Cytochrome P45 Suppliers USA
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Product | Description | |
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11,12-EET Quick inquiry Where to buy Suppliers range | 11,12-EET is a cytochrome P450-derived molecule that is reported to inhibit the epithelial sodium channel (ENaC). It is also reported to be involved in the recovery of Ca2+ pool-depleted cells as sustained increases in EETs may amplify Ca2+ signaling. Group: Biochemicals. Alternative Names: 11,12-epoxyeicosatrienoic acid, 11,12-Eet, 11,12-epoxy-5,8,14-eicosatrienoic acid, 11,12-Oxido-5,8,14-eicosatrienoic acid, 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid. Grades: Highly Purified. CAS No. 123931-40-8. Pack Sizes: 100ug. Molecular Formula: C20 H32 O3, Molecular Weight: 320.5. US Biological Life Sciences. | Worldwide |
1-(1-Methyl-1-phenylethyl)piperidine Quick inquiry Where to buy Suppliers range | 2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 μM; IC50 = 5.1 μM). A selective inactivator of CYP2B6. Uses: Enzyme inhibitor. a selective inactivator of cyp2b6. Synonyms: 1-(2-phenylpropan-2-yl)piperidine; 1-(2-phenylpropan-2-yl)piperidine. Grades: ≥ 95 %. CAS No. 92321-29-4. Molecular formula: C14H21N. Mole weight: 203.32. | |
12(S)-hydroxy-16-heptadecynoic acid Quick inquiry Where to buy Suppliers range | 12(S)-hydroxy-16-heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. Synonyms: 16-Heptadecynoic acid,12-hydroxy-, (S)- (9CI); 12-Hydroxy-heptadec-16-ynoic acid. Grades: ≥98%. CAS No. 148019-74-3. Molecular formula: C17H30O3. Mole weight: 282.4. | |
1,5-Di(methyl-d3)-naphthalene Quick inquiry Where to buy Suppliers range | 1,5-Di(methyl-d3)-naphthalene is the labeled analogue of 1,5-Dimethylnaphthalene (D476365), a polycyclic aromatic hydrocarbon that has been used in the study of structure-based QSAR model on cytochrome P450 2A6 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 94784-15-3. Pack Sizes: 5mg, 50mg. Molecular Formula: C12H6D6, Molecular Weight: 162.26. US Biological Life Sciences. | Worldwide |
1,5-Dimethylnaphthalene Quick inquiry Where to buy Suppliers range | 1,5-Dimethylnaphthalene is a polycyclic aromatic hydrocarbon that has been used in the study of structure-based QSAR model on cytochrome P450 2A6 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 571-61-9. Pack Sizes: 1g, 10g. Molecular Formula: C12H12, Molecular Weight: 156.22. US Biological Life Sciences. | Worldwide |
16α-Hydroxy estrone Quick inquiry Where to buy Suppliers range | 16α-Hydroxy estrone is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. Synonyms: 16α-OHE1; 16a-Hydroxyestrone. Grades: ≥98%. CAS No. 566-76-7. Molecular formula: C18H22O3. Mole weight: 286.4. | |
16 β-Hydroxytestosterone Quick inquiry Where to buy Suppliers range | 16 β-Hydroxytestosterone is a testosterone metabolite synthesized using an active site substitution in cytochrome P450 resulting in steroid hydroxylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 17528-90-4. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C19H28O3, Molecular Weight: 304.42. US Biological Life Sciences. | Worldwide |
1,6-Dihydro-5H-pyrazolo[3,4-c]pyridin-5-one Quick inquiry Where to buy Suppliers range | 1,6-Dihydro-5H-pyrazolo[3,4-c]pyridin-5-one is an aromatic heterocycle that can bind to heme iron in inhibition of cytochrome P450. Group: Biochemicals. Grades: Highly Purified. CAS No. 1049672-77-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H5N3O, Molecular Weight: 135.12. US Biological Life Sciences. | Worldwide |
(±)17(18)-EpETE-Ethanolamide Quick inquiry Where to buy Suppliers range | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grades: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. | |
(±)17-HETE Quick inquiry Where to buy Suppliers range | Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. Synonyms: 17-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic Acid; 17-hydroxyeicosa-all-cis-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 128914-47-6. Molecular formula: C20H32O3. Mole weight: 320.5. | |
