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| Product | Description | |
|---|---|---|
| 1,3,5-Tri-O-benzoyl-2-O-methyl-α-D-ribofuranose | 1,3,5-Tri-O-benzoyl-2-O-methyl-α-D-ribofuranose is used as a reactant in the preparation of 2'-O-methylpyrimidine ribonucleosides via stereoselective Vorbruggen glycosidation of pyrimidines. It is also used as a reactant in solid-phase synthesis, fluorescence, and ambiguous base pairing of canonical DNA nucleobases containing benzotriazole and 1,2,3-triazolo[4,5-d]pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 68045-07-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C27H24O8, Molecular Weight: 476.47. US Biological Life Sciences. |  Worldwide |
| 1-α-L-Arabinofuranosylcytosine | 1-α-L-Arabinofuranosylcytosine, also known as cytarabine (Ara-C), is a nucleoside analog consisting of a cytosine base attached to an α-L-arabinofuranose sugar. This compound is widely used as a chemotherapeutic agent, particularly in the treatment of hematological malignancies such as acute myeloid leukemia (AML). Its mechanism involves incorporation into DNA during replication, leading to chain termination and inhibition of DNA synthesis, thereby inducing apoptosis in rapidly dividing cancer cells. Synonyms: alpha-L-ara-cytidine; Cytarabine impurity 42; 4-Amino-1-α-L-arabinofuranosyl-2(1H)-pyrimidinone; 1-alpha-L-arabinofuranosyl cytosine; 4-Amino-1-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; α-L-Ara-Furan-C. Grade: ≥95%. CAS No. 16033-23-1. Molecular formula: C9H13N3O5. Mole weight: 243.22. |  |
| 1-Bromopyrene | 1-Bromopyrene is used in the cleavage of DNA in studies. It is also used in the preparation of DNA base analogs. Group: Biochemicals. Alternative Names: 1-Bromopyrene; 3-Bromopyrene. Grades: Highly Purified. CAS No. 1714-29-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 2-[2- (2-Chloroethoxy) ethoxy]ethanol | 2-[2- (2-Chloroethoxy) ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2- (2-Chloroethoxy) ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection. Group: Biochemicals. Alternative Names: 2-[ (2-Chloroethoxy) ethoxy]ethanol; 8-Chloro-3,6-dioxa-1-octanol; 8-Chloro-3,6-dioxaoctanol; Diethylene Glycol Mono(2-chloroethyl) Ether; NSC 2636; Triethylene Glycol Monochloride; Triethylene Glycol Monochlorohydrin. Grades: Highly Purified. CAS No. 5197-62-6. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2,4-Diamino-1,3,5-triazine | 2,4-Diamino-1,3,5-triazine is a reactant or reagent that has numerous uses. A triazine-modified dendrimer G5-DAT66 was synthesized and used as a vector for osteosarcoma TRAIL gene therapy in vitro and in vivo. 2,4-Diamino-1,3,5-triazine was also used to synthesize water soluble copper(II)-dipeptide complexes which exhibited considerable in vitro cytotoxicity against four human carcinoma cell lines (HepG2, HeLa, A549 and U87). These water soluble DNA minor groove binding diamino-s-triazine copper based complexes are potential chemotherapeutic agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 504-08-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C3H5N5, Molecular Weight: 111.11. US Biological Life Sciences. | Worldwide |
| 2',5'-Anhydroarabinocytidine | 2',5'-Anhydroarabinocytidine is a modified nucleoside where the typical 3'-5' phosphodiester linkage between the sugar units is replaced by a 2',5'-anhydro linkage, connecting the sugar's 2' and 5' carbon atoms. The base is arabinocytidine, where the sugar is an arabinose derivative. This modification creates a unique structure that could affect the stability and interaction of the nucleoside with enzymes, such as nucleases, and may make it resistant to typical DNA or RNA degradation pathways. 2',5'-Anhydroarabinocytidine could have potential applications in nucleic acid-based therapies, where enhanced stability or altered enzymatic interactions are desired, and might be used for the development of antiviral drugs or in the synthesis of modified oligonucleotides for research purposes. Synonyms: Cytarabine Impurity F; 4-Amino-1-(2,5-anhydro-β-D-arabinofuranosyl)pyrimidin-2(1H)-one; Cytarabine EP impurity F; Cytarabine impurity 10 (or 1, 4, 17); 2',5'-Anhydro-1-(beta-D-arabinofuranosyl)cytosine; 4-Amino-1-(2,5-anhydro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone; (2',5'-Anhydroarabinosyl)cytosine; NSC 340843; 4-Amino-1-((1R,3R,4S,7R)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidin-2(1H)-one. Grade: ≥95%. CAS No. 32830-01-6. Molecular formula: C9H11N3O4. Mole weight: 225.20. | |
| 2-Aminopurine | 2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 452-06-2. Pack Sizes: 100 mg. Product ID: HY-W012642. |  |
| 2-Aminopurine-riboside-5'-monophosphate | 2-Aminopurine-riboside-5'-monophosphate, a biochemical agent employed in scientific research, exhibits multifaceted benefits as an investigative tool. By being integrated into oligonucleotides, it enables the study of base-pair mismatches, as well as facilitating enzyme activity during nucleic acid synthesis. Furthermore, its competence in countering viral infections makes it a promising therapeutic agent. Such versatile properties have marked 2-Aminopurine-riboside-5'-monophosphate a crucial component in the field of DNA and RNA research. Synonyms: 2-Aminopurine-riboside-5'-monophosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H14N5O7P (free acid). Mole weight: 347.22 (free acid). | |
| 2'-Azido-N4-benzoyl-2'-deoxy-5'-O-DMT-cytidine | 2'-Azido-N4-benzoyl-2'-deoxy-5'-O-DMT-cytidine, a potent chemical compound employed in the biomedical sector, prominently serves as a crucial entity for combating viral infections induced by DNA-based viruses. Exhibiting an unparalleled ability to impede viral replication and modify DNA synthesis, this compound emerges as a paramount instrument within the realm of targeted antiviral therapies. Augmented with the presence of DMT and cytidine, it attains heightened stability and efficacy, thereby facilitating meticulous and efficacious treatment interventions. Molecular formula: C37H34N6O7. Mole weight: 674.70. | |
