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| Product | Description | |
|---|---|---|
| 1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester | Inhibiting the activity of the enzymes crucial to the inflammation process, 1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester serves as a crucial drug in treating inflammatory diseases like rheumatoid arthritis. Its therapeutic effect involves regulating the immune system by modulating the activity of immune cells, thus curtailing the release of cytokines responsible for inflammation. In addition, its anti-inflammatory action extends beyond suppressing cytokine levels, owing to its ability to halt inflammation cascade reactions with marked efficacy, thereby making it a reliable remedy for patients suffering from inflammatory diseases. Synonyms: Methyl 1,2,3,4-tetra-O-pivaloyl-beta-D-glucopyranosyluronate. CAS No. 86448-91-1. Molecular formula: C27H44O11. Mole weight: 544.63. |  |
| 1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol | 1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol can be obtained from DL-Norepinephrine Hydrochloride (N674500) which is Antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Analytical Standard, Impurity of Drug. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H19NO3, Molecular Weight: 297.35. US Biological Life Sciences. |  Worldwide |
| 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 | 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 is a labelled analogue of 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone (C365325) and an intermediate in synthesizing DL-Norepinephrine-d6 Hydrochloride 85% (N674502), which is an antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C8H2D5ClO3. US Biological Life Sciences. | Worldwide |
| 2-Chloroterephthalic acid | 2-Chloroterephthalic acid, a chemical entity of interest in biomedical research, is employed in the synthesis of versatile organic crystals and polymers. This compound has displayed promising therapeutic potential owing to its profound impact on the modulation of immune pathways, as well as its anti-inflammatory activity in the inhibiting of cytokine release. Such properties render it a highly effective candidate for the treatment of autoimmune diseases. Synonyms: 2-chloroterephthalic acid. Grades: 95%. CAS No. 1967-31-3. Molecular formula: C8H5ClO4. Mole weight: 200.57. | |
| (+)-[6]-Gingerol | (+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]-Gingerol has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Group: Biochemicals. Alternative Names: (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-[6]-Gingerol; (S)-(+)-[6]Gingerol; (S)-[6]Gingerol; [6]-Gingerol. Grades: Highly Purified. CAS No. 23513-14-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7,3',4'-Tri-O-Methylluteolin | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2. Group: Inhibitors. CAS No. 29080-58-8. Molecular formula: C18H16O6. Mole weight: 328.32. Purity: 0.99. Catalog: ACM29080588. |  |
| AP1189 acetate | AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ~3-fold. Group: Agonists. Alternative Names: AP-1189; AP 1189; AP1189; AP1189 acetate. CAS No. 959850-74-9. Molecular formula: C16H18N6O4. Mole weight: 358.36. Appearance: Solid powder. Purity: >98%. IUPACName: (E)-N-[trans-3-{1-(2-Nitrophenyl)-1H-pyrrol-2-yl} allylidenamino]guanidinium acetate. Canonical SMILES: NC (N/N=C/C=C/C1=CC=CN1C2=CC=CC=C2[N+] ([O-])=O)=N. CC (O)=O. Catalog: ACM959850749. | |
| Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| BAY 11-7082 | IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor Inhibits platelet aggregation. Group: Biochemicals. Alternative Names: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile. Grades: Highly Purified. CAS No. 19542-67-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H9NO2S. US Biological Life Sciences. | Worldwide |
| BAY 61-3606 hydrochloride | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grades: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period. Synonyms: 4-Acetylamino-N-(2-Amino-4-Fluorophenyl)-Benzamide; CHEMBL4293858; SCHEMBL15551809; BDBM178100. Grades: 98%. CAS No. 1550053-02-5. Molecular formula: C15H14FN3O2. Mole weight: 287.29. | |
| CP-456773 sodium | CP-456773, also known as MCC950 and CRID3, is a potent, orally bioavailable NLRP3 inflammasome inhibitor and inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production for the treatment of inflammatory diseases. Synonyms: sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide; MCC950; MCC 950; MCC-950; CP-45677; CP45677; CP 45677; CRID-3; CRID3; CRID 3; CP-456773 sodium salt; CP 456773 sodium salt; CP456773 sodium salt; Cytokine release inhibitory drug 3. CAS No. 256373-96-3. Molecular formula: C20H24N2NaO5S. Mole weight: 427.46. | |
| Crisaborole | Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AN-2728; PF-06930164. CAS No. 906673-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10978. |  |
