Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Crizotinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Crizotinib | Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grades: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343. |  |
| Crizotinib | Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Crizotinib | Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. |  |
| Crizotinib-D5 | Crizotinib-D5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1395950-84-1. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. Catalog: APB1395950841. | |
| Crizotinib hydrochloride | Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. | |
| Crizotinib hydrochloride | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grades: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
| Crizotinib Hydrochloride | Crizotinib Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. Catalog: APB1415560698. | |
| Crizotinib Impurity 26 | Crizotinib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1394346-24-7. Molecular formula: C13H8BrCl2FN2O3. Mole weight: 410.02. Catalog: APB1394346247. | |
| Crizotinib Impurity 4 | Crizotinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine. CAS No. 1233484-06-4. Molecular formula: C13H9Cl2FN2O3. Mole weight: 331.13. Catalog: APB1233484064. | |
| Crizotinib Impurity 41 | Crizotinib Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 141699-59-4. Molecular formula: C11H21NO5S. Mole weight: 279.35. Catalog: APB141699594. | |
| Crizotinib Impurity 47 | Crizotinib Impurity 47. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1675225-85-0. Molecular formula: C13H12Cl2N2O. Mole weight: 283.15. Catalog: APB1675225850. | |
| 2-Keto Crizotinib | 2-Keto Crizotinib. Group: Biochemicals. Alternative Names: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: Highly Purified. CAS No. 1415558-82-5. Pack Sizes: 5mg. Molecular Formula: C21H20Cl2FN5O2, Molecular Weight: 464.32. US Biological Life Sciences. | Worldwide |
| 2-Keto Crizotinib | 2-Keto Crizotinib is an impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: > 95%. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. | |
| 2-Keto Crizotinib | 2-Keto Crizotinib. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-2-one. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. Catalog: APB1415558825. | |
| (S)-crizotinib | (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells. Synonyms: S-Crizotinib; ent-crizotinib. Grades: >98%. CAS No. 1374356-45-2. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.34. | |
| (S)-Crizotinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| (S)-Crizotinib | (S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC 50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374356-45-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100549. | |
| 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; Crizotinib. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C21H22Cl2FN5O. US Biological Life Sciences. | Worldwide |
| ASP-3026 | ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. Synonyms: ASP3026; ASP 3026. Grades: 0.98. CAS No. 1097917-15-1. Molecular formula: C29H40N8O3S. Mole weight: 580.74. | |
| KRCA-0008 | Potent and selective dual ALK (anaplastic lymphoma kinase ) and ACK1 inhibitor (IC50 values 12 nM and 4 nM for ALK and Ack1, respectively) with good drug-like properties: good water-solubility with moderate plasma protein binding and low brain exposure. It has good liver microsomal stability and little to no CYP inhibition. KRCA0008 also shows promising pharmacokinetic parameters in both mice and rat (oral bioavailability=66-94.5%) and a modest tumor growth inhibition in vivo activity in H3122 human lung cancer bearing mice model comparable to Crizotinib without significant body weight change. Synonyms: KRCA-0008; KRCA 0008; KRCA0008. Grades: >98%. CAS No. 1472795-20-2. Molecular formula: C30H37ClN8O4. Mole weight: 609.12. | |
| LDK378 dihydrochloride | Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib. LDK378 blocks the ALK protein and stops it sending growth signals to cancer cells, which may stop them growing. Synonyms: LDK 378 dihydrochloride; LDK-378 dihydrochloride; LDK378 dihydrochloride; Ceritinib dihydrochloride. Grades: >98%. CAS No. 1380575-43-8. Molecular formula: C28H38Cl3N5O3S. Mole weight: 631.06. | |
| PRO-6E | PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker?Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353493-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160506. | |
| Taletrectinib | Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC 50 s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-6051b; AB-106; IBI-344. CAS No. 1505515-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131003. | |
Our database is helping our users find suppliers everyday.
