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| Product | Description | |
|---|---|---|
| DNA ligase (ATP) | The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP). Group: Enzymes. Synonyms: polydeoxyribonucleotide synthase (ATP);. Enzyme Commission Number: EC 6.5.1.1. CAS No. 9015-85-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5820; DNA ligase (ATP); EC 6.5.1.1; 9015-85-4; polydeoxyribonucleotide synthase (ATP); polynucleotide ligase (ambiguous); sealase; DNA repair enzyme (ambiguous); DNA joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleate ligase (ambiguou |  |
| DNA ligase (ATP, ADP or GTP) | The enzymes from the archaea Hyperthermus butylicus and Sulfophobococcus zilligii are active with ATP, ADP or GTP. They show no activity with NAD+. Different from EC 6.5.1.1, DNA ligase (ATP), which is specific for ATP, and EC 6.5.1.6, DNA ligase (ATP or NAD+) which can utilize either ATP or NAD+. Group: Enzymes. Enzyme Commission Number: EC 6.5.1.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5826; DNA ligase (ATP, ADP or GTP); EC 6.5.1.7. Cat No: EXWM-5826. | |
| DNA ligase (ATP or NAD+) | The enzymes from the archaea Thermococcus fumicolans and Thermococcus onnurineus show high activity with either ATP or NAD+, and significantly lower activity with TTP, GTP, and CTP. Different from EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.2, DNA ligase (NAD+) and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP). Group: Enzymes. Enzyme Commission Number: EC 6.5.1.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5825; DNA ligase (ATP or NAD+); EC 6.5.1.6. Cat No: EXWM-5825. | |
| DNA ligase (NAD+) | Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. cf. EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP). Group: Enzymes. Synonyms: polydeoxyribonucleotide synthase (NAD+); polynucleotide ligase (NAD+); DNA repair enzyme (ambiguous); DNA joinase (ambiguous); polynucleotide synthetase (nicotinamide ad. Enzyme Commission Number: EC 6.5.1.2. CAS No. 37259-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5821; DNA ligase (NAD+); EC 6.5.1.2; 37259-52-2; polydeoxyribonucleotide synthase (NAD+); polynucleotide ligase (NAD+); DNA repair enzyme (ambiguous); DNA joinase (ambiguous); polynucleotide synthetase (nicotinamide adenine dinucleotide); deoxyribonucleic-joining enzyme (ambiguous); deoxyribonucleic ligase (ambiguous); deoxyribonucleic repair enzyme (ambiguous); deoxyribonucleic joinase (ambiguous); DNA ligase (ambiguous); deoxyribonucleate ligase (ambiguous); polynucleotide ligase (ambiguous); deoxyribonucleic acid ligase (ambiguous); polynucleotide synthetase (ambiguous); deoxyribonucleic acid joinase (ambiguous); DNA-joining enzyme (ambiguous); polynucleotide ligase (nicotinamide adenine dinucleotide). Cat No: EXWM-5821. | |
| DNA Ligase T4 Reaction Buffer, 10X | DNA Ligase T4 Reaction Buffer, 10X. Group: Molecular Biology. Grades: Molecular Biology Grade. CAS No. 9015-85-4. Pack Sizes: 1.5ml. US Biological Life Sciences. |  Worldwide |
| DNA Ligase, T4, Recombinant, BioAssay Kit, 10mM ATP | DNA Ligase, T4, Recombinant, BioAssay Kit, 10mM ATP. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ul. US Biological Life Sciences. | Worldwide |
| DNA Ligase, T4, Recombinant, BioAssay Kit, Reaction Buffer (10X) | DNA Ligase, T4, Recombinant, BioAssay Kit, Reaction Buffer (10X). Group: Molecular Biology. Grades: Purified. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| DNA Ligase, T4, Recombinant, BioAssay Kit, T4 DNA Ligase | DNA Ligase, T4, Recombinant, BioAssay Kit, T4 DNA Ligase. Group: Molecular Biology. Grades: Purified. Pack Sizes: 20KU. US Biological Life Sciences. | Worldwide |
| T4 DNA Ligase | T4 DNA Ligase. T4 dna ligase catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna or rna with blunt or cohesive end. the enzyme repairs single-strand nicks in duplex dna, rna or dna/rna hybrids but has no activity on single-strand nucleic acids. t4 dna ligase requires atp as a cofactor. Group: DNA Modifying Enzymes. Purity: 10KU; 20KU. Storage: Store at -20°C. Cat No: ME-4005. | |
