-Methoxyacetic Acid-d3 | Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl (alkyloxy) [ (methylsulfonyl) phenyl]furanones as COX-2 inhibitors. Group: Biochemicals. Alternative Names: 2-Methoxyacetic Acid-d3; Methoxyacetic Acid-d3; Methoxyethanoic Acid-d3; NSC 7300-d3; Methoxyacetic Acid-d3. Grades: Highly Purified. CAS No. 345910-00-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Methyl-1-[4- (methylsulfonyl) phenyl]-2-propen-1-one | Used in the preparation of DFP analog as potent COX-2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 516453-68-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Methyl-5- (3- (4- (methylsulfonyl) phenyl) furan-2-yl) pyridine | 2-Methyl-5- (3- (4- (methylsulfonyl) phenyl) furan-2-yl) pyridine is a byproduct from the preparation of methyl sulfonyl phenyl bipyridine, a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 307531-96-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C17H15NO3S, Molecular Weight: 313.37. US Biological Life Sciences. | Worldwide |
| 2-Methyl-Celecoxib | 2-Methyl-Celecoxib is an analog of the anti-inflammatory drug Celecoxib (C251000). Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 170570-09-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H16F3N3O2S, Molecular Weight: 395.4. US Biological Life Sciences. | Worldwide |
| 2-Phenoxyaniline | An impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: 2-phenoxyaniline. Grades: 99 %. CAS No. 2688-84-8. Molecular formula: C12H11NO. Mole weight: 185.22. | |
| 2-Phenylthio-5-propionylphenylacetic Acid | 2-Phenylthio-5-propionylphenylacetic Acid is a useful synthetic intermediate in the synthesis of Zaltoprofen (Z146000); an inhibitor of Cox-1 and Cox-2. Zaltoprofen preferentially inhibits Cox-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 103918-73-6. Pack Sizes: 1g, 10g. Molecular Formula: C17H16O3S. US Biological Life Sciences. | Worldwide |
| 3-[[3-fluoro-5- (tetrahydro-4-methoxy-2H-pyran-4-yl) phenoxy]methyl]-1-[4- (methylsulfonyl) phenyl]-5-phenyl-1H-pyrazole | 3-[[3-fluoro-5- (tetrahydro-4-methoxy-2H-pyran-4-yl) phenoxy]methyl]-1-[4- (methylsulfonyl) phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 and 5-LO. Group: Biochemicals. Grades: Highly Purified. CAS No. 443919-96-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C29H29FN2O5S, Molecular Weight: 536.61. US Biological Life Sciences. | Worldwide |
| 3-Amino-2-chloro-propenal | 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 221615-73-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C3H4ClNO. US Biological Life Sciences. | Worldwide |
| 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen | 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-L-Cysteine; PCM-M; 3-[(5-Acetamido-2-Hydroxyphenyl)thio]-N-Acetylalanine; Acetaminophen Mercapturate; N-Acetyl-2-(N-Acetyl-L-Cysteinyl)-4-Aminophenol; S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine; Acetaminophen-2-mercapturate. Grades: 96%. CAS No. 52372-86-8. Molecular formula: C13H16N2O5S. Mole weight: 312.34. | |
| 4-[3-(Acryloyloxy)propoxy]benzoic acid | 4-[3-(Acryloyloxy)propoxy]benzoic acid, an essential raw material in the synthesis of pharmaceuticals and agrochemicals, possesses enormous potential as a COX-2 inhibitor, thereby providing considerable therapeutic benefits in alleviating inflammation and pain. Moreover, it serves as an indispensable reagent in organic chemistry and is exclusively utilized in the synthesis of polymeric compounds and surface functionalization. Its multifaceted applications in various fields highlight its enormous industrial significance. Synonyms: 4-[3-[(1-Oxo-2-propen-1-yl)oxy]propoxy]benzoic acid. CAS No. 245349-46-6. Molecular formula: C13H14O5. Mole weight: 250.25. | |
| 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 151752-08-8. Pack Sizes: 25 mg; 1 mg; 5 mg; 10 mg. Product ID: HY-N8184. | |
| 4-Hydroxy nimesulide | An impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide; 4-Hydroxynimesulide. Grades: > 95%. CAS No. 109032-22-6. Molecular formula: C13H12N2O6S. Mole weight: 324.31. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. | |
| 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfanylphenyl)pyridine | An impurity of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor. Synonyms: 3-[4-(Methylthio)phenyl]-5-chloro-6'-methyl-2,3'-bipyridine; Etoricoxib B; 5-chloro-6'-methyl-3-(4-(methylthio)phenyl)-2,3'-bipyridine. Grades: ≥95%. CAS No. 292067-97-1. Molecular formula: C18H15ClN2S. Mole weight: 326.84. | |
| 5-Methoxy-2-mercaptobenzimidazole | Reagent used in the synthesis of COX-2 inhibitors. Group: Biochemicals. Alternative Names: 1,3-Dihydro-5-methoxy-2H-benzimidazole-2-thione; 2-Mercapto-5-methoxy-1H-benzimidazole; 2-Mercapto-5-methoxybenzimidazole; 5-Methoxy-1H-benzimidazole-2-thiol; 5-Methoxy-2-benzimidazolethiol. Grades: Highly Purified. CAS No. 37052-78-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 6-ROX | 6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 6-Carboxy-X-rhodamine. CAS No. 194785-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0053. | |
