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| Product | Description | |
|---|---|---|
| 1,3,5-Tri-O-benzoyl-2-O-methyl-α-D-ribofuranose | 1,3,5-Tri-O-benzoyl-2-O-methyl-α-D-ribofuranose is used as a reactant in the preparation of 2'-O-methylpyrimidine ribonucleosides via stereoselective Vorbruggen glycosidation of pyrimidines. It is also used as a reactant in solid-phase synthesis, fluorescence, and ambiguous base pairing of canonical DNA nucleobases containing benzotriazole and 1,2,3-triazolo[4,5-d]pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 68045-07-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C27H24O8, Molecular Weight: 476.47. US Biological Life Sciences. |  Worldwide |
| 1-Bromopyrene | 1-Bromopyrene is used in the cleavage of DNA in studies. It is also used in the preparation of DNA base analogs. Group: Biochemicals. Alternative Names: 1-Bromopyrene; 3-Bromopyrene. Grades: Highly Purified. CAS No. 1714-29-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 2-[2- (2-Chloroethoxy) ethoxy]ethanol | 2-[2- (2-Chloroethoxy) ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2- (2-Chloroethoxy) ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection. Group: Biochemicals. Alternative Names: 2-[ (2-Chloroethoxy) ethoxy]ethanol; 8-Chloro-3,6-dioxa-1-octanol; 8-Chloro-3,6-dioxaoctanol; Diethylene Glycol Mono(2-chloroethyl) Ether; NSC 2636; Triethylene Glycol Monochloride; Triethylene Glycol Monochlorohydrin. Grades: Highly Purified. CAS No. 5197-62-6. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2,4-Diamino-1,3,5-triazine | 2,4-Diamino-1,3,5-triazine is a reactant or reagent that has numerous uses. A triazine-modified dendrimer G5-DAT66 was synthesized and used as a vector for osteosarcoma TRAIL gene therapy in vitro and in vivo. 2,4-Diamino-1,3,5-triazine was also used to synthesize water soluble copper(II)-dipeptide complexes which exhibited considerable in vitro cytotoxicity against four human carcinoma cell lines (HepG2, HeLa, A549 and U87). These water soluble DNA minor groove binding diamino-s-triazine copper based complexes are potential chemotherapeutic agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 504-08-5. Pack Sizes: 250mg, 500mg. Molecular Formula: C3H5N5, Molecular Weight: 111.11. US Biological Life Sciences. | Worldwide |
| 2-Aminopurine | 2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 452-06-2. Pack Sizes: 100 mg. Product ID: HY-W012642. |  |
| 2-Aminopurine-riboside-5'-monophosphate | 2-Aminopurine-riboside-5'-monophosphate, a biochemical agent employed in scientific research, exhibits multifaceted benefits as an investigative tool. By being integrated into oligonucleotides, it enables the study of base-pair mismatches, as well as facilitating enzyme activity during nucleic acid synthesis. Furthermore, its competence in countering viral infections makes it a promising therapeutic agent. Such versatile properties have marked 2-Aminopurine-riboside-5'-monophosphate a crucial component in the field of DNA and RNA research. Synonyms: 2-Aminopurine-riboside-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14N5O7P (free acid). Mole weight: 347.22 (free acid). |  |
| 2'-Azido-N4-benzoyl-2'-deoxy-5'-O-DMT-cytidine | 2'-Azido-N4-benzoyl-2'-deoxy-5'-O-DMT-cytidine, a potent chemical compound employed in the biomedical sector, prominently serves as a crucial entity for combating viral infections induced by DNA-based viruses. Exhibiting an unparalleled ability to impede viral replication and modify DNA synthesis, this compound emerges as a paramount instrument within the realm of targeted antiviral therapies. Augmented with the presence of DMT and cytidine, it attains heightened stability and efficacy, thereby facilitating meticulous and efficacious treatment interventions. Molecular formula: C37H34N6O7. Mole weight: 674.70. | |
| 2-Chloro-5-hydrazinyl-phenol Hydrochloride | 2-Chloro-5-hydrazinyl-phenol Hydrochloride was identified to inhibit the E. coli SC and SC-mediated DNA replication in vitro. 2-Chloro-5-hydrazinyl-phenol Hydrochloride is the derivative of 5-Amino-2-chlorophenol (A603890) which is used in the synthesis of antimalarial quinolones. Also, used in the synthesis of potent anti-HIV agent based upon pyrimidinylphenylamine 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 1636917-89-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C6H7ClN2O HCl, Molecular Weight: 158.593646. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-5'-O-DMT-guanosine-(DMF)-succinyl CPG | 2'-Deoxy-5'-O-DMT-guanosine-(DMF)-succinyl CPG, an indispensable asset in the realm of biomedical research. Leveraged for synthesizing oligonucleotides, this remarkable entity plays a pivotal role in nurturing nucleic acid-based therapeutics, anatomizing genetic disorders, and comprehending diseases. It spearheads the realm of drug discovery and personalized medicine by endowing scientists with efficacious and controlled DNA sequence synthesis. Prepare to embark on riveting scientific endeavors with this groundbreaking product. | |
