Cysteine Protease Suppliers USA
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Product | Description | |
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Cysteine Protease inhibitor Quick inquiry Where to buy Suppliers range | Cysteine Protease inhibitor is a inhibitor of cysteine protease. Synonyms: 2-Pyrimidinecarbonitrile, 4-[[4'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-. Grades: >98%. CAS No. 921625-62-9. Molecular formula: C18H14N4O. Mole weight: 302.33. | |
1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester Quick inquiry Where to buy Suppliers range | 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 28697-07-6. Pack Sizes: 25g, 100g. Molecular Formula: C14H17NO4, Molecular Weight: 263.29. US Biological Life Sciences. | Worldwide |
1,3-Bis-(Z-Leu-Leu)-diaminoacetone Quick inquiry Where to buy Suppliers range | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
[1- (4-Bromophenyl) cyclopropyl]methanol Quick inquiry Where to buy Suppliers range | Used for preparation of amino acid derivatives as cathepsin cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Bromophenyl)-1-cyclopropanemethanol; 1- (p-Bromophenyl) cyclopropanemethanol. Grades: Highly Purified. CAS No. 98480-31-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
(2E)-5-Hydroxy-2-pentenoic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | (2E)-5-Hydroxy-2-pentenoic Acid Methyl Ester is an intermediate in the preparation of unusual amino acids that are potential Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors. Group: Biochemicals. Alternative Names: (E)-5-Hydroxy-2-pentenoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 62592-80-7. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
2-Pyrimidinecarbonitrile Quick inquiry Where to buy Suppliers range | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
3-Amino-1,4-dimethylpyrazole Quick inquiry Where to buy Suppliers range | 3-Amino-1,4-dimethylpyrazole is used in the preparation of peptides as cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1,4-Dimethyl-1H-pyrazol-3-amine. Grades: Highly Purified. CAS No. 85485-61-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Ac-DEVD-pNA Quick inquiry Where to buy Suppliers range | Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. Synonyms: Ac-DL-Asp-DL-Glu-DL-Val-DL-Asp-pNA; DEVD; 4-[(2-acetamido-3-carboxypropanoyl)amino]-5-[[1-[[3-carboxy-1-(4-nitroanilino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid; NAc-Asp-Glu-Val-Asp-pNA. CAS No. 189950-66-1. Molecular formula: C26H34N6O13. Mole weight: 638.58. | |
Adenovirus Proteinase Inhibitor, NSC 37249 (2- (Dicyclohexylamino) -N- (4- (4- ( (2- (dicyclohexylamino) acetyl) amino) phenyl) sulfonylphenyl) acetamide, N, N?- (Sulfonyldi-4, 1-phenylene) bis (2- (dicyclohexylamino) acetamide, AVP Inhibitor) Quick inquiry Where to buy Suppliers range | A sulfonyl diphenyl ene -bis-dicyclohexyl aminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150nM) and AVP-pVIc substrate-binding site (Ki = 400nM), blocking both AVP-pVIc active complex formation (IC50 = 140nM; [substrate] = 5uM & [pVIc] = 40uM) and catalytic activity (IC50 = 490nM; [substrate] = 5uM) without affecting trypsin or papain protease activity even at concentrations as high as 10uM. Group: Biochemicals. Grades: Purified. CAS No. 2907-88-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
b-AP15 Quick inquiry Where to buy Suppliers range | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grades: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
Calpain Inhibitor II Quick inquiry Where to buy Suppliers range | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
Calpain Inhibitor VI Quick inquiry Where to buy Suppliers range | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grades: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. | |
Clasto-Lactacystin β-lactone Quick inquiry Where to buy Suppliers range | Clasto-Lactacystin β-lactone is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. It is 20-fold more potent than Lactacystin. Synonyms: β-Clastolactacystin; Omuralide. Grades: ≥95%. CAS No. 154226-60-5. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
(E)-4-Hydroxycrotonoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | (E)-4-Hydroxycrotonoic Acid Ethyl Ester is an intermediate used to prepare unusual amino acids that are potential Michael acceptor-based anti-plasmodium and anti-trypanosomal cysteine protease inhibitors. Synonyms: Ethyl trans-4-Hydroxy-2-butenoate; (2E)-4-Hydroxy-2-butenoic Acid Ethyl Ester; 2-Butenoic acid, 4-hydroxy-, ethyl ester, (2E)-. Grades: 95%. CAS No. 10080-68-9. Molecular formula: C6H10O3. Mole weight: 130.14. | |