17(R)-HETE Quick inquiry Where to buy Suppliers range | 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. Synonyms: (5Z,8Z,11Z,14Z,17R)-17-hydroxyicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-24-2. Molecular formula: C20H32O3. Mole weight: 320.5. | |
17(S)-HETE Quick inquiry Where to buy Suppliers range | 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM. Synonyms: 17-hydroxyicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-25-3. Molecular formula: C20H32O3. Mole weight: 320.5. | |
17(S)-HETE Quick inquiry Where to buy Suppliers range | 17(S)-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 183509-25-3. Pack Sizes: 25ug, 50ug. Molecular Formula: C20H32O3, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
1-Aminobenzotriazole Quick inquiry Where to buy Suppliers range | 1-Aminobenzotriazole is a cytochrome P450 inhibitor that acts as a suicide substrate of CYP. It exhibits an inhibitory effect on oxidative drug metabolism and suppresses ω-oxidation of arachidonic acid devoid of epoxidation. Synonyms: 1H-Benzotriazol-1-amine; Benzotriazol-1-amine; ABT. Grades: ≥98% by HPLC. CAS No. 1614-12-6. Molecular formula: C6H6N4. Mole weight: 134.14. | |
20-HEPE Quick inquiry Where to buy Suppliers range | 20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. Grades: ≥95%. CAS No. 116477-57-7. Molecular formula: C20H30O3. Mole weight: 318.5. | |
20-HETE Quick inquiry Where to buy Suppliers range | 20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature. Group: Biochemicals. Grades: Highly Purified. CAS No. 79551-86-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C20H32O3, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid Quick inquiry Where to buy Suppliers range | 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid is a potent vasoconstrictor produced in vascular smooth muscle cells. Its EC50 value is < 10 nM. It is a cytochrome P450 metabolite. It induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop in kidney. It is involved in the regulation of sodium, potassium, and chloride transport in the renal tubules. It is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction in rat cerebral microvessels. It is excreted mainly as the glucuronide conjugate. It can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2. It regulates blood pressure in a complex way. It sensitizes smooth muscle cells to the constrictor stimuli and promotes the proliferation of endothelial cells. It has the ability to induce proinflammatory changes. It blocked the 70 pS K+ channel localized in the apical membrane in TALH cells. It was found to be a potent vasoconstrictor through activating the kinase pathways that contribute to the vascular tone regulation including MAPK, PKC, rho kinase and src-type tyrosine kinase. It may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Synonyms: 20-Hydroxyeicosatetraeonic acid; 20 Hydroxyeicosatetraeonic acid; 20Hydroxyeicosatetraeonic acid; 20HETE; 20 HETE; 20-HETE;(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid;20-Hydroxyeicosatetraenoic acid;20-hydroxy-5,8,11,14-eicosatetraenoic acid. Grades: >98%. CAS No. 79551-86-3. Molecular formula: C20H32O3. Mole weight: 320.47. | |
20(S)-Ginsenoside F1 Quick inquiry Where to buy Suppliers range | Ginsenoside F1 is a bioactive metabolite of the ginsenoside component of Panax ginseng with the ability to inhibit human cytochrome P450 enzymes. This has application in anti-cancer therapeutics as well as protective liver effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 53963-43-2. Pack Sizes: 10mg, 25 mg. Molecular Formula: C36H62O9. US Biological Life Sciences. | Worldwide |
