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| Product | Description | |
|---|---|---|
| Cytosolic 5'-nucleotidase II from Huamn, Recombinant | E.coli. Applications: Human cytosolic imp/gmp specific 5'-nucleotidase/phosphotransferase ii (cn-II) is a pure and active protein of 65kda cloned by rt-pcr amplification of mrna extracted from human hepatoma cells and expressed in e.coli. the sequence of the cloned nt5c2 gene (genbank accession number p49902) was confirmed by dna sequencing (100% identity). Group: Enzymes. Synonyms: uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; EC 3.. Enzyme Commission Number: EC 3.1.3.5. CAS No. 9027-73-0. AMPase. Mole weight: 65kDa. Activity: ≥ 0.150 unit/mg protein. Storage: -20 °C in a solution containing 50 mM Tris-HCl, pH 7.6, 2 mM β-mercaptoethanol, 50% glycerol. Source: Human. Species: cN-II. uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; EC 3.1.3.5; CD73; NT5E; ecto-5'-nucleotidase. Pack: stable lyophilized form. Cat No: NATE-1742. |  |
| Abl Cytosolic Substrate | Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: L-Lysine, L-α-glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N-[N-[1-[N-[N-[N-[N-(N-L-α-glutamyl-L-alanyl)-L-isoleucyl]-L-tyrosyl]-L-alanyl]-L-alanyl]-L-prolyl]-L-phenylalanyl]-L-alanyl]-L-lysyl]-L-lysyl]-; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-lysine; Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys. Grades: ≥95%. CAS No. 168202-46-8. Molecular formula: C64H101N15O16. Mole weight: 1336.58. |  |
| Abl Cytosolic Substrate acetate | Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys acetate salt; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-Lysine acetate salt. Grades: ≥95%. CAS No. 2918768-10-0. Molecular formula: C64H101N15O16.C2H4O2. Mole weight: 1396.63. | |
| Native Bovine Protamine Kinase, Cytosolic | Cytosolic protamine kinase is involved in the regulation of protein synthesis and is indirectly associated with numerous cellular processes. Cytosolic protamine kinase is a distinct insulin-stimulated kinase involved in the phosphorylation of eukaryotic Initiation Factor 4E (eIF4E) which is key to initiating translation by mRNA. This protein appears to be inactivated by protein phosphatase 2A family members and may also be inhibited by microcystin, okadeic acid, and ATP. The phosphorylation process is reversible and MBPK1 and MBPK2 (Myelin Basic Protein Kinase 1 and 2) may reactivate cytosolic protamine kinase. Applications: Cytosolic protamine kinase (cpk) is isolated from bovine kidney and has a molecular mass of approximately 45 kda. it phosphorylates the eukaryotic initiation factor 4e (eif4e), which initiates translation by mrna. it is used to study protein synthesis and various cellular processes. Group: Enzymes. Synonyms: Protamine Kinase, Cytosolic; Cytosolic protamine kinase; CPK; Cpk. Purity: >90% (SDS-PAGE). CPK. Activity: > 15,000 units/mg protein. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protamine Kinase, Cytosolic; Cytosolic protamine kinase; CPK; Cpk. Cat No: NATE-0155. | |
| 10β-Hydroperoxy Norethindrone Acetate | 10β-Hydroperoxy Norethindrone Acetate is a derivative of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 10-Hydroperoxy-17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one 17-Acetate; Norethindrone Impurity 4; 19-Nor-17α-pregn-4-en-20-yn-3-one, 10-hydroperoxy-17-hydroxy-, 17-acetate; Norethindrone Acetate Impurity 15. CAS No. 13236-11-8. Molecular formula: C22H28O5. Mole weight: 372.45. | |
| 10-beta Hydroxy Norethindrone | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 10β-Hydroxy Norethindrone; (17α)-10,17-Dihydroxy-19-norpregn-4-en-20-yn-3-one; 10,17-Dihydroxy-19-nor-17α-pregn-4-en-20-yn-3-one. Grades: > 95%. CAS No. 1236-00-6. Molecular formula: C20H26O3. Mole weight: 314.43. | |
| 16β-Hydroxy-17-epi-norethisterone | 16β-Hydroxy-17-epi-norethisterone is an impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 16β,17-Dihydroxy-19-norpregn-4-en-20-yn-3-one; 16β-Hydroxy-18-methyllevonorgestrel; (8R,9S,10R,13S,14S,16R,17S)-17-ethynyl-16,17-dihydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one. Molecular formula: C20H26O3. Mole weight: 314.42. | |