| 2'-Deoxy-5'-O-DMT-inosine 3'-succinyl CPG | 2'-Deoxy-5'-O-DMT-inosine 3'-succinyl CPG is a crucial tool in biomedical research for the synthesis of modified oligonucleotides. It is extensively utilized as a solid support matrix for automated DNA/RNA synthesis, enabling the efficient incorporation of nucleotide modifications. This product plays a vital role in studying and developing various nucleic acid-based therapies, diagnostics, and drug delivery systems targeting specific diseases like cancer and viral infections. | |
| 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite | 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite, a highly regarded biochemical agent, has garnered considerable attention in the realm of biomedicine research. This extraordinary compound serves as an instrumental tool for facilitating DNA synthesis and modification, offering unprecedented opportunities for investigating intricate cellular mechanisms and disease etiology. By employing its unique modifications, researchers can delve into a myriad of applications, encompassing the development of precision drug delivery systems and the conception of revolutionary gene-based therapies targeting a wide spectrum of ailments, such as cancer and hereditary disorders. Synonyms: Pac-dA-Me Phosphoramidite; 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyl-D-adenosine 3'-Me phosphoramidite; 5'-O-DMT-N6-phenoxyacetyl-2'-deoxyadenosine 3'-Me phosphoramidite. Molecular formula: C46H53N6O8P. Mole weight: 848.94. | |
| 2'-Deoxyadenosine-5'-monophosphate | 2-Deoxyadenosine 5-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2-Deoxyadenosine 5-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage [1]. Uses: Scientific research. Group: Natural products. CAS No. 653-63-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W016009. | |
| 2'-Deoxyadenosine monohydrate (dA) | 2'-Deoxyadenosine monohydrate (dA) is a crucial biomolecule widely used in the biomedical industry, serving as a key building block for DNA synthesis and repair. Additionally, it has shown potential in reserching diseases related to DNA damage and replication errors, such as certain types of cancer and genetic disorders. Grades: ≥ 98% by HPLC. Molecular formula: C10H13N5O3. Mole weight: 251.24 (free base). | |
| 2'-Deoxyguanosine | 2(acute)-Deoxyguanosine is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). It is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. It is useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides. Synonyms: Deoxyguanosine; Guanine deoxyriboside; 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9H-Purin-6-ol, 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)guanine. Grades: ≥95%. CAS No. 961-07-9. Molecular formula: C10H13N5O4. Mole weight: 267.24. | |
| 2'-Deoxyguanosine monohydrate | 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1 O 2 , the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer [1]. Uses: Scientific research. Group: Natural products. CAS No. 312693-72-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-D0185. | |
| 2'-Deoxyguanosine, Monohydrate | Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides. Group: Biochemicals. Alternative Names: 2-Deoxyguanosine monohydrate; Guanine 2-deoxyribonucleoside; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine monohydrate; NSC 22837. Grades: Molecular Biology Grade. CAS No. 961-07-9, 312693-72-4. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C10H13N5O4 H2O, Molecular Weight: 285.26. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine 3'-CE phosphoramidite | 2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine 3'-CE phosphoramidite is a crucial tool in biomedicine for oligonucleotide synthesis. It serves as a phosphoramidite monomer used for incorporation into DNA or RNA sequences during solid-phase synthesis. This product is particularly useful in designing therapeutic oligonucleotides targeting specific genes or pathways involved in diseases like cancer and genetic disorders. It offers enhanced stability and specificity, allowing researchers to develop precise and efficient nucleic acid-based therapies. Molecular formula: C43H52FN8O7P. Mole weight: 842.89. | |
| 2'-Deoxy-N-(4-hydroxybutyl)cytidine | 2'-Deoxy-N-(4-hydroxybutyl)cytidine is a DNA adduct resulting from reaction of THF with DNA bases. CAS No. 905844-52-2. Molecular formula: C13H21N3O5. Mole weight: 299.32. | |
| 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytosine | 2-Fluoro-2-deoxy-arabinofuranosyl-cytosine is an efficacious and safe antiviral compound, having applications in research of combating diverse viral infections such as hepatitis B and C. Its mode of action relies on targeting the viral polymerase enzyme, thereby impeding the research and development of viral DNA and hindering replication. Synonyms: 2'-FANA-C; 1-(2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride. Grades: ≥ 97%. Molecular formula: C9H12FN3O4 (free base). Mole weight: 245.21 (free base). | |
| 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt | 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt, a potent nucleotide analogue, displays antiviral activity by inhibiting viral DNA polymerase. Employed in the treatment of Hepatitis B and Herpes, it is noted for its ability to enhance the pharmacological features of nucleotide-based antiviral medications through its structural modifications. The utilization of this molecule is paramount in the development of novel antiviral therapies. Synonyms: 2'-Fluoro-dGTP trisodium salt; 2'-Deoxy-2'-fluoroguanosine 5'-(tetrahydrogen triphosphate) trisodium salt. Grades: ≥97% by HPLC. Molecular formula: C10H12FN5Na3O13P3. Mole weight: 591.12. | |