2,3-Difluoroaniline Quick inquiry Where to buy Suppliers range | 2,3-Difluoroaniline is part of a group of halogenated anilines that are capable of inhibiting human cytochrome P450 2E1, ultimately affecting the metabolism of xenobiotics in the body. Group: Biochemicals. Grades: Highly Purified. CAS No. 4519-40-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5F2N, Molecular Weight: 129.11. US Biological Life Sciences. | Worldwide |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Quick inquiry Where to buy Suppliers range | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Synonyms: PhIP; 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine. Grades: ≥98%. CAS No. 105650-23-5. Molecular formula: C13H12N4. Mole weight: 224.3. | |
2-Amino-5-bromo-1,3,4-thiadiazole Quick inquiry Where to buy Suppliers range | 2-Amino-5-bromo-1,3,4-thiadiazole was used to prepare arylthiadiazole H3 antagonists as Cytochrome P450 inhibitors. It can also be used to synthesize 6-fluoro-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones. Group: Biochemicals. Grades: Highly Purified. CAS No. 37566-39-5. Pack Sizes: 2.5g, 5g. Molecular Formula: C2H2BrN3S, Molecular Weight: 180.03. US Biological Life Sciences. | Worldwide |
2-Chloroethyl Methyl Ether Quick inquiry Where to buy Suppliers range | 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly. Group: Biochemicals. Grades: Highly Purified. CAS No. 627-42-9. Pack Sizes: 25g, 100g. Molecular Formula: C3H7ClO, Molecular Weight: 94.54. US Biological Life Sciences. | Worldwide |
2-Ethoxy-2-(2-naphthyl)acetonitrile Quick inquiry Where to buy Suppliers range | 2-Ethoxy-2-(2-naphthyl)acetonitrile is a new substrate for Cytochrom P450 suitable for fluorescence assays. Group: Biochemicals. Grades: Highly Purified. CAS No. 33224-80-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C14H13NO, Molecular Weight: 211.26. US Biological Life Sciences. | Worldwide |
2-Isopropylnaphthalene Quick inquiry Where to buy Suppliers range | 2-Isopropylnaphthalene has been seen to likely act as CYP2F2 substrates through molecular modelling of the mouse cytochrome P450 CYP2F2. Group: Biochemicals. Grades: Highly Purified. CAS No. 2027-17-0. Pack Sizes: 500mg, 1g. Molecular Formula: C13H14, Molecular Weight: 170.25. US Biological Life Sciences. | Worldwide |
2-Methyl-4-(bromomethyl)pyridine Quick inquiry Where to buy Suppliers range | 2-Methyl-4-(bromomethyl)pyridine is used as a reagent in the synthesis of propargyl pyridinyl ethers which are potential cytochrome P450 inhibitors. It is also used in the preparation of 4-azaindole derivatives which are muscarinic M1 receptor modulators that can be used in treatment of cognitive deficits. Group: Biochemicals. Grades: Highly Purified. CAS No. 1167055-68-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C7H8BrN, Molecular Weight: 186.05. US Biological Life Sciences. | Worldwide |
(2S,5R)-2,5-Dimethylmorpholine Quick inquiry Where to buy Suppliers range | (2S,5R)-2,5-Dimethylmorpholine is a variation of Morpholine (M723725) which is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190). Group: Biochemicals. Grades: Highly Purified. CAS No. 1639924-58-5. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H13NO, Molecular Weight: 115.17. US Biological Life Sciences. | Worldwide |
3- (2-Fluorobenzyl) -4-[ (2-fluorobenzyl) oxy]benzaldehyde Quick inquiry Where to buy Suppliers range | 3- (2-Fluorobenzyl) -4-[ (2-fluorobenzyl) oxy]benzaldehyde is a component used in the synthesis of cytochrome P450 inhibitors in the treatment of various diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1000370-25-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C21H16F2O2, Molecular Weight: 338.35. US Biological Life Sciences. | Worldwide |
(3 β)-24-Bromochol-5-en-3-ol Quick inquiry Where to buy Suppliers range | (3 β)-24-Bromochol-5-en-3-ol is used as an substrate in the study of ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes. Group: Biochemicals. Grades: Highly Purified. CAS No. 74041-57-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3β-Hydroxy-5-cholestenoic acid Quick inquiry Where to buy Suppliers range | 3β-Hydroxy-5-cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. Synonyms: Cholest-5-en-26-oic acid, 3-hydroxy-, (3β)-; (3β)-3-Hydroxycholest-5-en-26-oic acid; Cholest-5-en-26-oic acid, 3β-hydroxy-; 3β-Hydroxycholest-5-en-26-oic acid; 3β-Hydroxycholest-5-en-27-oic acid; (6R)-6-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptanoic acid; Cholesterol-26-carboxylic Acid. Grades: ≥95%. CAS No. 6561-58-6. Molecular formula: C27H44O3. Mole weight: 416.64. | |
