Cytokine Release Suppliers USA
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Product | Description | |
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1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester Quick inquiry Where to buy Suppliers range | Inhibiting the activity of the enzymes crucial to the inflammation process, 1,2,3,4-Tetra-O-pivaloyl-b-D-glucuronide methyl ester serves as a crucial drug in treating inflammatory diseases like rheumatoid arthritis. Its therapeutic effect involves regulating the immune system by modulating the activity of immune cells, thus curtailing the release of cytokines responsible for inflammation. In addition, its anti-inflammatory action extends beyond suppressing cytokine levels, owing to its ability to halt inflammation cascade reactions with marked efficacy, thereby making it a reliable remedy for patients suffering from inflammatory diseases. Synonyms: Methyl 1,2,3,4-tetra-O-pivaloyl-beta-D-glucopyranosyluronate. CAS No. 86448-91-1. Molecular formula: C27H44O11. Mole weight: 544.63. | |
1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol Quick inquiry Where to buy Suppliers range | 1-(4-(4-Hydroxyphenyl)butan-2-yl)-1H-indole-5,6-diol can be obtained from DL-Norepinephrine Hydrochloride (N674500) which is Antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Analytical Standard, Impurity of Drug. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H19NO3, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 Quick inquiry Where to buy Suppliers range | 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone-d5 is a labelled analogue of 2-Chloro-1- (3, 4-dihydroxyphenyl) ethanone (C365325) and an intermediate in synthesizing DL-Norepinephrine-d6 Hydrochloride 85% (N674502), which is an antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C8H2D5ClO3. US Biological Life Sciences. | Worldwide |
2-Chloroterephthalic acid Quick inquiry Where to buy Suppliers range | 2-Chloroterephthalic acid, a chemical entity of interest in biomedical research, is employed in the synthesis of versatile organic crystals and polymers. This compound has displayed promising therapeutic potential owing to its profound impact on the modulation of immune pathways, as well as its anti-inflammatory activity in the inhibiting of cytokine release. Such properties render it a highly effective candidate for the treatment of autoimmune diseases. Synonyms: 2-chloroterephthalic acid. Grades: 95%. CAS No. 1967-31-3. Molecular formula: C8H5ClO4. Mole weight: 200.57. | |
(+)-[6]-Gingerol Quick inquiry Where to buy Suppliers range | (+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]-Gingerol has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Group: Biochemicals. Alternative Names: (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-[6]-Gingerol; (S)-(+)-[6]Gingerol; (S)-[6]Gingerol; [6]-Gingerol. Grades: Highly Purified. CAS No. 23513-14-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Anamorelin Fumarate Quick inquiry Where to buy Suppliers range | Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate; RC1291 Fumarate; ONO7643 Fumarate; RC 1291 Fumarate; ONO 7643 Fumarate. Grades: >98%. CAS No. 339539-92-3. Molecular formula: C35H46N6O7. Mole weight: 662.78. | |
Ascomycin (High Purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) Quick inquiry Where to buy Suppliers range | Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Group: Biochemicals. Grades: Highly Purified. CAS No. 104987-12-4. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
BAY 11-7082 Quick inquiry Where to buy Suppliers range | IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor Inhibits platelet aggregation. Group: Biochemicals. Alternative Names: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile. Grades: Highly Purified. CAS No. 19542-67-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H9NO2S. US Biological Life Sciences. | Worldwide |
BAY 61-3606 hydrochloride Quick inquiry Where to buy Suppliers range | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grades: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
BRD3308 Quick inquiry Where to buy Suppliers range | BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period. Synonyms: 4-Acetylamino-N-(2-Amino-4-Fluorophenyl)-Benzamide; CHEMBL4293858; SCHEMBL15551809; BDBM178100. Grades: 98%. CAS No. 1550053-02-5. Molecular formula: C15H14FN3O2. Mole weight: 287.29. | |