| (17α)-17-Hydroxy-19-norpregn-5-en-20-yn-3-one Cyclic 1,2-Ethanediyl Acetal | (17α)-17-Hydroxy-19-norpregn-5-en-20-yn-3-one Cyclic 1,2-Ethanediyl Acetal is an impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: Spiro[3H-cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane] 19-Norpregn-5-en-20-yn-3-one deriv.; Spiro[3H-cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol, 17-ethynyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-13-methyl-, (8R,9S,10R,13S,14S,17R)-. CAS No. 22170-58-7. Molecular formula: C22H30O3. Mole weight: 342.47. | |
| (17α)-19-Norpregn-5-en-20-yne-3,17-diol | (17α)-19-Norpregn-5-en-20-yne-3,17-diol is an intermediate in the preparation of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: Norethindrone Impurity 36; (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol; Estr-5-ene-3,17-diol, 17-ethynyl-, (17β)-. Grades: ≥95%. CAS No. 1492-41-7. Molecular formula: C20H28O2. Mole weight: 300.43. | |
| 17α-Cyanomethyl-19-nortestosterone | 17α-Cyanomethyl-19-nortestosterone is a metabolite of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: STS 384; STS 528; 17α-Cyanomethyl-17β-hydroxyestr-4-en-3-one; (17α)-17-Hydroxy-3-oxo-19-norpregn-4-ene-21-nitrile; Dienogest EP Impurity F; 2-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile. Grades: ≥95%. CAS No. 67473-36-3. Molecular formula: C20H27NO2. Mole weight: 313.43. | |
| 17-Desethynyl 17-Dibromomethylaceto-norethindrone Acetate | 17-Desethynyl 17-Dibromomethylaceto-norethindrone Acetate is an intermediate of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 17-Dibromomethylaceto-19-norpregn-4-ene-3,20-dione; Norethindrone Acetate Impurity 13; (17α)-21,21-Dibromo-3,20-dioxo-19-norpregn-4-en-17-yl acetate; (8R,9S,10R,13S,14S,17S)-17-(2,2-dibromoacetyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate; Estr-4-en-3-one, 17-(acetyloxy)-17-(2,2-dibromoacetyl)-, (17β)-. Grades: ≥95%. CAS No. 40228-41-9. Molecular formula: C22H28Br2O4. Mole weight: 516.26. | |
| 17-epi-Norethindrone (Impurity G) | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Uses: Contraceptives, oral, synthetic. Synonyms: 17-epi-Norethindrone; 17-Hydroxy-19-norpregn-4-en-20-yn-3-one; 18-Methyllevonorgestrel; Norethisterone Impurity G (EP); Norethindrone EP Impurity G. Grades: > 95%. CAS No. 38673-36-8. Molecular formula: C20H26O2. Mole weight: 298.43. | |
| 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone | 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone is an impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Uses: Tibolone intermediate. Synonyms: (17α)-17-[(Trimethylsilyl)oxy]-19-norpregna-4,6-dien-20-yn-3-one; 19-Norpregna-4,6-dien-20-yn-3-one, 17-[(trimethylsilyl)oxy]-, (17α)-; Tibolone Impurity 12. Grades: 98%. CAS No. 300542-58-9. Molecular formula: C23H32O2Si. Mole weight: 368.58. | |
| 17-O-Trimethylsilyl Norethindrone | 17-O-Trimethylsilyl Norethindrone is a derivative of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: (17α)-17-[(Trimethylsilyl)oxy]-19-norpregn-4-en-20-yn-3-one; 17-(Trimethylsiloxy)-19-nor-17α-pregn-4-en-20-yn-3-one. Grades: 98%. CAS No. 28426-43-9. Molecular formula: C23H34O2Si. Mole weight: 370.60. | |
| 306Oi9-cis2 | 306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 3027930-39-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-167012. |  |
| 3α,5α-Tetrahydronorethisterone | 3α,5α-Tetrahydronorethisterone is a metabolite of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: Norethindrone Impurity 5; (3α,5α,17α)-19-Norpregn-20-yne-3,17-diol; 19-Nor-5α,17α-pregn-20-yne-3α,17-diol; 17α-Ethynyl-5α-estrane-3α,17β-diol; 17α-Ethynyl-5α-oestrane-3α,17β-diol. Grades: ≥95%. CAS No. 16392-60-2. Molecular formula: C20H30O2. Mole weight: 302.45. | |
| 4-Diethylaminobenzaldehyde | DEAB is a potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB is also an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Uses: 4-(diethylamino)benzaldehyde is a mechanism-based inhibitor for human aldehyde dehydrogenase isoenzymes. potent and reversible inhibitor of mouse and human class i aldehyde dehydrogenase. Synonyms: 4-(diethylamino)benzaldehyde. Grades: 99 %. CAS No. 120-21-8. Molecular formula: C11H15NO. Mole weight: 177.24. | |
