Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| (±)14,15-Epoxyeicosatrienoic acid | (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)14(15)-EET. CAS No. 197508-62-6. Pack Sizes: 50 μg (312.04 μM * 500 μL in Ethanol). Product ID: HY-150084. |  |
| 16α-Hydroxy estrone | 16α-Hydroxy estrone is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. Synonyms: 16α-OHE1; 16a-Hydroxyestrone. Grades: ≥98%. CAS No. 566-76-7. Molecular formula: C18H22O3. Mole weight: 286.4. |  |
| 1,8-cineole 2-exo-monooxygenase | A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase). Group: Enzymes. Synonyms: CYP3A4. Enzyme Commission Number: EC 1.14.13.157. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0757; 1,8-cineole 2-exo-monooxygenase; EC 1.14.13.157; CYP3A4. Cat No: EXWM-0757. |  |
| [1(S)-Phenylethoxy]-Aprepitant | [1(S)-Phenylethoxy]-Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Group: Biochemicals. Grades: Highly Purified. CAS No. 170902-81-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. |  Worldwide |
| (2R,3R,1S)-Aprepitant | (2R,3R,1S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1242175-34-3. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| (2S,3R,1R)-Aprepitant | (2S,3R,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185502-97-9. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| (2S,3S,1R)-Aprepitant | (2S,3S,1R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 172822-28-5. Pack Sizes: 1mg. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.429999999999. US Biological Life Sciences. | Worldwide |
| 4',5'-Dihydro-8-Hydroxy Psoralen | 4',5'-Dihydro-8-hydroxypsoralen is a furancouramin with inhibitory activity on CYP3A4 as well as inhibitory effects on prostaglandin E2 production. 4',5'-Dihydro-8-hydroxypsoralen is an impurity of 8-Methoxypsoralen , also known as Methoxsalen. Group: Biochemicals. Alternative Names: 2,3-Dihydro-9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one; 2,3-Dihydro-6,7-dihydroxy-5-benzofuranacrylic Acid δ-Lactone; 2,3-Dihydroxanthotoxol. Grades: Highly Purified. CAS No. 68123-30-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy atorvastatin hemicalcium | 4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 265989-44-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137310. | |
| 6,7-Dihydroxy bergamottin | 6,7-Dihydroxy bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 μM). Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 6,7-DHB; 6,7-dihydroxybergamottin. Grades: ≥98%. CAS No. 145414-76-2. Molecular formula: C21H24O6. Mole weight: 372.4. | |
| 6',7'-Dihydroxybergamottin | 6',7'-Dihydroxybergamottin (6,7-DHB), a furanocoumarin, is a potent CYP3A4 inhibitor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 6,7-DHB. CAS No. 145414-76-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8354. | |
| 6',7'-Epoxybergamottin | 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. Synonyms: Epoxybergamottin; 4-[(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enoxy]furo[3,2-g]chromen-7-one. Grades: ≥98%. CAS No. 206978-14-5. Molecular formula: C21H22O5. Mole weight: 354.4. | |
| 6β-Hydroxycortisone | 6β-Hydroxycortisone can be used as a probe to detect inhibition of CYP3A4 in vivo. Synonyms: (6β)-6,17,21-Trihydroxy-pregn-4-ene-3,11,20-trione; 11-Dehydro-6β,17-dihydroxy-corticosterone; 6β,17,21-Trihydroxy-pregn-4-ene-3,11,20-trione; 6β,17α,21-Trihydroxy-4-pregnene-3,11,20-trione; NSC 15457. Grades: > 95%. CAS No. 16355-28-5. Molecular formula: C21H28O6. Mole weight: 376.44. | |
| 7-Benzyloxy-4-(trifluoromethyl)coumarin | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-BFC. CAS No. 220001-53-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W267897. | |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grades: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Atazanavir | Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632. CAS No. 198904-31-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367. | |
| Atazanavir sulfate | Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor. Atazanavir sulfate is a substrate and inhibitor of CYP3A4 , and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: BMS-232632 sulfate. CAS No. 229975-97-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17367A. | |
| Avanafil metabolite M4 | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grades: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
