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1,3-Diazepane-2-thione (Diap) is used in the synthesis of new cadmium chloride complexes (e.g. Cd(Diap)2Cl2 ) which exhibit substantial antibacterial activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5700-4-9. Pack Sizes: 500mg, 5g. Molecular Formula: C5H10N2S, Molecular Weight: 130.21. US Biological Life Sciences.
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1-(4-Chlorobenzyl)-1,4-diazepane
1-(4-Chlorobenzyl)-1,4-diazepane. Group: Biochemicals. Grades: Highly Purified. CAS No. 40389-65-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H17ClN2, Molecular Weight: 224.73. US Biological Life Sciences.
Carglumic Acid Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 2,7-dioxo-1,3-diazepane-4-carboxylate. Molecular Formula: C7H10N2O4. Mole Weight: 186.17. Catalog: APB05010.
Carglumic Acid Impurity 15
Carglumic Acid Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2,7-dioxo-1,3-diazepane-4-carboxylic acid. CAS No. 2380660-24-0. Molecular Formula: C6H8N2O4. Mole Weight: 172.14. Catalog: APB2380660240.
Carglumic Acid Impurity C
Carglumic Acid Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,7-dioxo-1,3-diazepane-4-carboxylic acid. CAS No. 1009553-88-1. Molecular Formula: C6H8N2O4. Mole Weight: 172.14. Catalog: APB1009553881.
CX-6258
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. Synonyms: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one; CX6258; CX-6258; CX 6258. CAS No. 1202916-90-2. Molecular formula: C26H24ClN3O3. Mole weight: 461.946.
CXCR3 Antagonist 6c
CXCR3 Antagonist 6c is a potent and selective chemokine CXCR3 antagonist (IC50 value of 60 nM in a calcium mobilization functional assay). It inhibits CXCR3 functional response to CXCL11 as measured by T-cell chemotaxis. Synonyms: 4-[2-[ (3-chlorobenzoyl) amino]-4-[2- (2, 4-dichlorophenyl) ethylcarbamoyl]phenyl]-N-ethyl-1, 4-diazepane-1-carboxamide. Grades: 99%. CAS No. 870998-13-3. Molecular formula: C30H32Cl3N5O3. Mole weight: 616.97.
Darexaban Maleate
Diazepane derivative used in the preparation of inhibitors of activated blood coagulation factor X. Group: Biochemicals. Alternative Names: N-[2-[[4-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxyphenyl]-4-methoxybenzamide (2Z)-2-Butenedioate. Grades: Highly Purified. CAS No. 365462-24-4. Pack Sizes: 10mg. US Biological Life Sciences.
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Emedastine N-Oxide
Emedastine N-Oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1,4-diazepane 1-oxide. CAS No. 122484-65-5. Molecular Formula: C17H26N4O2. Mole Weight: 318.21. Catalog: APB122484655.
Fasudil Dimer
Fasudil Dimer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,4-bis(isoquinolin-5-ylsulfonyl)-1,4-diazepane. CAS No. 1337967-93-7. Molecular Formula: C23H22N4O4S2. Mole Weight: 482.58. Catalog: APB1337967937.
Fasudil Impurity 12
Fasudil Impurity 12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,4-ditosyl-1,4-diazepane. CAS No. 5769-35-7. Molecular Formula: C19H24N2O4S2. Mole Weight: 408.53. Catalog: APB5769357.
Fasudil Impurity 17
Fasudil Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-tosyl-1,4-diazepane hydrochloride. Molecular Formula: C12H19ClN2O2S. Mole Weight: 290.81. Catalog: APB05916.
Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine. Group: Biochemicals. Alternative Names: 1-Benzyl-5-methyl-1,4-diazepane. Grades: Highly Purified. CAS No. 150651-61-9. Pack Sizes: 100mg. US Biological Life Sciences.
Hexahydro-6-methyl-1H-1,4-Diazepine-1-carboxylic Acid 1,1-Dimethylethyl Ester. Group: Biochemicals. Alternative Names: tert-Butyl 6-methyl-1,4-diazepane-1-carboxylate. Grades: Highly Purified. CAS No. 1211595-59-3. Pack Sizes: 1g. US Biological Life Sciences.