4'-Hydroxy chalcone Quick inquiry Where to buy Suppliers range | 4'-Hydroxy chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4'-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV). Synonyms: 2-Benzal-4'-hydroxyacetophenone; 2-Benzylidene-4'-hydroxyacetophenone; p-Cinnamoylphenol; NSC 242264; 4'-Hydroxychalcone. Grades: ≥98%. CAS No. 2657-25-2. Molecular formula: C15H12O2. Mole weight: 224.3. | |
(±)5(6)-EET Quick inquiry Where to buy Suppliers range | 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. Synonyms: (±)5,6-EpETrE. Grades: ≥95% (mixture of free acid and lactone). CAS No. 87173-80-6. Molecular formula: C20H32O3. Mole weight: 320.5. | |
5-fluoro 203 Quick inquiry Where to buy Suppliers range | The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. 5-fluoro 203 is a cytotoxic compound that at 1 μM activates AhR signaling. Synonyms: NSC 703786; 4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylaniline. Grades: ≥98%. CAS No. 260443-89-8. Molecular formula: C14H11FN2S. Mole weight: 258.3. | |
5-Hydroxy-6-methoxy (S)-duloxetine Quick inquiry Where to buy Suppliers range | 5-Hydroxy-6-methoxy (S)-duloxetine is a metabolite of (S)-duloxetine. It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. Synonyms: 2-methoxy-5-[(1S)-3-(methylamino)-1-thiophen-2-ylpropoxy]naphthalen-1-ol. Grades: ≥95%. CAS No. 741693-79-8. Molecular formula: C19H21NO3S. Mole weight: 343.44. | |
6',7'-Epoxybergamottin Quick inquiry Where to buy Suppliers range | 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. Synonyms: Epoxybergamottin; 4-[(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enoxy]furo[3,2-g]chromen-7-one. Grades: ≥98%. CAS No. 206978-14-5. Molecular formula: C21H22O5. Mole weight: 354.4. | |
6a-Hydroxy Paclitaxel Quick inquiry Where to buy Suppliers range | 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel (Item No. 10461), produced by the action of the cytochrome P450 isoform CYP2C8.1,2 The generation of 6α-hydroxy paclitaxel by CYP2C8 can be impacted by other drugs (e.g., fluvastatin, Item No. 10010334) or dietary components that interefere with CYP2C8 activity, as well as by CYP2C8 genetic polymorphisms.3,4,5. Group: Biochemicals. Alternative Names: 6α-hydroxy Taxol; βS-(benzoylamino)-αR-hydroxy-(2aR, 3S, 4R, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS, )-6, 12b-bis(acetyloxy)-12-(benzoyloxy)-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-3, 4, 11-trihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7, 11-methano-1H-cyclodeca[3, 4]benz[1, 2-b]oxet-9-yl ester-benzenepropanoic acid. Grades: Highly Purified. CAS No. 153212-75-0. Pack Sizes: 1mg. Molecular Formula: C??H??NO??, Molecular Weight: 869.91. US Biological Life Sciences. | Worldwide |
6-Hydroxy Chlorzoxazone Quick inquiry Where to buy Suppliers range | A major metabolite of chlorzoxazone. Formed by the actions of cytochrome P450IIE1. Synonyms: 5-Chloro-6-hydroxy-2(3H)-benzoxazolone; 6-Hydroxychlorzoxazone; NSC 24955. Grades: > 95%. CAS No. 1750-45-4. Molecular formula: C7H4ClNO3. Mole weight: 185.57. | |
6-Hydroxy Chlorzoxazone-13C6 Quick inquiry Where to buy Suppliers range | A major labeled metabolite of chlorzoxazone. Formed by the actions of cytochrome P450IIE1. Group: Biochemicals. Alternative Names: 5-Chloro-6-hydroxy-2(3H)-benzoxazolone-13C6. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
6-Hydroxychlorzoxazone (NSC 24955) Quick inquiry Where to buy Suppliers range | A major metabolite of chlorzoxazone. Formed by the actions of cytochrome P450IIE1. Group: Biochemicals. Alternative Names: 5-Chloro-6-hydroxy-2(3H)-benzoxazolone; NSC 24955. Grades: Highly Purified. CAS No. 1750-45-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C?H?ClNO?, Molecular Weight: 185.57. US Biological Life Sciences. | Worldwide |
