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| Product | Description | |
|---|---|---|
| DNA-3-methyladenine glycosylase I | Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Enzyme Commission Number: EC 3.2.2.20. CAS No. 89287-37-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3974; DNA-3-methyladenine glycosylase I; EC 3.2.2.20; 89287-37-6; deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Cat No: EXWM-3974. |  |
| DNA-3-methyladenine glycosylase II | Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Enzyme Commission Number: EC 3.2.2.21. CAS No. 89287-38-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3975; DNA-3-methyladenine glycosylase II; EC 3.2.2.21; 89287-38-7; deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Cat No: EXWM-3975. | |
| DNA-deoxyinosine glycosylase | DNA-deoxyinosine glycosylase (EC 3.2.2.15) is an enzyme with systematic name DNA-deoxyinosine deoxyribohydrolase. Group: Enzymes. Synonyms: DNA(hypoxanthine) glycohydrolase; deoxyribonucleic acid glycosylase; hypoxanthine-DNA glycosylase. Enzyme Commission Number: EC 3.2.2.15. CAS No. 68247-62-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3969; DNA-deoxyinosine glycosylase; EC 3.2.2.15; 68247-62-1; DNA(hypoxanthine) glycohydrolase; deoxyribonucleic acid glycosylase; hypoxanthine-DNA glycosylase. Cat No: EXWM-3969. | |
| DNA-formamidopyrimidine glycosylase | May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA. Group: Enzymes. Synonyms: Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein. Enzyme Commission Number: EC 3.2.2.23. CAS No. 78783-53-6. Fpg Protein. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3977; DNA-formamidopyrimidine glycosylase; EC 3.2.2.23; 78783-53-6; Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein. Cat No: EXWM-3977. | |
| double-stranded uracil-DNA glycosylase | No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. Group: Enzymes. Synonyms: Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Enzyme Commission Number: EC 3.2.2.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3982; double-stranded uracil-DNA glycosylase; EC 3.2.2.28; Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Cat No: EXWM-3982. | |
| G/U Mismatch-Specific DNA Glycosylase from E.coli, Recombinant | G/U mismatch-specific DNA glycosylase (mug) is a part of the TDG/mug DNA glycosylase family. Mug is necessary for DNA damage lesion repair in stationary-phase cells. Mug protein removes three N4-ethenocytosine and takes away s the uracil base from mismatches in the order of U:G>U:A. The enzyme Uracil-N-Glycosylase removes uracil from the DNA leaving an AP position. Mug is also able to hydrolyzing the carbon-nitrogen bond among the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine plays a role in substrate recognition. Group: Enzymes. Synonyms: Xanthine DNA glycosylase; dug; ECK3058; JW3040; ygjF; G/U mismatch-specific DNA glycosylase; Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; mug. Enzyme Commission Number: EC 3.2.2.28. Purity: Greater than 90% as determined by SDS-PAGE. MUG. Mole weight: 21.1 kDa. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. Form: Sterile Filtered colorless solution. Source: E.coli. Species: E.coli. Cat No: NATE-1911. | |
| Reaction Buffer for Uracil DNA Glycosylase (10X) | Reaction buffer for U1900-05: Uracil DNA Glycosylase. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 400ul. US Biological Life Sciences. |  Worldwide |
| thymine-DNA glycosylase | Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T. Group: Enzymes. Synonyms: mismatch-specific thymine-DNA glycosylase; mismatch-specific thymine-DNA N-glycosylase; hTDG; hsTDG; TDG; thymine DNA glycosylase; G/T glycosylase; uracil/thymine DNA glycosylase; T:G mismatch-specific thymidine-DNA glycosylase; G:T mismatch-specific thymine DNA-glycosylase. Enzyme Commission Number: EC 3.2.2.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3983; thymine-DNA glycosylase; EC 3.2.2.29; mismatch-specific thymine-DNA glycosylase; mismatch-specific thymine-DNA N-glycosylase; hTDG; hsTDG; TDG; thymine DNA glycosylase; G/T glycosylase; uracil/thymine DNA glycosylase; T:G mismatch-specific thymidine-DNA glycosylase; G:T mismatch-specific thymine DNA-glycosylase. Cat No: EXWM-3983. | |
| uracil-DNA glycosylase | Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. EC 3.2.2.27 and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. Group: Enzymes. Synonyms: UdgB (ambiguous); uracil-DNA N-glycosylase; UDG (ambiguous); uracil DNA glycohydrolase. Enzyme Commission Number: EC 3.2.2.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3981; uracil-DNA glycosylase; EC 3.2.2.27; UdgB (ambiguous); uracil-DNA N-glycosylase; UDG (ambiguous); uracil DNA glycohydrolase. Cat No: EXWM-3981. | |