| 7-Propargylamino-7-deaza-dATP - 6-FAM | 7-Propargylamino-7-deaza-dATP - 6-FAM is a vital tool in the biomedical industry for studying DNA replication and repair mechanisms. It is commonly used as a substrate in enzymatic assays to investigate the activity of DNA polymerases and ligases. Furthermore, this compound plays a crucial role in labeling and detection of DNA during fluorescence-based techniques, assisting in the research of various genetic disorders. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyadenosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H30N5O18P3 (free acid). Mole weight: 901.56 (free acid). |  |
| Abs I | One unit of the enzyme is the amount required to hydrolyze 1 μg of pUC19SE/DriI -digest in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold overdigestion with enzyme about 90% of the dna fragments can be ligated with t4 dna ligase at 16°c and recut. Group: Restriction Enzymes. Purity: 50U; 250U. CC↑TCGAGG GGAGCT↓CC. Activity: 500-1000u.a./ml. Appearance: 10 X SE-buffer AbsI. Storage: -20°C. Form: Liquid. Source: Arthrobacter species 7M06. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1002EN. | |
| AclW I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dam-) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme about 50% of the dna fragments can be ligated with t4 dna ligase and recut. in the presence of 10% peg ligation is better. Group: Restriction Enzymes. Purity: 100U; 500U. GGATC(N)4↑ CCTAG(N)5&darr. Activity: 1000-3000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Form: Liquid. Source: Acinetobacter calcoaceticus W2131. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1010EN. | |
| Aco I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA(dam-, dcm-) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with acoi more than 90% of lambda dna fragments can be ligated with t4 dna ligase at 16°c and recut. Group: Restriction Enzymes. Y↑GGCCR RCCGG↓Y. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Acinetobacter calcoaceticus. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 100 μg/ml BSA; 50% glycerol. Cat No: RE-1011EN. | |
| AluB I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme 80% of the lambda dna fragments can be ligated with t4 dna ligase and can be recut. Group: Restriction Enzymes. Purity: 200U; 1000U. AG↑CT TC↓GA. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: Arthrobacter luteus B. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1019EN. | |
| Antarctic Phosphatase from E. coli, Recombinant | Antarctic Phosphatase catalyzes the removal of 5? phosphate from DNA and RNA. Since phosphatase-treated fragments lack the 5? phosphoryl termini required by ligases, they cannot self-ligate. This property can be used to decrease the vector background in cloning strategies. Applications: Removing 5? phosphates from dna, rna, rntps and dntps preparation of templates for 5? end labeling prevention of recircularization of cloning vectors removal of dntps and pyrophosphate from pcr reactions dephosphorylation of proteins. Group: Enzymes. Synonyms: Antarctic Phosphatase. Purity: >95% estimated by SDS-PAGE. Antarctic Phosphatase. Mole weight: Apparent: 35 kDa Theoretical: 69 kDa. Storage: at -20°C. Form: 10 mM Tris-HCl (pH 7.4), 1 mM MgCl2, 0.01 mM ZnCl2, 1 mM DTT and 50% glycerol. Source: E. coli. Species: E. coli. Antarctic Phosphatase. Cat No: NATE-1399. | |
| Ara-CTP | ara-Cytidine-5'-triphosphate (ara-CTP) is an inhibitor of DNA synthesis, DNA ligases and polymerases that is used for the treatment of acute myeloid leukemia. Uses: Nucleic acid synthesis inhibitors. Synonyms: 1-β-D-arabinofuranosylcytosine TP; Aracytidine-5'-Triphosphate; ara-Cytidine-5'-triphosphate; Arabinofuranosylcytosine triphosphate. Grades: ≥90% by AX-HPLC. CAS No. 13191-15-6. Molecular formula: C9H16N3O14P3 (free acid). Mole weight: 483.15 (free acid). | |
