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Dasatinib Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825. CAS No. 302962-49-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10181. MedChemExpress MCE
Dasatinib analog-1 Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a K i value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174416-41-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156883. MedChemExpress MCE
Dasatinib Carboxylic Acid An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: 4-[6-[[5-[[ (2-Chloro-6-methylphenyl) amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineacetic Acid. Grades: Highly Purified. CAS No. 910297-53-9. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
Dasatinib Carboxylic Acid Dasatinib Carboxylic Acid is an oxidative metabolite of Dasatinib (M6 metabolite), used in the treatment of cancers and immune diseases. Synonyms: 4-[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineacetic Acid. Grades: > 95%. CAS No. 910297-53-9. Molecular formula: C22H24ClN7O3S. Mole weight: 501.99. BOC Sciences 8
Dasatinib Carboxylic Acid Ethyl Ester Protected Dasatinib Carboxylic Acid. An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: 4-[6-[[5-[[ (2-Chloro-6-methylphenyl) amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineacetic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 910297-62-0. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
Dasatinib-d8 A new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. Group: Biochemicals. Alternative Names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl-d8]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; BMS-354825-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
Dasatinib-d8 Dasatinib-d 8 is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-354825-d8. CAS No. 1132093-70-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10181S. MedChemExpress MCE
Dasatinib-d8 N-Oxide The labeled oxidative metabolite of Dasatinib (M5 metabolite). Group: Biochemicals. Alternative Names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl-d8]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide. Grades: Highly Purified. CAS No. 1189988-36-0. Pack Sizes: 500ug. US Biological Life Sciences. USBiological 2
Worldwide
Dasatinib Dimeric Impurity Dasatinib Dimeric Impurity. Group: Biochemicals. Alternative Names: 2, 2'-[1, 4-Piperazinediylbis[ (2-methyl-6, 4-pyrimidinediyl) imino]]bis[N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide. Grades: Highly Purified. CAS No. 910297-61-9. Pack Sizes: 1mg. Molecular Formula: C36H34Cl2N12O2S2, Molecular Weight: 801.77. US Biological Life Sciences. USBiological 3
Worldwide
Dasatinib Dimeric Impurity Dasatinib Dimeric Impurity is an impurity of Dasatinib (M24 metabolite), used in the treatment of cancers and immune diseases. Synonyms: 2,2'-((6,6'-(Piperazine-1,4-diyl)bis(2-methylpyrimidine-6,4-diyl))bis(azanediyl))bis(N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide). Grades: ≥95%. CAS No. 910297-61-9. Molecular formula: C36H34Cl2N12O2S2. Mole weight: 801.77. BOC Sciences 8
Dasatinib Free Base Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitor approved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is also being assessed for use in metastatic melanoma. Group: Biochemicals. Alternative Names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; BMS-354825. Grades: Highly Purified. CAS No. 302962-49-8. Pack Sizes: 100mg, 500mg. Molecular Formula: C22H26ClN7O2S, Molecular Weight: 488.01. US Biological Life Sciences. USBiological 1
Worldwide
Dasatinib hydrochloride Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib hydrochloride also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825 hydrochloride. CAS No. 854001-07-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10181A. MedChemExpress MCE
Dasatinib hydrochloride Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor. It inhibits c-Kit (WT)/c-Kit (D816V). Synonyms: BMS-354825 hydrochloride; BMS 354825 hydrochloride; BMS354825 hydrochloride;Sprycel hydrochloride. Grades: >98%. CAS No. 854001-07-3. Molecular formula: C22H27Cl2N7O2S. Mole weight: 524.47. BOC Sciences 10
Dasatinib Impurity 2 Cas No. 302964-24-5. BOC Sciences 8
Dasatinib Impurity 5 Dasatinib Impurity 5 isan impurity of Dasatinib, a targeted therapy for chronic myeloid leukemia and certain types of acute lymphoblastic leukemia. Synonyms: 2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl acetate. Grades: > 95%. CAS No. 1245157-85-0. Molecular formula: C24H28ClN7O3S. Mole weight: 530.04. BOC Sciences 8