| 2'-O-ribosyladenosine (phosphate) | 2'-O-ribosyladenosine (phosphate), a significant enzyme in RNA production, modifies nucleotides in RNA formation for mRNA molecule production used in protein synthesis. In addition, the product is crucial for biosynthesis of purine, a crucial molecular base in DNA and RNA. With targeted inhibition of certain cancer cells, this potent tool finds wide application in cancer treatment research. Synonyms: Adenosine, 2'-O-(5-O-phosphono-b-D-ribofuranosyl)-; O-beta-ribosyl(1''--2')adenosine-5''-phosphate; 2'-O-(5-O-Phosphono-beta-D-ribofuranosyl)adenosine. CAS No. 28050-13-7. Molecular formula: C15H22N5O11P. Mole weight: 479.34. | |
| (2R,3R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol | (2R,3R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol is a breakthrough drug that shows promise in the biomedical sphere. Its potential lies in its ability to act as an inhibitor for enzymes which are responsible for DNA replication and repair, thus proving lethal to swiftly dividing cancer cells and viral particles. Distinctive chemical base and mode of operation grants it a targeted high-effectivity therapeutic option for the cure of cancer and viral infections. Synonyms: (2R,3R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-alcohol. CAS No. 156058-35-4. Molecular formula: C11H12F2N4O3. Mole weight: 286.23. | |
| 3'-(6-FAM) PS | 3'-(6-FAM) PS: a phosphorothioate oligonucleotide labeled with fluorescence, notorious in biomedical research as a nucleic acid detection probe. Its fluorescence can assist in DNA or RNA sample identification and quantification, utilizing prominent applications like PCR, hybridization, and sequencing. On top of all that, this product holds significant therapeutic value for sequencing-based diagnostics and drug discovery. Synonyms: 1-Dimethoxytrityloxy-3-[O-(N-carboxy-(di-O-pivaloyl-fluorescein)-3-aminopropyl)]-propyl-2-O-succinoyl-polystyrene. Mole weight: 569.46. | |
| 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite | 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite is a modified nucleotide used in the synthesis of Threose Nucleic Acid (TNA) molecules for biomedical research. TNA is a promising alternative to DNA and RNA for gene and drug delivery due to its chemical stability and resistance to nuclease degradation. This specific phosphoramidite derivative incorporates a benzoyl-adenosine moiety, making it ideal for designing TNA-based drugs for the treatment of viral infections, inflammatory diseases, and cancer. Synonyms: N-Benzoyl-9-[(2R)-3alpha-[(diisopropylamino)(2-cyanoethoxy)phosphinooxy]-4beta-(4,4'-dimethoxytrityloxy)tetrahydrofuran-2beta-yl]-9H-purine-6-amine; A-TNA Phosphoramidite. Grades: ≥97% by HPLC. Molecular formula: C46H50N7O7P. Mole weight: 843.92. | |
| 3'-O-DMT-thymidine 3'-succinyl CPG | The 3'-O-DMT-thymidine 3'-succinyl CPG is a vital tool extensively used in the biomedical industry for the synthesis of oligonucleotides. It enables the modification of DNA strands, facilitating research on drug discovery and development, gene expression analysis, and nucleic acid-based diagnostics. This product plays a crucial role in studying DNA-protein interactions, epigenetics, and investigating diseases such as cancer and genetic disorders. | |
| 3'-O-Methylguanosine | 3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. Synonyms: 3'-O-Methyl-D-guanosine; 3'-O-Methyl guanosine; O3'-methyl-guanosine; 3'-OMe-G; 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one. Grades: ≥95%. CAS No. 10300-27-3. Molecular formula: C11H15N5O5. Mole weight: 297.27. | |
| 3'-Qusar570 Frits column (100nmol) | The 3'-Qusar570 Frits column (100nmol) is a biomedicine product used in fluorescence-based bioanalytical assays such as DNA sequencing and drug discovery studies. It has excellent photostability and is highly fluorescent, making it ideal for detecting low concentrations of target molecules. The product is also used in cancer research as a diagnostic tool to detect tumors early. Synonyms: 3'-Qusar570 Frits column. | |
| 4-(2-Cyanoethylthio)-2'-deoxy-5'-DMT-uridine 3'-CE phosphoramidite | 4-(2-Cyanoethylthio)-2'-deoxy-5'-DMT-uridine 3'-CE phosphoramidite is a phosphoramidite compound, utilized in the biomedical industry for the synthesis of modified oligonucleotides, specifically in the field of nucleic acid research and drug development. It serving as a key component for the introduction of 4-(2-cyanoethylthio)-2'-deoxy-5'-DMT-uridine nucleotide residues during DNA or RNA synthesis. These modified nucleotides find applicability in the development of therapeutics, diagnostics is and nucleic acid-based tools for targeting various diseases. Molecular formula: C42H50N5O7PS. Mole weight: 799.93. | |
| 4-Methylquinoline | 4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-35-0. Pack Sizes: 1g, 10g. Molecular Formula: C10H9N. US Biological Life Sciences. | Worldwide |
