Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Cl-amidine is an inhibitor of irreversible protein pan-peptidylarginine deiminase (PAD) with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine that is important for its catalytic activity. Synonyms: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide monohydrochloride. Grades: ≥95%. CAS No. 1373232-26-8. Molecular formula: C14H19ClN4O2·HCl. Mole weight: 347.24.
The lysine analog, thialysine, has been implicated in the mechanism for the inhibitory effect of the on human acute leukemia Jurkat T cells. When Jurkat T cells were treated with thialysine (0.32-2.5mM), apoptotic cell death along with several biochemical events such as mitochondrial cytochrome c release, caspase-9 activation, caspase-3 activation, degradation of poly (ADP-ribose) polymerase, and DNA fragmentation was induced in a dose- and time-dependent manner. However, these thialysine-induced apoptotic events were significantly abrogated by an ectopic expression of Bcl-xL, which is known to block mitochondrial cytochrome c release. Decylubiquinone, a mitochondrial permeability transition pore inhibitor, also suppressed thialysine-induced apoptotic events. Comparison of the thialysine-induced alterations in the cell cycle distribution between Jurkat T cells transfected with Bcl-xL gene (J/Bcl-xL) and Jurkat T cells transfected with vector (J/Neo) revealed that the apoptotic cells we Group: Biochemicals. Alternative Names: S-(2-Aminoethyl)-L-cysteine Monohydrochloride; NSC 186915;S-(2-Aminoethyl)-L-cysteine Hydrochloride;S-(2-Aminoethyl)-L-cysteine Monohydrochloride;S-( β-Aminoethyl)-L-cysteine Hydrochloride; Thialysine Hydrochloride. Grades: Highly Purified. CAS No. 4099-35-8. Pack Sizes: 1g, 5g. Molecular Formula: C5H12N2O2S·HCl, Molecular Weight: 200.7. US Biological Life Sciences.
Worldwide
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.