(E)-4-Hydroxycrotonoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | (E)-4-Hydroxycrotonoic Acid Ethyl Ester is an intermediate in the preparation of unusual amino acids that are potential Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors. Group: Biochemicals. Alternative Names: Ethyl trans-4-Hydroxy-2-butenoate; (2E)-4-Hydroxy-2-butenoic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 10080-68-9. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
E-64 Quick inquiry Where to buy Suppliers range | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Synonyms: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]- (2S, 3S) -oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. Grades: ≥99% by HPLC. CAS No. 66701-25-5. Molecular formula: C15H27N5O5. Mole weight: 357.41. | |
E-76 Quick inquiry Where to buy Suppliers range | E-76, a potent anticoagulant, is an inhibitor of coagulation factor VIIa. It acts by binding to an exosite on the VIIa protease domain and non-competitively inhibits the activation of factor X and amide hydrolytic activity. Synonyms: E-76; Acetyl-ALCDDPRVDRWYCQFVEG-amide; Ac-Ala-Leu-D-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge: Cys3-Cys13); N-acetyl-L-alanyl-L-leucyl-D-cysteinyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-valyl-L-alpha-aspartyl-L-arginyl-L-tryptophyl-L-tyrosyl-L-cysteinyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-alpha-glutamyl-glycinamide (3->13)-disulfide. Grades: ≥95% by HPLC. CAS No. 1926163-13-4. Molecular formula: C97H139N27O29S2. Mole weight: 2211.47. | |
Fumaric Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | Fumaric Acid tert-Butyl Ester is a tert-Butyl ester derivative of Fumaric Acid (F500380). Fumaric Acid tert-Butyl Ester is a reactant used in the preparation of cysteine protease inhibitors based on fumaric acid-derived oligopeptides. It is also used in the preparation of Nε-fumaroylated diketopiperazine of L-Lys used for pulmonary drug delivery. Group: Biochemicals. Alternative Names: (2E)-2-Butenedioic Acid Mono(1,1-dimethylethyl) Ester; (E)-4-tert-Butoxy-4-oxobut-2-enoic Acid. Grades: Highly Purified. CAS No. 135355-96-3. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
Geldanamycin Quick inquiry Where to buy Suppliers range | Geldanamycin is an ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. It has a role as an antiviral agent, an antineoplastic agent, an antimicrobial agent, a cysteine protease inhibitor and a Hsp90 inhibitor. Uses: Microbial Fermentation Products. CAS No. 30562-34-6. Product ID: MFP-021. | |
H-D-allo-Threonine Methyl Ester Hydrochloride Quick inquiry Where to buy Suppliers range | H-D-allo-Threonine Methyl Ester Hydrochloride is used to prepare hepatitis A virus 3C cysteine protease inhibitors. Synonyms: H-D-allo-Thr-OMe HCl; (2R,3R)-Methyl 2-Amino-3-hydroxybutanoate Hydrochloride; Methyl D-allo-Threoninate Hydrochloride. Grades: ≥95%. CAS No. 60538-18-3. Molecular formula: C5H12ClNO3. Mole weight: 169.61. | |
ICMT Inhibitor (Cysmethynil) Quick inquiry Where to buy Suppliers range | An inhibitor of protein prenylation. Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt.A cell-permeable indole acetamide that acts as a substrate-competitive and AdoMet-noncompetitive Icmt (isoprenylcysteine carboxyl methyltransferase) inhibitor (Ki=0.02uM; IC50=0.29uM; Substrate=S-farnesyl-L-cysteine), exhibiting no activity against FTase, gernayl geranyl transferase type I, CaaX protease Rce1, AdoMet-dependent DNA methyltransferase, SssI DNA methyltransferase, or PCMT1 protein methyltransferase. Cysmethynil (25uM) induces G1 cell cycle-arrest and autophagy-mediated, but not apoptotic, cell death in prostate cancer PC3 cells with concomitant PI 3-K/Akt and mTOR signaling blockage, consistent with inhibition of Icmt-mediated activation of Ras and Rheb GTPases. Murine PC3 xenograft studies reveal limited in vivo efficacy. Group: Biochemicals. Alternative Names: Cysmethynil; 2-(5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl)acetamide, 2-(1-Octyl-5-m-tolyl-1H-indol-3-yl) acetamide; Isoprenylcysteine Carboxyl Methyltransferase Inhibitor). Grades: Highly Purified. CAS No. 851636-83-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C25H32N2O, Molecular Weight: 376.5. US Biological Life Sciences. | Worldwide |