| 7,3',4'-Trihydroxyisoflavone (3-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, 3-Hydroxydiadzein, THIF, 7,3,4-THIF) | An ATP-competitive inhibitor of Cot and MKK4 that subsequently suppresses UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 485-63-2. Pack Sizes: 25mg, 100mg. US Biological Life Sciences. | Worldwide |
| 7-(Trifluoromethyl)1H-indole-2,3-dione | An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin. Grades: Highly Purified. CAS No. 391-12-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 7-(Trifluoromethyl)-1H-indole-2,3-dione-d2 | 7-(Trifluoromethyl)1H-indole-2,3-dione-d2 is a labelled 7-(Trifluoromethyl)1H-indole-2,3-dione (T791300), an inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin-d2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Acetaminophen | Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent. [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide. CAS No. 103-90-2. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-66005. | |
| Acetaminophen-cysteine | Acetaminophen-cysteine is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: S-[4-(Acetylamino)phenyl]-L-cysteine; L-Cysteine, S-[4-(acetylamino)phenyl]-. Grades: 95%. CAS No. 64014-06-8. Molecular formula: C11H14N2O3S. Mole weight: 254.30. | |
| Acetaminophen glucuronide | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) [1] [2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: APAP-glu. CAS No. 16110-10-4. Pack Sizes: 5 mg. Product ID: HY-113083. | |
| Acetaminophen glutathione | Acetaminophen glutathione is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Uses: A metabolite of acetaminophen. Synonyms: L-γ-Glutamyl-S-[5-(acetylamino)-2-hydroxyphenyl]-L-cysteinylglycine; 3-(Glutathion-S-yl)acetaminophen; 3-Glutathionylacetaminophen; Acetaminophen-glutathione Adduct; Acetaminophen Impurity 3; AA-Glutathion; AA-Gsh; N-(S-(5-(Acetylamino)-2-hydroxyphenyl)-N-L-gamma-glutamyl-L-cysteinylglycine. Grades: ≥95%. CAS No. 64889-81-2. Molecular formula: C18H24N4O8S. Mole weight: 456.47. | |
| Acetaminophen Mercapurate Disodium Salt | Acetaminophen Mercapurate Disodium Salt is a metabolite of Acetaminophen, which is a selective COX-2 inhibitor used as an antipyretic, analgesic, and anti-inflammatory agent. Synonyms: Paracetamol 3-Mercapturate Disodium Salt; 2-Acetamido-3-((5-acetamido-2-hydroxyphenyl)thio)propanoic Acid Disodium Salt; N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-DL-cysteine Disodium Salt; N-Acetyl-S-[5-(acetylamino)-2-hydroxyphenyl]-cysteine Disodium Salt. Grades: 98%. Molecular formula: C13H14N2Na2O5S. Mole weight: 356.30. | |
| Acetaminophen (Standard) | Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 ( COX-2 ) inhibitor with an IC 50 of 25.8 μM; is a widely used antipyretic and analgesic agent [1] [2] [3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard). CAS No. 103-90-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-66005R. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
| α-Demethylnaproxen | α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23981-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W086896. | |
| Amfenac Sodium Hydrate | Amfenac Sodium Hydrate is a COX-2 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 61618-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17479A. | |
| Amino Hydroxynimesulide NAC Adduct | Amino Hydroxynimesulide NAC Adduct is an analog of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-Acetyl-S-[2-amino-4-(4-hydroxyphenoxy)-5-[(methylsulfonyl)amino]phenyl]-L-cysteine. Grades: ≥90%. CAS No. 1094566-37-6. Molecular formula: C18H21N3O7S2. Mole weight: 455.50. | |
| Amino Nimesulide NAC Adduct Sodium Salt | Amino Nimesulide NAC Adduct Sodium Salt is an impurity of Nimesulide, which is a selective COX-2 inhibitor. Synonyms: N-Acetyl-S-[2-amino-5-[(methylsulfonyl)amino]-4-phenoxyphenyl]-L-cysteine Sodium Salt; sodium N-acetyl-S-(2-amino-5-(methylsulfonamido)-4-phenoxyphenyl)-L-cysteinate; L-Cysteine, N-acetyl-S-[2-amino-5-[(methylsulfonyl)amino]-4-phenoxyphenyl]-, sodium salt (1:1). Grades: ≥95%. CAS No. 1798888-56-8. Molecular formula: C18H20N3NaO6S2. Mole weight: 461.49. | |
| APHS | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209125-28-0. Pack Sizes: 1 mg (38.11 mM * 100 μL in Methyl acetate); 5 mg (38.11 mM * 500 μL in Methyl acetate); 10 mg (38.11 mM * 1 mL in Methyl acetate). Product ID: HY-129284. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Aspirin | Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid; ASA. CAS No. 50-78-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14654. | |
| Aspirin (Standard) | Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid(Standard); ASA (Standard). CAS No. 50-78-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-14654R. | |