7-Ethoxyresorufin Quick inquiry Where to buy Suppliers range | 7-Ethoxyresorufin is a fluorometric substrate for and competitive inhibitor of cytochrome P450 1A1. Synonyms: 7-Ethoxy-3H-phenoxazin-3-one; 7-O-Ethoxyresorufin. Grades: > 95%. CAS No. 5725-91-7. Molecular formula: C14H11NO3. Mole weight: 241.24. | |
7-Ethoxyresorufin (7-Ethoxy-3H-phenoxazin-3-one, Resorufin Ethyl Ester) Quick inquiry Where to buy Suppliers range | A fluorometric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine. Group: Biochemicals. Alternative Names: 7-Ethoxy-3H-phenoxazin-3-one, Resorufin Ethyl Ester. Grades: Highly Purified. CAS No. 5725-91-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(±)8(9)-EET Quick inquiry Where to buy Suppliers range | (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. Synonyms: (±)8,9-EpETrE; (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid; 8S,9R-epoxy-5Z,11Z,14Z-eicosatrienoic acid; (Z)-7-[(2S,3R)-3-[(2Z,5Z)-undeca-2,5-dienyl]oxiran-2-yl]hept-5-enoic acid. Grades: ≥98%. Molecular formula: C20H32O3. Mole weight: 320.5. | |
Abiraterone Acetate 99+% Quick inquiry Where to buy Suppliers range | Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase) and a potential agent for the treatment of prostatic cancer. Group: Biochemicals. Alternative Names: 17-(3-Pyridinyl)-androsta-5,16-dien-3-beta-ol acetate. Grades: Reagent Grade. CAS No. 154229-18-2. Pack Sizes: 1g. Molecular Formula: C??H??NO?, Molecular Weight: 391.55. US Biological Life Sciences. | Worldwide |
Acetaminophen-cysteine Quick inquiry Where to buy Suppliers range | Acetaminophen-cysteine is a metabolite of Acetaminophen (A161220) and a serum biomarker of acetaminophen exposure (1,2). Acetaminophen-cysteine can be used to identify acetaminophen-induced acute liver failure when standard testing is inconclusive. Acetaminophen is oxidized by cytochrome P450 to a reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (3). Group: Biochemicals. Grades: Highly Purified. CAS No. 64014-06-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C11H14N2O3S, Molecular Weight: 254.31. US Biological Life Sciences. | Worldwide |
AFP-464 Quick inquiry Where to buy Suppliers range | AFP-464 is a synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with antiproliferative and antineoplastic activities. AFP464 is rapidly converted to aminoflavone in plasma. Aminoflavone activates the aryl hydrocarbon receptor (AhR) signaling pathway leading to an increase in cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1A2 (CYP1A2) expression and, to a lesser extent, an increase in cytochrome P450 1B1 (CYP1B1) expression. Synonyms: AFP464; AFP 464; Hexanamide, 2,6-diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-1-benzopyran-2-yl)-2-fluorophenyl)-, (2S)-. CAS No. 468719-52-0. Molecular formula: C23H27F3N4O6S. Mole weight: 448.44. | |
Avanafil metabolite M4 Quick inquiry Where to buy Suppliers range | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grades: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
AZD 3988 Quick inquiry Where to buy Suppliers range | AZD 3988 is a selective and potent diacylglycerol O-acyltransferase (DGAT) enzyme inhibitor with IC50 value of 0.6 nM. It is selective for DGAT-1 over DGAT-2, cytochrome P450 enzymes and Kv11.1 (hERG). It suppresses adipose tissue TAG synthesis and triacylglyceride (TAG) plasma excursion in rats. It reduces body weight of diet-induced obese rats and may be used as a potential treatment for diabetes and other metabolic diseases. It is orally bioavailable and cell permeable. Synonyms: AZD 3988; AZD-3988; AZD3988; trans-4- [- [ [ [5- [ (3, 4-Difluorophenyl) amino] -1, 3, 4-oxadiazol-2-yl] carbonyl] amino] phenyl] cyclohexaneacetic acid. Grades: ≥98% by HPLC. CAS No. 892489-52-0. Molecular formula: C23H22F2N4O4. Mole weight: 456.44. | |