| Azamulin | Highly selective human CYP3A4 inhibitor. A mutilin derivative. Group: Biochemicals. Alternative Names: 14-O- (5- (2-Amino1, 3, 4-triazolyl) thioacetyl) dihydromutilin; Antibiotic TDM 85-530; SA 85530b; (5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS, 4R, 5S, 6R, 8R, 9R, 9aR, 10R)-6-ethyldecahydro-5-hydroxy-4, 6, 9, 10-tetramethyl-1-oxo-3a, 9-propano-3aH-cyclopentacycloocten-8-yl ester. Grades: Highly Purified. CAS No. 76530-44-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| AZD7325 | AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor ( K i =0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes [1] [4]. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro [2]. AZD7325 has the potential for the investigation of anxiety and dravet syndrome [3]. PAM: positive allosteric modulator. Uses: Scientific research. Group: Signaling pathways. CAS No. 942437-37-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111052. | |
| Bergaptol | A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 and 42.93 μM, respectively. Recent studies suggest that it may have antiproliferative and anticancer properties. Group: Biochemicals. Alternative Names: 4-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-one; 4-Hydroxybergapten; 5-Hydroxy-6,7-furanocoumarin; 5-Hydroxypsoralen; NSC 341958. Grades: Highly Purified. CAS No. 486-60-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Bergaptol | Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC 50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 5-Hydroxypsoralen; 4-Hydroxybergapten. CAS No. 486-60-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-76316. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| BMS695735 | BMS695735 is a benzimidazole inhibitor of the insulin-like growth factor-1 receptor. It was also found to have potent CYP3A4 inhibition. It has broad spectrum in vivo antitumor activity. Uses: Bms695735 has broad spectrum antitumor activity. Synonyms: BMS-695735; BMS 695735; BMS695735; CHEMBL459729; BDBM27888; DNC008930; 2(1H)-Pyridinone, 4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-3-(5-(1-(3-fluoropropyl)-4-piperidinyl)-7-methyl-1H-benzimidazol-2-yl)-;(3Z)-4-[2-(4-chloropyrazol-1-yl)ethylamino]-3-[6-[1-(3-fluoropropyl)piperidin-4-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one. Grades: 95%. CAS No. 1054315-48-8. Molecular formula: C26H31ClFN7O. Mole weight: 512.02. | |
| Capmatinib | Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280; INCB28060. CAS No. 1029712-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13404. | |
| Capmatinib dihydrochloride hydrate | Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate. CAS No. 1865733-40-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13404C. | |
| Capmatinib hydrochloride | Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280 hydrochloride; INCB-28060 hydrochloride. CAS No. 1029714-89-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13404B. | |
| Carbosulfan | Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Uses: Scientific research. Group: Signaling pathways. CAS No. 55285-14-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B2015. | |
| Casopitant mesylate | Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW679769B. CAS No. 414910-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14405A. | |
| Cedrol | Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities. Group: Inhibitors. Alternative Names: Cypress camphor. CAS No. 77-53-2. Molecular formula: C15H26O. Mole weight: 222.37. Appearance: Pale yellow to yellow green solid. Purity: 0.99. IUPACName: (1S, 2R, 5S, 7R, 8R)-2, 6, 6, 8-Tetramethyltricyclo[5.3.1.01, 5]undecan-8-ol. Canonical SMILES: CC1CCC2C13CCC(C(C3)C2(C)C)(C)O. Density: 0.9479 g/cm³. Catalog: ACM77532. |  |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration ( IC 50 ) and 90% inhibitory concentration ( IC 90 ) values of 1.90 and 4.46?μM [1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model [2] [3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N6972. | |
| Clarithromycin | Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4 -catalyzed triazolam alpha-hydroxylation with the IC 50 ( K i ) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current [3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 81103-11-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-17508. | |
| Clarithromycin | Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM. Clarithromycin significantly inhibits the HERG potassium current.Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. Group: Inhibitors. Alternative Names: Erythromycin, 6-O-methyl-. CAS No. 81103-11-9. Molecular formula: C38H69NO13. Mole weight: 747.95. Purity: 0.999. Catalog: ACM81103119-1. | |