| 2-Chloro-5-hydrazinyl-phenol Hydrochloride | 2-Chloro-5-hydrazinyl-phenol Hydrochloride was identified to inhibit the E. coli SC and SC-mediated DNA replication in vitro. 2-Chloro-5-hydrazinyl-phenol Hydrochloride is the derivative of 5-Amino-2-chlorophenol (A603890) which is used in the synthesis of antimalarial quinolones. Also, used in the synthesis of potent anti-HIV agent based upon pyrimidinylphenylamine 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 1636917-89-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C6H7ClN2O HCl, Molecular Weight: 158.593646. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-2'-fluoro-5-ethynyluridine-3'-CE-phosphoramidite | 2'-Deoxy-2'-fluoro-5-ethynyluridine-3'-CE-phosphoramidite is a modified phosphoramidite analog used in oligonucleotide synthesis. Its structure includes a uridine base with a fluorine atom replacing the 2'-hydroxyl group, an ethynyl group attached at the 5-position of the base, and a 3'-cyanoethyl (CE) phosphoramidite group for coupling during automated solid-phase synthesis. This compound is used to introduce modified nucleotides into DNA sequences, enhancing stability, biological activity, or enabling labeling for biochemical and structural studies. Synonyms: 5-Ethynyl-2'-Fluoro-U Phosphoramidite; 5-Ethynyl-5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-ethynyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-ethynyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Fluoro-5-ethynyl-rU-3'-phosphoramidite; DMT-5-ethynyl-2'-F-dU-CE-Phosphoramidite. Grade: ≥95%. Molecular formula: C41H46FN4O8P. Mole weight: 772.81. | |
| 2'-Deoxy-5'-O-DMT-guanosine-(DMF)-succinyl CPG | 2'-Deoxy-5'-O-DMT-guanosine-(DMF)-succinyl CPG, an indispensable asset in the realm of biomedical research. Leveraged for synthesizing oligonucleotides, this remarkable entity plays a pivotal role in nurturing nucleic acid-based therapeutics, anatomizing genetic disorders, and comprehending diseases. It spearheads the realm of drug discovery and personalized medicine by endowing scientists with efficacious and controlled DNA sequence synthesis. Prepare to embark on riveting scientific endeavors with this groundbreaking product. | |
| 2'-Deoxy-5'-O-DMT-inosine 3'-succinyl CPG | 2'-Deoxy-5'-O-DMT-inosine 3'-succinyl CPG is a crucial tool in biomedical research for the synthesis of modified oligonucleotides. It is extensively utilized as a solid support matrix for automated DNA/RNA synthesis, enabling the efficient incorporation of nucleotide modifications. This product plays a vital role in studying and developing various nucleic acid-based therapies, diagnostics, and drug delivery systems targeting specific diseases like cancer and viral infections. | |
| 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite | 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite, a highly regarded biochemical agent, has garnered considerable attention in the realm of biomedicine research. This extraordinary compound serves as an instrumental tool for facilitating DNA synthesis and modification, offering unprecedented opportunities for investigating intricate cellular mechanisms and disease etiology. By employing its unique modifications, researchers can delve into a myriad of applications, encompassing the development of precision drug delivery systems and the conception of revolutionary gene-based therapies targeting a wide spectrum of ailments, such as cancer and hereditary disorders. Synonyms: Pac-dA-Me Phosphoramidite; 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine 3'-Me phosphoramidite; 5'-O-DMT-N6-phenoxyacetyl-2'-deoxyadenosine 3'-Me phosphoramidite. Molecular formula: C46H53N6O8P. Mole weight: 848.94. | |
| 2'-Deoxy-7-deaza-2'-fluoroguanosine | 2'-Deoxy-7-deaza-2'-fluoroguanosine is a modified nucleoside where the guanine base undergoes two key modifications. The 7-deaza modification replaces the nitrogen at position 7 of the guanine base with a carbon atom, and the 2'-hydroxyl group on the ribose sugar is replaced with a fluorine atom. These modifications improve the stability of the nucleoside, reducing its susceptibility to enzymatic degradation. The compound is often used in oligonucleotide synthesis and research, where it can enhance the stability, binding affinity, and biological activity of DNA sequences, making it suitable for therapeutic applications or gene editing technologies. Synonyms: 2'-Deoxy-7-deaza-2'-fluoro guanosine; 2-Amino-7-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one; 2-Amino-7-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one; 2-Amino-7-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one. Grade: ≥95%. CAS No. 444019-30-1. Molecular formula: C11H13FN4O4. Mole weight: 284.24. | |
| 2'-Deoxyadenosine-5'-monophosphate | 2-Deoxyadenosine 5-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2-Deoxyadenosine 5-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage [1]. Uses: Scientific research. Group: Natural products. CAS No. 653-63-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W016009. | |
| 2'-Deoxyadenosine 5'-triphosphate | 2'-Deoxyadenosine 5'-triphosphate is a nucleotide used in molecular biology for DNA sequencing, PCR amplification, and labeling. It is also used as a substrate in DNA polymerase-based reactions for footprinting and crosslinking studies. Additionally, it has therapeutic potential for treating leukemia and viral infections. | |
| 2'-Deoxyadenosine monohydrate (dA) | 2'-Deoxyadenosine monohydrate (dA) is a crucial biomolecule widely used in the biomedical industry, serving as a key building block for DNA synthesis and repair. Additionally, it has shown potential in reserching diseases related to DNA damage and replication errors, such as certain types of cancer and genetic disorders. Grade: ≥ 98% by HPLC. Molecular formula: C10H13N5O3. Mole weight: 251.24 (free base). | |
| 2'-Deoxyguanosine | 2(acute)-Deoxyguanosine is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). It is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. It is useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides. Synonyms: Deoxyguanosine; Guanine deoxyriboside; 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9H-Purin-6-ol, 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)guanine. Grade: ≥95%. CAS No. 961-07-9. Molecular formula: C10H13N5O4. Mole weight: 267.24. | |
| 2'-Deoxyguanosine monohydrate | 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1 O 2 , the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer [1]. Uses: Scientific research. Group: Natural products. CAS No. 312693-72-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-D0185. | |