CP-456773 sodium Quick inquiry Where to buy Suppliers range | CP-456773, also known as MCC950 and CRID3, is a potent, orally bioavailable NLRP3 inflammasome inhibitor and inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production for the treatment of inflammatory diseases. Synonyms: sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide; MCC950; MCC 950; MCC-950; CP-45677; CP45677; CP 45677; CRID-3; CRID3; CRID 3; CP-456773 sodium salt; CP 456773 sodium salt; CP456773 sodium salt; Cytokine release inhibitory drug 3. CAS No. 256373-96-3. Molecular formula: C20H24N2NaO5S. Mole weight: 427.46. | |
DCVC Quick inquiry Where to buy Suppliers range | DCVC is one of cysteine impurities. It has potential anticancer activity against tumor cell growth. DCVC has been found to influence sort of cytokines release stimulated by pathogen. Uses: Dcvc has been found to influence sort of cytokines release stimulated by pathogen. Synonyms: S-(trans-1,2-Dichlorovinyl)-L-cysteine; (E)-S-(1,2-Dichloroethenyl)-L-cysteine; L-Cysteine, S-((1E)-1,2-dichloroethenyl)-; ALANINE, 3-((1,2-DICHLOROVINYL)THIO)-, (E)-L-; AC1O5GGP. Grades: 98%. CAS No. 13419-46-0. Molecular formula: C5H7Cl2NO2S. Mole weight: 216.09. | |
Everolimus, Cyclosporine and Tacrolimus Mix Standard Quick inquiry Where to buy Suppliers range | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
IkB alpha Control Cell Extracts Quick inquiry Where to buy Suppliers range | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
IQ 1S Quick inquiry Where to buy Suppliers range | IQ 1S is a c-Jun N-terminal kinase (JNK) inhibitor. It inhibits the production of nitric oxide in vitro and inhibits the release of nitric oxide upon metabolism by liver microsomes. It attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. It also inhibits the production of LPS-induced proinflammatory cytokine. It has anti-inflammatory and immunosuppressive effects. Synonyms: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt. Grades: ≥99% by HPLC. CAS No. 1421610-21-0. Molecular formula: C15H8N3NaO. Mole weight: 269.23. | |
JTE 607 dihydrochloride Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of JTE 607, which has been found to be a cytokine release inhibitor. Synonyms: JTE 607 dihydrochloride; JTE607 dihydrochloride; JTE-607 dihydrochloride; N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 188791-09-5. Molecular formula: C25H31Cl2N3O5.2HCl. Mole weight: 597.36. | |
Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable biphenyl carbamoyl benzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC500nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFB leading to nuclear localization of CBFB and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breaown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NO?, Molecular Weight: 317.3. US Biological Life Sciences. | Worldwide |
L-651,582 Quick inquiry Where to buy Suppliers range | L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxidative phosphorylation in cancer cells and exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages. It may be used as a potential anti-cancer drug. It ameliorates experimental colitis by inhibiting nuclear factor-κB activation, colonic fibrosis and cytokine production. It has antimetastatic, antiangiogenic and antiproliferative activity in vivo. It displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. It blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of calcium-release-activated calcium channel (CRAC) function, cell proliferation and maintenance of mitochondrial membrane potential. Synonyms: Carboxyamidotriazole; CAI; RFE-007; NSC-609974; L-651582; RFE007; NSC609974; L651582; 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 99519-84-3. Molecular formula: C17H12Cl3N5O2. Mole weight: 424.67. | |
Lck Inhibitor Quick inquiry Where to buy Suppliers range | Lck Inhibitor is a small-molecule inhibitor. It takes participate in the T-cell receptor (TCR) signal transduction and affects the expression of genes associated with cell proliferation, cytokine release and T-cell survival. It has been designed and developed as therapeutic agents for the treatment for T-cell-mediated autoimmune and organ transplant rejection. It showed high selectivity against Lck over another Src family kinase Src and the kinases. It also showed more than 1000-fold greater selectivity over CDK, MAPK and the RSK family. Synonyms: TC-S 7003; TC S 7003; TCS 7003; TC-S-7003; TCS7003; TCS-7003. Grades: >98%. CAS No. 847950-09-8. Molecular formula: C31H30N8O. Mole weight: 530.62. | |