| 5(S),6(R)-DiHETE | 5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. 5(S),6(R)-DiHETE is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM. Synonyms: (5S,6R,7E,9E,11Z,14Z)-5,6-dihydroxyicosa-7,9,11,14-tetraenoic acid. Grades: ≥95%. CAS No. 82948-88-7. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| 6,10-di-Hydroxy Norethindrone Acetate | 6,10-di-Hydroxy Norethindrone Acetate is an impurity of Norethindrone Acetate, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6,10-Dihydroxy Norethindrone Acetate. Grades: 98%. Molecular formula: C22H28O5. Mole weight: 372.45. | |
| 6,7-Dehydro Norethindrone Acetate | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6,7-Dehydro Norethindrone Acetate; 17-Hydroxy-19-Nor-17α-pregna-4,6-dien-20-yn-3-one Acetate; ?-6(7)-Norenthindrone Acetate; Grades: > 95%. CAS No. 106765-04-2. Molecular formula: C22H26O3. Mole weight: 338.45. | |
| 6,7-Didehydro Norethindrone | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: (17α)-17-Hydroxy-19-norpregna-4,6-dien-20-yn-3-one; 17-Hydroxy-19-nor-17α-pregna-4,6-dien-20-yn-3-one; 7α-Ethynyl-17β-hydroxyestra-4,6-dien-3-one; 6,7-Dehydronorethindrone; Norethindrone EP Impurity A. Grades: > 95%. CAS No. 31528-46-8. Molecular formula: C20H24O2. Mole weight: 296.41. | |
| 6-alpha-Hydroxy Norethindrone Acetate | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6α-Hydroxy Norethindrone Acetate; (6α,17α)-17-(Acetyloxy)-6-hydroxy-19-norpregn-4-en-20-yn-3-one. Grades: > 95%. CAS No. 6856-28-6. Molecular formula: C22H28O4. Mole weight: 356.47. | |
| 6β,17-Norethindrone Diacetate | 6β,17-Norethindrone Diacetate is an impurity of Norethindrone Acetate, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: (6β,17α)-17-(Acetyloxy)-6-acetyl-19-norpregn-4-en-20-yn-3-one. Grades: 95%. Molecular formula: C24H30O4. Mole weight: 382.49. | |
| 6-Beta-Hydroxy-19-Norandrostenedione | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6-Beta-Hydroxy-19-Norandrostenedione; 6beta-Hydroxyestr-4-ene-3,17-dione; Estr-4-ene-3,17-dione, 6-hydroxy-, (6beta)-. Grades: > 95%. CAS No. 5949-49-5. Molecular formula: C18H24O3. Mole weight: 288.39. | |
| 6-beta-Hydroxy Norethindrone Acetate (Norethindrone Acetate Impurity F) | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: (6β,17α)-17-(Acetyloxy)-6-hydroxy-19-norpregn-4-en-20-yn-3-one; 6β,17-Dihydroxy-19-nor-17α-pregn-4-en-20-yn-3-one 17-Acetate. Grades: > 95%. CAS No. 6856-27-5. Molecular formula: C22H28O4. Mole weight: 356.47. | |
| 6-beta-Hydroxy Norethindrone (Norethindrone Impurity H) | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6β-Hydroxy Norethindrone; (6β,17α)-6,17-Dihydroxy-19-norpregn-4-en-20-yn-3-one; 6β,17β-Dihydroxy-17α-ethynylestr-4-en-3-one; 6β,17β-Dihydroxy-19-nor-17α-pregn-4-en-20-yn-3-one; 6β-Hydroxynorethindrone; 6β-Hydroxynorethisterone. Grades: > 95%. CAS No. 51724-44-8. Molecular formula: C20H26O3. Mole weight: 314.45. | |
| 6-Ketocholestanol (5a-Cholestan-6-one) | An oxygenated cholesterol which can be used as a ligand for cytosolic-nuclear tumor promoter binding protein. Group: Biochemicals. Alternative Names: 5a-Cholestan-6-one. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| 6-Keto Norethindrone Acetate (Norethindrone Impurity G) | An impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 6-Oxo Norethindrone Acetate; (17α)-17-(Acetyloxy)-19-norpregn-4-en-20-yne-3,6-dione; 6-Ketonorethindrone Acetate; Norethindrone Acetate EP Impurity G. Grades: > 95%. CAS No. 438244-27-0. Molecular formula: C22H26O4. Mole weight: 354.45. | |
| 6-Oxo Norethindrone | 6-Oxo Norethindrone is an impurity of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: (17α)-17-Hydroxy-19-norpregn-4-en-20-yne-3,6-dione; 17α-Hydroxy-19-norpregn-4-en-20-yne-3,6-dione; 6-Ketonorethindrone. Grades: 95%. CAS No. 67696-78-0. Molecular formula: C20H24O3. Mole weight: 312.40. | |
| 6-phosphogluconolactonase | 6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway. Group: Enzymes. Synonyms: phosphogluconolactonase; 6-PGL. Enzyme Commission Number: EC 3.1.1.31. CAS No. 37278-45-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3457; 6-phosphogluconolactonase; EC 3.1.1.31; 37278-45-8; phosphogluconolactonase; 6-PGL. Cat No: EXWM-3457. | |