| Avicularin | Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4. Purity: 0.98. IUPACName: 3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one. Canonical SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(O4)CO)O)O)O)O. Product ID: ACM572305. Alfa Chemistry ISO 9001:2015 Certified. | |
| Berberine hydrochloride | Berberine hydrochloride is an isoqinoline alkaloid and acts as a COX-2 inhibitor that exhibits chemopreventive activity against colon tumor formation. Study in humans and hamsters shows that berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. It also inhibits c-Jun and suppresses inflammation and cancers. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Berberine chloride; Natural Yellow 18; Benzodioxide; Berberinium chloride. Grades: ≥ 98%. CAS No. 633-65-8. Molecular formula: C20H18ClNO4. Mole weight: 371.817. | |
| BMS-347070 | BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer. Synonyms: (3Z) -3-[ (4-bromophenyl) - (4-methylsulfonylphenyl) methylidene]oxolan-2-one; BMS-347070; BMS 347070; BMS347070; UNII-0CKM4H090C; 0CKM4H090C; SCHEMBL6882900; SCHEMBL6882905. Grades: >98%. CAS No. 197438-73-6. Molecular formula: C18H15BrO4S. Mole weight: 407.28. | |
| Bromfenac sodium | Bromfenac sodium is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91714-93-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888A. | |
| Bromfenac sodium hydrate | Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium hydrate can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bromfenac monosodium salt sesquihydrate. CAS No. 120638-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888B. | |
| Bromfenac Sodium Salt | Bromfenac Sodium Salt is a potent inhibitor of both COX-1 and COX-2. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: AHR 10282R; AHR10282R; AHR-10282R. Grades: > 95%. CAS No. 91714-93-1. Molecular formula: C15H11BrNO3.Na. Mole weight: 356.15. | |
| BTB 02472 | BTB 02472 is an active-site-targeting COX-2 inhibitor. Synonyms: COX-2 Inhibitor III; N-(5-Acetyl-2-piperidinophenyl)-N' -(2,5-dichlorophenyl)thiourea. CAS No. 1177728-24-3. Molecular formula: C20H23Cl2N3OS. Mole weight: 424.39. | |
| BW 755C | Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grades: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20. | |
| Canagliflozin | (3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, Invokana. non-steroidal, anti-inflammatory drug, cyclooxygenase-2 (COX-2) selective inhibitor. CAS No. 842133-18-0. Product ID: 8-04788. Molecular formula: C24H25FO5S. Mole weight: 444.52. Purity: 0.99. |  |
| Carboxylic acid celecoxib | Celecoxib Carboxylic Acid is a metabolite of Celecoxib, a Cox-2 inhibitor. Synonyms: 4-[1-[4-(Aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoic Acid; Celebrex Carboxylic Acid. Grades: > 95%. CAS No. 170571-01-4. Molecular formula: C17H12F3N3O4S. Mole weight: 411.36. | |
| Cardamonin | Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cardamonin. Product Category: Inhibitors. Appearance: Solid. CAS No. 18956-16-6. Molecular formula: C16H14O4. Mole weight: 270.28. Purity: 0.96. IUPACName: (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one. Canonical SMILES: COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O. Density: 1.282g/cm³. Product ID: ACM18956166. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cardamomin. | |
| Carprofen | Carprofen is a COX-2 inhibitor used as a non-steroidal anti-inflammatory drug. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 6-Chloro-α-methyl-9H-carbazole-2-acetic Acid; (dl)-6-Chloro-α-methylcarbazole- 2-acetic Acid; C 5720; Carprodyl; (+/-)-Carprofen; Imadyl; NSC 297935; Rimadyl; Ro 20-5720. Grades: >98%. CAS No. 53716-49-7. Molecular formula: C15H12ClNO2. Mole weight: 273.71. | |
| Carprofen | Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC 50 s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively. Uses: Scientific research. Group: Natural products. CAS No. 53716-49-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1227. | |
| CAY10404 | CAY10404 is a potent, selective COX-2 inhibitor. Synonyms: CAY 10404; CAY-10404; CAY10404; 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole. CAS No. 340267-36-9. Molecular formula: C17H12F3NO3S. Mole weight: 367.4. | |
| CAY10416 | CAY10416 is a dual COX-2/5-LO inhibitor. Synonyms: CHEMBL423638; CAY10416; CHEMBL 423638; CAY 10416; CHEMBL-423638; CAY-10416; ; 43919-96-8; 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole; 3-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-(4-(methylsulfonyl)phenyl)-5-phenyl-1H-pyraz. CAS No. 443919-96-8. Molecular formula: C29H29FN2O5S. Mole weight: 536.6. | |
| CAY10589 | CAY10589 is a dual inhibitor of mPGES-1 with IC50 of 1.3 μM and 5-LO with IC50 of 1.0 μM. It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively. Synonyms: CAY 10589; CAY-10589. Grades: ≥98%. CAS No. 1077626-52-8. Molecular formula: C25H28ClN3O2S. Mole weight: 470. | |
Our database is helping our users find suppliers everyday.
