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| Product | Description | |
|---|---|---|
| Darunavir | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C27H37N3O7S. CAS No. 206361-99-1. Prepack ID 90027035-25mg. Molecular Weight 547.66. See USA prepack pricing. |  |
| Darunavir | [(3R,3aS,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[5,4-b]furan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate. HIV-1-protease inhibitor. CAS No. 206361-99-1. Product ID: 2-08348. Molecular formula: C27H37N3O7S. Mole weight: 547.66. Reference: J. Med. Chem., 48, 1813, 2005. |  |
| Darunavir | Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM). Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively. Uses: Hiv protease inhibitors. Synonyms: TMC-114; TMC 114; TMC114; Prezista. Grades: ≥98%. CAS No. 206361-99-1. Molecular formula: C27H37N3O7S. Mole weight: 547.67. |  |
| Darunavir | Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC 50 = 0.003 μM; IC 90 = 0.009 μM) with minimal cytotoxicity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC114; UIC-94017. CAS No. 206361-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-17040. |  |
| Darunavir ([ (1S, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenyl-methyl) propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester, TMC-114, UIC-94017) | Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. Group: Biochemicals. Alternative Names: [ (1S, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenyl-methyl) propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester; TMC-114; UIC-94017. Grades: Highly Purified. CAS No. 206361-99-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Darunavir-d9 ([ (1S, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl-d9) amino]-2-hydroxy-1- (phenyl-methyl) propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester, TMC-114-d9, UIC-94017-d9) | Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. Group: Biochemicals. Alternative Names: [ (1S, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl-d9) amino]-2-hydroxy-1- (phenyl-methyl) propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester; TMC-114-d9; UIC-94017-d9. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Darunavir Ethanolate | Darunavir Ethanolate. Group: Biochemicals. Alternative Names: N-[ (1S, 2R) -3-[[ (4-aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenylmethyl) propyl]carbamic Acid (3R, 3aS, 6aR)Hexahydrofuro[2, 3-b]furan-3-yl Ester compd. with Ethanol. Grades: Highly Purified. CAS No. 635728-49-3. Pack Sizes: 5mg. Molecular Formula: C29H43N3O8S, Molecular Weight: 593.73. US Biological Life Sciences. | Worldwide |
| Darunavir Ethanolate | Darunavir Ethanolate is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. Uses: Hiv protease inhibitors. Synonyms: Phosphonoformate. Grades: >98%. CAS No. 635728-49-3. Molecular formula: C27H37N3O7S·C2H5OH. Mole weight: 593.73. | |
| Darunavir Ethanolate | Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K i of 1 nM for wild type HIV-1 protease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC114 Ethanolate. CAS No. 635728-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-17041. | |
| Darunavir impurity 10 | Darunavir impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 799241-86-4. Molecular Formula: C11H13NO7. Mole Weight: 271.23. Catalog: APB799241864. |  |
| Darunavir impurity 11 | Darunavir impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 866594-61-8. Molecular Formula: C7H10O4. Mole Weight: 158.15. Catalog: APB866594618. | |
| Darunavir impurity 12 | Darunavir impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1932353-11-1. Molecular Formula: C7H10O4. Mole Weight: 158.15. Catalog: APB1932353111. | |
| Darunavir impurity 14 | Darunavir impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 252873-50-0. Molecular Formula: C6H10O3. Mole Weight: 130.14. Catalog: APB252873500. | |
| Darunavir impurity 15 | Darunavir impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2307745-62-4. Molecular Formula: C34H53N3O6. Mole Weight: 599.81. Catalog: APB2307745624. | |
| Darunavir impurity 16 | Darunavir impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2173101-59-0. Molecular Formula: C34H53N3O6. Mole Weight: 599.81. Catalog: APB2173101590. | |