| Clarithromycin (Standard) | Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current [3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 81103-11-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-17508R. | |
| Cletoquine oxalate | Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment. Group: Inhibitors. Alternative Names: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]amino]ethanol Oxalate; (+/-)-Desethylhydroxychloroquine Oxalate. CAS No. 14142-64-4. Molecular formula: C18H24ClN3O5. Mole weight: 397.85. Appearance: Brown Solid. Purity: 0.96. IUPACName: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;oxalic acid. Canonical SMILES: CC(CCCNCCO)NC1=C2C=CC(=CC2=NC=C1)Cl. C(=O)(C(=O)O)O. Catalog: ACM14142644. | |
| Clobetasol propionate | Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC 50 of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 25122-46-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-13600. | |
| Cobicistat | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grades: 0.99. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028. | |
| Curcumenol | Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC 50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria , with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Curcumenol. CAS No. 19431-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N2259. | |
| CYP3cide | CYP3cide is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3A4 is an important enzymes involved in the metabolism of xenobiotics in the human body and constitutes to about a quarter of all CYPs in the human body. CYP3cide provides a useful in vitro tool in defining the individual roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Group: Biochemicals. Alternative Names: PF-04981517. Grades: Highly Purified. CAS No. 1390637-82-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Dasatinib analog-1 | Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a K i value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174416-41-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156883. | |
| Dehydroaripiprazole | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OPC-14857; DM-14857. CAS No. 129722-25-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-100665. | |
| DMU2139 | DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. DMU2139 showed a very high level of selectivity towards CYP1B1 with respect to the IC50 values obtained with CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2C9 and CYP2C19 Sacchrosomes. Group: Inhibitors. Alternative Names: DMU2139; DMU-2139; DMU 2139. CAS No. 1821143-80-9. Molecular formula: C19H15NO2. Mole weight: 289.33. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-1-(6-methoxynaphthalen-2-yl)-3-(pyridin-3-yl)prop-2-en-1-one. Canonical SMILES: O=C (C1=CC=C2C=C (OC)C=CC2=C1)/C=C/C3=CC=CN=C3. Catalog: ACM1821143809. | |
| Dronedarone | Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents , including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR 33589. CAS No. 141626-36-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0016. | |
| Ellipticine (NSC 71795) | Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7uM. Group: Biochemicals. Alternative Names: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole, NSC 71795. Grades: Highly Purified. CAS No. 519-23-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H14N2, Molecular Weight: 246.3. US Biological Life Sciences. | Worldwide |
| Ethiprole | Ethiprole is an insecticide.Metabolic sulfones are produced faster than Fipronil (HY-B0822) in CYP3A4-expressing cells and in vivo in mouse brain and liver.Ethiprole's sulfide, sulfoxide, sulfone and desulfinyl derivatives have better biological activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 181587-01-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-120425. | |
| Faldaprevir | Faldaprevir, also known as BI-201335, is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. Group: Inhibitors. Alternative Names: Faldaprevir; BI-201335; BI 201335; BI201335. CAS No. 801283-95-4. Molecular formula: C40H49BrN6O9S. Mole weight: 869.83. Appearance: Solid powder. Purity: >98%. IUPACName: (1R,2S)-1-((2S,4R)-4-((8-bromo-2-(2-isobutyramidothiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-1-((S)-2-(((cyclopentyloxy)carbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-vinylcyclopropane-1-carboxylic acid. Canonical SMILES: O=C ([C@]1 (NC ([C@H]2N (C ([C@@H] (NC (OC3CCCC3)=O)C (C) (C)C)=O)C[C@H] (OC4=CC (C5=CSC (NC (C (C)C)=O)=N5)=NC6=C (Br)C (OC)=CC=C46)C2)=O)[C@H] (C=C)C1)O. Catalog: ACM801283954. | |