K-11777 Quick inquiry Where to buy Suppliers range | K-11777 is a potent, irreversible cysteine protease inhibitor. Besides, K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4. Synonyms: 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide; APC-3316; APC3316; APC 3316; K-11777; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316. Grades: >98%. CAS No. 233277-99-1. Molecular formula: C32H38N4O4S. Mole weight: 574.74. | |
L-685,458 ((5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide) Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent and selective γ-secretase inhibitor (IC50 = 17 nM). Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β40 and A β42 peptides (IC50 values are 48 and 67nM respectively in human neuroblastoma cells). Group: Biochemicals. Alternative Names: (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide. Grades: Highly Purified. CAS No. 292632-98-5. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
Lactacystin Quick inquiry Where to buy Suppliers range | Lactacystin is a microbial metabolite isolated from streptomyces. It is a 20S proteasome inhibitor. Synonyms: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester. Grades: ≥95%. CAS No. 133343-34-7. Molecular formula: C15H24N2O7S. Mole weight: 376.42. | |
Leupeptin hemisulfate Quick inquiry Where to buy Suppliers range | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. Synonyms: Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfat. Grades: >98%. CAS No. 103476-89-7. Molecular formula: C20H38N6O4.1/2(H2SO4). Mole weight: 475.04. | |
Odanacatib Quick inquiry Where to buy Suppliers range | Odanacatib, also known as MK-0822, is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. Uses: For research used only. Synonyms: MK0822; MK-0822; MK 0822; Odanacatib. Grades: >98%. CAS No. 603139-19-1. Molecular formula: C25H27F4N3O3S. Mole weight: 525.56. | |
Parstatin (human) Quick inquiry Where to buy Suppliers range | Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. Parstatin (human) attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. It promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Synonyms: H-Met-Gly-Pro-Arg-Arg-Leu-Leu-Leu-Val-Ala-Ala-Cys-Phe-Ser-Leu-Cys-Gly-Pro-Leu-Leu-Ser-Ala-Arg-Thr-Arg-Ala-Arg-Arg-Pro-Glu-Ser-Lys-Ala-Thr-Asn-Ala-Thr-Leu-Asp-Pro-Arg-OH; L-methionyl-glycyl-L-prolyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-valyl-L-alanyl-L-alanyl-L-cysteinyl-L-phenylalanyl-L-seryl-L-leucyl-L-cysteinyl-glycyl-L-prolyl-L-leucyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-threonyl-L-arginyl-L-alanyl-L-arginyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-alanyl-L-threonyl-L-asparagyl-L-alanyl-L-threonyl-L-leucyl-L-alpha-aspartyl-L-prolyl-L-arginine. Grades: ≥98%. CAS No. 1065755-99-8. Molecular formula: C191H330N64O53S3. Mole weight: 4467.29. | |
Protease Inhibitor Library Quick inquiry Where to buy Suppliers range | A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1100. Categories: Protease Inhibitor Libraries. | |
Q-VD-OPH Quick inquiry Where to buy Suppliers range | QVD-OPH, also known as Quinoline-Val-Asp-Difluorophenoxymethylketone, is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 (IC50 = 25nm), caspase-1 (IC50 = 50nM), caspase-8 (IC50 = 100nM) and caspase-9 (IC50 = 430nM). It can be used in Alzheimer's studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor. Synonyms: Q-VD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone; quinoline-val-asp(OMe)-CH2-OPH. Grades: >98%. CAS No. 1135695-98-5. Molecular formula: C26H25F2N3O6. Mole weight: 513.8. | |
(Ser(PO3H2)273)-Nek11 (268-283) Quick inquiry Where to buy Suppliers range | In undisturbed and DNA-damaged cells, depletion of NEK11 prevents proteasome-dependent CDC25A degradation. NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) is activated directly by phosphorylation of NEK11 at Ser273. NEK11 is an important component of the G2/M checkpoint pathway, and genetic mutations in NEK11 may contribute to cancer development. Synonyms: H-Leu-Asn-Lys-Asn-Pro-Ser(PO3H2)-Leu-Arg-Pro-Ser-Ala-Ile-Glu-Ile-Leu-Cys-OH; L-Cysteine, L-leucyl-L-asparaginyl-L-lysyl-L-asparaginyl-L-prolyl-O-phosphono-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-seryl-L-alanyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-leucyl-. Grades: ≥95%. CAS No. 2243207-06-7. Molecular formula: C77H135N22O26PS. Mole weight: 1848.09. | |