| Crisaborole (Standard) | Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 906673-24-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10978R. | |
| DCVC | DCVC is one of cysteine impurities. It has potential anticancer activity against tumor cell growth. DCVC has been found to influence sort of cytokines release stimulated by pathogen. Uses: Dcvc has been found to influence sort of cytokines release stimulated by pathogen. Synonyms: S-(trans-1,2-Dichlorovinyl)-L-cysteine; (E)-S-(1,2-Dichloroethenyl)-L-cysteine; L-Cysteine, S-((1E)-1,2-dichloroethenyl)-; ALANINE, 3-((1,2-DICHLOROVINYL)THIO)-, (E)-L-; AC1O5GGP. Grades: 98%. CAS No. 13419-46-0. Molecular formula: C5H7Cl2NO2S. Mole weight: 216.09. | |
| DCVC | DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-[(1E)-1,2-Dichloroethenyl]-L-cysteine. CAS No. 13419-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19717. | |
| DL-Tetrahydropalmatine | DL-Tetrahydropalmatine is a plant alkaloid that has a wide range of pharmacological activities. It has been shown to have an inhibitory effect on the release of proinflammatory cytokines and nitric oxide, which is mediated by the activation of toll-like receptor 4 (TLR4). Tetrahydropalmatine also has an anti-inflammatory effect on the kidneys by inhibiting the production of reactive oxygen species and TNF-&alpha. In addition, tetrahydropalmatine has a relaxant effect on smooth muscle cells and acts as an analgesic through its inhibition of NMDA receptors. This compound is also found in glycol ethers, which are used as solvents in paint removers. Group: Other alkaloids. CAS No. 2934-97-6. Molecular formula: C21H25NO4. Mole weight: 355.43 g/mol. Canonical SMILES: COC1=C (C2=C (CC3C4=CC (=C (C=C4CCN3C2)OC)OC)C=C1)OC. Catalog: ACM2934976-1. | |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
| Heparanase 1 from Human, Recombinant | Heparanase is an endo β-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and a 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival. Recombinant heparanase protein hpa1 is produced in cho cells. the protein is purified by several orthogonal chromatography steps. Applications: Positive control for western blot analysis. Group: Enzymes. Synonyms: Heparanase; Hpa1 heparan. HPA1. Storage: Store at -20°C, avoid repeated freeze-thaw cycles. Source: CHO. Species: Human. Heparanase; Hpa1 heparanase; Hpa1; heparanase 1; heparanase-1; C1A heparanase; HPSE; HPA1. Cat No: NATE-0843. |  |
| Idr-1 | IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release. Group: Inhibitors. Alternative Names: CTK8F0240, 940291-10-1. CAS No. 940291-10-1. Molecular formula: C65H118N18O15. Mole weight: 242.314680 [g/mol]. Appearance: Solid. Purity: 0.96. IUPACName: (2S)-1-formyl-N-[(2S)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide;propane. Canonical SMILES: CCC.CC(C=O)NC(=O)C1CCCN1C=O. Catalog: ACM940291101. | |
| IDR-1 | IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 940291-10-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2320. | |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| IQ 1S | IQ 1S is a c-Jun N-terminal kinase (JNK) inhibitor. It inhibits the production of nitric oxide in vitro and inhibits the release of nitric oxide upon metabolism by liver microsomes. It attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. It also inhibits the production of LPS-induced proinflammatory cytokine. It has anti-inflammatory and immunosuppressive effects. Synonyms: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt. Grades: ≥99% by HPLC. CAS No. 1421610-21-0. Molecular formula: C15H8N3NaO. Mole weight: 269.23. | |
| JT001 sodium | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3-IN-19 sodium. CAS No. 2238820-09-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156034A. | |
| JTE 607 dihydrochloride | The hydrochloride salt form of JTE 607, which has been found to be a cytokine release inhibitor. Synonyms: JTE 607 dihydrochloride; JTE607 dihydrochloride; JTE-607 dihydrochloride; N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 188791-09-5. Molecular formula: C25H31Cl2N3O5.2HCl. Mole weight: 597.36. | |
| Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) | A cell-permeable biphenyl carbamoyl benzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC500nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFB leading to nuclear localization of CBFB and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breaown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NO?, Molecular Weight: 317.3. US Biological Life Sciences. | Worldwide |
| L-651,582 | L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxidative phosphorylation in cancer cells and exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages. It may be used as a potential anti-cancer drug. It ameliorates experimental colitis by inhibiting nuclear factor-κB activation, colonic fibrosis and cytokine production. It has antimetastatic, antiangiogenic and antiproliferative activity in vivo. It displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. It blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of calcium-release-activated calcium channel (CRAC) function, cell proliferation and maintenance of mitochondrial membrane potential. Synonyms: Carboxyamidotriazole; CAI; RFE-007; NSC-609974; L-651582; RFE007; NSC609974; L651582; 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67. | |