| 1, 4-Anhydro-5-O-[bis (4-methoxyphenyl) phenylmethyl]-2-deoxy-D-erythro-pentitol | 1, 4-Anhydro-5-O-[bis (4-methoxyphenyl) phenylmethyl]-2-deoxy-D-erythro-pentitol is used as a reactant in the solution conformation of an abasic DNA undecamer duplex with unpaired thymine. Also used in direct fluorescence monitoring of uracil DNA glycosylase activity in vitro and in bacterial cells using short single-stranded DNA oligomers containing pyrene α-deoxyriboside adjacent to uracil. Group: Biochemicals. Grades: Highly Purified. CAS No. 95049-01-7. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H28O5, Molecular Weight: 420.5. US Biological Life Sciences. | Worldwide |
| 1-[(5E)-5,6-Dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil | 1-[(5E)-5,6-Dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil, an extraordinary biomedicine, manifests its potential as a breakthrough antiviral agent. By adeptly targeting the viral uracil-DNA glycosylase enzyme, it inhibits viral replication and hinders viral DNA synthesis. Its molecular architecture, distinctive and resolute, engenders unrivaled selectivity and efficacy across diverse viral strains. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-; 1-[(2R,3R,4R,5R)-5-[(E)-2-diethoxyphosphorylethenyl]-4-hydroxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 2095417-05-1. Molecular formula: C15H23N2O8P. Mole weight: 390.33. |  |
| 2-Amino-6,8-dihydroxypurine-15N5 | 2-Amino-6,8-dihydroxypurine-15N5 is the isotope labelled analog of 2-Amino-6,8-dihydroxypurine (A604921, HCl); an 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase &lambda:. Group: Biochemicals. Grades: Highly Purified. CAS No. 1358676-24-0. Pack Sizes: 1mg, 10mg. Molecular Formula: C5H515N5O2, Molecular Weight: 172.09. US Biological Life Sciences. | Worldwide |
| 2'-Deoxycytidine-5-carboxylic Acid Sodium Salt (>85%) | 2'-Deoxycytidine-5-carboxylic Acid Sodium Salt, is derivative of 5-Hydroxy-2'-deoxycytidine, which have been used as a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species. Synonyms: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,2-dihydro-2-oxo-5-pyrimidinecarboxylic Acid Sodium Salt. Grades: 85%. Molecular formula: C10H12N3NaO6. Mole weight: 293.21. | |
| 2-Deoxycytidine-5-carboxylic Acid Sodium Salt (>85%) | 2-Deoxycytidine-5-carboxylic Acid Sodium Salt, is derivative of 5-Hydroxy-2-deoxycytidine (H946650), which have been used as a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C10H12N3NaO6, Molecular Weight: 293.209999999999. US Biological Life Sciences. | Worldwide |
| 5-Hydroxy-2'-deoxycytidine | 5-Hydroxy-2'-deoxycytidine have been used as a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species. Synonyms: 2'-Deoxy-5-hydroxy-cytidine. CAS No. 52278-77-0. Molecular formula: C9H13N3O5. Mole weight: 243.22. | |
| 5-Hydroxy-2-deoxycytidine-13C,15N2 | 5-Hydroxy-2-deoxycytidine-13C,15N2 is the Isotope labelled analogue of 5-Hydroxy-2-deoxycytidine (H946650), a substrate for uracil DNA N-glycosylase and has been used to study the oxidation of DNA due to exposure to reactive oxygen species. Group: Biochemicals. Alternative Names: 2'-Deoxy-5-hydroxy-cytidine-13C,15N2. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 5-Iodouracil | 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones. Group: Biochemicals. Alternative Names: 5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848. Grades: Highly Purified. CAS No. 696-07-1. Pack Sizes: 25g. US Biological Life Sciences. | Worldwide |
| 6-Amino-1-methyluracil | 6-Amino-1-methyluracil is known to exert inhibitory effects towards DNA repair glycosylase. It is also known to be used as a flame retardant. Group: Biochemicals. Alternative Names: 6-Amino-1-methyl-2,4-pyrimidinedione; 1-Methyl-6-aminouracil; 6-Amino-1-methyl-1H-pyrimidine-2,4-dione; 6-Amino-1-methyluracil; NSC 7369. Grades: Highly Purified. CAS No. 2434-53-9. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 6-Chlorouracil | 6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases. Group: Biochemicals. Alternative Names: 4-Chloro-2,6-dihydroxypyrimidine; 6-Chloro-2,4-dihydroxypyrimidine; 6-Chloro-2,4-pyrimidinediol; 6-Chloropyrimidine-2,4(1H,3H)-dione; NSC 210419; NSC 43265. Grades: Highly Purified. CAS No. 4270-27-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 8-Hydroxyguanine | A crucial nucleotide derivative, 8-Hydroxyguanine, reigns supreme in the biomedical industry for its multifaceted functions. Serving as a DNA damage biomarker for several human diseases, including cancer, it plays a significant role in furthering our understanding of complicated cellular mechanisms. Moreover, its use in research facilitates the evaluation of the efficacy of certain chemotherapy drugs, greatly assisting the development of effective cancer treatments. A product of immense importance, 8-Hydroxyguanine is the key to unlocking the mysteries of DNA repair mechanisms and expanding the frontiers of medical science. Uses: An 8-oxo-guanine repair pathway coordinated by mutyh glycosylase and dna polymerase &lambda. Synonyms: 2-Amino-6,8-purinediol; 8-Oxo-7,8-dihydroguanine; NSC 22720; 2-Amino-6,8-dihydroxypurine; 7,8-dihydro-8-oxoguanine; 2-Aminopurine-6,8-diol; 2-amino-7,9-dihydro-3H-purine-6,8-dione. Grades: ≥95% by HPLC. CAS No. 5614-64-2. Molecular formula: C5H5N5O2. Mole weight: 167.13. | |