| β-Nicotinamide Adenine Dinucleotide Sodium Salt Hydrate | β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(Trihydrogen Diphosphate), P'?5'-Ester with 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium Hydroxide Sodium Salt Hydrate; Adenine-nicotinamide Dinucleotide Sodium Salt Hydrate; CO-I Sodium Salt Hydrate; Codehydrase I Sodium Salt Hydrate; Codehydrogenase I Sodium Salt Hydrate; Coenzyme I Sodium Salt Hydrate; Cozymase I Sodium Salt Hydrate; DPN Sodium Salt Hydrate; Diphosphopyridine Nucleotide Sodium Salt Hydrate; Enzopride Sodium Salt Hydrate; NAD Sodium Salt Hydrate; NAD+ Sodium Salt Hydrate; NSC 20272 Sodium Salt Hydrate; Nadide Sodium Salt Hydrate; Nicotinamide-adenine Dinucleotide Sodium Salt Hydrate; Oxidized diphosphopyridine Nucleotide Sodium Salt Hydrate; β-Diphosphopyridine Nucleotide Sodium Salt Hydrate; β-NAD Sodium Salt Hydrate; β-NAD+ Sodium Salt Hydrate. Grades: 95%. Molecular formula: C21H26N7NaO14P2 X(H2O). Mole weight: 685.41. | |
| Bse21 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold overdigestion with enzyme about 50% of dna fragments can be ligated by using of high concentration t4 dna ligase with presence of 10% peg. of these more than 90% can be recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CC↑TNAGG GGANT↓CC. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Bacillus species 21. Pack: 10 mM KH2PO4 (pH 7.4); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1045RE. | |
| BspAC I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 95% of the lambda dna fragments can be ligated with t4 dna ligase at 16°c and 50% of these can be recut. Group: Restriction Enzymes. Purity: 200U; 1000U. C↑CGC GGC↓G. Activity: 2000-5000u.a./ml. Appearance: 10 X SE-buffer O, BSA. Storage: -20°C. Form: Liquid. Source: Bacillus species AC. Pack: 10 mM KH2PO4(pH 7.2); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1055RE. | |
| Bsu I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme ~10% of dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GTATCC(N)6↑ CATAGG(N)5&darr. Activity: 2000-5000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Bacillus sphaericus. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA, 0.05% Triton X-100, 50% glycerol. Cat No: ET-1091RE. | |
| Cdc25A (80-93) (human) | Cdc25A abundance fluctuates periodically during the cell division cycle and is mainly regulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, which later promote complex/cyclosome and Skp1/Cul1/F-box proteins. Due to the presence of the destruction motif (KEN-box) in Cdc25A, ubiquitination and degradation occur at the mitotic outlet and G1, while phosphorylation events modulate the stability of Cdc25A protein in the S phase, both in undisturbed cells and in cells exposed to DNA damage agents or DNA replication inhibitors. Synonyms: H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH. Grades: ≥95%. CAS No. 851538-67-5. Molecular formula: C60H90N14O24S. Mole weight: 1423.52. | |
| DNA relaxation-IN-1 | DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 ( DNA Lig1 ) inhibitor, which inhibits DNA ligation and disrupts Lig Is DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2190506-29-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161152. |  |
| FaeI | One unit of the enzyme is the amount required to hydrolyze 1 μg of pUC19 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme more then 90% of the dna fragments can be ligated with t4 dna ligase at 16°c and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CATG↑ ↓GTAC. Activity: 500-2000 u.a./ml. Appearance: 10 X SE-buffer FaeI, BSA. Storage: -20°C. Form: Liquid. Source: Flavobacterium aquatile N3. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1105RE. | |