| 4-Thiothymidine-5'-Triphosphate | 4-Thiothymidine-5'-Triphosphate is a key component in biomedical research for studying DNA research and development and replication. It is a modified nucleotide that incorporates into DNA during replication, acting as an artificial base analog. This compound is used to investigate various processes such as DNA repair mechanisms, mutagenesis, antiviral drug development. Synonyms: 4-Thio-dTTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H17N2O13P3S. Mole weight: 498.24. | |
| 5-[(3-Indolyl)propionamide-N-allyl]-2'-deoxyuridine-5'-Triphosphate | 5-[(3-Indolyl)propionamide-N-allyl]-2'-deoxyuridine-5'-Triphosphate is an indole-based molecular entity serving as a potent investigative tool in orchestrating DNA synthesis and repair mechanisms. Synonyms: 5-Indolyl-AA-dUTP; Tryptamino-dUTP Analog. Grades: ≥90% by AX-HPLC. Molecular formula: C23H29N4O15P3. Mole weight: 694.40. | |
| 5'-Amino-5'-deoxyguanosine | 5'-Amino-5'-deoxyguanosine is a nucleoside analog used in biomedical research. It can be incorporated into oligonucleotides and DNA to study the effects of modified bases on genome stability and function. Additionally, this compound has shown promising anticancer activity through its ability to disrupt DNA replication and induce apoptosis in cancer cells. Synonyms: Guanosine, 5'-amino-5'-deoxy-; 5'-Amino-5'-deoxyguanosine. Grades: 97%. CAS No. 4099-84-7. Molecular formula: C10H14N6O4. Mole weight: 282.26. | |
| 5-aza-5,6-dihydro-dC-CE Phosphoramidite | 5-aza-5,6-dihydro-dC-CE Phosphoramidite, a vital reagent utilized in oligonucleotide synthesis with altered bases, is a key player in investigating epigenetic regulation and DNA methylation in various maladies such as cancer and neurological disorders. Its substantial purification, alongside unmatched stability, propels it to the forefront of drug discovery and developmental applications, a must-have for discerning researchers seeking unparalleled performance metrics in their scientific endeavors. Synonyms: 5'-Dimethoxytrityl-N4-dimethylformamidine-5,6-dihydro-5-aza-2'-deoxyCytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C41H54N7O7P. Mole weight: 787.89. | |
| 5-Bromouracil (5-Bromo-2,4-(1H,3H)-pyrimidinedione) | A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine. Group: Biochemicals. Alternative Names: 5-Bromo-2,4-(1H,3H)-pyrimidinedione. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 5-Carboxy-dC-CE Phosphoramidite | 5-Carboxy-dC-CE Phosphoramidite, an essential chemical for oligonucleotide synthesis, offers immense potential for exploratory biomedical research. Its incorporation into DNA can facilitate the identification of mutations, crucial for disease detection, such as cancer. Moreover, the carboxy group on the dC base can be artfully employed for concurrent conjugation with fluorescent dyes or other molecules, enlivening the imaging and recognition capabilities of biomedical applications. Synonyms: 5'-Dimethoxytrityl-N-benzoyl-5-ethylcarboxy-2'-deoxyCytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C49H56N5O10P. Mole weight: 905.97. | |
| 5'-DMT-2'-deoxyguanosine (N-Fmoc) | 5'-DMT-2'-deoxyguanosine (N-Fmoc), a chemical utilized in DNA-based drug advances and the synthesis of oligonucleotides, has shown its potential in treating various diseases including cancer, viral infections, and genetic disorders. Additionally, its distinctive structure facilitates targeted drug delivery to specific cells and tissues, ultimately amplifying efficacy levels and minimizing undesired adverse effects. Furthermore, it is also utilized in cutting-edge gene therapy and DNA vaccines research, propelling the development of future healthcare innovations. Grades: ≥ 98% by HPLC. Molecular formula: C46H41N5O8. Mole weight: 791.85. | |
| 5'-DMT-7-deaza-2'-deoxyguanosine (N-iBu) | 5'-DMT-7-deaza-2'-deoxyguanosine (N-iBu): a compound integral to the advancement of antiviral medications against hepatitis B and C. Its exceptional nucleoside analog characteristics enable the inhibition of viral DNA synthesis, inducing viral DNA base-pairing dysfunction, thereby proving efficacious for antiviral treatments. This compound also uniquely supports the study of DNA-protein interactions through its exceptional structural qualities. Grades: ≥ 98% by HPLC. Molecular formula: C36H38N4O7. Mole weight: 638.71. | |
| 5-Ethynyl-2'-deoxyuridine | 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a Click reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation [1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [2]. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 61135-33-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-118411. | |
| 5-Hydroxymethylcytidine | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 5-Iodouracil | 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones. Group: Biochemicals. Alternative Names: 5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848. Grades: Highly Purified. CAS No. 696-07-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 5'-O-Acetyl-2'-deoxyuridine 3'-CE phosphoramidite | 5'-O-Acetyl-2'-deoxyuridine 3'-CE phosphoramidite is a crucial reagent in biomedicine. It is commonly used in the synthesis of DNA analogs for research and diagnostics. This phosphoramidite plays a significant role in the development of nucleoside-based drugs for treating viral infections and certain cancers, where specific modifications to DNA sequences are necessary. Its high purity and compatibility with automated DNA synthesis make it an essential tool in biomedical research. Synonyms: 5'-O-Acetyl-2'-deoxy-D-uridine 3'-CE phosphoramidite. Molecular formula: C20H31N4O7P. Mole weight: 470.46. | |