| 8-Oxoguanine Hydrochloride (8-Hydroxyguanine Hydrochloride; 2-Amino-6,8-dihydroxypurine Hydrochloride) | An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Group: Biochemicals. Alternative Names: 8-Hydroxyguanine Hydrochloride; 2-Amino-6,8-dihydroxypurine Hydrochloride. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| deoxyribodipyrimidine endonucleosidase | Deoxyribodipyrimidine endonucleosidase (EC 3.2.2.17) is an enzyme with systematic name deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase. Group: Enzymes. Synonyms: pyrimidine dimer DNA-glycosylase; endonuclease V; deoxyribonucleate pyrimidine dimer glycosidase; pyrimidine dimer DNA glycosylase; T4-induced UV endonuclease; PD-DNA glycosylase. Enzyme Commission Number: EC 3.2.2.17. CAS No. 75302-33-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3971; deoxyribodipyrimidine endonucleosidase; EC 3.2.2.17; 75302-33-9; pyrimidine dimer DNA-glycosylase; endonuclease V; deoxyribonucleate pyrimidine dimer glycosidase; pyrimidine dimer DNA glycosylase; T4-induced UV endonuclease; PD-DNA glycosylase. Cat No: EXWM-3971. | |
| deoxyribonuclease IV | The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' α,β-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion α-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA. Group: Enzymes. Synonyms: deoxyribonuclease IV. coli endonuclease IV; endodeoxyribonuclease (misleading); redoxyendonuclease; deoxriboendonuclease (misleading); endonuclease II; endonuclease IV; DNA-adenine-transferase; nfo (gene name). Enzyme Commission Number: EC 3.1.21.2. CAS No. 63363-78-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3572; deoxyribonuclease IV; EC 3.1.21.2; 63363-78-0; deoxyribonuclease IV (phage-T4-induced) (misleading); endodeoxyribonuclease IV (phage T4-induced) (misleading); E. coli endonuclease IV; endodeoxyribonuclease (misleading); redoxyendonuclease; deoxriboendonuclease (misleading); endonuclease II; endonuclease IV; DNA-adenine-transferase; nfo (gene name). Cat No: EXWM-3572. | |
| Fpg Protein from Escherichia coli, Recombinant | Fpg protein, a key enzyme in the DNA base excision repair pathway (BER), catalyses the excision of a broad spectrum of modified purines such as formamidopyrimidine (Fapy) and 8-oxoguanine (8-oxo-G). Fpg possess both DNA glycosylase activity that removes the mutated base and AP-lyase activity that releases ribose, leaving both 5'-and 3'-phosphorylated ends in the DNA. Several analytical methods based on Fpg protein activity in vitro were developed for detection and quantitation of oxidative damage to DNA mainly for FapyA, FapyG and 8-oxo-G. The fpg gene was cloned by Boiteux, et al. Fpg protein possess a zinc finger motif at its C-terminus (one zinc atom per molecule). ... Protein. Mole weight: mol wt 30.2 kDa (269 amino acids, predicted from the nucleotide sequence). Activity: >20 ,000 units/mg protein. Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 50 mM potassium HEPES, pH 7.5, 1 mM DTT, 1 mM EDTA, and 200 mM NaCl. Source: E. coli. Species: Escherichia coli. Fapy-DNA glycosylase; deoxyribonucleate glycosidase; 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase; 2,6-diamino-4-hydroxy-5 (N-methyl)formamidopyrimidine-DNA glycosylase; formamidopyrimidine-DNA glycosylase; DNA-formamidopyrimidine glycosidase; Fpg protein; DNA-formamidopyrimidine glycosylase; EC 3.2.2.23; 78783-53-6; | |
| Methoxyamine hydrochloride | Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3 hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: O-Methylhydroxylamine hydrochloride. CAS No. 593-56-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-Y0958. |  |
| O8 OGG1 Inhibitor | O8 OGG1 Inhibitor is a potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1. Synonyms: 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide; 3,4-dichloro-1-benzothiophene-2-carbohydrazide. Grades: ≥98% by HPLC. CAS No. 350997-39-6. Molecular formula: C9H6Cl2N2OS. Mole weight: 261.13. | |
| TH 5487 | TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with IC50 value of 342 nM. It inhibits OGG1 binding to 8-oxoG in DNA, suppressing proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro, and also inhibiting proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo. Synonyms: 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 2304947-71-3. Molecular formula: C19H18BrIN4O2. Mole weight: 541.18. | |
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