| FaiI | One unit is defined as the amount of enzyme required to cleave 1 pmol of the double-stranded oligonucleotide of the above indicated structure in 1 hour at 50°C in a total reaction volume of 20 μl. Applications: After 3-fold overdigestion with enzyme about 90% of the puc19 dna fragments can be ligated with dna ligase and recut. Group: Restriction Enzymes. Purity: 100U; 500U. YA↑TR RT↓AY. Activity: 2000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Flavobacterium aquatile B15. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM KCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1106RE. | |
| HLI373 dihydrochloride | HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. Antimalarial activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782531-99-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108640A. | |
| HpySE526 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of pUC19 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme about 95% of the dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. A↑CGT TGC↓A. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned HpySE 526I gene from Helicobacter pylori SE526. Pack: 10 mM Tris-HCl (pH 7.6); 100 mM NaCl; 0,1 mM EDTA; 200 μg/ml BSA; 1 mM DTT; and 50% glycerol. Cat No: ET-1123RE. | |
| HQ461 | HQ461 is a Molecular-glue degrader. HQ461 acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK). Degradation of CCNK mediated by HQ461 compromised CDK12 function, leading to reduced phosphorylation of a CDK12 substrate, downregulation of DNA damage response genes, and cell death. Structure-activity relationship analysis of HQ461 revealed the importance of a 5-methylthiazol-2-amine pharmacophore and resulted in an HQ461 derivate with improved potency. Group: Inhibitors. Alternative Names: HQ461; HQ-461; HQ 461. CAS No. 1226443-41-9. Molecular formula: C15H15N5OS2. Mole weight: 345.44. Appearance: Solid powder. Purity: >98%. IUPACName: 2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide. Canonical SMILES: CC1C=CC=C (NC2=NC (CC (=O)NC3=NC=C (C)S3)=CS2)N=1. Catalog: ACM1226443419. |  |
| l189 | L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer. Group: Inhibitors. CAS No. 64232-83-3. Molecular formula: C11H10N4OS?xH2O. Mole weight: C11H10N4OS. Appearance: Solid. Purity: ≥98.0%. Canonical SMILES: OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2. Catalog: ACM64232833. | |
| L189 | L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. Synonyms: L189; L 189; L-189. Grades: 98%. CAS No. 64232-83-3. Molecular formula: C11H10N4OS. Mole weight: 246.29. | |
| L67 | L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC 50 are 10 μM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1 -dependent apoptosis pathway in cancer cells, can be used in cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DNA Ligase Inhibitor. CAS No. 325970-71-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15586. | |
| L67 | L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I and III with IC50 values of 10 μM and 10 μM.). Synonyms: L67; L-67; L 67. Grades: 98%. CAS No. 325970-71-6. Molecular formula: C16H14Br2N4O4. Mole weight: 486.12. | |
| L82 | L82 is a selective and uncompetitive DNA ligase 1 ( DNA Lig1 ) inhibitor (hLig1 IC 50 =12 μM). L82 shows anti-proliferative activity to breast cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329227-30-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15587. | |
| Mant-dATP | Mant-dATP is a vital tool acting as a modified form of deoxyadenosine triphosphate (dATP) labeled with the mant fluorophore. Mant-dATP is beneficial for studying various enzymatic activities, including DNA polymerases, DNA ligases and helicases, due to its ability to monitor nucleotide incorporation during DNA synthesis. Additionally, it plays a crucial role in investigating diseases related to DNA replication and repair mechanisms. Synonyms: 3'-O-(N-Methyl-anthraniloyl)-2'-deoxyadenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 128113-53-1. Molecular formula: C18H23N6O13P3(free acid). Mole weight: 624.33 (free acid). | |
| Mfe I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. C↑AATTG GTTAA↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene Mfe I from Mycoplasma fermentans. Pack: 10 mM Tris-HCl (pH 7.6); 50 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1131RE. | |
