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| Product | Description | |
|---|---|---|
| Cytochrome p450 14a-demethylase inhibitor 1a | Heterocyclic Organic Compound. Alternative Names: CYTOCHROME P450 14A-DEMETHYLASE INHIBITOR 1A. CAS No. 1155360-99-8. Molecular formula: 384.42. Mole weight: C21H22F2N4O. Purity: >99%. IUPACName: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-a. Catalog: ACM1155360998. |  |
| Cytochrome p450 14a-demethylase inhibitor 1b | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1b, 1155361-00-4, S2136_Selleck, CHEMBL549601, Cytochrome P450 14a-demethylase inhibitor 1b-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(2-fluorophenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-00-4. Molecular formula: 402.41. Mole weight: C21H21F3N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(2-fluorophenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Catalog: ACM1155361004. | |
| Cytochrome p450 14a-demethylase inhibitor 1c | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1c, 1155361-01-5, S2137_Selleck, CHEMBL551753, Cytochrome P450 14a-demethylase inhibitor 1c-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(3-fluorophenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-01-5. Molecular formula: 402.41. Mole weight: C21H21F3N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(3-fluorophenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Catalog: ACM1155361015. | |
| Cytochrome p450 14a-demethylase inhibitor 1d | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1d, 1155361-02-6, S2138_Selleck, CHEMBL561816, Cytochrome P450 14a-demethylase inhibitor 1d-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(4-fluorophenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-02-6. Molecular formula: 402.41. Mole weight: C21H21F3N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(4-fluorophenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Catalog: ACM1155361026. | |
| Cytochrome p450 14a-demethylase inhibitor 1e | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1e, 1155361-03-7, S2139_Selleck, CHEMBL561754, Cytochrome P450 14a-demethylase inhibitor 1e-Supplied by Selleck Chemicals, 1-{[(2-chlorophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-03-7. Molecular formula: 418.87. Mole weight: C21H21ClF2N4O. Purity: >99%. IUPACName: 1-[(2-chlorophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Catalog: ACM1155361037. | |
| Cytochrome p450 14a-demethylase inhibitor 1f | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1f, 1155361-04-8, S2140_Selleck, CHEMBL561695, Cytochrome P450 14a-demethylase inhibitor 1f-Supplied by Selleck Chemicals, 1-{[(3-chlorophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-04-8. Molecular formula: 418.87. Mole weight: C21H21ClF2N4O. Purity: >99%. IUPACName: 1-[(3-chlorophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=CC (=CC=C1)Cl)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361048. | |
| Cytochrome p450 14a-demethylase inhibitor 1g | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1g, 1155361-05-9, S2141_Selleck, CHEMBL562017, Cytochrome P450 14a-demethylase inhibitor 1g-Supplied by Selleck Chemicals, 1-{[(4-chlorophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-05-9. Molecular formula: 418.87. Mole weight: C21H21ClF2N4O. Purity: >99%. IUPACName: 1-[(4-chlorophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=CC=C (C=C1)Cl)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361059. | |
| Cytochrome p450 14a-demethylase inhibitor 1h | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1h, 1155361-06-0, S2142_Selleck, CHEMBL562018, Cytochrome P450 14a-demethylase inhibitor 1h-Supplied by Selleck Chemicals, 1-{[(2-bromophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-06-0. Molecular formula: 463.32. Mole weight: C21H21BrF2N4O. Purity: >99%. IUPACName: 1-[(2-bromophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=CC=CC=C1Br)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361060. | |
| Cytochrome p450 14a-demethylase inhibitor 1i | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1i, 1155361-07-1, S2143_Selleck, CHEMBL551756, Cytochrome P450 14a-demethylase inhibitor 1i-Supplied by Selleck Chemicals, 1-{[(4-bromophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-07-1. Molecular formula: 463.32. Mole weight: C21H21BrF2N4O. Purity: >99%. IUPACName: 1-[(4-bromophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=CC=C (C=C1)Br)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361071. | |