(+)-Lyoniresinol-3a-O-(6-3-methoxy-4-hydroxybenzoyl)-b-D-glucopyranoside Quick inquiry Where to buy Suppliers range | (+)-Lyoniresinol-3a-O-(6-3-methoxy-4-hydroxybenzoyl)-b-D-glucopyranoside is a naturally occurring compound, sought after in the biomedical industry for its noteworthy capacity to act against tumors and inflammation. Research indicates that this compound has shown efficacy in thwarting the proliferation of human lung cancer cells and holds promise in the treatment of other malignancies. Moreover, it has demonstrated the ability to forestall the release of pro-inflammatory cytokines, and thus holds prospects for use in alleviating inflammatory disorders. | |
MIF-Antagonist, ISO-1 (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole Acetic Acid, Methyl Ester) Quick inquiry Where to buy Suppliers range | Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS-treated wild type mice but has no effect on cytokine release from MIF deficient macrophages. Group: Biochemicals. Grades: Highly Purified. CAS No. 478336-92-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
NCX 466 ((aS)-6-Methoxy-a-methyl-2-naphthalene acetic acid (5S)-5,6-bis(nitrooxy)hexyl ester) Quick inquiry Where to buy Suppliers range | Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD). Inhibits COX-1 and COX-2 while releasing NO. Demonstrates higher efficacy than naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-beta and oxidative stress in a mouse model of bleomycin-induced lung fibrosis. Orally available. Group: Biochemicals. Grades: Highly Purified. CAS No. 1262956-64-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Norepinephrine Sulfonic Acid Quick inquiry Where to buy Suppliers range | Norepinephrine Sulfonic Acid is a derivative of DL-Norepinephrine Hydrochloride, antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Group: Biochemicals. Grades: Highly Purified. CAS No. 24159-36-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H11NO5S, Molecular Weight: 233.24. US Biological Life Sciences. | Worldwide |
Pimecrolimus (Elidel, SDZ-ASM-981, D05480) Quick inquiry Where to buy Suppliers range | Pimecrolimus, a rapamycin (sirolimus) derivative, is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type psoriasis, and irritant contact dermatitis. It reduces the production of inflammatory cytokines in T cells and mast cells and inhibits the release of preformed inflammatory mediators from mast cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 137071-32-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Ponesimod Quick inquiry Where to buy Suppliers range | Ponesimod is an orally active and selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator that acts as a functional antagonist. It has potential immunomodulating activity. It may be used as a new therapeutic approach in lymphocyte-mediated autoimmune diseases. It is also an experimental drug for the treatment of multiple sclerosis (MS) and psoriasis. It protects against lymphocyte-mediated tissue inflammation. It activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity in vitro. It prevented edema formation, inflammatory cell accumulation and cytokine release in the skin of mice with delayed-type hypersensitivity. It also prevented the increase in paw volume and joint inflammation in rats with adjuvant-induced arthritis. It reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues by preventing egress of lymphocytes. It was developed by Actelion. It is in Clinical stage three. Uses: Ponesimod acts as a functional antagonist. it has potential immunomodulating activity. it may be used as a new therapeutic approach in lymphocyte-mediated autoimmune diseases. it is also an experimental drug for the treatment of multiple sclerosis (ms) and psoriasis. Synonyms: ACT-128800; ACT 128800; ACT128800; Ponesimod. (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propyliMino)-3-(o-tolyl)thiazolidin-4-one;4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]Methylene]-3-(2-Methylphenyl)-2-(propyliMino)-, (2Z,5Z)-;ACT-128800;5-[3-Chloro-4-[((2R)-2,3-dihydroxypropyl)oxy]benz-(Z)-ylidene]-2-((Z)-propylimino)-3-(o-tolyl)thiazolidin-4-one;(5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one. Grades: ≥ 95.0%. CAS No. 854107-55-4. Molecular formula: C23H25ClN2O4S. Mole weight: 460.97. | |