| Darunavir impurity 17 | Darunavir impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 192800-79-6. Molecular Formula: C20H29N3O3S. Mole Weight: 391.53. Catalog: APB192800796. | |
| Darunavir impurity 18 | Darunavir impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1402142-62-4. Molecular Formula: C20H29N3O3S. Mole Weight: 391.53. Catalog: APB1402142624. | |
| Darunavir impurity 19 | Darunavir impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1932330-83-0. Molecular Formula: C7H10O4. Mole Weight: 158.15. Catalog: APB1932330830. | |
| Darunavir impurity 2 | Darunavir impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C26H35N3O7S. Mole Weight: 533.64. Catalog: APB07645. | |
| Darunavir Impurity 2 | Darunavir Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. CAS No. 1526916-57-3. Molecular Formula: C22H31N3O5S. Mole Weight: 449.56. Catalog: APB1526916573. | |
| Darunavir impurity 20 | Darunavir impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1546918-97-1. Molecular Formula: C34H45N3O11S. Mole Weight: 703.8. Catalog: APB1546918971. | |
| Darunavir impurity 3 | Darunavir impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1402142-63-5. Molecular Formula: C27H37N3O7S. Mole Weight: 547.67. Catalog: APB1402142635. | |
| Darunavir Impurity 3 | Darunavir Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-N-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide. Molecular Formula: C20H29N3O3S. Mole Weight: 391.53. Catalog: APB05191. | |
| Darunavir impurity 4 | Darunavir impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1546918-95-9. Molecular Formula: C27H37N3O7S. Mole Weight: 547.67. Catalog: APB1546918959. | |
| Darunavir impurity 5 | Darunavir impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 850141-19-4. Molecular Formula: C27H37N3O7S. Mole Weight: 547.67. Catalog: APB850141194. | |
| Darunavir impurity 6 | Darunavir impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 313682-97-2. Molecular Formula: C27H37N3O8S. Mole Weight: 563.67. Catalog: APB313682972. | |
| Darunavir impurity 8 | Darunavir impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 253265-98-4. Molecular Formula: C11H13NO7. Mole Weight: 271.23. Catalog: APB253265984. | |
| Darunavir impurity 9 | Darunavir impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 799241-85-3. Molecular Formula: C11H13NO7. Mole Weight: 271.23. Catalog: APB799241853. | |
| Darunavir Impurity A | Darunavir Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide. CAS No. 169280-56-2. Molecular Formula: C20H29N3O3S. Mole Weight: 391.53. Catalog: APB169280562. | |
| Darunavir N-β-D-Glucuronide | Darunavir N-β-D-Glucuronide is a metabolite of Darunavir, an inhibitor of human immunodeficiency virus protease. Synonyms: 1-Deoxy-1-[[4-[[[ (2R, 3S) -3-[[[[ (3R, 3aS, 6aR) -hexahydrofuro[2, 3-b]furan-3-yl]oxy]carbonyl]amino]-2-hydroxy-4-phenylbutyl] (2-methylpropyl) amino]sulfonyl]phenyl]amino]-β -D-glucopyranuronic Acid. Grades: > 95%. CAS No. 1159613-25-8. Molecular formula: C33H45N3O13S. Mole weight: 723.79. | |
| Darunavir-O-Glucuronide | Darunavir-O-Glucuronide is a metabolite of Darunavir, an inhibitor of human immunodeficiency virus protease. Synonyms: Darunavir O-β-D-Glucuronide. Grades: > 95%. CAS No. 1159613-27-0. Molecular formula: C33H45N3O13S. Mole weight: 723.79. | |
| 1-epi-Darunavir | Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. Group: Biochemicals. Alternative Names: [ (1R, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenyl-methyl) propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (1R,2S)-Darunavir | 1R,2S)-Darunavir is a diastereomer of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 1402142-63-5. Pack Sizes: 500ug, 5mg. Molecular Formula: C27H37N3O7S, Molecular Weight: 547.66. US Biological Life Sciences. | Worldwide |
| 2-epi-Darunavir | 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 850141-19-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H37N3O7S. US Biological Life Sciences. | Worldwide |
| 3-Hydroxy Darunavir | Cas No. 1159613-24-7. | |