| 2'-Deoxyguanosine, Monohydrate | Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides. Group: Biochemicals. Alternative Names: 2-Deoxyguanosine monohydrate; Guanine 2-deoxyribonucleoside; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine monohydrate; NSC 22837. Grades: Molecular Biology Grade. CAS No. 961-07-9, 312693-72-4. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C10H13N5O4 H2O, Molecular Weight: 285.26. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine 3'-CE phosphoramidite | 2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine 3'-CE phosphoramidite is a crucial tool in biomedicine for oligonucleotide synthesis. It serves as a phosphoramidite monomer used for incorporation into DNA or RNA sequences during solid-phase synthesis. This product is particularly useful in designing therapeutic oligonucleotides targeting specific genes or pathways involved in diseases like cancer and genetic disorders. It offers enhanced stability and specificity, allowing researchers to develop precise and efficient nucleic acid-based therapies. Molecular formula: C43H52FN8O7P. Mole weight: 842.89. | |
| 2'-Deoxy-N-(4-hydroxybutyl)cytidine | 2'-Deoxy-N-(4-hydroxybutyl)cytidine is a DNA adduct resulting from reaction of THF with DNA bases. CAS No. 905844-52-2. Molecular formula: C13H21N3O5. Mole weight: 299.32. | |
| 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytosine | 2-Fluoro-2-deoxy-arabinofuranosyl-cytosine is an efficacious and safe antiviral compound, having applications in research of combating diverse viral infections such as hepatitis B and C. Its mode of action relies on targeting the viral polymerase enzyme, thereby impeding the research and development of viral DNA and hindering replication. Synonyms: 2'-FANA-C; 1-(2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride. Grade: ≥ 97%. Molecular formula: C9H12FN3O4 (free base). Mole weight: 245.21 (free base). | |
| 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt | 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt, a potent nucleotide analogue, displays antiviral activity by inhibiting viral DNA polymerase. Employed in the treatment of Hepatitis B and Herpes, it is noted for its ability to enhance the pharmacological features of nucleotide-based antiviral medications through its structural modifications. The utilization of this molecule is paramount in the development of novel antiviral therapies. Synonyms: 2'-F-2'-dGTP.Na3; 2'-F-dGTP trisodium salt; 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate trisodium salt; 2'-Deoxy-2'-fluoroguanosine 5'-(tetrahydrogen triphosphate) trisodium salt; 2'-Fluoro GTP trisodium salt; 2'-Fluoro-2'-deoxy-GTP trisodium salt; 2'-Fluoro-2'-deoxyguanosine triphosphate trisodium salt; 2'-Fluoro-dGTP trisodium salt. Grade: ≥97% by HPLC. Molecular formula: C10H12FN5Na3O13P3. Mole weight: 591.12. | |
| 2'-O-Methyl-3'-deoxycytidine | 2'-O-Methyl-3'-deoxycytidine is a modified nucleoside with a 2'-O-methyl group and a 3'-deoxy structure. This modification is typically used in DNA synthesis. The 3'-deoxy group acts as a chain terminator, preventing further elongation, while the 2'-O-methyl modification increases the stability of the nucleoside against exonucleases. This makes it particularly useful for designing oligonucleotides with enhanced stability and specificity in therapeutic applications such as antisense oligonucleotides, gene editing, or other nucleic acid-based therapies. Synonyms: 4-Amino-1-((2R,3R,5S)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 3'-Deoxy-2'-O-methylcytidine. Grade: ≥95%. Molecular formula: C10H15N3O4. Mole weight: 241.25. | |
| 2'-O-ribosyladenosine (phosphate) | 2'-O-ribosyladenosine (phosphate), a significant enzyme in RNA production, modifies nucleotides in RNA formation for mRNA molecule production used in protein synthesis. In addition, the product is crucial for biosynthesis of purine, a crucial molecular base in DNA and RNA. With targeted inhibition of certain cancer cells, this potent tool finds wide application in cancer treatment research. Synonyms: Adenosine, 2'-O-(5-O-phosphono-b-D-ribofuranosyl)-; O-beta-ribosyl(1''--2')adenosine-5''-phosphate; 2'-O-(5-O-Phosphono-beta-D-ribofuranosyl)adenosine. CAS No. 28050-13-7. Molecular formula: C15H22N5O11P. Mole weight: 479.34. | |
| (2R,3R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol | (2R,3R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol is a breakthrough drug that shows promise in the biomedical sphere. Its potential lies in its ability to act as an inhibitor for enzymes which are responsible for DNA replication and repair, thus proving lethal to swiftly dividing cancer cells and viral particles. Distinctive chemical base and mode of operation grants it a targeted high-effectivity therapeutic option for the cure of cancer and viral infections. Synonyms: (2R,3R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-alcohol. CAS No. 156058-35-4. Molecular formula: C11H12F2N4O3. Mole weight: 286.23. | |
| 3'-(6-FAM) PS | 3'-(6-FAM) PS: a phosphorothioate oligonucleotide labeled with fluorescence, notorious in biomedical research as a nucleic acid detection probe. Its fluorescence can assist in DNA or RNA sample identification and quantification, utilizing prominent applications like PCR, hybridization, and sequencing. On top of all that, this product holds significant therapeutic value for sequencing-based diagnostics and drug discovery. Synonyms: 1-Dimethoxytrityloxy-3-[O-(N-carboxy-(di-O-pivaloyl-fluorescein)-3-aminopropyl)]-propyl-2-O-succinoyl-polystyrene. Mole weight: 569.46. | |
| 3'-NH-Tr-2',3'-ddA(Bz)-5'-CE-Phosphoramidite | 3'-NH-Tr-2',3'-ddA(Bz)-5'-CE-Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing specific modifications into DNA sequences. Overall, this phosphoramidite can be used in custom oligonucleotide synthesis, where modifications like chain termination, functionalization, or base protection are required. Synonyms: Adenosine, N-benzoyl-2',3'-dideoxy-3'-[(triphenylmethyl)amino]-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Adenosine, N-benzoyl-2',3'-dideoxy-3'-[(triphenylmethyl)amino]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Benzoyl-3'-(trityl)amino-2',3'-dideoxyadenosine-5'-cyanoethyl phosphoramidite; ((2S,3S,5R)-5-(6-Benzamido-9H-purin-9-yl)-3-(tritylamino)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite; 3'-Tritylamino-N6-benzoyl-2',3'-dideoxyadenosine-5'-(2-cyanoethyl)-N,N-diisopropylphosphoramidite. Grade: ≥95%. CAS No. 195375-64-5. Molecular formula: C45H49N8O4P. Mole weight: 796.90. | |