SNOG Quick inquiry Where to buy Suppliers range | SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). Uses: Bronchodilator agents. Synonyms: S-Nitroso-L-glutathione;S-Nitrosoglutathione; Nitrosoglutathione; Glutathione thionitrite; GNSO. Grades: ≥97%. CAS No. 57564-91-7. Molecular formula: C10H16N4O7S. Mole weight: 336.32. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpains I and II and papain (another cysteine protease). Synonyms: Suc-LY-AMC. Grades: >98%. CAS No. 94367-20-1. Molecular formula: C29H33N3O8. Mole weight: 551.6. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease), and used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli. Uses: Peptide Inhibitors. CAS No. 94367-20-1. Product ID: R0810. | |
Tosyl phenylalanyl chloromethyl ketone Quick inquiry Where to buy Suppliers range | Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases. It also inhibits some cysteine proteases such as caspase, papain, bromelain or ficin. Uses: Alkylating agents. Synonyms: Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone; TPCK; Tos-Phe-CH2Cl. Grades: ≥98%. CAS No. 402-71-1. Molecular formula: C17H18ClNO3S. Mole weight: 351.8. | |
WP1130 (Degrasyn) Quick inquiry Where to buy Suppliers range | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
WRR483 Quick inquiry Where to buy Suppliers range | WRR483 is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model. It is an analogue of K-11777. It demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. It also eradicates parasite infection in a mouse model of acute Chagas' disease. It binds covalently to the active site cysteine of the protease. It has potential to be developed as a treatment for Chagas disease. Uses: Wrr483 has potential to be developed as a treatment for chagas disease. Synonyms: WRR-483; WRR 483; WRR483. N-((S)-5-guanidino-1-oxo-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)pentan-2-yl)-4-methylpiperazine-1-carboxamide. Grades: >98%. CAS No. 1076088-50-0. Molecular formula: C29H41N7O4S. Mole weight: 583.75. | |
Z-FA-FMK Quick inquiry Where to buy Suppliers range | Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibitits papain and cruzain. Group: Biochemicals. Grades: Highly Purified. CAS No. 197855-65-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H23FN2O4, Molecular Weight: 386.42. US Biological Life Sciences. | Worldwide |
Z-Ile-Glu(O-t-butyl)-Ala-Leucinal Quick inquiry Where to buy Suppliers range | PSI is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It causes dopaminergic cell death in vitro and prevents activation of NF-κB in response to TNF-α and okadaic acid by inhibiting IκB-α degradation. Uses: Cysteine proteinase inhibitors. Synonyms: Proteasome Inhibitor I; PSI peptide; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester. Grades: ≥ 90 % by HPLC. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. | |
Z-Leu-Leu-Tyr-α-keto aldehyde Quick inquiry Where to buy Suppliers range | Z-Leu-Leu-Tyr-α-keto aldehyde, an excellent inhibitor of serine and cysteine proteases, is an excellent inhibitor of chymotryptic-like activity of the proteasome with a Ki of about 3.0 nM. It may be valuable in identifying the role of the proteasome in the normal and abnormal pathways of protein catabolism in cells. Synonyms: L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[(4-hydroxyphenyl)methyl]-2,3-dioxopropyl]-; Z-LLY-α-keto aldehyde; N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(4-hydroxyphenyl)-3,4-dioxo-2-butanyl]-L-leucinamide; benzyl ((S)-1-(((S)-1-(((S)-1-(4-hydroxyphenyl)-3,4-dioxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate; Cbz-Leu-Leu-Tyr-α-keto aldehyde. Grades: ≥95%. CAS No. 204649-66-1. Molecular formula: C30H39N3O7. Mole weight: 553.66. | |
Z-LVG-CHN2 Quick inquiry Where to buy Suppliers range | Z-LVG-CHN2 is a tripeptide derivative that mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50 = 190 nM) via inhibition of SARS-COV-2 3CL pro protease. Synonyms: L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(3-diazo-2-oxopropyl)-(9CI); Z-LVG-DMK. Grades: 95%. CAS No. 119670-30-3. Molecular formula: C22H31N5O5. Mole weight: 445.51. | |
Z-Phe-DL-Ala-FMK Quick inquiry Where to buy Suppliers range | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. Grades: ≥95%. CAS No. 197855-65-5. Molecular formula: C21H23FN2O4. Mole weight: 386.42. |