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| Product | Description | |
|---|---|---|
| Crizotinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Crizotinib | Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grade: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343. |  |
| Crizotinib | Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Crizotinib | Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. |  |
| Crizotinib-[d5] | Crizotinib-d5 is a labelled Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: Crizotinib D5; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine-d5; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine-d5; PF 02341066-d5; PF 2341066-d5. Grade: 95% by HPLC; 95% atom D. CAS No. 1395950-48-7. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. | |
| Crizotinib-D5 | Crizotinib-D5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1395950-84-1. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. Catalog: APB1395950841. | |
| Crizotinib hydrochloride | Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. | |
| Crizotinib hydrochloride | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grade: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
| Crizotinib Hydrochloride | Crizotinib Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. Catalog: APB1415560698. | |
| Crizotinib Impurity 26 | Crizotinib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1394346-24-7. Molecular formula: C13H8BrCl2FN2O3. Mole weight: 410.02. Catalog: APB1394346247. | |
| Crizotinib Impurity 4 | Crizotinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine. CAS No. 1233484-06-4. Molecular formula: C13H9Cl2FN2O3. Mole weight: 331.13. Catalog: APB1233484064. | |
| Crizotinib Impurity 41 | Crizotinib Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 141699-59-4. Molecular formula: C11H21NO5S. Mole weight: 279.35. Catalog: APB141699594. | |
| Crizotinib Impurity 47 | Crizotinib Impurity 47. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1675225-85-0. Molecular formula: C13H12Cl2N2O. Mole weight: 283.15. Catalog: APB1675225850. | |
| Crizotinib piperidin-1-Hydroxy Impurity | An impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Grade: ≥95%. Molecular formula: C21H22Cl2FN5O2. Mole weight: 466.34. | |
| 2-Keto Crizotinib | 2-Keto Crizotinib. Group: Biochemicals. Alternative Names: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: Highly Purified. CAS No. 1415558-82-5. Pack Sizes: 5mg. Molecular Formula: C21H20Cl2FN5O2, Molecular Weight: 464.32. US Biological Life Sciences. | Worldwide |
| 2-Keto Crizotinib | 2-Keto Crizotinib is an impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grade: > 95%. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. | |
| 2-Keto Crizotinib | 2-Keto Crizotinib. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-2-one. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. Catalog: APB1415558825. | |
| (R)-Crizotinib-[d5] (piperidine-[3,3,4,5,5-d5]) | One of the isotopic labelled form of (R)-Crizotinib, which is probably be a potent ALK inhibitor as well as c-MET inhibitor. Synonyms: (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine. Grade: 95% by HPLC; 98% atom D. CAS No. 1395950-84-1. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. | |
| (S)-crizotinib | (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells. Synonyms: S-Crizotinib; ent-crizotinib. Grade: >98%. CAS No. 1374356-45-2. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.34. | |
| (S)-Crizotinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| (S)-Crizotinib | (S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC 50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374356-45-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100549. | |
| 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; Crizotinib. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C21H22Cl2FN5O. US Biological Life Sciences. | Worldwide |
| ALK/ROS1-IN-1 | ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor, with IC50s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively. CAS No. 2365497-07-8. Molecular formula: C30H35F3N6O3. Mole weight: 584.63. | |
| ASP-3026 | ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. Synonyms: ASP3026; ASP 3026. Grade: 0.98. CAS No. 1097917-15-1. Molecular formula: C29H40N8O3S. Mole weight: 580.74. | |
| Ensartinib dihydrochloride | Ensartinib is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. Ensartinib has the potential for the treatment of crizotinib-resistant, ALK-positive non-small-cell lung cancer. Synonyms: X-396 dihydrochloride; X-396 2HCl. CAS No. 2137030-98-7. Molecular formula: C26H29Cl4FN6O3. Mole weight: 634.36. | |
| PRO-6E | PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker?Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2353493-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160506. | |
| Taletrectinib | Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC 50 s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-6051b; AB-106; IBI-344. CAS No. 1505515-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131003. | |
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