| Cytochrome p450 14a-demethylase inhibitor 1j | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1j, 1155361-08-2, S2144_Selleck, S2144 _Selleck, CHEMBL561954, Cytochrome P450 14a-demethylase inhibitor 1j-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(2-methylphenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-08-2. Molecular formula: 398.45. Mole weight: C22H24F2N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(2-methylphenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: CC1=CC=CC=C1CN (CC=C)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361082. | |
| Cytochrome p450 14a-demethylase inhibitor 1k | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1k, 1155361-09-3, S2145_Selleck, CHEMBL564239, Cytochrome P450 14a-demethylase inhibitor 1k-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(4-methylphenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-09-3. Molecular formula: 398.45. Mole weight: C22H24F2N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(4-methylphenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: CC1=CC=C (C=C1)CN (CC=C)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361093. | |
| Cytochrome p450 14a-demethylase inhibitor 1l | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1L, 1155361-10-6, S2146_Selleck, CHEMBL562092, Cytochrome P450 14a-demethylase inhibitor 1L-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(4-nitrophenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-10-6. Molecular formula: 429.42. Mole weight: C21H21F2N5O3. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(4-nitrophenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=CC=C (C=C1)[N+] (=O)[O-])CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361106. | |
| Cytochrome p450 14a-demethylase inhibitor 1m | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1m, 1155361-11-7, S2147_Selleck, CHEMBL539995, Cytochrome P450 14a-demethylase inhibitor 1m-Supplied by Selleck Chemicals, 2-(2,4-difluorophenyl)-1-{[(4-ethylphenyl)methyl](prop-2-en-1-yl)amino}-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-11-7. Molecular formula: 412.48. Mole weight: C23H26F2N4O. Purity: >99%. IUPACName: 2-(2,4-difluorophenyl)-1-[(4-ethylphenyl)methyl-prop-2-enylamino]-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: CCC1=CC=C (C=C1)CN (CC=C)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361117. | |
| Cytochrome p450 14a-demethylase inhibitor 1n | Heterocyclic Organic Compound. Alternative Names: Cytochrome P450 14a-demethylase inhibitor 1n, 1155361-12-8, S2148_Selleck, CHEMBL550013, Cytochrome P450 14a-demethylase inhibitor 1n-Supplied by Selleck Chemicals, 1-{[(2,4-dichlorophenyl)methyl](prop-2-en-1-yl)amino}-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. CAS No. 1155361-12-8. Molecular formula: 453.31. Mole weight: C21H20Cl2F2N4O. Purity: >99%. IUPACName: 1-[(2,4-dichlorophenyl)methyl-prop-2-enylamino]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol. Canonical SMILES: C=CCN (CC1=C (C=C (C=C1)Cl)Cl)CC (CN2C=NC=N2) (C3=C (C=C (C=C3)F)F)O. Catalog: ACM1155361128. | |
| Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Downstream Primer | Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. |  Worldwide |
| Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Upstream Primer | Cytochrome P450 4A1, Rat, primers, 902bp amplimer, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Downstream Primer | Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Upstream Primer | Cytochrome P450 4A2, Rat, primers, 302bp amplimer, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Downstream Primer | Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Upstream Primer | Cytochrome P450 4A3, Rat, primers, 302bp amplimer, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Downstream Primer | Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Downstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Upstream Primer | Cytochrome P450 4A8, Rat, primers, 1956bp amplimer, Upstream Primer. Group: Molecular Biology. Pack Sizes: 1x50ul. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 Monooxygenase | hydroxylation (C-H activation) and oxidation of heteroatoms. Group: Enzymes. Synonyms: Cytochrome P450 Monooxygenase; CYP. Form: 1. Enzyme Powder: 8 items*50mg / item, or other quantity2. Screening Kit: 8 items*1mg / item. Cytochrome P450 Monooxygenase; CYP; Screening Kit; library of enzyme; enzyme library. Cat No: ENLC-010. |  |