| 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite | 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite, a critical and indispensable reagent in the highly esteemed biomedical industry, manifests its profound significance in the realm of modified nucleic acids synthesis. Its exceptional utility primarily lies in its adeptness for effectuating the introduction of the esteemed 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine moiety during phosphoramidite-mediated DNA synthesis. This unparalleled product unveils a wealth of opportunities within the sphere of nucleic acid-based therapeutic development, acting as a fulcrum for groundbreaking research directed towards unravelling the complexities of diverse disease entities and optimizing drug targeting strategies. Synonyms: 8-I-rA phosphoramidite. Grades: ≥97% by HPLC. Molecular formula: C53H65IN7O8PSi. Mole weight: 1114.11. | |
| 5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite | 5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite is a chemical reagent used in solid phase DNA synthesis. It serves as a key component in the automated synthesis of nucleic acid polymers for research, diagnostics, and therapeutics. This phosphoramidite is particularly useful for introducing a 4-methoxythymidine base into DNA sequences, which can have implications in gene regulation and anticancer drug development. Synonyms: 5'-O-DMT-O4-methylthymidine 3'-CE phosphoramidite; 5'-O-DMT-4-methoxy-D-thymidine 3'-CE phosphoramidite. Molecular formula: C41H51N4O8P. Mole weight: 758.86. | |
| 5'-O-p-Anisoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite | 5'-O-p-Anisoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite is a phosphoramidite recompound used as an indispensable tool for DNA research and development. Its significance lies in facilitating the compoundion of oligonucleotides, thereby assuming a pivotal role in fostering the development of nucleic acid-based therapeutics and diagnostics. Molecular formula: C32H49N4O9PSi. Mole weight: 692.83. | |
| 5'-O-tert-Butyldimethylsilylthymidine 3'-CE phosphoramidite | 5'-O-tert-Butyldimethylsilylthymidine 3'-CE phosphoramidite is a critical intermediate for the synthesis of oligonucleotides, often used in the research of DNA-based therapeutics and diagnosis of genetic diseases. Its high yield, purity, and stability ensure efficient oligonucleotide synthesis for various applications, including gene therapy, RNA interference, and molecular diagnostics. Molecular formula: C25H45N4O6PSi. Mole weight: 556.72. | |
| 5-Propargylamino-dCTP - ATTO-532-XX | 5-Propargylamino-dCTP - ATTO-532-XX, a fluorescent nucleotide analog, is a multi-functional tool for DNA research. This powerful compound, integrated seamlessly by polymerases during PCR, acts as an efficient indicator for DNA methylation, mutations, and base modifications alike. Its use in in situ hybridization assays makes this fluorescent compound an essential component of any DNA labeling protocol. With the ability to be imaged using fluorescent microscopy, even the most subtle variations in DNA can be detected with confidence. Synonyms: (6-amino-hexanoyl-6-aminohexanoyl)-5-(3-propagylamino)-2'-deoxycytidine-5'-triphosphate, labeled with ATTO 532, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C53H71N9O24P3S2 (free acid). Mole weight: 1375.23 (free acid). | |
| 5-Propargylamino-ddCTP - ATTO-465 | 5-Propargylamino-ddCTP - ATTO-465, a fluorescently labeled nucleotide extensively applied for DNA sequencing and PCR-based procedures, is widely used to detect and label DNA and RNA in numerous downstream applications. Microarray analysis, in situ hybridization, and other gene expression technologies benefit from its properties. Synonyms: 5-Propargylamino-2',3'-dideoxycytidine-5'-triphosphate, labeled with ATTO 465, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C29H34N7O13P3 (free acid). Mole weight: 781.54 (free acid). | |
| 5-Propargylamino-ddCTP - ATTO-700 | 5-Propargylamino-ddCTP - ATTO-700, a labeled nucleotide with fluorescent properties, serves as a tool in biomedicine to investigate DNA repair and replication processes. Due to its exceptional sensitivity and specificity, it utilizes a robust approach towards monitoring DNA polymerase activities, thus enabling the detection of individual base mutations. High potential applications include genetic mutations identification associated with cancer development and progression. Synonyms: 5-Propargylamino-2',3'-dideoxycytidine-5'-triphosphate, labeled with ATTO 700, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C12H19N4O12P3- ATTO 700 (free acid). Mole weight: 1051.22 (free acid). | |
| 5-Propargylamino-ddUTP - MANT | 5-Propargylamino-ddUTP - MANT, a modified nucleotide which finds application in nucleic acid detection and labeling, presents a potential avenue for studying DNA polymerase with utmost precision. Furthermore, it is specifically devised for RNA labeling utilizing click chemistry and fluorescence-based detection. Synonyms: 5-Propargylamino-2',3'-dideoxyuridine-5'-triphosphate, labeled with MANT, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H25N4O14P3 (free acid). Mole weight: 638.35 (free acid). | |