Dasatinib monohydrate Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib monohydrate also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825 monohydrate. CAS No. 863127-77-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10181B. MedChemExpress MCE
Dasatinib Monohydrate Dasatinib Monohydrate is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. It is a COVID19-related research product. Group: Biochemicals. Alternative Names: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate (9CI); BMS 35482503;Dasatinib hydrate. Grades: Highly Purified. CAS No. 863127-77-9. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClN?O?S (H?O), Molecular Weight: 506.02. US Biological Life Sciences. USBiological 7
Worldwide
Dasatinib Monohydrate Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others). Uses: Antineoplastic agents. Synonyms: BMS-354825 Monohydrate; BMS 354825 Monohydrate; BMS354825 Monohydrate; N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate. Grades: >98%. CAS No. 863127-77-9. Molecular formula: C22H28ClN7O3S. Mole weight: 506.02. BOC Sciences 11
Dasatinib Monohydrate N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide. Grades: USP. CAS No. 863127-77-9. Product ID: 8-04222. Molecular formula: C22H26ClN7O2S.H2O. Mole weight: 506.02. Purity: 0.99. CarboMer Inc
Dasatinib N-oxide Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 910297-52-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-133794. MedChemExpress MCE
Dasatinib N-Oxide An oxidative metabolite of Dasatinib (M5 metabolite). Group: Biochemicals. Alternative Names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide. Grades: Highly Purified. CAS No. 910297-52-8. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
Dasatinib N-Oxide Dasatinib N-Oxide is an oxidative metabolite of Dasatinib (M5 metabolite). Synonyms: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide. Grades: > 95%. CAS No. 910297-52-8. Molecular formula: C22H26ClN7O3S. Mole weight: 504. BOC Sciences 9
2’-Deschloro-2’-hydroxy Dasatinib Cas No. 1159977-25-9. BOC Sciences 8
3-Chloro-dasatinib 3-Chloro-dasatinib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C22H25Cl2N7O2S, Molecular Weight: 522.45. US Biological Life Sciences. USBiological 3
Worldwide
4-Chloro-dasatinib 4-Chloro-dasatinib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C22H25Cl2N7O2S, Molecular Weight: 522.45. US Biological Life Sciences. USBiological 3
Worldwide
4’-Hydroxy Dasatinib Cas No. 910297-57-3. BOC Sciences 8
5-Chloro-dasatinib 5-Chloro-dasatinib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C22H25Cl2N7O2S, Molecular Weight: 522.45. US Biological Life Sciences. USBiological 3
Worldwide
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is an intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Synonyms: N-[2-Chloro-6-(hydroxymethyl)phenyl]-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide. Grades: > 95%. CAS No. 910297-71-1. Molecular formula: C16H13Cl2N5O2S. Mole weight: 410.28. BOC Sciences 8
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro-O-pivalate Dasatinib is an intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Synonyms: 2,2-Dimethyl-propanoic Acid [3-Chloro-2- [ [ [2- [ (6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazolyl] carbonyl] amino] phenyl] methyl Ester. Grades: > 95%. CAS No. 910297-70-0. Molecular formula: C21H21Cl2N5O3S. Mole weight: 494.39. BOC Sciences 8
Deschloro Dasatinib Deschloro Dasatinib is an impurity of Dasatinib (M24 metabolite), used in the treatment of cancers and immune diseases. Synonyms: 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-(2-methylphenyl)-5-thiazolecarboxamide. Grades: ≥95%. CAS No. 1184919-23-0. Molecular formula: C22H27N7O2S. Mole weight: 453.56. BOC Sciences 8
Hydroxymethyl Dasatinib An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: N-[2-Chloro-6-(hydroxymethyl)phenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. Grades: Highly Purified. CAS No. 910297-58-4. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
Hydroxymethyl Dasatinib Hydroxymethyl Dasatinib is an oxidative metabolite of Dasatinib (M24 metabolite), used in the treatment of cancers and immune diseases. Synonyms: N-[2-Chloro-6-(hydroxymethyl)phenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. Grades: > 95%. CAS No. 910297-58-4. Molecular formula: C22H26ClN7O3S. Mole weight: 504. BOC Sciences 8