| (3R, 3aS, 6aR) -Hexahydrofuro[2, 3-b]furan-3-yl-4- (N- ( (2R, 3S) -3-amino-2-hydroxy-4-phenylbutyl) -N-isobutyl-d9-sulfamoyl) phenylcarbamate (Darunavir-d9 Impurity) | Process impurity of Darunavir-d9 synthesis. Group: Biochemicals. Alternative Names: Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (3R, 3aS, 6aR) -Hexahydrofuro[2, 3-b]furan-3-yl-4- (N- ( (2R, 3S) -3-amino-2-hydroxy-4-phenylbutyl) -N-isobutylsulfamoyl) phenylcarbamate (Darunavir Impurity) | Process impurity of Darunavir synthesis. Group: Biochemicals. Alternative Names: Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| D-(+)-Darunavir | Synonyms: (+)-Darunavir; 1399859-60-9; D-(+)-Darunavir; Darunavir, (+)-; NCL9DHY4E3; UNII-NCL9DHY4E3; (3S,3aR,6aS)-Hexahydrofuro(2,3-b)furan-3-yl ((2R,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate; [(3aR,4S,6aS)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2R,3S)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; Carbamic acid, N-((1R,2S)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S,3aR,6aS)-hexahydrofuro(2,3-b)furan-3-yl ester; (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl ((2R,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. Grades: > 95%. CAS No. 1399859-60-9. Molecular formula: C27H37N3O7S. Mole weight: 547.66. | |
| Hydroxy darunavir | Hydroxy darunavir. Group: Biochemicals. Alternative Names: N-[3-[[ (4-aminophenyl) sulfonyl] (2-hydroxy-2-methylpropyl) amino]-2-hydroxy-1- (phenylmethyl) propyl]carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester. Grades: Highly Purified. CAS No. 1130635-75-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C27H37N3O8S. US Biological Life Sciences. | Worldwide |
| Hydroxy Darunavir | Hydroxy Darunavir is a metabolite of Daranavir. Synonyms: N-[3-[[(4-aminophenyl)sulfonyl](2-hydroxy-2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid Hexahydrofuro[2,3-b]furan-3-yl Ester. Grades: > 95%. CAS No. 1130635-75-4. Molecular formula: C27H37N3O8S. Mole weight: 563.66. | |
| [ (1S, 2R) -1-Benzyl-2-hydroxy-3- [isobutyl- [ (4-aminophenyl) sulfonyl] amino] propyl] carbamic Acid tert-Butyl Ester | Darunavir intermediate, a potent inhibitor of HIV-1 protease. Group: Biochemicals. Alternative Names: [ (1S, 2R) -3-[[ (4-Aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenylmethyl) propyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 183004-94-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2,3-Dideoxy-4,5-O-(1-methylethylidene)-3-(nitromethyl)-L-threo-pentonic Acid Ethyl Ester | 2,3-Dideoxy-4,5-O-(1-methylethylidene)-3-(nitromethyl)-L-threo-pentonic Acid Ethyl Ester is an impurity in the synthesis of Darunavir (D193500). Darunavir is a second generation HIV-1-protease inhibitor, which is structurally similar to Amprenavir (A634400). Group: Biochemicals. Grades: Highly Purified. CAS No. 501921-23-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C11H19NO6, Molecular Weight: 261.27. US Biological Life Sciences. | Worldwide |
| (3aS,4S,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one | (3aS,4S,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one is an impurity of Darunavir. Group: Biochemicals. Alternative Names: (3aS, 4S, 6aR) -4-Methoxytetrahydrofuro [3, 4-b]furan-2 (3H) -one. Grades: Highly Purified. CAS No. 866594-60-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol | (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol. CAS No. 156928-09-5. Product ID: 2-08493. Molecular formula: C6H10O3. Mole weight: 130.14. Source : Darunavir intermediate. | |
| [ (3R, 3aS, 6aR) -Hydroxyhexahydrofuro [2, 3-b]furanyl Succinimidyl Carbonate | Darunavir intermediate. Group: Biochemicals. Alternative Names: Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl] Ester; 1-[[[[(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-. Grades: Highly Purified. CAS No. 253265-97-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl Acetate | Darunavir intermediate. Group: Biochemicals. Alternative Names: (3S,3aR,6aS)-Hexahydro-furo[2,3-b]furan-3-ol Acetate; 3S-(3α,3a β,6a β)]-Hexahydrofuro[2,3-b]furan-3-ol Acetate. Grades: Highly Purified. CAS No. 162020-29-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Amino-N- ( (2R, 3S) -3-amino-2-hydroxy-4-phenylbutyl) -N- (2-hydroxy-2-methylpropyl) benzenesulfonamide Ditrifluoroacetic Acid Salt | 4-Amino-N- ( (2R, 3S) -3-amino-2-hydroxy-4-phenylbutyl) -N- (2-hydroxy-2-methylpropyl) benzenesulfonamide Ditrifluoroacetic Acid Salt. Group: Biochemicals. Alternative Names: N-Des-(hexahydrofuro[2,3-b]furan-3-oxycarbonyl) Hydroxy Darunavir Ditrifluoroacetic Acid Salt. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C24H31F6N3O8S, Molecular Weight: 635.57. US Biological Life Sciences. | Worldwide |