| Cytochrome P450 Reductase from Human, Recombinant | Cytochrome P450 reductase is a membrane bound enzyme required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. The cytochrome P450 enzyme system is mainly involved in the detoxification of xenobiotics in the liver. It also participates in the activation of procarcinogens and the metabolism of endogeneous substrates such as steroids. Applications: Human cytochrome p450 reductase has been used in a study to assess the biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat. human cytochrome p450 reductase has also been u...AD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Enzyme Commission Number: EC 1.6.2.4. CAS No. 9023-3-4. Purity: >90% (SDS-PAGE). CPR. Mole weight: 76.5 kDa. Activity: >30 U/mg. Storage: Store at -70°C. Form: Supplied in a solution containing 10 mM potassium phosphate, pH 7.4, 0.1 mM EDTA, 0.5 mM DTT, 20% (v/v) glycerol. Source: Baculovirus infected insect cells. Species: Human. EC 1.6.2.4; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Cat No: NATE-1586. | |
| Dafadine-A ( (5- ( (2, 6-Dimethylphenoxy) methyl) isoxazol-3-yl) (4- (pyridin-4-yl) piperidin-1-yl) methanone, 4- (1- ( (5- ( (2, 6-Dimethylphenoxy) methyl) -3-isoxazolyl) carbonyl) -4-piperidinyl) pyridine, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A) | A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20uM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C. elegans (at ~25uM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Native Rabbit Cytochrome P450 Reductase induced with phenobarbital | The enzyme catalyses electron transfer to cytochrome P450. This system plays a major role in detoxification of drugs and xenobiotics, activation of carcinogens, and metabolism of endogenous substrates such as steroids. Group: Enzymes. Synonyms: EC 1.6.2.4; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Enzyme Commission Number: EC 1.6.2.4. CAS No. 9023-82-9. Purity: ~90% (SDS-PAGE). CPR. Mole weight: mol wt ~80 kDa. Activity: 25-75 units/mg protein (Bradford). Storage: -20°C. Form: buffered aqueous glycerol solution. Solution in 30 mM potassium phosphate buffer, pH 7.7, and 0.1 mM EDTA containing 50% (v/v) glycerol. Source: Rabbit liver. Species: Rabbit. EC 1.6.2.4; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Cat No: NATE-0158. | |
| 11,12-EET | 11,12-EET is a cytochrome P450-derived molecule that is reported to inhibit the epithelial sodium channel (ENaC). It is also reported to be involved in the recovery of Ca2+ pool-depleted cells as sustained increases in EETs may amplify Ca2+ signaling. Group: Biochemicals. Alternative Names: 11,12-epoxyeicosatrienoic acid, 11,12-Eet, 11,12-epoxy-5,8,14-eicosatrienoic acid, 11,12-Oxido-5,8,14-eicosatrienoic acid, 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid. Grades: Highly Purified. CAS No. 123931-40-8. Pack Sizes: 100ug. Molecular Formula: C20 H32 O3, Molecular Weight: 320.5. US Biological Life Sciences. | Worldwide |
| 1-(1-Methyl-1-phenylethyl)piperidine | 2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 μM; IC50 = 5.1 μM). A selective inactivator of CYP2B6. Uses: Enzyme inhibitor. a selective inactivator of cyp2b6. Synonyms: 1-(2-phenylpropan-2-yl)piperidine; 1-(2-phenylpropan-2-yl)piperidine. Grades: ≥ 95 %. CAS No. 92321-29-4. Molecular formula: C14H21N. Mole weight: 203.32. |  |
| 12(S)-hydroxy-16-heptadecynoic acid | 12(S)-hydroxy-16-heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. Synonyms: 16-Heptadecynoic acid,12-hydroxy-, (S)- (9CI); 12-Hydroxy-heptadec-16-ynoic acid. Grades: ≥98%. CAS No. 148019-74-3. Molecular formula: C17H30O3. Mole weight: 282.4. | |
| (±)14,15-Epoxyeicosatrienoic acid | (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)14(15)-EET. CAS No. 197508-62-6. Pack Sizes: 50 μg (312.04 μM * 500 μL in Ethanol). Product ID: HY-150084. |  |
| 1,5-Di(methyl-d3)-naphthalene | 1,5-Di(methyl-d3)-naphthalene is the labeled analogue of 1,5-Dimethylnaphthalene (D476365), a polycyclic aromatic hydrocarbon that has been used in the study of structure-based QSAR model on cytochrome P450 2A6 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 94784-15-3. Pack Sizes: 5mg, 50mg. Molecular Formula: C12H6D6, Molecular Weight: 162.26. US Biological Life Sciences. | Worldwide |
| 1,5-Dimethylnaphthalene | 1,5-Dimethylnaphthalene is a polycyclic aromatic hydrocarbon that has been used in the study of structure-based QSAR model on cytochrome P450 2A6 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 571-61-9. Pack Sizes: 1g, 10g. Molecular Formula: C12H12, Molecular Weight: 156.22. US Biological Life Sciences. | Worldwide |
| 16α-Hydroxy estrone | 16α-Hydroxy estrone is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. Synonyms: 16α-OHE1; 16a-Hydroxyestrone. Grades: ≥98%. CAS No. 566-76-7. Molecular formula: C18H22O3. Mole weight: 286.4. | |