N-Boc-N-deshydroxyethyl Dasatinib N-Boc-N-deshydroxyethyl Dasatinib. Group: Biochemicals. Alternative Names: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-(4-boc-piperazinyl))-4-pyrimidinyl]amino]-5-thiazolecarboxamide; 4-[6-[[5-[[ (2-Chloro-6-methylphenyl) amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1159977-13-5. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
N-Boc-N-deshydroxyethyl Dasatinib-d8 N-Boc-N-deshydroxyethyl Dasatinib-d8. Group: Biochemicals. Alternative Names: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-(4-boc-piperazinyl-d8))-4-pyrimidinyl]amino]-5-thiazolecarboxamide. Grades: Highly Purified. CAS No. 1263379-04-9. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
N-Deshydroxyethyl dasatinib N-Deshydroxyethyl dasatinib. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide;N-Deshydroxyethyl Dasatinib;Dasatinib metabolite M4. Product Category: Heterocyclic Organic Compound. Appearance: White to Off-White Solid. CAS No. 910297-51-7. Molecular formula: C20H22ClN7OS. Product ID: ACM910297517. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry. 5
N-Deshydroxyethyl Dasatinib A metabolite of Dasatinib. Used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide; Dasatinib metabolite M4. Grades: Highly Purified. CAS No. 910297-51-7. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
N-Deshydroxyethyl Dasatinib N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib. Synonyms: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide; Dasatinib metabolite M4. Grades: > 95%. CAS No. 910297-51-7. Molecular formula: C20H22ClN7OS. Mole weight: 443.95. BOC Sciences 9
N-Deshydroxyethyl Dasatinib-d8 A labeled metabolite of Dasatinib. Used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl-d8)-4-pyrimidinyl]amino]-5-thiazolecarboxamide; Dasatinib Metabolite M4-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
2,2-Dimethyl-propanoic Acid [2-[[ (2-Amino-5-thiazolyl) carbonyl]amino]-3-chlorophenyl]methyl Ester Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 910297-69-7. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
2,2-Dimethyl-propanoic Acid [3-Chloro-2- [ [ [2- [ (triphenylmethyl) amino] -5-thiazolyl] carbonyl] amino] phenyl] methyl Ester Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 910298-41-8. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 2
Worldwide
2-Amino-N-(2,3-dichloro-6-methylphenyl)thiazole-5-carboxamide 2-Amino-N-(2,3-dichloro-6-methylphenyl)thiazole-5-carboxamide is an impurity of the anti-cancer drug Dasatinib (D193600). Dasatinib is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. Molecular Formula: C11H9Cl2N3OS, Molecular Weight: 302.18. US Biological Life Sciences. USBiological 10
Worldwide
2-Amino-N-(2,4-dichloro-6-methylphenyl)thiazole-5-carboxamide 2-Amino-N-(2,4-dichloro-6-methylphenyl)thiazole-5-carboxamide is an impurity of the anti-cancer drug Dasatinib (D193600). Dasatinib is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H9Cl2N3OS, Molecular Weight: 302.18. US Biological Life Sciences. USBiological 10
Worldwide
2-Amino-N-(3,6-dichloro-2-methylphenyl)thiazole-5-carboxamide 2-Amino-N-(3,6-dichloro-2-methylphenyl)thiazole-5-carboxamide is an impurity of the anti-cancer drug Dasatinib (D193600). Dasatinib is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H9Cl2N3OS, Molecular Weight: 302.18. US Biological Life Sciences. USBiological 10
Worldwide
2-Amino-N-(o-tolyl)-thiazole-5-carboxamide 2-Amino-N-(o-tolyl)-thiazole-5-carboxamide is an impurity of the anti-cancer drug Dasatinib (D193600). Dasatinib is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1184914-03-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H11N3OS, Molecular Weight: 233.29. US Biological Life Sciences. USBiological 10
Worldwide
2-Chloro-N-[2-chloro-6-(hydroxymethyl)phenyl]-acetamide Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 910297-66-4. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 2
Worldwide
N-[2-Chloro-6- (hydroxymethyl) phenyl]-2-[ (triphenylmethyl) amino]-5-thiazolecarboxamide Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 910297-68-6. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib intermediate. A protein tyrosine kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 302964-08-5. Pack Sizes: 250mg. US Biological Life Sciences. USBiological 2
Worldwide
Radotinib Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Synonyms: IY-5511; IY 5511; IY5511; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide. Grades: >98%. CAS No. 926037-48-1. Molecular formula: C27H21F3N8O. Mole weight: 530.515. BOC Sciences 8

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