| 5'(R)-C-Methyluridine | 5'(R)-C-Methyluridine is an essential biomedical compound, serving as an indispensable weapon in research of viral infections and cancer. Its remarkable antiviral properties enable the effective suppression of RNA-based viruses such as hepatitis and HIV. Moreover, by actively participating in the intricate process of RNA and DNA research and development, this compound greatly aids in unraveling the complexities of genetic diseases. Synonyms: 1-(6-Deoxy-b-D-allofuranosyl)-2,4(1H,3H)pyrimidinedione; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-((R)-1-hydroxy-ethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione; 1-(6-deoxy-β-D-allofuranosyl)uracil; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 72159-54-7. Molecular formula: C10H14N2O6. Mole weight: 258.23. | |
| (5'S)-8,5'-Cyclodeoxyadenosine CE phosphoramidite | (5'S)-8,5'-Cyclodeoxyadenosine CE phosphoramidite is a crucial compound used in the synthesis of modified DNA strands for biomedical research. It enables the introduction of 8,5'-cyclodeoxyadenosine into nucleic acid sequences, offering opportunities for drug development and DNA-based diagnostics targeting various diseases including cancer and viral infections. Synonyms: 5'-Dimethoxytrityl-N-benzoyl-(5'S)-8,5'-cyclo-2'-deoxyAdenosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 8,5'-Cyclo-dA CE Phosphoramidite. CAS No. 211919-91-4. Molecular formula: C47H50N7O7P. Mole weight: 855.92. | |
| 5'-Tetrachloro-Fluorescein CE Phosphoramidite(6-TET) | 5'-Tetrachloro-Fluorescein CE Phosphoramidite (6-TET) is an exceptional nucleoside derivatizing reagent. Significantly, its high sensitivity and specificity are beneficial for the fluorescence-based detection methods when examining single nucleotide polymorphisms, gene expression, or DNA sequencing. Moreover, novel investigations show that it could be imperative when studying mitochondrial DNA damages commonly implicated in both cancer and neurological disorders. Synonyms: 6-[(4,7,2',7'-Tetrachloro-3',6'-dipivaloylfluoresceinyl)-carboxamido]-hexyl-1-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Grades: >97% by HPLC. Molecular formula: C46H54CI4N3O10P. Mole weight: 981.73. | |
| 5-Trifluoromethyl-dUTP | 5-Trifluoromethyl-dUTP, a modified nucleotide that has been specifically designed for the purpose of DNA labeling and detection, has become a popular choice for PCR-based assays aimed at identifying genetic variations and mutations within DNA sequences. With its incredible precision and versatility, it has become a critical tool for researchers investigating genetic diseases and identifying potential targets for therapeutic interventions. Synonyms: 5-Trifluoromethyl-2'-deoxyuridine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14N2O14P3F3 (free acid). Mole weight: 536.14 (free acid). | |
| (6-4)DNA photolyase | A flavoprotein (FAD). The overall repair reaction consists of two distinct steps, one of which is light-independent and the other one light-dependent. In the initial light-independent step, a 6-iminium ion is thought to be generated via proton transfer induced by two histidines highly conserved among the (6-4) photolyases. This intermediate spontaneously rearranges to form an oxetane intermediate by intramolecular nucleophilic attack. In the subsequent light-driven reaction, one electron is believed to be transferred from the fully reduced FAD cofactor (FADH-) to the oxetane intermediate thus forming a neutral FADH radical and an anionic oxetane radical, which spontaneously fractures. The excess electron is then back-transferred to the flavin radical restoring the fully reduced flavin cofactor and a pair of pyrimidine bases. Group: Enzymes. Synonyms: DNA photolyase; H64PRH; NF-10; phr (6-4); PL-(6-4); OtCPF1; (6-4) PHR; At64PHR. Enzyme Commission Number: EC 4.1.99.13. CAS No. 37290-70-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4928; (6-4)DNA photolyase; EC 4.1.99.13; 37290-70-3; DNA photolyase; H64PRH; NF-10; phr (6-4); PL-(6-4); OtCPF1; (6-4) PHR; At64PHR. Cat No: EXWM-4928. |  |
| 7-Deaza-7-propargylamino-dGTP | 7-Deaza-7-propargylamino-dGTP, a derivative of deoxyguanosine triphosphate, has proved useful in studies of DNA polymerase activity. Through modification of the guanine base to 7-deaza-guanine, selectivity for obstructing certain DNA polymerases is achieved, while replication continues to be disrupted. This nucleotide can be leveraged for probing DNA synthesis and repair pathways, and further applied in the diagnosis of diseases such as cancer. Synonyms: 7-Deaza-7-Propargylamino-2'-deoxyguanosine-5'-Triphosphate; 7-Deaza-7-Prop-NH2-dGTP. Grades: ≥ 95% by HPLC. Molecular formula: C14H20N5O13P3 (free acid). Mole weight: 559.25 (free acid). | |
| 7-Propargylamino-7-deaza-dATP - 6-FAM | 7-Propargylamino-7-deaza-dATP - 6-FAM is a vital tool in the biomedical industry for studying DNA replication and repair mechanisms. It is commonly used as a substrate in enzymatic assays to investigate the activity of DNA polymerases and ligases. Furthermore, this compound plays a crucial role in labeling and detection of DNA during fluorescence-based techniques, assisting in the research of various genetic disorders. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyadenosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H30N5O18P3 (free acid). Mole weight: 901.56 (free acid). | |
