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| Product | Description | |
|---|---|---|
| Dabrafenib | Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC 50 s of 5 nM and 0.6 nM for C-Raf and B-Raf V600E , respectively [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK2118436A; GSK2118436. CAS No. 1195765-45-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-14660. |  |
| Dabrafenib | Dabrafenib / GSK2118436 is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively. Group: Fluorinated apis. Alternative Names: GSK2118436. CAS No. 1195765-45-7. Molecular formula: C23H20F3N5O2S2. Mole weight: 519.56. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide. Catalog: OFC1195765457. |  |
| Dabrafenib Impurity 1 | Dabrafenib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1907654-22-1. Molecular Formula: C24H21F3N4O3S2. Mole Weight: 534.57. Catalog: APB1907654221. |  |
| Dabrafenib Impurity 4 | Dabrafenib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,2-dimethylpropanethioamide. CAS No. 630-22-8. Molecular Formula: C5H11NS. Mole Weight: 117.21. Catalog: APB630228. | |
| Dabrafenib Mesylate | Dabrafenib, also known as GSK2118436, is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. On May 29, 2013, FDA approved this drug. Synonyms: N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide methanesulfonate; Dabrafenib mesylate; GSK 2118436B; GSK2118436B; GSK-2118436B; GSK2118436 Methane sulfonate salt; Brand name: Taflinar. Grades: >98%. CAS No. 1195768-06-9. Molecular formula: C24H24F3N5O5S3. Mole weight: 615.67. |  |
| Dabrafenib Mesylate | Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC 50 s of 0.6 and 5.0 nM for Raf V600E and c-Raf, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK2118436 Mesylate; GSK 2118436B. CAS No. 1195768-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14660A. | |
| 2, 6-Difluoro Benzene sulfonyl Chloride | 2, 6-Difluoro Benzene sulfonyl chloride is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2, 6-Difluoro Benzene sulfonyl chloride is also a potential inhibitor of zinc proteases. Group: Biochemicals. Grades: Highly Purified. CAS No. 60230-36-6. Pack Sizes: 5g, 10g. Molecular Formula: C6H3ClF2O2S, Molecular Weight: 212.6. US Biological Life Sciences. |  Worldwide |
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