| 3'-NH-Tr-2',3'-ddG(iBu)-5'-CE Phosphoramidite | 3'-NH-Tr-2',3'-ddG(iBu)-5'-CE Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a 2',3'-dideoxyguanosine (ddG) base, which lacks the 3'-hydroxyl group necessary for chain elongation, thus halting DNA strand elongation. This compound is useful for creating controlled-length DNA strands or for studying DNA replication mechanisms. Synonyms: Guanosine, 2',3'-dideoxy-N-(2-methyl-1-oxopropyl)-3'-[(triphenylmethyl)amino]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Guanosine, 2',3'-dideoxy-N-(2-methyl-1-oxopropyl)-3'-[(triphenylmethyl)amino]-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N2-Isobutyryl-3'-(trityl)amino-2',3'-dideoxyguanosine-5'-cyanoethyl Phosphoramidite; N2-Isobutyryl-2',3'-dideoxy-3'-methoxytritylaminoguanidine-5'-O-N,N-diisopropylaminocyanoethylphosphoramidite. Grade: ≥97%. CAS No. 195375-66-7. Molecular formula: C42H51N8O5P. Mole weight: 778.88. | |
| 3'-O-Acetyl-N4-acetyl-4'-thio-2'-deoxy-beta-D-cytidine | 3'-O-Acetyl-N4-acetyl-4'-thio-2'-deoxy-beta-D-cytidine is a modified nucleoside with multiple structural changes. The 3'-O-acetyl group is attached to the 3' hydroxyl group of the sugar, which can protect the molecule from exonuclease degradation and contribute to stability. The N4-acetyl group is attached to the N4 position of the cytosine base, potentially altering the interactions of the nucleoside with other nucleic acids or proteins. The 4'-thio modification replaces the oxygen atom at the 4' position of the sugar with a sulfur atom, which enhances stability and can increase binding affinity. The 2'-deoxy structure means the nucleoside lacks the 2'-hydroxyl group, making it a deoxyribonucleotide and suitable for DNA synthesis. This modified nucleoside can be used in the synthesis of DNA oligonucleotides, especially for applications requiring enhanced stability, altered enzyme interactions, or resistance to degradation. Synonyms: Cytidine, N-acetyl-2'-deoxy-4'-thio-, 3'-acetate; N-Acetyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine; N4-Acetyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine. Molecular formula: C13H17N3O5S. Mole weight: 327.36. | |
| 3'-O-Acetyl-N4-benzoyl-4'-thio-2'-deoxy-beta-D-cytidine | 3'-O-Acetyl-N4-benzoyl-4'-thio-2'-deoxy-beta-D-cytidine is a modified nucleoside with several structural modifications. The 3'-O-acetyl group is attached to the 3' hydroxyl of the sugar, providing steric protection and increasing the stability of the nucleoside. The N4-benzoyl modification is attached to the nitrogen at the N4 position of the cytosine base, which can affect its interactions with other nucleic acids or enzymes, potentially enhancing binding affinity or altering recognition. The 4'-thio modification replaces the oxygen atom at the 4' position of the ribose sugar with a sulfur atom, which can increase the stability and binding affinity of the nucleoside. The 2'-deoxy structure indicates the absence of the 2'-hydroxyl group, making it a deoxyribonucleotide, suitable for DNA synthesis. This modified nucleoside can be used in DNA research, gene editing, or therapeutic applications where increased stability, nuclease resistance, and specific interactions with biological targets are important. Synonyms: Cytidine, N-benzoyl-2'-deoxy-4'-thio-, 3'-acetate; N-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine; N4-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thio-cytidine. Grade: ≥95%. CAS No. 667882-71-5. Molecular formula: C18H19N3O5S. Mole weight: 389.43. | |
| 3'-O-Acetyl-N6-benzoyl-4'-thio-2'-deoxy-beta-D-adenosine | 3'-O-Acetyl-N6-benzoyl-4'-thio-2'-deoxy-beta-D-adenosine is a modified nucleoside with several structural changes. The 3'-O-acetyl group is attached to the 3' position of the sugar, providing steric protection and increasing the stability of the nucleoside. The N6-benzoyl modification is attached to the adenine base at the N6 position, which can alter the interactions of the nucleoside with enzymes or other nucleic acids. The 4'-thio modification involves replacing the oxygen at the 4' position of the sugar with a sulfur atom, which can enhance the stability and binding properties of the nucleoside. Finally, the 2'-deoxy structure indicates the absence of the hydroxyl group at the 2' position, making it a deoxyribonucleotide. This modified nucleoside can be used in DNA synthesis, particularly for research applications involving stability enhancement, resistance to nucleases, and altered interactions with biological systems. Synonyms: Adenosine, N-benzoyl-2'-deoxy-4'-thio-, 3'-acetate; N-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thioadenosine; N6-Benzoyl-2'-deoxy-3'-O-acetyl-4'-thioadenosine. Grade: ≥95%. CAS No. 667882-73-7. Molecular formula: C19H19N5O4S. Mole weight: 413.45. | |
| 3'-O-Allyl-2'-deoxycytidine | 3'-O-Allyl-2'-deoxycytidine is a modified nucleoside where an allyl group is attached to the 3' position of the 2'-deoxyribose sugar in a cytidine molecule. The modification of the 3' hydroxyl group with an allyl group alters the compound's chemical reactivity and may affect its interaction with enzymes or other molecular targets. Such modifications can enhance the stability of the nucleoside in DNA sequences, potentially improving its pharmacokinetic properties for applications in nucleic acid-based therapies, such as gene therapy, or for use in oligonucleotide synthesis. The allyl group could also serve as a handle for further chemical modifications or conjugation to other biomolecules. Synonyms: 2'-Deoxy-3'-O-2-propen-1-ylcytidine; 3'-O-Allyl dC; 3-O-Allyl-2-Deoxycytidine; 1-((2R,4S,5R)-4-(Allyloxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one. Grade: ≥98%. CAS No. 925915-24-8. Molecular formula: C12H17N3O4. Mole weight: 267.28. | |