| Lck Inhibitor | Lck Inhibitor is a small-molecule inhibitor. It takes participate in the T-cell receptor (TCR) signal transduction and affects the expression of genes associated with cell proliferation, cytokine release and T-cell survival. It has been designed and developed as therapeutic agents for the treatment for T-cell-mediated autoimmune and organ transplant rejection. It showed high selectivity against Lck over another Src family kinase Src and the kinases. It also showed more than 1000-fold greater selectivity over CDK, MAPK and the RSK family. Synonyms: TC-S 7003; TC S 7003; TCS 7003; TC-S-7003; TCS7003; TCS-7003. Grades: >98%. CAS No. 847950-09-8. Molecular formula: C31H30N8O. Mole weight: 530.62. | |
| Lipoxin A4 | Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties [1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways [2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC 50 value of 25.74 nM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: LXA4. CAS No. 89663-86-5. Pack Sizes: 25 μg (283.71 μM * 250 μL in Ethanol). Product ID: HY-113509. | |
| (±)-Lisofylline | (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Lisophylline. CAS No. 6493-6-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-126042. | |
| L-Lysine (Standard) | L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation [1] [2] [3] [4]. IC 50 & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium [1]. L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity [2]. In Vivo: L-lysine (10 mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model [1]. L-lysine (5 or 10 mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model [3]. Uses: Scientific research. Group: Natural products. CAS No | |
| (+)-Lyoniresinol-3a-O-(6-3-methoxy-4-hydroxybenzoyl)-b-D-glucopyranoside | (+)-Lyoniresinol-3a-O-(6-3-methoxy-4-hydroxybenzoyl)-b-D-glucopyranoside is a naturally occurring compound, sought after in the biomedical industry for its noteworthy capacity to act against tumors and inflammation. Research indicates that this compound has shown efficacy in thwarting the proliferation of human lung cancer cells and holds promise in the treatment of other malignancies. Moreover, it has demonstrated the ability to forestall the release of pro-inflammatory cytokines, and thus holds prospects for use in alleviating inflammatory disorders. | |
| MIF-Antagonist, ISO-1 (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole Acetic Acid, Methyl Ester) | Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS-treated wild type mice but has no effect on cytokine release from MIF deficient macrophages. Group: Biochemicals. Grades: Highly Purified. CAS No. 478336-92-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Norepinephrine Sulfonic Acid | Norepinephrine Sulfonic Acid is a derivative of DL-Norepinephrine Hydrochloride, antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Group: Biochemicals. Grades: Highly Purified. CAS No. 24159-36-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H11NO5S, Molecular Weight: 233.24. US Biological Life Sciences. | Worldwide |
| Pimecrolimus (Elidel, SDZ-ASM-981, D05480) | Pimecrolimus, a rapamycin (sirolimus) derivative, is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type psoriasis, and irritant contact dermatitis. It reduces the production of inflammatory cytokines in T cells and mast cells and inhibits the release of preformed inflammatory mediators from mast cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 137071-32-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ponesimod | Ponesimod is an orally active and selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator that acts as a functional antagonist. It has potential immunomodulating activity. It may be used as a new therapeutic approach in lymphocyte-mediated autoimmune diseases. It is also an experimental drug for the treatment of multiple sclerosis (MS) and psoriasis. It protects against lymphocyte-mediated tissue inflammation. It activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity in vitro. It prevented edema formation, inflammatory cell accumulation and cytokine release in the skin of mice with delayed-type hypersensitivity. It also prevented t...tal drug for the treatment of multiple sclerosis (ms) and psoriasis. Synonyms: ACT-128800; ACT 128800; ACT128800; Ponesimod. (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propyliMino)-3-(o-tolyl)thiazolidin-4-one;4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]Methylene]-3-(2-Methylphenyl)-2-(propyliMino)-, (2Z,5Z)-;ACT-128800;5-[3-Chloro-4-[((2R)-2,3-dihydroxypropyl)oxy]benz-(Z)-ylidene]-2-((Z)-propylimino)-3-(o-tolyl)thiazolidin-4-one;(5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one. Grades: ≥ 95.0%. CAS No. 854107-55-4. Molecular formula: C23H25ClN2O4S. Mole weight: 460.97. | |