R112 Quick inquiry Where to buy Suppliers range | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. | |
Ro 20-1724 Quick inquiry Where to buy Suppliers range | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
tocilizumab Quick inquiry Where to buy Suppliers range | Tocilizumab is a humanized monoclonal antibody resistant against the interleukin-6 receptor (IL-6R). It is an immunosuppressive agent commonly used for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis. Actemra (tocilizumab) 162 mg syringe for subcutaneous injection and Actemra 162 mg auto-injector for subcutaneous injection was approved in Japan for the treatment of Takayasu arteritis (TAK) and giant cell arteritis (GCA), as well as its intravenous injection was approved by FDA for severe cytokine release syndrome (CRS). Uses: The treatment of rheumatoid arthritis (ra), systemic juvenile idiopathic arthritis, takayasu arteritis (tak), giant cell arteritis (gca), severe cytokine release syndrome (crs), etc. Synonyms: Anti-Human IL6R, Humanized Antibody; Actemra; R 1569; RoActemra; Atlizumab; Actemra 200; R1569; R-1569. Grades: ≥95%. CAS No. 375823-41-9. Molecular formula: C6428H9976N1720O2018S42. Mole weight: 145000. | |
Trehalose 6,6-dimycolate Quick inquiry Where to buy Suppliers range | Cord Factor is a glycolipid released from mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids; it possesses immunomodulatory properties. Cord Factor induces the activation of macrophages, independent of TLR2 or TLR4, to release inflammatory cytokines. Synonyms: Cord Factor; 6,6'-Di-O-mycoloyl-α,α-trehalose; T6DM. CAS No. 61512-20-7. Mole weight: 2600 - 3000. | |
Vesnarinone Quick inquiry Where to buy Suppliers range | Vesnarinone, a quinolinone derivative, is a cardiotonic agent. It has pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Its IC50 value is 1 μM and 300 μM for inhibition of HERG channels and PDE. It is a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. It is a new and novel inotropic drug that has unique and complex mechanisms of action. It inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. It plays an important role in the regulation of cytokines and suggests that the reduction of cytokine release may contribute to the beneficial effects of the drug in the treatment of heart failure. It inhibits the production of TFN-a and IFN-y by LPS stimulated whole blood from patients with heart failure and from healthy volunteers. Uses: Vesnarinone inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. it improves ventricular performance most in patients with the worst degree of heart failure. Synonyms: RG-0210; RG 0210; RG0210; OPC-8212; OPC 8212; OPC8212; Piteranometozine; Vesnarinone; Arkin; Arkin-Z. OPC 8212;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone;3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1h)-quinolinone. Grades: >98%. CAS No. 81840-15-5. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
VRT-043198 Quick inquiry Where to buy Suppliers range | VRT-043198, the active metabolite of VX-765, is a Caspase inhibitor. VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9. VRT-043198 inhibited the release of interleukin (IL)-1beta and IL-18, but it had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8. Synonyms: VRT043198; VRT 043198; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide; (S)-3-({1-((S)-1-((S)-2-{(1-(4-Amino-3-chlorophenyl)methanoyl)amino}-3,3-dimethyl-butanoyl)pyrrolidin-2-yl)methanoyl}amino)-4-oxobutyric acid. Grades: ≥98%. CAS No. 244133-31-1. Molecular formula: C22H29ClN4O6. Mole weight: 480.94. | |
YM 58483 Quick inquiry Where to buy Suppliers range | YM 58483 is a calcium release-activated calcium (CRAC) channel inhibitor. YM 58483 suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM), cytokine production and proliferation of T cells in vitro. YM 58483 exhibits immuno-modulatory and anti-inflammatory activity. Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; Btp2; YM-58483; YM 58483; CRAC Channel Inhibitor, BTP2. Grades: ≥99% by HPLC. CAS No. 223499-30-7. Molecular formula: C15H9F6N5OS. Mole weight: 421.32. |