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Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 368. CAS No. 7261-97-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12542.
Dantrolene
Dantrolene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DANTROLENE;DANTROLENE FREE BASE (FOR R&D ONLY). Product Category: Heterocyclic Organic Compound. CAS No. 85008-71-5. Molecular formula: C14H10N4O5. Mole weight: 314.25. Purity: 0.96. IUPACName: 1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione. Canonical SMILES: C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]. ECNumber: 230-684-8. Product ID: ACM85008715. Alfa Chemistry ISO 9001:2015 Certified.
Dantrolene
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Dantrolene-13C3
A labeled muscle relaxant (skeletal). Used in the treatment of malignant hyperthermia. Group: Biochemicals. Alternative Names: 1- [ [ [5- (4-Nitrophenyl) -2-furanyl] methylene] amino] -2, 4-imidazolidinedione-13C3; Dantrium-13C3. Grades: Highly Purified. CAS No. 1185234-99-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Dantrolene Impurity 2
5-(4-Nitrophenyl)-2-furaldehyde-(2-carboxymethyl) Semicarbazone is an impurity in the synthesis of Dantrolene, a muscle relaxant (skeletal). Dantrolene is used in the treatment of malignant hyperthermia. Synonyms: 5-(4-Nitrophenyl)-2-furaldehyde-(2-carboxymethyl) Semicarbazone; [(Aminocarbonyl)[[5-(4-nitrophenyl)-2-furanyl]methylene]hydrazino]acetic Acid; Dantrolene Impurity. Grades: > 95%. CAS No. 57268-33-4. Molecular formula: C14H12N4O6. Mole weight: 332.27.
Dantrolene Impurity 3
2-[1-(Aminocarbonyl)-2-[[5-(4-nitrophenyl)-2-furanyl]methylene]hydrazinyl]-acetic Acid Ethyl Ester is an intermediate used in the synthesis of 1-(5-Phenylfurfurylideneamino)hydantoins. Synonyms: 2-[1-(Aminocarbonyl)-2-[[5-(4-nitrophenyl)-2-furanyl]methylene]hydrazinyl]-acetic Acid Ethyl Ester. Grades: > 95%. CAS No. 55227-60-6. Molecular formula: C16H16N4O6. Mole weight: 360.32.
Dantrolene Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Dantrolene Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Dantrolene Related Compound C
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 440. CAS No. 14663-23-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14657.
Dantrolene sodium
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Dantrolene Sodium
Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It suppresses the release of calcium previously sequestered by skeletal, but not cardiac, muscle sarcoplasmic reticulum. Synonyms: Dantrolene sodium salt; Dantrium; Sodium 3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate. Grades: 98.0%~102.0%. CAS No. 14663-23-1. Molecular formula: C14H9N4NaO5. Mole weight: 336.239.
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by blocking excitation-contraction coupling in the muscle fiber. Uses: Muscle relaxants, central. Synonyms: Dantrolene sodium salt; Dantrium; Sodium dantrolene. Grades: ≥99%. CAS No. 24868-20-0. Molecular formula: C14H9N4O5·7/2H2O·Na. Mole weight: 399.29.
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dantrolene sodium hydrate. CAS No. 24868-20-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12542A.
Dantrolene Sodium Salt, Anhydrous
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum. Group: Biochemicals. Alternative Names: 1- [ [ [5- (4-Nitrophenyl) -2-furanyl] methylene] amino] -2, 4-imidazolinedione Sodium Salt; Dantrium; Dantrium; F 440; Sodium Dantrolene. Grades: Highly Purified. CAS No. 14663-23-1. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C??H?N?NaO?, Molecular Weight: 336.23. US Biological Life Sciences.
Worldwide
Dantrolene sodium salt hemiheptahydrate
Dantrolene sodium salt hemiheptahydrate. Group: Biochemicals. Alternative Names: 1- [ [ [5- (4-Nitrophenyl) -2-furanyl] methylene] amino] -2, 4-imidazolidinedione sodium salt hemiheptahydrate; Dantrium; Dantrolene sodium hemiheptahydrate. Grades: Highly Purified. CAS No. 24868-20-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H9N4NaO5·3.5H2O. US Biological Life Sciences.
A muscle relazant (sketal). Used in the treatment of malignant hyperthermia. Group: Biochemicals. Alternative Names: Dantrium, 1- [ [ [5- (4-Nitrophenyl) -2-furanyl] methylene] amino] -2, 4-imidazolidinedione. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
5-Hydroxy dantrolene
5-Hydroxy dantrolene. Group: Biochemicals. Alternative Names: 5-Hydroxy-1- [ [ [5- (4-nitrophenyl) -2-furanyl] methylene] amino] -2, 4-imidazolidinedione. Grades: Highly Purified. CAS No. 52130-25-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C14H10N4O6. US Biological Life Sciences.
Worldwide
5-Hydroxy Dantrolene
5-Hydroxy Dantrolene is a metabolite of Dantrolene that has shown to have muscle relaxant effects. Synonyms: 5-Hydroxy-1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione. Grades: > 95%. CAS No. 52130-25-3. Molecular formula: C14H10N4O6. Mole weight: 330.25.
A metabolite of Dantrolene that has shown to have muscle relaxant effects. Group: Biochemicals. Alternative Names: 2,4-Imidazolidinedione, 5-hydroxy-1- [ [ [5- (4-nitrophenyl) -2-furanyl] methylene] amino] . Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
1-Amino-5-hydroxyhydantonin
1-Amino-5-hydroxyhydantonin is an substituent in the synthesis of Dantrolene (D185000) metabolites shown to have muscle relaxant effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 42839-65-6. Pack Sizes: 25mg, 100mg. Molecular Formula: C3H5N3O3. US Biological Life Sciences.
Worldwide
5-(3-Chlorophenyl)-2-furoic Acid
5-(3-Chlorophenyl)-2-furoic acid is a reactant in the preparation of dantrolene which has a potential to treat vascular dysfunction. Synonyms: 5-(3-Chlorophenyl)-2-furancarboxylic Acid; 5-(3-Chlorophenyl)-2-furoic Acid; 5-(m-Chlorophenyl)-2-furancarboxylic Acid. Grades: 97%. CAS No. 41019-44-7. Molecular formula: C11H7ClO3. Mole weight: 222.01.
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