| Protectin D1 | Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3 , ASC , and Caspase-1 , and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Neuroprotectin D1; NPD1. CAS No. 660430-03-5. Pack Sizes: 10 μg (138.7 μM * 200 μL in ethanol). Product ID: HY-130413. | |
| PSMα3 | PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1001405-52-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2358. | |
| QS-21 | QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Stimulon. CAS No. 141256-04-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101092. | |
| Quisovalimab | Quisovalimab (AVTX-002; AEVI 002; SAR 252067) is a human monoclonal antibody against LIGHT , a tumor necrosis factor (TNF)-related cytokine (TNFSF14) that plays an important role in acute respiratory distress syndrome (ARDS) and cytokine release syndrome (CRS) COVID-19. Quisovalimab can be used in COVID-19 acute respiratory distress syndrome and other studies [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AVTX-002; AEVI 002; SAR 252067. CAS No. 2427667-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99810. | |
| R112 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. | |
| Ro 20-1724 | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| Theralizumab | Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti- CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TGN1412. CAS No. 906068-56-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9975. | |
| tocilizumab | Tocilizumab is a humanized monoclonal antibody resistant against the interleukin-6 receptor (IL-6R). It is an immunosuppressive agent commonly used for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis. Actemra (tocilizumab) 162 mg syringe for subcutaneous injection and Actemra 162 mg auto-injector for subcutaneous injection was approved in Japan for the treatment of Takayasu arteritis (TAK) and giant cell arteritis (GCA), as well as its intravenous injection was approved by FDA for severe cytokine release syndrome (CRS). Uses: The treatment of rheumatoid arthritis (ra), systemic juvenile idiopathic arthritis, takayasu arteritis (tak), giant cell arteritis (gca), severe cytokine release syndrome (crs), etc. Synonyms: Anti-Human IL6R, Humanized Antibody; Actemra; R 1569; RoActemra; Atlizumab; Actemra 200; R1569; R-1569. Grades: ≥95%. CAS No. 375823-41-9. Molecular formula: C6428H9976N1720O2018S42. Mole weight: 145000. | |
| Trehalose 6,6-dimycolate | Cord Factor is a glycolipid released from mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids; it possesses immunomodulatory properties. Cord Factor induces the activation of macrophages, independent of TLR2 or TLR4, to release inflammatory cytokines. Synonyms: Cord Factor; 6,6'-Di-O-mycoloyl-α,α-trehalose; T6DM. CAS No. 61512-20-7. Mole weight: 2600 - 3000. | |
| VRT-043198 | VRT-043198, the active metabolite of VX-765, is a Caspase inhibitor. VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9. VRT-043198 inhibited the release of interleukin (IL)-1beta and IL-18, but it had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8. Synonyms: VRT043198; VRT 043198; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide; (S)-3-({1-((S)-1-((S)-2-{(1-(4-Amino-3-chlorophenyl)methanoyl)amino}-3,3-dimethyl-butanoyl)pyrrolidin-2-yl)methanoyl}amino)-4-oxobutyric acid. Grades: ≥98%. CAS No. 244133-31-1. Molecular formula: C22H29ClN4O6. Mole weight: 480.94. | |
| YM 58483 | YM 58483 is a calcium release-activated calcium (CRAC) channel inhibitor. YM 58483 suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM), cytokine production and proliferation of T cells in vitro. YM 58483 exhibits immuno-modulatory and anti-inflammatory activity. Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; Btp2; YM-58483; YM 58483; CRAC Channel Inhibitor, BTP2. Grades: ≥99% by HPLC. CAS No. 223499-30-7. Molecular formula: C15H9F6N5OS. Mole weight: 421.32. | |
| Anamorelin Fumarate | Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate; RC1291 Fumarate; ONO7643 Fumarate; RC 1291 Fumarate; ONO 7643 Fumarate. Grades: >98%. CAS No. 339539-92-3. Molecular formula: C35H46N6O7. Mole weight: 662.78. | |
| NCX 466 ((aS)-6-Methoxy-a-methyl-2-naphthalene acetic acid (5S)-5,6-bis(nitrooxy)hexyl ester) | Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-beta and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available. Group: Biochemicals. Grades: Highly Purified. CAS No. 1262956-64-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| S-Propargylcysteine | S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H 2 S-releasing compound. S-Propargylcysteine reduces Ca 2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SPRC. CAS No. 3262-64-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W001538. | |
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