| 16α-Hydroxyprednisolone | 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OH-PRED. CAS No. 13951-70-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-117580. | |
| 16 β-Hydroxytestosterone | 16 β-Hydroxytestosterone is a testosterone metabolite synthesized using an active site substitution in cytochrome P450 resulting in steroid hydroxylation. Group: Biochemicals. Grades: Highly Purified. CAS No. 17528-90-4. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C19H28O3, Molecular Weight: 304.42. US Biological Life Sciences. | Worldwide |
| 1,6-Dihydro-5H-pyrazolo[3,4-c]pyridin-5-one | 1,6-Dihydro-5H-pyrazolo[3,4-c]pyridin-5-one is an aromatic heterocycle that can bind to heme iron in inhibition of cytochrome P450. Group: Biochemicals. Grades: Highly Purified. CAS No. 1049672-77-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H5N3O, Molecular Weight: 135.12. US Biological Life Sciences. | Worldwide |
| (±)17(18)-EpETE-Ethanolamide | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grades: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. | |
| (±)17-HETE | Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. Synonyms: 17-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic Acid; 17-hydroxyeicosa-all-cis-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 128914-47-6. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| (17R,18S)-Epoxyeicosatetraenoic acid | (17R,18S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EETeTr) is a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (HY-B0660). (17R,18S)-Epoxyeicosatetraenoic acid shows exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca 2+ overload. (17R,18S)-Epoxyeicosatetraenoic acid has the potential for the research of antiarrhythmic agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 17(R),18(S)-EETeTr. CAS No. 725246-18-4. Pack Sizes: 25 μg (314.02 μM * 250 μL in Ethanol). Product ID: HY-113040A. | |
| 17(R)-HETE | 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. Synonyms: (5Z,8Z,11Z,14Z,17R)-17-hydroxyicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-24-2. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| 17(S)-HETE | 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM. Synonyms: 17-hydroxyicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-25-3. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| 17(S)-HETE | 17(S)-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 183509-25-3. Pack Sizes: 25ug, 50ug. Molecular Formula: C20H32O3, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
| 1-Aminobenzotriazole | 1-Aminobenzotriazole is a cytochrome P450 inhibitor that acts as a suicide substrate of CYP. It exhibits an inhibitory effect on oxidative drug metabolism and suppresses ω-oxidation of arachidonic acid devoid of epoxidation. Synonyms: 1H-Benzotriazol-1-amine; Benzotriazol-1-amine; ABT. Grades: ≥98% by HPLC. CAS No. 1614-12-6. Molecular formula: C6H6N4. Mole weight: 134.14. | |
| 1-Aminobenzotriazole | 1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 ( P450 ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT; 3-Aminobenzotriazole. CAS No. 1614-12-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-103389. | |
| 1-Ethynylpyrene | 1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1 , 1A2 , and 2B1 with IC 50 s of 0.18, 0.32, and 0.04 μM, respectively [1]. 1-Ethynylpyrene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 34993-56-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-131452. | |
| 20-HEPE | 20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. Grades: ≥95%. CAS No. 116477-57-7. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| 20-HETE | 20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature. Group: Biochemicals. Grades: Highly Purified. CAS No. 79551-86-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C20H32O3, Molecular Weight: 320.47. US Biological Life Sciences. | Worldwide |
