Crizotinib Suppliers USA
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Product | Description | |
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Crizotinib Quick inquiry Where to buy Suppliers range | Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grades: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343. | |
Crizotinib Quick inquiry Where to buy Suppliers range | Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Crizotinib hydrochloride Quick inquiry Where to buy Suppliers range | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grades: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
2-Keto Crizotinib Quick inquiry Where to buy Suppliers range | 2-Keto Crizotinib is an impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: > 95%. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. | |
2-Keto Crizotinib Quick inquiry Where to buy Suppliers range | 2-Keto Crizotinib. Group: Biochemicals. Alternative Names: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: Highly Purified. CAS No. 1415558-82-5. Pack Sizes: 5mg. Molecular Formula: C21H20Cl2FN5O2, Molecular Weight: 464.32. US Biological Life Sciences. | Worldwide |
(S)-crizotinib Quick inquiry Where to buy Suppliers range | (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells. Synonyms: S-Crizotinib; ent-crizotinib. Grades: >98%. CAS No. 1374356-45-2. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.34. | |
3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine Quick inquiry Where to buy Suppliers range | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; Crizotinib. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C21H22Cl2FN5O. US Biological Life Sciences. | Worldwide |
ASP-3026 Quick inquiry Where to buy Suppliers range | ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. Synonyms: ASP3026; ASP 3026. Grades: 0.98. CAS No. 1097917-15-1. Molecular formula: C29H40N8O3S. Mole weight: 580.74. | |
Chlorodihydrido{(R)-(+)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III), >97% (>99% ee) Ir-(R)-DTB-SpiroPAP-3-Me Quick inquiry Where to buy Suppliers range | Chlorodihydrido{(R)-(+)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III), >97% (>99% ee) Ir-(R)-DTB-SpiroPAP-3-Me. Uses: Catalyst for the enantioselective synthesis of chiral disubstituted oxa-cyclic ethers Catalyst for the enantioselective hydrogenation for the asymmetric synthesis of Rivastigmine Catalyst for the asymmetric hydrogenation for the synthesis of Crizotinib Catalyst for the asymmetric hydrogenation of α-keto acids Catalyst for the kinetic resolution of racemic aliphatic alcohols via selective asymmetric hydrogenation. Alternative Names: 1396201-63-0;Chlorodihydrido{(R)-(+)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III). CAS No. 1396201-63-0. Molecular formula: C52H67ClIrN2P. Mole weight: 978.763g/mol. IUPAC Name: (3R)-4'-bis(3,5-ditert-butylphenyl)phosphanyl-N-[(3-methylpyridin-2-yl)methyl]-3,3'-spirobi[1,2-dihydroindene]-4-amine;chloro(dihydrido)iridium. Rotatable Bond Count: 10. Exact Mass: 978.436g/mol. SMILES: CC1=C (N=CC=C1)CNC2=CC=CC3=C2C4 (CC3)CCC5=C4C (=CC=C5)P (C6=CC (=CC (=C6)C (C) (C)C)C (C) (C)C)C7=CC (=CC (=C7)C (C) (C)C)C (C) (C)C. Cl[IrH2]. InChI: InChI=1S/C52H65N2P.ClH.Ir.2H/c1-34-17-16-26-53-44(34)33-54-43-20-14-18-35-22-24-52(46(35)43)25-23-36-19-15-21-45(47(36)52)55(41-29-37(48(2,3)4)27-38(30-41)49(5,6)7)42-31-39(50(8,9)10)28-40(32-42)51(11,12)13;;;;/h14-21,26-32,54H,22-25,33H2,1-13H3;1H;;;/q;;+1;;/p-1/t52-;;;;/m1./s1. InChIKey: PBHYFCJJIBYGAE-ZCYYXTSSSA-M. H-Bond Donor: 1. H-Bond Acceptor: 2. Monoisotopic Mass: 978.436g/mol. | |
Chlorodihydrido{(S)-(-)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III), >97% (>99% ee) Ir-(S)-DTB-SpiroPAP-3-Me Quick inquiry Where to buy Suppliers range | Chlorodihydrido{(S)-(-)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III), >97% (>99% ee) Ir-(S)-DTB-SpiroPAP-3-Me. Uses: Catalyst for the enantioselective synthesis of chiral disubstituted oxa-cyclic ethers Catalyst for the enantioselective hydrogenation for the asymmetric synthesis of Rivastigmine Catalyst for the asymmetric hydrogenation for the synthesis of Crizotinib Catalyst for the asymmetric hydrogenation of α-keto acids Catalyst for the kinetic resolution of racemic aliphatic alcohols via selective asymmetric hydrogenation. Alternative Names: 1418483-59-6;Chlorodihydrido{(S)-(-)-7-Bis(3,5-di-t-butylphenyl)phosphino-7'-[(3-methylpyridine-2-ylmethyl)amino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane}iridium(III). CAS No. 1418483-59-6. Molecular formula: C52H67ClIrN2P. Mole weight: 978.763g/mol. IUPAC Name: [(3S)-4'-bis(3, 5-ditert-butylphenyl)phosphaniumyl-3, 3'-spirobi[1, 2-dihydroindene]-4-yl]-[(3-methylpyridin-2-yl)methyl]azanide; chloro(dihydrido)iridium. Rotatable Bond Count: 6. Exact Mass: 978.436g/mol. SMILES: CC1=C (N=CC=C1)C[N-]C2=CC=CC3=C2C4 (CC3)CCC5=C4C (=CC=C5)[PH+] (C6=CC (=CC (=C6)C (C) (C)C)C (C) (C)C)C7=CC (=CC (=C7)C (C) (C)C)C (C) (C)C. Cl[IrH2]. InChI: InChI=1S/C52H64N2P.ClH.Ir.2H/c1-34-17-16-26-53-44(34)33-54-43-20-14-18-35-22-24-52(46(35)43)25-23-36-19-15-21-45(47(36)52)55(41-29-37(48(2,3)4)27-38(30-41)49(5,6)7)42-31-39(50(8,9)10)28-40(32-42)51(11,12)13;;;;/h14-21,26-32H,22-25,33H2,1-13H3;1H;;;/q-1;;+1;;/t52-;;;;/m0./s1. InChIKey: WOPBJABIVGWVDU-IUKTUPIYSA-N. H-Bond Acceptor: 2. Monoisotopic Mass: 978.436g/mol. | |
KRCA-0008 Quick inquiry Where to buy Suppliers range | Potent and selective dual ALK (anaplastic lymphoma kinase ) and ACK1 inhibitor (IC50 values 12 nM and 4 nM for ALK and Ack1, respectively) with good drug-like properties: good water-solubility with moderate plasma protein binding and low brain exposure. It has good liver microsomal stability and little to no CYP inhibition. KRCA0008 also shows promising pharmacokinetic parameters in both mice and rat (oral bioavailability = 66-94.5%) and a modest tumor growth inhibition in vivo activity in H3122 human lung cancer bearing mice model comparable to Crizotinib without significant body weight change. Synonyms: KRCA-0008; KRCA 0008; KRCA0008. Grades: >98%. CAS No. 1472795-20-2. Molecular formula: C30H37ClN8O4. Mole weight: 609.12. | |
LDK378 dihydrochloride Quick inquiry Where to buy Suppliers range | Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Synonyms: LDK 378 dihydrochloride; LDK-378 dihydrochloride; LDK378 dihydrochloride; Ceritinib dihydrochloride. Grades: >98%. CAS No. 1380575-43-8. Molecular formula: C28H38Cl3N5O3S. Mole weight: 631.06. |