| 7-Propargylamino-7-deaza-ddATP - 6-FAM | 7-Propargylamino-7-deaza-ddATP is a fluorescently-labeled nucleotide used in biomedical research for various applications, including DNA sequencing, gene expression analysis and drug development. This compound is incorporated into DNA molecules during amplification or development reactions to enable detection and visualization using fluorescence-based techniques like fluorescence resonance energy transfer (FRET) or fluorescence in situ hybridization (FISH). It is commonly used in the study of DNA-protein interactions, nucleotide modifications and DNA repair mechanisms. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyadenosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H30N5O17P3 (free acid). Mole weight: 885.56 (free acid). | |
| 7-Propargylamino-7-deaza-ddATP - ATTO-Rho12 | 7-Propargylamino-7-deaza-ddATP - ATTO-Rho12, a fluorescence, photostable and water-soluble base analogue, is a quintessential reagent employed in biomedical research. Its indispensible role in identifying DNA polymerases makes it crucial in treating Herpes Simplex Virus (HSV) and the Human Immunodeficiency Virus (HIV), rendering it a valuable asset to the field of virology. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyadenosine-5'-triphosphate, labeled with ATTO Rho12, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H69N8O14P3 (free acid). Mole weight: 1158.41 (free acid). | |
| 7-Propargylamino-7-deaza-ddGTP - ATTO-633 | 7-Propargylamino-7-deaza-ddGTP - ATTO-633, a fluorescent nucleotide analog, is a product of great importance in biomedical research, specializing in studying DNA replication and repair mechanisms. Its usage is specifically geared towards single-molecule fluorescence-based assays in analyzing the behaviors of DNA polymerases and helicases. Enabling the detection of DNA damage-related diseases like cancer, this product is ideal due to its unique fluorescence properties. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C14H20N5O12P3- ATTO 633 (free acid). Mole weight: 1076.26 (free acid). | |
| 7-Propargylamino-7-deaza-ddGTP - ATTO-Rho101 | 7-Propargylamino-7-deaza-ddGTP- ATTO-Rho101 is an innovative fluorescent nucleotide analog that has revolutionized DNA sequencing and detection of DNA damage. Thanks to its incredible versatility, this product can seamlessly integrate into DNA via polymerases, allowing for unparalleled accuracy in identifying nucleotide misincorporation events. Moreover, its unique properties make it a go-to for pinpointing base changes due to oxidation or loss of amino groups and functional in detecting DNA damage caused by UV radiation. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with ATTO Rho101, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C51H57N8O15P3 (free acid). Mole weight: 1114.32 (free acid). | |
| 7-Propargylamino-7-deaza-dGTP - ATTO-550 | 7-Propargylamino-7-deaza-dGTP - ATTO-550 - behold a fluorescent-labeled nucleotide analog, grandiose in its capability to partake in DNA synthesis! A truly versatile product, it adds value as a key tool for apoorvsequencing and real-time PCR, allowing for the detection and analysis of DNA mutations and variations. Uniquely designed for labeling and detecting modified bases in DNA, it acts as a powerful aid in the investigation of DNA methylation patterns and epigenetic changes associated with ailments such as cancer. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with ATTO 550, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C14H20N5O13P3- ATTO 550 (free acid). Mole weight: 1134.25 (free acid). | |
| 7-Propargylamino-7-deaza-dGTP - ATTO-580Q | 7-Propargylamino-7-deaza-dGTP - ATTO-580Q is a fluorescent nucleotide analog used for labeling DNA during polymerase chain reaction (PCR) or sequencing. It can specifically label adenine bases and is useful for detecting mutations or identifying DNA-protein interactions. Its unique structure also makes it resistant to nucleases and exonucleases. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with ATTO 580Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C14H20N5O13P3- ATTO 580Q (free acid). Mole weight: 1235.25 (free acid). | |
| 7-Propargylamino-7-deaza-dGTP - ATTO-MB2 | 7-Propargylamino-7-deaza-dGTP - ATTO-MB2 is a fluorescent nucleotide analog used for labeling DNA during PCR or sequencing. It is commonly used in labeling and detecting modified bases in DNA. Its unique properties allow for selective detection of mismatches, base changes, and mutations in DNA sequences. It is also used in studying DNA-protein interactions and in drug discovery research related to DNA replication and repair. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with ATTO-MB2, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C33H39N8O14P3S (free acid). Mole weight: 896.69 (free acid). | |