| 7-methylguanosine nucleotidase | The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP. Group: Enzymes. Synonyms: cytosolic nucleotidase III-like; cNIII-like; N7-methylguanylate 5'-phosphatase. Enzyme Commission Number: EC 3.1.3.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3698; 7-methylguanosine nucleotidase; EC 3.1.3.91; cytosolic nucleotidase III-like; cNIII-like; N7-methylguanylate 5'-phosphatase. Cat No: EXWM-3698. | |
| AACOCF | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
| AACOCF3 | AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl trifluoromethyl ketone. CAS No. 149301-79-1. Pack Sizes: 5 mg (28.05 mM * 500 μL in Ethanol); 10 mg (28.05 mM * 1 mL in Ethanol). Product ID: HY-108611. | |
| Absinthin | Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46 , which reduces cytosolic Ca 2+ -rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 1362-42-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0742. | |
| ABT 702 | ABT 702 is a non-nucleoside adenosine kinase (ADK) inhibitor (IC50 = 2 nM and 50 nM in cytosolic and intact cell assays, respectively). Study conformed that ABT702 could reduce pain and inflammation in animal models, yet be clastogenic in an in vitro Chinese Hamster micronucleus assay. Synonyms: ABT 702; ABT702; ABT-702; 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine. Grades: 99%. CAS No. 214697-26-4. Molecular formula: C22H19BrN6O. Mole weight: 463.33. | |
| Acetyl-Coenzyme A acetyltransferase 2 from Human, Recombinant | ACAT2 enzyme participates in lipid metabolism. ACAT2 takes part in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. ACAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. ACAT2 deficiency contributes to severe mental retardation and hypotonus. Acat2 recombinant human produced in e. coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-397 a.a.) and having a molecular mass of 45.4 kda. the acat2 is fused to 36 amino acid his-tag at n-terminus and purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Purity: Greater than 95.0% as determined by SDS-PAGE. ACAT-2. Mole weight: 45.4 kDa. Stability: ACAT2 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Cat No: NATE-0798. | |
| Adenosine 3,5-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt (Adenosine 3,5-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA) | A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH.CAS No.71774-13-5. Group: Biochemicals. Grades: Highly Purified. CAS No. 71774-13-5. Pack Sizes: 10umol. Molecular Formula: C??H??N?O?PS · (CH?CH?)?NH. US Biological Life Sciences. | Worldwide |
| AG 205 | AG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. It inhibits cell cycle progression and cell viability in cancer cell lines. It inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro. Synonyms: Cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone. Grades: ≥98%. CAS No. 442656-02-2. Molecular formula: C22H23ClN6OS. Mole weight: 454.98. | |
| Aldehyde Dehydrogenase 2 from Human, Recombinant | ALDH2 is part of the aldehyde dehydrogenase family of proteins which catalyze the chemical transformation from acetaldehyde to acetic acid. ALDH2 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2 has 2 major liver isoforms: cytosolic and mitochondrial, which differ by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Nearly all Caucasians have 2 major isozymes, whereas roughly 50% of Orientals have only the cytosolic isozyme, omitting the mitochondrial isozyme. The extremely higher rate of acute alcohol intoxication with Orientals compared to Caucasians is due to the fact of the absence of mitochondrial... & having a molecular mass of 54.5 kda. the aldh2 is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Purity: Greater than 90.0% as determined by SDS-PAGE. ALDH2. Mole weight: 54.5 kDa. Activity: > 0.14 units/ml. Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. ALDM; ALDHI; ALDH-E2; MGC1806; ALDH2; Aldehyde dehydrogenase mitochondrial; ALDH class 2. Cat No: NATE-0804. | |