Banoxantrone Quick inquiry Where to buy Suppliers range | Banoxantrone is a bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. Synonyms: AQ-4N; AZD-1689; AQ4N; AZD1689; AQ 4N; AZD 1689. CAS No. 136470-65-0. Molecular formula: C22H28N4O6. Mole weight: 444.48. | |
Bendamustine-d5 (major) Hydrochloride (5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid-d5 Hydrochloride; Cytostasan-d5; Ribomustin-d5; Treanda-d5) Quick inquiry Where to buy Suppliers range | Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. After intravenous infusion it is extensively metabolised in the liver by cytochrome p450. >95% of the drug is bound to protein - primarily albumin. Only free bendamustine is active. Elimination is biphasic with a half-life of 6-10 minutes and a terminal half-life of approximately 30 minutes. It is eliminated primarily by the renal route. Group: Biochemicals. Alternative Names: 5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid-d5 Hydrochloride; Cytostasan-d5; Ribomustin-d5; Treanda-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Bergamottin Quick inquiry Where to buy Suppliers range | Bergamottin (5-geranoxypsoralen) is a natural furanocoumarin found in the pulp of pomelos and grapefruits. It is also found in the peel and pulp of the bergamot orange, from which it was first isolated and from which its name is derived. It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation. Bergamottin inhibits the cytochrome P450 isoform 3A4 with Ki of 7.7 μM and is a mixed inhibitor of simvastatin drug metabolism with Ki of 174 μM. It also increases glucose consumption in HepG2 cells in a dose-dependent manner. Synonyms: 5-Geranoxypsoralen; Bergamottin. Grades: ≥98%. CAS No. 7380-40-7. Molecular formula: C21H22O4. Mole weight: 338.4. | |
Bilobalide Quick inquiry Where to buy Suppliers range | Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 33570-04-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H18O8. US Biological Life Sciences. | Worldwide |
BMS-582949 hydrochloride Quick inquiry Where to buy Suppliers range | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
BMS 753 Quick inquiry Where to buy Suppliers range | BMS 753 is a RARα-selective agonist (Ki = 2 nM) that modulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1). Synonyms: BMS753; BMS 753; BMS-753. 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid. Grades: ≥99% by HPLC. CAS No. 215307-86-1. Molecular formula: C21H21NO4. Mole weight: 351.4. | |
Bufuralol hydrochloride Quick inquiry Where to buy Suppliers range | Bufuralol (Ro-34787) is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is potentially useful for the treatment of hypertension. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation. Most beta blockers are aryloxypropanolamine-based, in this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor. Synonyms: Ro 3-4787. Grades: ≥95%. CAS No. 60398-91-6. Molecular formula: C16H23NO2·HCl. Mole weight: 297.8. | |
BVT-948 Quick inquiry Where to buy Suppliers range | BVT 948 is a non-competitive and cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM). BVT 948 displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP, and enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Some cytochrome P450 isoforms are also suppressed by BVT 948 (IC50 <10 μM). Synonyms: BVT948; BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione. Grades: ≥98% by HPLC. CAS No. 39674-97-0. Molecular formula: C14H11NO3. Mole weight: 241.24. | |
CAY10434 Quick inquiry Where to buy Suppliers range | 20-HETE is an important metabolite of arachidonic acid in the vasculature, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 displaying an IC50 value of 8.8 nM when tested in human renal microsomes. It is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes. Synonyms: CAY 10434; CAY-10434. Grades: ≥98%. CAS No. 769917-29-5. Molecular formula: C17H25N3O. Mole weight: 287.4. | |