| 7-TFA-ap-7-Deaza-2'-dG | 7-TFA-ap-7-Deaza-2'-dG is a distinctive and innovative synthetic compound, extensively employed in biomedical research for probing DNA modifications and their impact on severe disorders like cancer and viral infections. Owing to its structural similarity to natural nucleotide bases, it easily assimilates into DNA strands during replication. The incorporation of this molecule into genetic material empowers the researchers to explore the altered DNA effects on diverse cellular processes, leading to an improved understanding of disease progression. Synonyms: 7-TFA-ap-7-Deaza-dG; N-[3-[2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-propyn-1-yl]-2,2,2-trifluoroacetamide; Acetamide, N-[3-[2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-propyn-1-yl]-2,2,2-trifluoro-; 2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-{3-[(trifluoroacetyl)amino]-1-propyn-1-yl}-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one. Grades: ≥98% by HPLC. CAS No. 666847-77-4. Molecular formula: C16H16F3N5O5. Mole weight: 415.33. | |
| 8-[(6-Amino)hexyl]-amino-GMP - ATTO-647N | 8-[(6-Amino)hexyl]-amino-GMP - ATTO-647N is a fluorescent dye used for labeling nucleotides in biomedical research and drug development. This product can be used for tracking and quantification of nucleotides in various biological systems, such as identifying the location and amount of DNA or RNA in a cell or tissue sample. It is also useful in drug discovery for studying the interaction between nucleotides and drug targets or determining the efficacy of nucleotide-based therapies for diseases. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with ATTO 647N, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H28N7O8P - ATTO 647N (free acid). Mole weight: 1104.41 (free acid). | |
| 8-Nitroguanine | 8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents. Synonyms: 2-Amino-8-nitro-7H-purin-6-ol. Grades: ≥95%. CAS No. 168701-80-2. Molecular formula: C5H4N6O3. Mole weight: 196.1. | |
| Ac-dC-Me Phosphonamidite | Ac-dC-Me Phosphonamidite, an esteemed chemical compound employed in the biochemical industry, enables the modification and synthesis of DNA, augmenting its utility. Its prominent utility is distinguished by the introduction of the methyl group, targeting the 5th position within the cytosine base of DNA, ultimately giving rise to a diverse spectrum of gene expression alterations and therapeutic benefits, which hold substantial potential in the field of disease management, particularly in cancer. Synonyms: 5'-Dimethoxytrityl-N4-acetyl-2'-deoxyCytidine, 3'-[(methyl)-(N,N-diisopropyl)]-phosphonamidite; N-Acetyl-3'-O-[methyl(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine. Molecular formula: C39H49N4O7P. Mole weight: 716.81. | |
| Acelarin | Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Synonyms: NUC-1031; NUC 1031; NUC1031; GTPL7389; GTPL 7389; GTPL-7389; SCHEMBL17171316; Benzyl (2S)-2-[ ({[ (2R, 3S, 5R)-5- (4-amino-2-oxo-1, 2-dihydropyrimidin-1-yl)-4, 4-difluoro-3-hydroxyoxolan-2-yl]methoxy} (phenoxy)phosphoryl)amino]propanoate. Grades: 98%. CAS No. 840506-29-8. Molecular formula: C25H27F2N4O8P. Mole weight: 580.48. | |
| Acridine Orange compd. with zinc chloride | Acridine Orange compd. with zinc chloride is a prominently utilized fluorescent dye in the biomedical realm. Renowned for its intrinsic capacity to stain and visualize an array of cellular constituents ranging from DNA, RNA to acidic organelles, this multifaceted compound holds tremendous value in diagnostic procedures, cancer analysis, and identification of infectious diseases. Its prevalence and significance within these areas render it an indispensable tool of modern scientific inquiry. Synonyms: Basic Orange 14;3,6-Acridinediamine, N3,N3,N6,N6-tetramethyl-, hydrochloride, compd. with zinc chloride (ZnCl2) (1:1:x); 3,6-Acridinediamine, N,N,N',N'-tetramethyl-, monohydrochloride, compd. with zinc chloride; 3,6-Acridinediamine, N,N,N',N'-tetramethyl-, monohydrochloride, compd. with zinc chloride (ZnCl2); Acridine, 3,6-bis(dimethylamino)-, monohydrochloride, compd. with zinc chloride; Zinc chloride (ZnCl2), compd. with N,N,N',N'-tetramethyl-3,6-acridinediamine monohydrochloride; Zinc chloride, compd. with 3,6-bis(dimethylamino)acridine monohydrochloride; Zinc chloride, compd. with N,N,N',N'-tetramethyl-3,6-acridinediamine monohydrochloride; Euchrysine 3RX; N,N,N',N'-Tetramethylacridine-3,6-diamine monohydrochloride compd. with zinc dichloride. CAS No. 10127-02-3. Molecular formula: C17H19N3.xCl2Zn.HCl. Mole weight: 301.81 (free base). | |
| Aminoallyl-dUTP - ATTO-540Q | A versatile tool for the discerning bioinformatician, Aminoallyl-dUTP - ATTO-540Q represents a culmination of modern fluorescent dye-based nucleotide technologies. Lending itself to a broad array of applications spanning from DNA sequencing to microarray analysis, this nucleotide is an indispensable tool for those seeking to optimize their approach to enzymatic reactions and the labeling of probes. By offering a reliable platform for nucleic acid hybridization capable of detecting highly specific DNA sequences, this product offers unmatched levels of precision. Synonyms: 5-(3-Aminoallyl)-2'-deoxyuridine-5'-triphosphate, labeled with ATTO 540Q, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C12H20N3O14P3- ATTO 540Q (free acid). Mole weight: 1063.22 (free acid). | |
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