| 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid | 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid is a potent vasoconstrictor produced in vascular smooth muscle cells. Its EC50 value is < 10 nM. It is a cytochrome P450 metabolite. It induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop in kidney. It is involved in the regulation of sodium, potassium, and chloride transport in the renal tubules. It is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction in rat cerebral microvessels. It is excreted mainly as the glucuronide conjugate. It can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2. It regulates blood pressure in a complex way. It sensitizes smooth muscle cells to the constrictor stimuli and promotes the proliferation of endothelial cells. It has the ability to induce proinflammatory changes. It blocked the 70 pS K+ channel localized in the apical membrane in TALH cells. It was found to be a potent vasoconstrictor through activating the kinase pathways that contribute to the vascular tone regulation including MAPK, PKC, rho kinase and src-type tyrosine kinase. It may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Synonyms: 20-Hydroxyeicosatetraeonic acid; 20 Hydroxyeicosatetraeonic acid; 20Hydroxyeicosatetraeonic acid; 20HETE; 20 HETE; 20-HETE;(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid;20-Hydroxyeicosatetraenoic acid;20-hydroxy-5,8,11,14-eicosatetraenoic acid. Grades: >98%. CAS No. 79551-86-3. Molecular formula: C20H32O3. Mole weight: 320.47. | |
| 20(S)-Ginsenoside F1 | Ginsenoside F1 is a bioactive metabolite of the ginsenoside component of Panax ginseng with the ability to inhibit human cytochrome P450 enzymes. This has application in anti-cancer therapeutics as well as protective liver effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 53963-43-2. Pack Sizes: 10mg, 25 mg. Molecular Formula: C36H62O9. US Biological Life Sciences. | Worldwide |
| 2,3-Difluoroaniline | 2,3-Difluoroaniline is part of a group of halogenated anilines that are capable of inhibiting human cytochrome P450 2E1, ultimately affecting the metabolism of xenobiotics in the body. Group: Biochemicals. Grades: Highly Purified. CAS No. 4519-40-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5F2N, Molecular Weight: 129.11. US Biological Life Sciences. | Worldwide |
| 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Synonyms: PhIP; 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine. Grades: ≥98%. CAS No. 105650-23-5. Molecular formula: C13H12N4. Mole weight: 224.3. | |
| 2-Amino-5-bromo-1,3,4-thiadiazole | 2-Amino-5-bromo-1,3,4-thiadiazole was used to prepare arylthiadiazole H3 antagonists as Cytochrome P450 inhibitors. It can also be used to synthesize 6-fluoro-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones. Group: Biochemicals. Grades: Highly Purified. CAS No. 37566-39-5. Pack Sizes: 2.5g, 5g. Molecular Formula: C2H2BrN3S, Molecular Weight: 180.03. US Biological Life Sciences. | Worldwide |
| 2-Chloroethyl Methyl Ether | 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly. Group: Biochemicals. Grades: Highly Purified. CAS No. 627-42-9. Pack Sizes: 25g, 100g. Molecular Formula: C3H7ClO, Molecular Weight: 94.54. US Biological Life Sciences. | Worldwide |
| 2-Isopropylnaphthalene | 2-Isopropylnaphthalene has been seen to likely act as CYP2F2 substrates through molecular modelling of the mouse cytochrome P450 CYP2F2. Group: Biochemicals. Grades: Highly Purified. CAS No. 2027-17-0. Pack Sizes: 500mg, 1g. Molecular Formula: C13H14, Molecular Weight: 170.25. US Biological Life Sciences. | Worldwide |
| 2-Methyl-4-(bromomethyl)pyridine | 2-Methyl-4-(bromomethyl)pyridine is used as a reagent in the synthesis of propargyl pyridinyl ethers which are potential cytochrome P450 inhibitors. It is also used in the preparation of 4-azaindole derivatives which are muscarinic M1 receptor modulators that can be used in treatment of cognitive deficits. Group: Biochemicals. Grades: Highly Purified. CAS No. 1167055-68-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C7H8BrN, Molecular Weight: 186.05. US Biological Life Sciences. | Worldwide |
| 2-Naphthol | 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). Uses: Scientific research. Group: Natural products. CAS No. 135-19-3. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-Y0110. | |
| (2S,5R)-2,5-Dimethylmorpholine | (2S,5R)-2,5-Dimethylmorpholine is a variation of Morpholine (M723725) which is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190). Group: Biochemicals. Grades: Highly Purified. CAS No. 1639924-58-5. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H13NO, Molecular Weight: 115.17. US Biological Life Sciences. | Worldwide |
| 3- (2-Fluorobenzyl) -4-[ (2-fluorobenzyl) oxy]benzaldehyde | 3- (2-Fluorobenzyl) -4-[ (2-fluorobenzyl) oxy]benzaldehyde is a component used in the synthesis of cytochrome P450 inhibitors in the treatment of various diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1000370-25-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C21H16F2O2, Molecular Weight: 338.35. US Biological Life Sciences. | Worldwide |