| 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite | 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite is a modified nucleotide used in the synthesis of Threose Nucleic Acid (TNA) molecules for biomedical research. TNA is a promising alternative to DNA and RNA for gene and drug delivery due to its chemical stability and resistance to nuclease degradation. This specific phosphoramidite derivative incorporates a benzoyl-adenosine moiety, making it ideal for designing TNA-based drugs for the treatment of viral infections, inflammatory diseases, and cancer. Synonyms: DMTr-TNA A(Bz)-amidite; TNA-A(Bz)-CE-Phosphoramidite; DMTr-TNA A(Bz)-Phosphoramidite; N-Benzoyl-9-[(2R)-3alpha-[(diisopropylamino)(2-cyanoethoxy)phosphinooxy]-4beta-(4,4'-dimethoxytrityloxy)tetrahydrofuran-2beta-yl]-9H-purine-6-amine; 1-{2'-O-[(2-Cyanoethoxy)(diisopropyl amino)phosphino]-3'-O-[(4,4'-dimethoxytriphenyl)methyl]-a-L-threofuranosyl}-N6-benzoyladenine; (2R,3R,4S)-2-[6-(Benzoylamino)-9H. Grade: 98%. CAS No. 325683-93-0. Molecular formula: C46H50N7O7P. Mole weight: 843.92. | |
| 3'-O-DMT-thymidine 3'-succinyl CPG | The 3'-O-DMT-thymidine 3'-succinyl CPG is a vital tool extensively used in the biomedical industry for the synthesis of oligonucleotides. It enables the modification of DNA strands, facilitating research on drug discovery and development, gene expression analysis, and nucleic acid-based diagnostics. This product plays a crucial role in studying DNA-protein interactions, epigenetics, and investigating diseases such as cancer and genetic disorders. | |
| 3'-O-Methylguanosine | 3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. Synonyms: 3'-(O-Methyl) Guanosine; 3'-O-Methyl-D-guanosine; 3'-O-Methyl guanosine; O3'-methyl-guanosine; 3'-OMe-G; 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one. Grade: ≥95%. CAS No. 10300-27-3. Molecular formula: C11H15N5O5. Mole weight: 297.27. | |
| 3'-O-Methyl iso-guanosine | 3'-O-Methyl iso-guanosine is a modified nucleoside where the guanosine base is altered to include a methyl group at the 3'-hydroxyl position of the ribose sugar. This modification is often used to protect the 3' position during nucleic acid synthesis or to alter the properties of the nucleoside for specific biochemical or biophysical applications. The ''iso'' modification of the guanine base may involve structural changes that influence the stability or reactivity of the nucleoside in the context of RNA or DNA analogs. Synonyms: 1,2-Dihydro-3'-O-methyl-2-oxo-adenosine; 2-Hydroxy-3'-O-methyladenosine; O3'-Methyl-isoguanosine; 6-Amino-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-1,9-dihydro-2H-purin-2-one; 3'-O-Methyl-isoguanosine. Grade: ≥95%. CAS No. 157309-10-9. Molecular formula: C11H15N5O5. Mole weight: 297.27. | |
| 3'-Qusar570 Frits column (100nmol) | The 3'-Qusar570 Frits column (100nmol) is a biomedicine product used in fluorescence-based bioanalytical assays such as DNA sequencing and drug discovery studies. It has excellent photostability and is highly fluorescent, making it ideal for detecting low concentrations of target molecules. The product is also used in cancer research as a diagnostic tool to detect tumors early. Synonyms: 3'-Qusar570 Frits column. | |
| 4-(2-Cyanoethylthio)-2'-deoxy-5'-DMT-uridine 3'-CE phosphoramidite | 4-(2-Cyanoethylthio)-2'-deoxy-5'-DMT-uridine 3'-CE phosphoramidite is a phosphoramidite compound, utilized in the biomedical industry for the synthesis of modified oligonucleotides, specifically in the field of nucleic acid research and drug development. It serving as a key component for the introduction of 4-(2-cyanoethylthio)-2'-deoxy-5'-DMT-uridine nucleotide residues during DNA or RNA synthesis. These modified nucleotides find applicability in the development of therapeutics, diagnostics is and nucleic acid-based tools for targeting various diseases. Molecular formula: C42H50N5O7PS. Mole weight: 799.93. | |
| 4-Methylquinoline | 4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-35-0. Pack Sizes: 1g, 10g. Molecular Formula: C10H9N. US Biological Life Sciences. | Worldwide |
| 4'-Thio-2'-deoxycytidine | 4'-Thio-2'-deoxycytidine is a modified nucleoside where the oxygen atom at the 4' position of the ribose sugar is replaced with a sulfur atom, creating a thio group. The 2'-deoxy structure means the nucleoside lacks the hydroxyl group at the 2' position, making it a deoxyribonucleotide, which is commonly used in DNA synthesis. The 4'-thio modification increases the stability of the nucleoside and can improve its resistance to nucleases. This modification can also affect the binding affinity and specificity of the nucleoside in interactions with other nucleic acids or proteins. 4'-Thio-2'-deoxycytidine is often used in DNA-based research, including gene editing, oligonucleotide design, and therapeutic applications, where stability and nuclease resistance are important. Synonyms: 2'-Deoxy-4'-thiocytidine; NSC 764276; 1-(2-Deoxy-4-thio-beta-D-ribofuranosyl)cytosine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidin-2(1H)-one. Grade: ≥95%. CAS No. 134111-30-1. Molecular formula: C9H13N3O3S. Mole weight: 243.28. | |
| 4'-Thio-2'-deoxyguanosine | 4'-Thio-2'-deoxyguanosine is a modified nucleoside where a sulfur atom replaces the oxygen atom at the 4' position of the deoxyribose sugar in 2'-deoxyguanosine. This sulfur substitution alters the properties of the nucleoside, potentially increasing its stability or changing its interactions in nucleic acid structures. It can be incorporated into oligonucleotides during DNA synthesis for applications in studying DNA structure, function, and stability, or for creating DNA probes and analogs with altered chemical properties. This modification can also be used to investigate the effects of sulfur substitutions on base pairing and DNA hybridization. Synonyms: 2'-Deoxy-4'-thioguanosine; 2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-1H-purin-6-one. Grade: ≥95%. CAS No. 135656-33-6. Molecular formula: C10H13N5O3S. Mole weight: 283.31. | |
| 4-Thio-2'-F-dU Phosphoramidite | 4-Thio-2'-F-dU Phosphoramidite is a chemically modified phosphoramidite in which the oxygen atom at the 4-position of the uracil base is replaced with a sulfur atom, and the ribose sugar is substituted with a fluorine atom at the 2'-position. The 3'-cyanoethyl (CE) phosphoramidite group facilitates its incorporation into oligonucleotides during automated synthesis. This modification enhances the stability and nuclease resistance of the resulting DNA strands and introduces unique structural and chemical properties, such as thiol-reactive functionality. It is widely used in therapeutic oligonucleotide development, molecular biology research, and the study of nucleic acid-protein interactions. Synonyms: 4-Thio-2'-F-dU CEP; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-deoxy-2'-fluoro-4-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-deoxy-2'-fluoro-4-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 4-S-(2-cyanoethyl)-2'-F-dU 3'-CE-phosphoramidite. Grade: ≥95%. Molecular formula: C42H49FN5O7PS. Mole weight: 817.91. | |