| 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide | Amprenavir, Darunavir and Fosamprenavir intermediate. CAS No. 169280-56-2. Product ID: 2-08343. Molecular formula: C20H29N3O3. Mole weight: 359.47. | |
| 4-Amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-isobutylbenzenesulfonamide | 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide is a metabolite of Darunavir. Synonyms: 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide; 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide. Grades: > 95 %. CAS No. 169280-56-2. Molecular formula: C20H29N3O3S. Mole weight: 391.53. | |
| Brecanavir | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Brecanavir is by a substantial margin the most potent and broadly active antiviral agent among the PIs tested in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brecanavir; GW-0385; GW-0385; GW0385; GW-640385; GW 640385; GW640385; GW-640385X; VX-385; VX 385; VX385. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. Purity:>98%. IUPACName: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Canonical SMILES: Cc1nc(cs1)COc2ccc(cc2)C[C@@H]([C@@H](CN(CC(C)C)S(=O)(=O)c3ccc4c(c3)OCO4)O)NC(=O)O[C@H]5CO[C@@H]6[C@H]5CCO6. Product ID: ACM313682085-1. Alfa Chemistry ISO 9001 |  |
| Brecanavir | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Uses: Hiv-1 protease inhibitor. Synonyms: Brecanavir; UNII-E367I8C7FI; CHEMBL206031; GW-0385; GW-640385; GW-640385X; VX-385; GW0385; GW640385; GW640385X; VX385; GW 0385; GW 640385; GW 640385X; VX 385; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Grades: ≥98%. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. | |
| Cobicistat | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grades: 0.99. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028. | |
| DNV-II impurity 1 | N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester is an impurity of Darunavir, a human immunodeficiency virus (HIV) protease inhibitor that is used to treat patients with drug-resistant HIV. Synonyms: N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: > 95%. CAS No. 1005324-46-8. Molecular formula: C25H35N3O7S. Mole weight: 521.63. | |
| DNV-II impurity 2 | N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester is an impurity of Darunavir, a human immunodeficiency virus (HIV) protease inhibitor that is used to treat patients with drug-resistant HIV. Synonyms: N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: > 95%. CAS No. 1133153-38-4. Molecular formula: C25H35N3O7S. Mole weight: 521.63. | |
| GS-7340 fumarate | Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate; TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing Elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil fumarate to elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide fumarate, the results showed the prodrug to be non inferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. Synonyms: GS-7340 fumarate; GS 7340 fumarate; GS7340 fumarate; (S)-isopropyl 2- ( ( (S)- ( ( ( (R)-1- (6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (phenoxy)phosphoryl)amino)propanoate fumarate; TAF; GS734; GS-734; GS 7340; Tenofovir alafenamide fumarate; trade name: Genvoya. Grades: >98%. CAS No. 379270-38-9. Molecular formula: C25H33N6O9P. Mole weight: 592.54. | |
| N-[ (1R) -2- (Methoxymethylamino) -2-oxo-1- (phenylmethyl) ethyl]carbamic Acid 1,1-Dimethylethyl Ester | N-[ (1R) -2- (Methoxymethylamino) -2-oxo-1- (phenylmethyl) ethyl]carbamic Acid 1,1-Dimethylethyl Ester is an protected intermediate in the synthesis of Darunavir (D193500), a second generation HIV-1-protease inhibitor. Group: Biochemicals. Alternative Names: [ (1R) -2- (methoxymethylamino) -2-oxo-1- (phenylmethyl) ethyl]carbamic Acid 1,1-Dimethylethyl Ester; [2- (Methoxymethylamino) -2-oxo-1- (phenylmethyl) ethyl]carbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl [(1R)-1-Benzyl-2-[methoxy(methyl)amino]-2-oxoethyl]carbamate. Grades: Highly Purified. CAS No. 115186-33-9. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| tert-Butyl ((1S)-1-Hydroxy-1(isobutylamino)-3-phenylpropan-2-yl)carbamate | tert-Butyl ((1S)-1-Hydroxy-1(isobutylamino)-3-phenylpropan-2-yl)carbamate is an protected intermediate in the synthesis of Darunavir (D193500), a second generation HIV-1-protease inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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