CAY10462 Quick inquiry Where to buy Suppliers range | 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10462 is the hydrochloride salt form of CAY10434. It is a selective inhibitor of the 20-HETE synthase CYP4A11, which exhibits an IC50 of 8.8 nM when tested in human renal microsomes. Synonyms: CAY 10462; CAY-10462. Grades: ≥98%. CAS No. 502656-68-0. Molecular formula: C17H25N3O·2HCl. Mole weight: 360.3. | |
CH-223191 Quick inquiry Where to buy Suppliers range | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant with many toxic effects, including endocrine disruption, reproductive dysfunction, immunotoxicity, liver damage, and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription. In addition, CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR. These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes, target genes of the AhR. CH-223191, may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology. Synonyms: CH223191; CH-223191; CH 223191. Grades: >98%. CAS No. 301326-22-7. Molecular formula: C19H19N5O. Mole weight: 333.39. | |
CITCO Quick inquiry Where to buy Suppliers range | CITCO is a constitutive androstane receptor (CAR) agonist (EC50 = 49 nM), inducing nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes, including several cytochrome P450 isoforms. Uses: Constitutive androstane receptor (car) agonist. Synonyms: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime. Grades: ≥98%. CAS No. 338404-52-7. Molecular formula: C19H12Cl3N3OS. Mole weight: 436.74. | |
Cobicistat Quick inquiry Where to buy Suppliers range | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grades: 0.99. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028. | |
Conquinine Quick inquiry Where to buy Suppliers range | Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. Uses: Conquinine is an alkaloid with class 1a antiarrhythmic and antimalarial effects. it also blocks muscarinic and alpha-adrenergic neurotransmission. Synonyms: Quinidine;Chinidin;Pitayine;(+)-Quinidine;Quinidex;Chinidin;(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol. Grades: 98%. CAS No. 56-54-2. Molecular formula: C20H24N2O2. Mole weight: 324.42. | |
Cycloguanil hydrochloride Quick inquiry Where to buy Suppliers range | Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Synonyms: Chloroguanide Triazine; NSC 3074; 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride. Grades: ≥95%. CAS No. 152-53-4. Molecular formula: C11H14ClN5·HCl. Mole weight: 288.2. | |
CYP3cide Quick inquiry Where to buy Suppliers range | CYP3cide is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3A4 is an important enzymes involved in the metabolism of xenobiotics in the human body and constitutes to about a quarter of all CYPs in the human body. CYP3cide provides a useful in vitro tool in defining the individual roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Group: Biochemicals. Alternative Names: PF-04981517. Grades: Highly Purified. CAS No. 1390637-82-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Cytochrome p450 1B1 (239-248) Quick inquiry Where to buy Suppliers range | Cytochrome p450 1B1. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-559. | |
Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Downstream Primer Quick inquiry Where to buy Suppliers range | Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
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Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Downstream Primer Quick inquiry Where to buy Suppliers range | Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
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Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Downstream Primer Quick inquiry Where to buy Suppliers range | Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Upstream Primer Quick inquiry Where to buy Suppliers range | Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Downstream Primer Quick inquiry Where to buy Suppliers range | Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |