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The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25, dihydroneopterin aldolase. Group: Enzymes. Synonyms: dihydropteroate pyrophosphorylase; DHPS; 7,8-dihydropteroatesynthase; 7,8-dihydr. Enzyme Commission Number: EC 2.5.1.15. CAS No. 9055-61-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2751; dihydropteroatesynthase; EC 2.5.1.15; 9055-61-2; dihydropteroate pyrophosphorylase; DHPS; 7,8-dihydropteroatesynthase; 7,8-dihydropteroate synthetase; 7,8-dihydropteroic acid synthetase; dihydropteroate synthetase; dihydropteroic synthetase; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase; (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase. Cat No: EXWM-2751.
Binds 2 Mg2+ ions that are essential for activity. The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase, the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroatesynthase, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities. Group: Enzymes. Synonyms: 2-amino-4-hydroxy-6-hydroxymethyldi. Enzyme Commission Number: EC 2.7.6.3. CAS No. 37278-23-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3222; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; EC 2.7.6.3; 37278-23-2; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; H2-pteridine-CH2OH pyrophosphokinase; 7,8-dihydroxymethylpterin-pyrophosphokinase; HPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; hydroxymethyldihydropteridine pyrophosphokinase; ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase. Cat No: EXWM-3222.
4-Amino-4'-chlorodiphenyl Sulfone
4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroatesynthase inhibitor. Group: Biochemicals. Alternative Names: 4-[ (4-Chlorophenyl) sulfonyl]benzenamine; p-[ (p-Chlorophenyl) sulfonyl]aniline; 4- (4-Chlorobenzenesulfonyl) phenylamine; 4-Amino-4'-chlorodiphenyl Sulfone; 4-Aminophenyl 4-chlorophenyl Sulfone; NSC 23812; NSC 51990; p- (p-Chlorophenylsulfonyl) aniline; p-Aminophenyl p-Chlorophenyl Sulfone. Grades: Highly Purified. CAS No. 7146-68-1. Pack Sizes: 1g. US Biological Life Sciences.
The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin. Group: Enzymes. Synonyms: MJ0301 (gene name); dihydropteroatesynthase (ambiguous). Enzyme Commission Number: EC 2.5.1.105. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2721; 7,8-dihydropterin-6-yl-methyl-4-(β-D-ribofuranosyl)aminobenzene 5'-phosphate synthase; EC 2.5.1.105; MJ0301 (gene name); dihydropteroatesynthase (ambiguous). Cat No: EXWM-2721.
Dapsone Impurity 2
4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroatesynthase inhibitor. Synonyms: 4-Amino-4'-chlorodiphenyl Sulfone; 4-[(4-Chlorophenyl)sulfonyl]benzenamine; p-[(p-Chlorophenyl)sulfonyl]aniline; 4-(4-Chlorobenzenesulfonyl)phenylamine; 4-Amino-4'-chlorodiphenyl Sulfone; 4-Aminophenyl 4-chlorophenyl Sulfone; NSC 23812; NSC 51990; p-(p-Ch. Grades: > 95%. CAS No. 7146-68-1. Molecular formula: C12H10ClNO2S. Mole weight: 267.73.
dihydrofolate synthase
In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.17, tetrahydrofolate synthase, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date. This enzyme is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa. Group: Enzymes. Synonyms: dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS. Enzyme Commission Number: EC 6.3.2.12. CAS No. 37318-62-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5733; dihydrofolate synthase; EC 6.3.2.12; 37318-62-0; dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS. Cat No: EXWM-5733.
dihydroneopterin aldolase
The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase). The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroatesynthase. Group: Enzymes. Synonyms: 7,8-dihydroneopterin aldolase; 2-amino-. Enzyme Commission Number: EC 4.1.2.25. CAS No. 37290-59-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4864; dihydroneopterin aldolase; EC 4.1.2.25; 37290-59-8; 7,8-dihydroneopterin aldolase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming); DHNA; mptD (gene name); folB (gene name). Cat No: EXWM-4864.
Sodium 4-aminosalicylate dihydrate
Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase ( DHFR ) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroatesynthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminosalicylic acid sodium salt dihydrate. CAS No. 6018-19-5. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-I0447A.
Sulfacetamide
Sulfacetamide is a sulfonamide antibiotic as a dihydropteroateSynthase inhibitor. It is a competitive inhibitor of bacterial para-aminobenzoic acid, which is required for bacterial synthesis of folic acid. Sulfacetamide is used for the treatment of skin infections and urinary tract infections. It is also used to treat acne and seborrheic dermatitis. Uses: Skin infections and urinary tract infections;treat acne and seborrheic dermatitis. Synonyms: NSC63871; NSC-63871; NSC 63871; Sulfacetamide; Region; Sebizon; N-[(4-aminophenyl)sulfonyl]acetamide; 4-(Acetylaminosulfonyl)aniline; A 500; Acetocid; Acetosulfamin; Acetosulfamine; Albamine; Albucid; Alesten; Formosulfacetamide; N-(4-Aminobenzenesulfonyl)acetamide; N-(p-Aminophenylsulfonyl)acetamide; N-Acetylsulfanilamide; N-Sulfanilylacetamide; N-[(4-Aminophenyl)sulfonyl]acetamide; N1-Acetylsulfanilamide; NSC 63871; N'-Acetylsulfanilamide; Ocusol; Region; Steramide; Sulamyd; Sulfacet; Sulfacetamide; Sulfacetimide; Sulfacyl; Sulphacetamide; Sulphasil; Urosulfon; p-Aminobenzenesulfonacetamide; N-[(4-aminophenyl)sulfonyl]acetamide; N-Sulfanilyacetamide. Grades: 98%. CAS No. 144-80-9. Molecular formula: C8H10N2O3S. Mole weight: 214.24.
Sulfacetamide Sodium Salt
Sulfacetamide Sodium Salt is an antibiotic that blocks synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroatesynthase. It can be used in biological study to explore topical application of benzoyl peroxide, antibiotics, sulfur and sodium sulfacetamide, azelaic acid for treatment of acne vulgaris in humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 127-56-0. Pack Sizes: 100g, 250g. Molecular Formula: C8H9N2NaO3S, Molecular Weight: 236.22. US Biological Life Sciences.
An impurity of Sulfadoxine. Sulfadoxine is an antibacterial. It competitively inhibits dihydropteroatesynthase, interfering with folate synthesis. Synonyms: 5,6-Dimethoxypyrimidin-4-ylamine; 5,6-Dimethoxy-4-pyrimidinamine; 4-Amino-5,6-dimethoxypyrimidine. Grades: > 95%. CAS No. 5018-45-1. Molecular formula: C6H9N3O2. Mole weight: 155.15.
Sulfamethoxazole
An antibacterial drug. Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroatesynthase. Group: Biochemicals. Alternative Names: 4-Amino-N- (5-methyl-3-isoxazolyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 723-46-6. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Sulfisoxazole acetyl
Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroatesynthase inhibitor. Sulfisoxazole acetyl has an antibacterial action [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N1-Acetylsulfisoxazole. CAS No. 80-74-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107923.
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