| Fenofibrate | Fenofibrate is a selective PPARα agonist with an EC 50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC 50 s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19 , CYP2B6 , CYP2C9 , CYP2C8 , and CYP3A4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 49562-28-9. Pack Sizes: 10 mM * 1 mL; 200 mg; 5 g; 10 g. Product ID: HY-17356. | |
| Fenofibrate (Standard) | Fenofibrate (Standard) is the analytical standard of Fenofibrate. This product is intended for research and analytical applications. Fenofibrate is a selective PPARα agonist with an EC 50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC 50 s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19 , CYP2B6 , CYP2C9 , CYP2C8 , and CYP3A4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 49562-28-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-17356R. | |
| Fipronil | Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC 50 s of 30 nM and 1600 nM for cockroach and rat GABA receptors , respectively. Glutamate-gated chloride channels ( GluCls ), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120068-37-3. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0822. | |
| Friedelin | Friedelin is derived from the leaves of Maytenus ilicifolia (Mart). Friedelin is an orally active non-competitive inhibitor of CYP3A4 , with IC 50 and K i values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 , with IC 50 and K i values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 559-74-0. Pack Sizes: 5 mg. Product ID: HY-N4110. | |
| Ginsenoside F1 | Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity. Uses: Scientific research. Group: Natural products. Alternative Names: 20(S)-Ginsenoside F1. CAS No. 53963-43-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-N0598. | |
| Ginsenoside Rd | Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC 50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca 2+ influx. Ginsenoside Rd inhibits CYP2D6 , CYP1A2 , CYP3A4 , and CYP2C9 , with IC 50 s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Gypenoside VIII. CAS No. 52705-93-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0043. | |
| GSK 962040 | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal;1-[4-(3-fluoroanilino)piperidin-1-yl]-2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone. Grades: >98%. CAS No. 923565-21-3. Molecular formula: C25H33FN4O. Mole weight: 424.55. | |
| Hyperforin DCHA | Key constituent of St. John's wort. Shows properties of potential pharmacological interest, including anti-bacterial, anti-malarial, anti-inflammatory, anti-cancer and anti-angiogenic effects. Anti-depressant and anxiolytic compound. Specific activator of TRPC6 channels. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate). Activator of the pregnane X receptor (PXR). Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism. Potential anti-Alzheimer compound. Potent SIRT1 (sirtuin 1) and SIRT2 (sirtuin 2) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 238074-03-8. Pack Sizes: 500ug, 1mg. Molecular Formula: C35H51O4 C12H24N. US Biological Life Sciences. | Worldwide |
| Hyperforin DCHA (5-hydroxy-6R-methyl-1R, 3, 7S-tris(3-methyl-2-butenyl)-5S-(2-methyl-1-oxopropyl)-6R-(4-methyl-3-pentenyl)-bicyclo[3.3.1]non-3-ene-2,9-dione, DHCA) | Displays a variety of biological activities including anti-bacterial, anti-inflammatory, anticancer and anti-angiogenic effects. Also acts as an antidepressant and anxiolytic agent. Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate). Also acts as a potent SIRT1 and SIRT2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 238074-03-8. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Isavuconazole | Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4. Group: Inhibitors. Alternative Names: Isavuconazole;4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile;2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;BAL 4815;RO 0094815; Isavuconazolep; 4-[2-[(1R, 2R)-2-(2, 5-Difluorophenyl)-2-hydroxy-1-Methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile; NaMe:Isavuconazole; 4-[2-[(2R, 3R)-3-(2, 5-difluorophenyl)-3-hydroxy-4-(1, 2, 4-triazol-1-yl)butan-2-yl]-1, 3-thiazol-4-yl]benzonitrile. CAS No. 241479-67-4. Molecular formula: C22H17F2N5OS. Mole weight: 437.4650864. Purity: 0.9997. Density: 1.38. Catalog: ACM241479674. | |