| 3,7a-Diepialexine | 3,7a-diepialexine is a natural product that can be found in plants. It has been shown to inhibit the glycosidases and vinyl ethers that are involved in the synthesis of polyhydroxylated compounds. 3,7a-diepialexine also inhibits the hydroxymethylation of chiral molecules and epoxidation reactions. This compound has been shown to have an inhibitory effect on human liver cells by binding to the protein cytochrome P450, thereby inhibiting oxygenation reactions. Group: Other alkaloids. Alternative Names: (+)-3-Epiaustraline. CAS No. 119065-82-6. Molecular formula: C8H15NO4. Mole weight: 189.21 g/mol. Canonical SMILES: C1CN2[C@H] ([C@H] ([C@@H] ([C@H]2[C@H]1O)O)O)CO. Catalog: ACM119065826. | |
| (3 β)-24-Bromochol-5-en-3-ol | (3 β)-24-Bromochol-5-en-3-ol is used as an substrate in the study of ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes. Group: Biochemicals. Grades: Highly Purified. CAS No. 74041-57-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3β-Hydroxy-5-cholestenoic acid | 3β-Hydroxy-5-cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. Synonyms: Cholest-5-en-26-oic acid, 3-hydroxy-, (3β)-; (3β)-3-Hydroxycholest-5-en-26-oic acid; Cholest-5-en-26-oic acid, 3β-hydroxy-; 3β-Hydroxycholest-5-en-26-oic acid; 3β-Hydroxycholest-5-en-27-oic acid; (6R)-6-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptanoic acid; Cholesterol-26-carboxylic Acid. Grades: ≥95%. CAS No. 6561-58-6. Molecular formula: C27H44O3. Mole weight: 416.64. | |
| 3-Cyano-7-ethoxycoumarin | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage Target: Cytochrome P450 3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies. Uses: Scientific research. Group: Fluorescent dye. CAS No. 117620-77-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-D0055. | |
| 3-epi-6-deoxocathasterone 23-monooxygenase | This enzyme is involved in brassinosteroid biosynthesis. C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone and lead directly from (22S,24R)-22-hydroxy-5α-ergostan-3-one and 3-epi-6-deoxocathasterone to 3-dehydro-6-deoxoteasterone and 6-deoxotyphasterol. Group: Enzymes. Synonyms: cytochrome P450 90C1; CYP90D1; CYP90C1. Enzyme Commission Number: EC 1.14.13.112. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0712; 3-epi-6-deoxocathasterone 23-monooxygenase; EC 1.14.13.112; cytochrome P450 90C1; CYP90D1; CYP90C1. Cat No: EXWM-0712. | |
| (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase | This cytochrome P450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency. Group: Enzymes. Synonyms: CYP82D61 (gene name). Enzyme Commission Number: EC 1.14.13.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0816; (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase; EC 1.14.13.214; CYP82D61 (gene name). Cat No: EXWM-0816. | |
| 4-Hydroxy atorvastatin hemicalcium | 4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 265989-44-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137310. | |
| 4'-Hydroxy chalcone | 4'-Hydroxy chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4'-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV). Synonyms: 2-Benzal-4'-hydroxyacetophenone; 2-Benzylidene-4'-hydroxyacetophenone; p-Cinnamoylphenol; NSC 242264; 4'-Hydroxychalcone. Grades: ≥98%. CAS No. 2657-25-2. Molecular formula: C15H12O2. Mole weight: 224.3. | |
| 4'-Hydroxy diclofenac | 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 64118-84-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15550. | |
| 4-hydroxyphenylacetaldehyde oxime monooxygenase | This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.41, tyrosine N-monooxygenase and EC 2.4.1.85, cyanohydrin β-glucosyltransferase. Group: Enzymes. Synonyms: 4-hydroxybenzeneacetaldehyde oxime monooxygenase; cytochrome P450II-dependent monooxygenase; NADPH-cytochrome P450 reductase (CYP71E1); CYP71E1; 4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase. Enzyme Commission Number: EC 1.14.13.68. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0874; 4-hydroxyphenylacetaldehyde oxime monooxygenase; EC 1.14.13.68; 4-hydroxybenzeneacetaldehyde oxime monooxygenase; cytochrome P450II-dependent monooxygenase; NADPH-cytochrome P450 reductase (CYP71E1); CYP71E1; 4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase. Cat No: EXWM-0874. | |
| (±)5(6)-EET | 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. Synonyms: (±)5,6-EpETrE. Grades: ≥95% (mixture of free acid and lactone). CAS No. 87173-80-6. Molecular formula: C20H32O3. Mole weight: 320.5. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. | |
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