| Aldose reductase from Human, Recombinant | In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Group: Enzymes. Synonyms: Aldehyde reductase; Aldo-keto reductase family 1 member B1. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Mole weight: 35853.4 Da. Source: Human. Aldehyde reductase; Aldo-keto reductase family 1 member B1; EC 1.1.1.21; Aldose reductase. Cat No: NATE-1198. | |
| α-bisabolene synthase | This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding. Group: Enzymes. Synonyms: bisabolene synthase. Enzyme Commission Number: EC 4.2.3.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5196; α-bisabolene synthase; EC 4.2.3.38; bisabolene synthase. Cat No: EXWM-5196. | |
| Amastatin hydrochloride | Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100938-10-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-115194. | |
| AminoAcylase-1 from Human, Recombinant | Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes. Acy1 recombinant human produced in e. coli is a single, non-... SDS-PAGE. ACY1. Mole weight: 48 kDa. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. N-acyl-L-amino-acid amidohydrolase; ACY-1, ACY1D; ACYLASE; ACY1; aminoacylase 1; aminoacylase I; dehydropeptidase II; histozyme; hippuricase; benzamidase; acylase I; hippurase; amido acid deacylase; L-aminoacylase; acylase; aminoacylase; L-amino-acid acylase; α-N-acylaminoacid hydrolase; long acyl amidoacylase; short | |
| aminopeptidase B | Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family). Group: Enzymes. Synonyms: arylamidase II; arginine aminopeptidase; arginyl aminopeptidase; Cl--activated arginine aminopeptidase; cytosol aminopeptidase IV; L-arginine aminopeptidase. Enzyme Commission Number: EC 3.4.11.6. CAS No. 9073-92-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4027; aminopeptidase B; EC 3.4.11.6; 9073-92-1; arylamidase II; arginine aminopeptidase; arginyl aminopeptidase; Cl--activated arginine aminopeptidase; cytosol aminopeptidase IV; L-arginine aminopeptidase. Cat No: EXWM-4027. | |
| ASB14780 | ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay) with anti-inflammatory property in ear edema and asthma models. ASB14780 has the potential for the treatment of nonalcoholic fatty liver diseases including fatty liver and hepatic fibrosis. ASB14780 significantly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA and TGFb1 in the liver, as well as the expression of monocyte/macrophage markers. Synonyms: ASB14780; ASB 14780; ASB-14780; 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol; 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol. Grades: 99%. CAS No. 1069046-00-9. Molecular formula: C31H27NO3.C4H11NO3. Mole weight: 582.69. | |
| aspartyl aminopeptidase | Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I. Group: Enzymes. Enzyme Commission Number: EC 3.4.11.21. CAS No. 9074-83-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4018; aspartyl aminopeptidase; EC 3.4.11.21; 9074-83-3. Cat No: EXWM-4018. | |
| ATP Citrate Lyase Active from Human, Recombinant | ATP Citrate lyase is an enzyme involved in fatty acid synthesis that generates cytosolic acetyl-CoA and oxaloacetate from Citrate and CoA. ATP Citrate lyase is often upregulated in cancer. Applications: Active human atp citrate lyase is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. active human atp citrate lyase has been used in a study to ascertain the nature of the catalytic phosphorylation that initiates the acl reaction, and to identity the active site residues involved. active human atp citrate lyase has also been used in a study to analyze tumor metabolism to reveal mitochondrial glucose oxidation in genetically diverse human glioblastomas. Group: Enzymes. S. Purity: > 90% (SDS-PAGE). ACLY. Mole weight: 147 kDa. Storage: Store at -70°C. Avoid multiple freeze-thaw cycles. Form: Aqueous solution, Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. Source: Baculovirus. Species: Human. ACLY; ATP-Citrate synthase; ATPCL; CLATP; ATP-citric lyase; ATP:Citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating); acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating); adenosine triphosphate Citrate lyase; Citrate cleavage enzyme; Citrate-ATP lyase; citric cleavage enzyme; ATP Citrate (pro-S)-lyase. Cat No: NATE-0944. | |