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Hydroxyfasudil
Hydroxyfasudil, formed through the metabolism action of Fasudil, could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active Rho-kinase inhibitor and vasodilator. IC50: 0.12 uM and 0.17 uM for ROCK1 and ROCK2, res. Uses: Hydroxyfasudil could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active rho-kinase inhibitor and vasodilator. Synonyms: 5-(1,4-Diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine;Hydroxyfasudil. Grades: >99 %. CAS No. 105628-72-6. Molecular formula: C14H17N3O3S. Mole weight: 307.37.
K-7174 dihydrochloride
K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Synonyms: 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride; K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride. Grades: >98%. CAS No. 191089-60-8. Molecular formula: C33H50Cl2N2O6. Mole weight: 641.67.
KU 0058948 hydrochloride
KU 0058948 hydrochloride is a potent poly ADP-ribose polymeras (PARP) inhibitor (IC50: 3.4 nM for PARP1). In vitro, KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells thus KU-0058948 can be potentially used to treat myeloid leukemia and myelodysplastic syndromes. Uses: Potential treatment of myeloid leukemia and myelodysplastic syndromes. Synonyms: KU 0058948 hydrochloride; KU0058948 hydrochloride; KU-0058948 hydrochloride; 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride. Grades: 99%. Molecular formula: C21H21FN4O2.HCl. Mole weight: 416.88.
ML-7
ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28.
ML-9 hydrochloride
ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant. Uses: Ml-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. it may be a new type of vascular relaxant. Synonyms: ML9; ML-9; ML 9; ML9 Hydrochloride;ML 9 Hydrochloride; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride. Grades: 95%. CAS No. 105637-50-1. Molecular formula: C15H18Cl2N2O2S. Mole weight: 361.29.
Used in the preparation of diazepane compounds as chymase inhibitors for treatement of bronchial asthma and urticaria. Group: Biochemicals. Alternative Names: N-[2-[4- (Aminosulfonyl) phenyl]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester; (4-Sulfamoylphenethyl) carbamic Acid tert-Butyl Ester. Grades: Highly Purified. CAS No. 258262-54-3. Pack Sizes: 250mg. US Biological Life Sciences.
Protected KU-0058948 (K660400), a poly (ADP-ribose) polymerase (PARP) inhibitor. Group: Biochemicals. Alternative Names: tert-Butyl 4-[2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl]-1,4-diazepane-1-carboxylate; 4- [5- [ (3, 4-Dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] hexahydro-1H-1, 4-diazepine-1-carboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 874116-49-1. Pack Sizes: 25mg. US Biological Life Sciences.
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SB756050
SB756050 is a selective TGR5 agonist currently undergone testing in a phase 1 clinical trials study in the treatment of type 2 diabetes. Synonyms: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane; SB756050; F1018-1711; 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane; SB-756050; SB 756050; SB756050. CAS No. 447410-57-3. Molecular formula: C21H28N2O8S2. Mole weight: 500.59.
1, 3-Dichloro-2- (trifluoromethoxy) benzene is a useful synthetic intermediate in the synthesis of 4-Chloro-3- (trifluoromethoxy) aniline (C421915); a reagent in the preparation of diazepanone compounds as chemokine receptor antagonists for the treatment of inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 97608-49-6. Pack Sizes: 1g, 5g. Molecular Formula: C7H3Cl2F3O, Molecular Weight: 231. US Biological Life Sciences.
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1,4-Diazepan-5-one Hydrochloride
1,4-Diazepan-5-one Hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 208245-76-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H11ClN2O, Molecular Weight: 150.61. US Biological Life Sciences.
BIX 01294 is a G9a histone methyltransferase inhibitor. It enhances the induction of pluripotent stem cells from somatic cells in vitro. BIX-01294 trihydrochloride induces necroptosis and autophagy. Synonyms: BIX 01294 trihydrochloride; BIX-01294; N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride. Grades: >98%. CAS No. 1392399-03-9. Molecular formula: C28H41Cl3N6O2. Mole weight: 600.02.
Emedastine
Emedastine is a potent, high affinity and selective antagonist of histamine H1-receptor with Ki of 1.3 for H1-receptors while significantly weaker at H2- (K1 = 49,067 nM) and H3-receptors (Ki = 12,430 nM). Uses: Anti-allergic agents. Synonyms: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole. Grades: ≥97%. CAS No. 87233-61-2. Molecular formula: C17H26N4O. Mole weight: 302.41.