| 4-Thiothymidine-5'-Triphosphate | 4-Thiothymidine-5'-Triphosphate is a key component in biomedical research for studying DNA research and development and replication. It is a modified nucleotide that incorporates into DNA during replication, acting as an artificial base analog. This compound is used to investigate various processes such as DNA repair mechanisms, mutagenesis, antiviral drug development. Synonyms: 4-Thio-dTTP. Grade: ≥90% by AX-HPLC. Molecular formula: C10H17N2O13P3S. Mole weight: 498.24. | |
| 5-[(3-Indolyl)propionamide-N-allyl]-2'-deoxyuridine-5'-Triphosphate | 5-[(3-Indolyl)propionamide-N-allyl]-2'-deoxyuridine-5'-Triphosphate is an indole-based molecular entity serving as a potent investigative tool in orchestrating DNA synthesis and repair mechanisms. Synonyms: 5-Indolyl-AA-dUTP; Tryptamino-dUTP Analog. Grade: ≥90% by AX-HPLC. Molecular formula: C23H29N4O15P3. Mole weight: 694.40. | |
| 5'-Amino-5'-deoxyguanosine | 5'-Amino-5'-deoxyguanosine is a nucleoside analog used in biomedical research. It can be incorporated into oligonucleotides and DNA to study the effects of modified bases on genome stability and function. Additionally, this compound has shown promising anticancer activity through its ability to disrupt DNA replication and induce apoptosis in cancer cells. Synonyms: Guanosine, 5'-amino-5'-deoxy-; 5'-Amino-5'-deoxyguanosine. Grade: 97%. CAS No. 4099-84-7. Molecular formula: C10H14N6O4. Mole weight: 282.26. | |
| 5-aza-5,6-dihydro-dC-CE Phosphoramidite | 5-aza-5,6-dihydro-dC-CE Phosphoramidite, a vital reagent utilized in oligonucleotide synthesis with altered bases, is a key player in investigating epigenetic regulation and DNA methylation in various maladies such as cancer and neurological disorders. Its substantial purification, alongside unmatched stability, propels it to the forefront of drug discovery and developmental applications, a must-have for discerning researchers seeking unparalleled performance metrics in their scientific endeavors. Synonyms: 5'-Dimethoxytrityl-N4-dimethylformamidine-5,6-dihydro-5-aza-2'-deoxyCytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C41H54N7O7P. Mole weight: 787.89. | |
| 5-Bromouracil (5-Bromo-2,4-(1H,3H)-pyrimidinedione) | A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine. Group: Biochemicals. Alternative Names: 5-Bromo-2,4-(1H,3H)-pyrimidinedione. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 5-Carboxy-dC-CE Phosphoramidite | 5-Carboxy-dC-CE Phosphoramidite, an essential chemical for oligonucleotide synthesis, offers immense potential for exploratory biomedical research. Its incorporation into DNA can facilitate the identification of mutations, crucial for disease detection, such as cancer. Moreover, the carboxy group on the dC base can be artfully employed for concurrent conjugation with fluorescent dyes or other molecules, enlivening the imaging and recognition capabilities of biomedical applications. Synonyms: 5'-Dimethoxytrityl-N-benzoyl-5-ethylcarboxy-2'-deoxyCytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C49H56N5O10P. Mole weight: 905.97. | |
| 5'-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite | 5'-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite is a protected phosphoramidite derivative used in oligonucleotide synthesis. The cytosine base is protected at the N4 position with a benzoyl (Bz) group to prevent side reactions during chemical synthesis. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group, enabling stepwise assembly of nucleotides in automated synthesis. The 3'-position features a methyl-N,N-diisopropyl phosphoramidite functional group, which facilitates efficient coupling into growing oligonucleotide chains. This compound is essential for synthesizing stable and high-fidelity DNA sequences in applications such as therapeutic nucleic acids, antisense technologies, and molecular biology research. Synonyms: N4-Benzoyl-5'-O-(dimethoxytrityl)-2'-deoxycytidine-3'-(methyl-N,N-diisopropyl (cyanoethyl)phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3'-O-{[di(propan-2-yl)amino](methoxy)phosphanyl}cytidine; dC(Bz)-3'-Methoxy Phosphoramidite; DNA C(Bz) OMe-amidite; 2'-Deoxycytidine-(N-Bz)-3'-Methyl-Phosphoramidite. Grade: 98%. CAS No. 84416-83-1. Molecular formula: C44H51N4O8P. Mole weight: 794.87. | |
| 5'-DMT-2'-deoxyguanosine (N-Fmoc) | 5'-DMT-2'-deoxyguanosine (N-Fmoc), a chemical utilized in DNA-based drug advances and the synthesis of oligonucleotides, has shown its potential in treating various diseases including cancer, viral infections, and genetic disorders. Additionally, its distinctive structure facilitates targeted drug delivery to specific cells and tissues, ultimately amplifying efficacy levels and minimizing undesired adverse effects. Furthermore, it is also utilized in cutting-edge gene therapy and DNA vaccines research, propelling the development of future healthcare innovations. Grade: ≥ 98% by HPLC. Molecular formula: C46H41N5O8. Mole weight: 791.85. | |
| 5'-DMT-7-deaza-2'-deoxyguanosine (N-iBu) | 5'-DMT-7-deaza-2'-deoxyguanosine (N-iBu): a compound integral to the advancement of antiviral medications against hepatitis B and C. Its exceptional nucleoside analog characteristics enable the inhibition of viral DNA synthesis, inducing viral DNA base-pairing dysfunction, thereby proving efficacious for antiviral treatments. This compound also uniquely supports the study of DNA-protein interactions through its exceptional structural qualities. Grade: ≥ 98% by HPLC. Molecular formula: C36H38N4O7. Mole weight: 638.71. | |
| 5-Ethylcarboxy-dC(Bz) Phosphoramidite | 5-Ethylcarboxy-dC(Bz) Phosphoramidite is a modified phosphoramidite where the cytosine base is functionalized with an ethylcarboxy group at the 5-position and protected with a benzoyl (Bz) group on the exocyclic amine. The sugar moiety is designed with a 3'-phosphoramidite functionality for compatibility with automated DNA synthesis. This compound is commonly used to introduce chemically modified cytosine residues into oligonucleotides, enabling studies on DNA-protein interactions, epigenetic modifications, and the effects of base alterations on nucleic acid stability and function. It is particularly useful in therapeutic oligonucleotide development and molecular biology research. Synonyms: 5-Pyrimidinecarboxylic acid, 4-(benzoylamino)-1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-1,2-dihydro-2-oxo-, ethyl ester; 5-Carboxy-dC-CE Phosphoramidite; 5'-Dimethoxytrityl-N-benzoyl-5-ethylcarboxy-2'-deoxycytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DNA 5-carbethoxy-C(Bz) amidite. Grade: ≥95%. CAS No. 1535202-71-1. Molecular formula: C49H56N5O10P. Mole weight: 905.97. | |