| Auranofin | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Synonyms: SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162; Ridaura; NSC 321521, Ridauragold thiol; Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-; [1-(Thio-κS)-β-D-glucopyranose 2, 3, 4, 6-tetraacetato] (triethylphosphine)gold; Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate; Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-; β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex; [ (Tetra-O-acetyl-β -D-glucopyranosyl)thio] (triethylphosphine)gold; Aktil; Crisinor; Crisofin Gold Salt; Ridauran; SKF 39162D. Grades: ≥98%. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.49. | |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grades: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grades: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
| BCATc Inhibitor 2 | BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 μM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 μM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration. Synonyms: Cytosolic Branched-Chain Amino Acid Transferase Inhibitor 2. Grades: ≥98%. CAS No. 406191-34-2. Molecular formula: C16H10ClF3N2O4S. Mole weight: 418.8. | |
| BCECF/AM - CAS 117464-70-7 | A variable mixture of cell-permeable ester derivatives of BCECF that are hydrolyzed by cytosolic esterases to yield intracellularly trapped indicator BCECF. Group: Fluorescence/luminescence spectroscopy. |  |
| β-aspartyl-peptidase | Other isopeptide bonds, e.g. γ-glutamyl and β-alanyl, are not hydrolysed. A mammalian, cytosolic enzyme. Group: Enzymes. Synonyms: β-aspartyl dipeptidase; β-aspartyl peptidase; β-aspartyldipeptidase. Enzyme Commission Number: EC 3.4.19.5. CAS No. 37288-74-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4089; β-aspartyl-peptidase; EC 3.4.19.5; 37288-74-7; β-aspartyl dipeptidase; β-aspartyl peptidase; β-aspartyldipeptidase. Cat No: EXWM-4089. | |
| BGT226 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BGT-226; BGT 226; BGT-226 free base; BGT226 free base; NVP-BGT226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-imidazo[4,5-c]quinolin-2-one. Grades: 98%. CAS No. 915020-55-2. Molecular formula: C32H29F3N6O6. Mole weight: 534.54. | |
| biotin-dependent malonate decarboxylase | Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP su...nyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, ACP-SH:acetate ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration. Group: Enzymes. Synonyms: malonate decarboxylase (with biotin); malonate decarboxylase (ambiguous). Enzyme Commission Number: EC 4.1.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4838; biotin-dependent malonate decarboxylase; EC 4.1.1.89; malonate decarboxylase (with biotin); malonate decarboxylase (ambiguous). Cat No: EXWM-4838. | |
| biotin-independent malonate decarboxylase | Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. This enzyme is a cytosolic protein that is biotin-independent. The other type is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components (cf. EC 4.1.1.89, biotin-dependent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. In both enzymes, this is achieved by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-ACP. The ACP subunit of both enzyme...enzyme complex are EC 2.3.1.187 (acetyl-S-ACP:malonate ACP transferase), EC 2.3.1.39 ([acyl-carrier-protein] S-malonyltransferase) and EC 4.1.1.87 (malonyl-S-ACP decarboxylase). The carboxy group is lost with retention of configuration. Group: Enzymes. Synonyms: malonate decarboxylase (without biotin); malonate decarboxylase (ambiguous); MDC. Enzyme Commission Number: EC 4.1.1.88. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4837; biotin-independent malonate decarboxylase; EC 4.1.1.88; malonate decarboxylase (without biotin); malonate decarboxylase (ambiguous); MDC. Cat No: EXWM-4837. | |