Emedastine
Emedastine. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole. CAS No. 87233-61-2. Molecular Formula: C17H26N4O. Mole Weight: 302.21. Catalog: APB87233612.
Emedastine EP Impurity C HCl
Emedastine EP Impurity C HCl. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 122423-32-9 (free base),2-(2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazol-1-yl)ethanol hydrochloride. Molecular Formula: C15H22N4O·HCl. Mole Weight: 310.64. Catalog: APB05743.
Emedastine EP Impurity D DiHCl
Emedastine EP Impurity D DiHCl. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(4-Methyl-1,4-diazepan-1-yl)-1-vinyl-1H-benzo[d]imidazole, hydrochloride (1:2). Molecular Formula: C15H20N4·2HCl. Mole Weight: 329.09. Catalog: APB05742.
Emedastine EP Impurity E
Emedastine EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(1,4-diazepan-1-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole. CAS No. 101954-20-5. Molecular Formula: C16H24N4O. Mole Weight: 288.39. Catalog: APB101954205.
Emedastine Impurity 7
Emedastine Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole. CAS No. 101953-62-2. Molecular Formula: C13H18N4. Mole Weight: 230.15. Catalog: APB101953622.
Emedastine Impurity 8
Emedastine Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(4-methyl-1,4-diazepan-1-yl)-1'H-1,2'-bibenzo[d]imidazole. Molecular Formula: C20H22N6. Mole Weight: 346.19. Catalog: APB06114.
Emedastine Impurity 9
Emedastine Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-ethyl-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole. Molecular Formula: C15H22N4. Mole Weight: 258.18. Catalog: APB06113.
Fasudil
Fasudil is a potent and selective Rho-kinase (ROCK) inhibitor and vasodilator. ROCK is an enzyme that participates in vasoconstriction and vascular remodeling. Fasudil is used for the treatment of cerebral vasospasm and has the potential to treat pulmonary hypertension as well as certain memory loss. Uses: Protein kinase inhibitors. Synonyms: Fasudil; AT 877; AT-877; AT877; HA 1077; HA-1077; HA1077; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline. Grades: >98%. CAS No. 103745-39-7. Molecular formula: C14H17N3O2S. Mole weight: 291.369.
Fasudil
Fasudil. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-((1,4-diazepan-1-yl)sulfonyl)isoquinoline. CAS No. 103745-39-7. Molecular Formula: C14H17N3O2S. Mole Weight: 291.37. Catalog: APB103745397.
Fasudil hydrochloride
Other Alkaloids. Alternative Names: Eril. CAS No. 105628-07-7. Molecular formula: C14H18ClN3O2S. Mole weight: 327.83. Purity: 98%+. IUPACName: 5-(1, 4-Diazepan-1-ylsulfonyl)isoquinoline; hydrochloride. Canonical SMILES: C1CNCCN (C1)S (=O) (=O)C2=CC=CC3=C2C=CN=C3. Cl. Catalog: ACM105628077.
Fasudil Impurity 13
Fasudil Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride. Molecular Formula: C14H18ClN3O3S. Mole Weight: 343.83. Catalog: APB05919.
Fasudil Impurity 14
Fasudil Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline 2-oxide. CAS No. 186544-56-9. Molecular Formula: C14H17N3O3S. Mole Weight: 307.37. Catalog: APB186544569.
Fasudil Impurity 14 (Trifluoroacetate)
Fasudil Impurity 14 (Trifluoroacetate). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline 2-oxide 2,2,2-trifluoroacetate. CAS No. 2748281-77-6. Molecular Formula: C14H17N3O3S·C2HF3O2. Mole Weight: 421.39. Catalog: APB2748281776.
Fasudil Impurity 16
Fasudil Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((4-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride. Molecular Formula: C15H20ClN3O2S. Mole Weight: 341.86. Catalog: APB05917.
Fasudil Impurity 18
Fasudil Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((4-ethyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride. Molecular Formula: C16H22ClN3O2S. Mole Weight: 355.88. Catalog: APB05915.
Fasudil Impurity 19
Fasudil Impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-((1,4-diazepan-1-yl)sulfonyl)quinoline hydrochloride. Molecular Formula: C14H18ClN3O2S. Mole Weight: 327.83. Catalog: APB05914.
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