| 5-Ethynyl-2'-deoxyuridine | 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a Click reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation [1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [2]. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 61135-33-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-118411. | |
| 5-Hydroxymethylcytidine | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 5-Iodouracil | 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones. Group: Biochemicals. Alternative Names: 5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848. Grades: Highly Purified. CAS No. 696-07-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 5-Me-dC(Bz)-3'-Methoxy Phosphoramidite | 5-Me-dC(Bz)-3'-Methoxy Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. The cytosine base is methylated at the 5-position (5-Me), which enhances duplex stability and modulates gene regulation in epigenetic studies. Additionally, the base is protected with a benzoyl (Bz) group at the exocyclic amine to ensure chemical stability during synthesis. The 3'-hydroxyl group is replaced by a methoxy group, providing unique structural properties and increased resistance to enzymatic degradation. The phosphoramidite functionality at the 3'-position allows for efficient incorporation into oligonucleotide chains. This compound is widely used in applications requiring modified oligonucleotides, such as epigenetic research, antisense technologies, and therapeutic nucleic acid development. Synonyms: 5'-O-DMTr-5-Me-dC(Bz)-3'-Methoxy-phosphoramidite; N4-Benzoyl-5-Methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-deoxycytidine-3'-Methoxy-phosphoramidite; dC (Bz) (5-Me) 3'-Methoxy-phosphoramidite; DNA 5-Me-C(Bz) OMe-amidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]. Grade: ≥98%. CAS No. 106022-55-3. Molecular formula: C45H53N4O8P. Mole weight: 808.91. | |
| 5-Methoxy-3-Methyl-Uridine 5'-Triphosphate Sodium | 5-Methoxy-3-Methyl-Uridine 5'-Triphosphate is a vital tool in biomedical research serving as a building block for the research and development of RNA and DNA during enzymatic reactions. The compound finds extensive use in studies related to RNA modification and the exploration of various diseases, including cancer and viral infections. Grade: ≥95%. Molecular formula: C11H19N2O16P3·xNa. Mole weight: 528.19 (free base). | |
| 5-Methylisocytidine | 5-Methylisocytidine is a modified nucleoside where the cytosine base is altered by methylation at the 5-position of the ring structure, similar to 5-methylcytosine, but with an isomeric shift at the 2,4-positions. This modification impacts the nucleoside's interactions with enzymes, such as DNA and RNA methyltransferases, and can affect the structure and function of RNA or DNA molecules. 5-Methylisocytidine can be used in research to study the effects of methylation on nucleic acid stability, gene expression regulation, and epigenetic processes. It could also serve as a building block for modified nucleic acids in therapeutic applications, such as gene therapy or oligonucleotide-based drugs. Synonyms: 5-Methyl-isocytidine; 2-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-4(1H)-one; 2-Amino-5-methyl-1-β-D-ribofuranosyl-4(1H)-pyrimidinone. Grade: ≥95%. CAS No. 159639-80-2. Molecular formula: C10H15N3O5. Mole weight: 257.24. | |
| 5-Nitroindole 3'-CE phosphoramidite | 5-Nitroindole 3'-CE Phosphoramidite is a modified phosphoramidite used in the synthesis of oligonucleotides with specific functional modifications. The 5-nitroindole component refers to an indole ring structure that is functionalized with a nitro group at the 5-position, which introduces electron-withdrawing properties that can influence the oligonucleotide's interaction with other molecules, such as nucleic acids or proteins. The nitroindole modification may enhance the stability, reactivity, or specificity of the oligonucleotide for particular applications. This phosphoramidite is useful in synthesizing oligonucleotides for applications in research involving fluorescence-based detection, molecular interactions, or RNA interference. The nitroindole modification may also offer advantages in terms of increased stability or enhanced binding properties for therapeutic applications, such as gene silencing or antisense oligonucleotides. Synonyms: 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-nitro-1H-indole; 5-Nitroindole-CE phosphoramidite; 5'-Dimethoxytrityl-2'-deoxy-5-nitroindole-ribofuranosyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DNA 5-NO2-indole amidite. Grade: ≥96%. CAS No. 911823-92-2. Molecular formula: C43H49N4O8P. Mole weight: 780.86. | |
| 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-(methyl-N,N-diisopropyl)phosphoramidite | dG(ibu)-3'-Methoxy Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. The guanine base is protected with an isobutyryl (ibu) group at the exocyclic amine to prevent undesired side reactions during the synthesis process. The 3'-hydroxyl group is replaced with a methoxy group, enhancing the stability and altering the structural properties of the resulting oligonucleotide. The phosphoramidite functionality ensures efficient coupling during automated oligonucleotide synthesis. This modification is particularly useful in creating oligonucleotides with increased chemical stability and resistance to enzymatic degradation, making it suitable for applications in therapeutic oligonucleotides, antisense RNA technologies, and advanced molecular biology research. Synonyms: dG(ibu)-3'-Methoxy Phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; DNA G(iBu) OMe-amidite; 2'-Deoxyguanosine-(N-iBu)-3'-methyl-phosphoramidite. Grade: ≥98%. CAS No. 84416-84-2. Molecular formula: C42H53N6O8P. Mole weight: 800.88. | |