| BMS-229724 | BMS-229724 is a selective tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2) in that it did not inhibit secreted phospholipase A2 in vitro, nor phospholipase C and phospholipase D in cells. BMS-22972 acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. Synonyms: 4-[4-[2-[2-[bis (4-chlorophenyl) methoxy]ethylsulfonyl]ethoxy]phenyl]-1, 1, 1-trifluorobutan-2-one; 4- (4- (2- (2- (bis (4-chlorophenyl) methoxy) ethylsulfonyl) ethoxy) phenyl) -1, 1, 1-trifluoro-2-butanone; BMS-229724; BMS 229724; BMS229724; 42AD6D8ECA; SCHEMBL3304414; LS-46643; UNII-42AD6D8ECA. Grades: >98%. CAS No. 221914-85-8. Molecular formula: C27H25Cl2F3O5S. Mole weight: 589.45. | |
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt | C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grades: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91. | |
| C16 Ceramide (N-Palmitoyl-D-Sphingosine, N-Hexadecanoyl-D-sphingosine, Palmitoyl Ceramide) | A predominant, rather hydrophobic natural ceramide. Activates a cytosolic serine/threonine protein phosphatase in T9 cells; induces EGF receptor phosphorylation in A-431 cells; stimulates ceramide-activated protein kinase. Group: Biochemicals. Alternative Names: N-Palmitoyl-D-Sphingosine; N-Hexadecanoyl-D-sphingosine; Palmitoyl Ceramide. Grades: Highly Purified. CAS No. 24696-26-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| cADP-Ribose (cADPR) Ammonium Salt | Cyclic ADP-ribose ammonium is a potent calcium-mobilized second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and extracellular influx through the opening of TRPM2 channels. Synonyms: cADP-Ribose Ammonium Salt; cADPR Ammonium Salt; cyclic ADP-ribose ammonium salt; Cyclic Adenosine Diphosphate Ribose ammonium salt; Cyclic adenosine 5'-diphosphate ribose ammonium salt. Grades: 90%. Molecular formula: C15H21N5O13P2.x(NH3). Mole weight: 541.30 (free base). | |
| calpain-1 | In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2. Group: Enzymes. Synonyms: μ-calpain; calcium-activated neutral protease I. Enzyme Commission Number: EC 3.4.22.52. CAS No. 78990-62-2. Calpain 1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4227; calpain-1; EC 3.4.22.52; 78990-62-2; μ-calpain; calcium-activated neutral protease I. Cat No: EXWM-4227. | |
| calpain-2 | Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1. Group: Enzymes. Synonyms: calcium-activated neutral protease II; m-calpain; milli-calpain. Enzyme Commission Number: EC 3.4.22.53. CAS No. 702693-80-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4228; calpain-2; EC 3.4.22.53; 702693-80-9; calcium-activated neutral protease II; m-calpain; milli-calpain. Cat No: EXWM-4228. | |
| CAY10502 | Phospholipases A2 (PLA2s) are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule. It catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. Synonyms: CAY10502; CAY-10502. Grades: ≥98% (mixture of isomers). CAS No. 888320-29-4. Molecular formula: C30H37NO7. Mole weight: 523.6. | |
| CAY10590 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). CAY10590 is a selective and potent inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2. Synonyms: CAY 10590; CAY-10590. Grades: ≥98%. CAS No. 1101136-50-8. Molecular formula: C21H33NO3. Mole weight: 347.5. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytosolic β-catenin levels in mouse L-cells. Synonyms: SR 01000418274; CCT 031374 hydrobromide; SR01000418274; CCT031374 hydrobromide; SR-01000418274; CCT-031374 hydrobromide; 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide. Grades: ≥98% by HPLC. CAS No. 1219184-91-4. Molecular formula: C23H19N3O.HBr. Mole weight: 434.33. | |
| CCT 031374 hydrobromide (1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide) | Inhibitor of TCF-dependent transcription. Blocks BIO-induced beta-catenin stabilization; reduces nuclear and cytosolic beta-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219184-91-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDIBA | CDIBA is a potent and selective cytosolic phospholipase A2 (cPLA2) inhibitor. Synonyms: 4-[2-(1-benzhydryl-5-chloro-2-methylindol-3-yl)ethoxy]benzoic acid. Grades: 99%. CAS No. 479422-22-5. Molecular formula: C31H26ClNO3. Mole weight: 496. | |
| cGAMP | cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12512. | |
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