| Isavuconazole | Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAL-4815; RO-0094815. CAS No. 241479-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14273. | |
| Isoniazid | Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). Group: Biochemicals. Alternative Names: 4-Pyridinecarboxylic Acid Hydrazide; Isonicotinic Acid Hydrazide; 4- (Hydrazinocarbonyl) pyridine; 4-Pyridinecarbonyl hydrazine; 4-Pyridinecarboxylic Hydrazide; 4-Pyridylcarbonyl hydrazide ; 5015 R.P.; Armazid; Armazide; Atcotibine;Isonizide; Isotebezid; Isozide; Robisellin; Sauterazid; Zinadon; Zonazide; Tubazid. Grades: Highly Purified. CAS No. 54-85-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Isosilybin | Isosilybin (Isosilybinin) is a flavonoid from Silybum marianum ; inhibits CYP3A4 induction with an IC 50 of 74 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Isosilybinin. CAS No. 72581-71-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0779. | |
| Itraconazole | Itraconazole, a triazole antifungal agent, is a relatively potent inhibitor of CYP3A4. Uses: Antifungal agents; antiprotozoal agents. Synonyms: Itraconazole, R51211, R 51211, R-51211, Orungal, Oriconazole, Sporanox, Itraconazolum, Itraconazol, Itrizole. Grades: >98%. CAS No. 84625-61-6. Molecular formula: C35H38Cl2N8O4. Mole weight: 705.63. | |
| K-11777 | K-11777 is a potent, irreversible cysteine protease inhibitor. Besides, K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4. Synonyms: 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide; APC-3316; APC3316; APC 3316; K-11777; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316. Grades: >98%. CAS No. 233277-99-1. Molecular formula: C32H38N4O4S. Mole weight: 574.74. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
| Ketoconazole | Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. Group: Inhibitors. Alternative Names: rel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine. CAS No. 65277-42-1. Molecular formula: C26H28Cl2N4O4. Mole weight: 531.43. Appearance: White solid. Purity: 0.98. Catalog: ACM65277421. | |
| Ketoconazole | Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketoconazol; R 41400. CAS No. 65277-42-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0105. | |
| (+)-Ketoconazole | (+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Ketoconazol; (+)-R 41400. CAS No. 142128-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0105A. | |
| Kushenol K | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2. Group: Inhibitors. CAS No. 101236-49-1. Molecular formula: C26H32O8. Mole weight: 472.53. Catalog: ACM101236491. | |
| Mitotane | Mitotane (2,4-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,4-DDD; o,p'-DDD. CAS No. 53-19-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13690. | |
| Naloxegol | Naloxegol is a CYP3A4 enzyme inhibitor. It is also a peripherally-selective opioid antagonist. It is used as the treatment of opioid-induced constipation. lt is a pegylated (polyethylene glycol-modified) derivative of α-naloxol and can be used to reduce opioid-induced symptoms. lt binds to and blocks mu-opioid receptors in the peripheral nervous system. It would reverse the effects of opiate drugs of abuse if it entered the central nervous system. It was approved in 2014 in adult patients with chronic, non-cancer pain. lt was developed by AstraZeneca, licensed from Nektar Therapeutics. It was approved in 2014 in adult patients with chronic, non-cancer pain. It has been listed. Uses: Naloxegol is used as the treatment of opioid-induced constipation. lt can be used to reduce opioid-induced symptoms. Synonyms: Movantik;NKTR-118; NKTR 118; NKTR118; (4R, 4aS, 7S, 7aR, 12bS) -7- [2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] -3-prop-2-enyl-1, 2, 4, 5, 6, 7, 7a, 13-octahydro-4, 12-methanobenzofuro [3, 2-e] isoquinoline-4a, 9-diol. Grades: >98%. CAS No. 854601-70-0. Molecular formula: C34H53NO11. Mole weight: 651.78. | |
| Naloxegol oxalate | Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation. Synonyms: Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5α,6α)-, ethanedioate (1:1); AZ 13337019 oxalate; AZ13337019 oxalate; AZ-13337019 oxalate; Moventig; NKTR 118 oxalate; (4R,4aS,7S,7aR,12bS)-7-((2,5,8,11,14,17,20-heptaoxadocosan-22-yl)oxy)-3-allyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol oxalate. Grades: >98%. CAS No. 1354744-91-4. Molecular formula: C36H55NO15. Mole weight: 741.82. | |
Our database is helping our users find suppliers everyday.