| 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(methyl-N,N-diisopropyl)phosphoramidite | dA(Bz)-3'-Methoxy Phosphoramidite is a modified phosphoramidite designed for specialized oligonucleotide synthesis. The adenine base is protected with a benzoyl (Bz) group at the N6 position to prevent side reactions during synthesis. At the 3' position, the methoxy group replaces the standard hydroxyl group, providing unique structural properties and increased chemical stability to the oligonucleotide. The phosphoramidite functionality ensures efficient incorporation into oligonucleotide chains via automated synthesis. This modification is particularly useful in applications requiring oligonucleotides with altered backbone properties, improved hybridization characteristics, or enhanced resistance to enzymatic degradation, such as in therapeutic nucleic acids and molecular biology studies. Synonyms: dA(Bz)-3'-Methoxy Phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-Me phosphonamidite; (2R,3S,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite; 2'-Deoxy Adenosine (n-Bz) methyl phosphoramidite; DNA A(Bz) OMe-amidite; dA(Bz) OMe-amidite. Grade: ≥98%. CAS No. 84416-82-0. Molecular formula: C45H51N6O7P. Mole weight: 818.90. | |
| 5'-O-Acetyl-2'-deoxyuridine 3'-CE phosphoramidite | 5'-O-Acetyl-2'-deoxyuridine 3'-CE phosphoramidite is a crucial reagent in biomedicine. It is commonly used in the synthesis of DNA analogs for research and diagnostics. This phosphoramidite plays a significant role in the development of nucleoside-based drugs for treating viral infections and certain cancers, where specific modifications to DNA sequences are necessary. Its high purity and compatibility with automated DNA synthesis make it an essential tool in biomedical research. Synonyms: 5'-O-Acetyl-2'-deoxy-D-uridine 3'-CE phosphoramidite. Molecular formula: C20H31N4O7P. Mole weight: 470.46. | |
| 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-α-methoxythymidine | 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-α-methoxythymidine is a chemically modified nucleoside used in oligonucleotide synthesis, particularly in automated DNA synthesis. The DMT group allows for selective deprotection and elongation of the nucleic acid chain, while the α-methoxy modification can influence base pairing and stability. Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-5-methoxythymidine; 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-(methoxymethyl)pyrimidine-2,4(1H,3H)-dione. Grade: 95%. CAS No. 115173-73-4. Molecular formula: C32H34N2O8. Mole weight: 574.63. | |
| 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite | 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite, a critical and indispensable reagent in the highly esteemed biomedical industry, manifests its profound significance in the realm of modified nucleic acids synthesis. Its exceptional utility primarily lies in its adeptness for effectuating the introduction of the esteemed 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine moiety during phosphoramidite-mediated DNA synthesis. This unparalleled product unveils a wealth of opportunities within the sphere of nucleic acid-based therapeutic development, acting as a fulcrum for groundbreaking research directed towards unravelling the complexities of diverse disease entities and optimizing drug targeting strategies. Synonyms: 8-I-rA phosphoramidite; DMT-2'-O-TBDMS-8-I-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-8-Iodoadenosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-TBDMS-8-I-A(Bz)-3'-CE-Phosphoramidite. Grade: ≥97% by HPLC. Molecular formula: C53H65IN7O8PSi. Mole weight: 1114.11. | |
| 5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite | 5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite is a chemical reagent used in solid phase DNA synthesis. It serves as a key component in the automated synthesis of nucleic acid polymers for research, diagnostics, and therapeutics. This phosphoramidite is particularly useful for introducing a 4-methoxythymidine base into DNA sequences, which can have implications in gene regulation and anticancer drug development. Synonyms: 5'-O-DMT-O4-methylthymidine 3'-CE phosphoramidite; 5'-O-DMT-4-methoxy-D-thymidine 3'-CE phosphoramidite. Molecular formula: C41H51N4O8P. Mole weight: 758.86. | |
| 5'-O-DMT-N1-Methy-N6-Chloroacetyl-2'-dA 3'-CE Phosphoramidite | 5'-O-DMT-N1-Methyl-N6-Chloroacetyl-2'-dA 3'-CE Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound features a 2'-deoxyadenosine (dA) base substituted with an N1-methyl group and an N6-chloroacetyl protecting group, while the 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, and the sugar moiety is functionalized with a 3'-cyanoethyl (CE) phosphoramidite group. These modifications enhance the stability and functionality of synthetic oligonucleotides, allowing for precise incorporation into DNA strands during automated synthesis. It is particularly useful in applications requiring site-specific methylation or alkylation for studying DNA-protein interactions or designing therapeutic nucleic acids. Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(chloroacetyl)-1-methyl-2'-deoxy-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Deoxy-5'-O-DMT-N1-methy-N6-Chloroacetyladenosine 3'-CE phosphoramidite; N1-Methy-N6-Chloroacetyl-5'-O-DMT-2'-O-deoxyadenosine 3'-CE phosphoramidite. Grade: ≥98%. Molecular formula: C43H51ClN7O7P. Mole weight: 844.35. | |
| 5'-O-DMTr-L-thymidine-3'-CED phosphoramidite | 5'-O-DMTr-L-thymidine-3'-CED phosphoramidite is a modified phosphoramidite used in solid-phase oligonucleotide synthesis. This compound is used for the preparation of custom oligonucleotides, such as for DNA sequencing, gene synthesis, or other nucleic acid-based applications. The L-configuration of the sugar in the name may imply a chiral modification, which could influence the nucleic acid's properties in certain contexts. Synonyms: 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-L-erythro-pentofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; (2S,3R,5S)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; L-DNA T amidite; beta-L-dT-CE Phosphoramidite; 5'-Dimethoxytrityl-beta-L-2'-deoxyThymidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-O-DMTr-L-dT-3'-CED phosphoramidite. Grade: ≥95%. CAS No. 141846-55-1. Molecular formula: C40H49N4O8P. Mole weight: 744.83. | |
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