| N6-(6-Amino)hexyl-dATP - 5-FAM | N6-(6-Amino)hexyl-dATP - 5-FAM, a fluorescently labeled nucleotide analog, finds its remarkable applicability in molecular biology for DNA synthesis, repair, and replication studies. One can efficiently detect polymerases, nicking enzymes, DNA ligases, and helicases, besides employing it in real-time PCR (polymerase chain reaction) and DNA sequencing. Remarkably, it can serve as a facile substrate for DNA polymerases in DNA synthesis reactions, making it a versatile compound paving new avenues for intriguing scientific pursuits. Synonyms: N; -(6-Amino)hexyl-2'-deoxyadenosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C37H39N6O18P3(free acid). Mole weight: 948.66 (free acid). | |
| Nicotinic Acid Adenine Dinucleotide | Nicotinic Acid Adenine Dinucleotide is an analog of β-Nicotinamide Adenine Dinucleotide; a coenzyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate groups. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(trihydrogen diphosphate), P'?5'-ester with 3-carboxy-1-β-D-ribofuranosylpyridinium, inner salt; 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide, 5'-ester with adenosine 5'-pyrophosphate, inner salt; Pyridinium, 3-carboxy-1-β-D-ribofuranosyl-, hydroxide, 5'?5'-ester with adenosine 5'-(trihydrogen pyrophosphate), inner salt; 1: PN: WO2006081329 PAGE: 47 claimed sequence; Adenine-nicotinic Acid Dinucleotide; Codehydrogenase I, carboxy deamido analog; Codehydrogenase I, nicotinic acid analog; Deamido-NAD; Deamidodiphosphopyridine Nucleotide; Desamido NAD; Nicotinate Adenine Dinucleotide; Nicotinic Acid-adenine Dinucleotide. CAS No. 6450-77-7. Molecular formula: C21H26N6O15P2. Mole weight: 664.41. | |
| NSC 207895 | NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. Synonyms: NSC 207895; NSC-207895; NSC207895; XI-006; XI006; XI 006. Grades: >98%. CAS No. 58131-57-0. Molecular formula: C11H13N5O4. Mole weight: 279.25. | |
| PciS I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme 90% of the dna fragments can be ligated with t4 dna ligase at 16°c and 95% of these can be recut. Group: Restriction Enzymes. Purity: 50U; 250U. GCTCTTCN↑ CGAGAAG(N)4&darr. Activity: 500-2000 u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Planococcus citreus S. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA and 50% glycerol. Cat No: ET-1146RE. | |
| PstN I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme > 95% of lambda dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CAGNNN↑CTG GTC↓NNNGAC. Activity: 5000-10000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Pseudomonas stutzeri 217. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA, 50% glycerol. Cat No: ET-1162RE. | |
| Rig I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Ad2 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme > 95% of ad2 dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 100U; 500U. GGCCGG↑CC CC↓GGCCGG. Activity: 2000u.a./ml. Appearance: 10 X SE-buffer RigI, BSA. Storage: -20°C. Storage at -70°C is recommended for periods longer than 7 days. Form: Liquid. Source: Rhizobium yangligense. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1165RE. | |
| RsaN I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. G↑TAC CAT↓G. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Rhodopseudomonas sphaeroides N. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 100 μg/ml BSA, 50% glycerol. Cat No: ET-1167RE. | |
| Sarafloxacin hydrochloride | Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis. Synonyms: Sarafloxacin HCl; A-56620; A 56620; A56620. Grades: >98%. CAS No. 91296-87-6. Molecular formula: C20H17F2N3O3.HCl. Mole weight: 421.83. | |
| Scr7 | SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity. Group: Inhibitors. Alternative Names: SCR7;5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol;5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone. CAS No. 1533426-72-0. Molecular formula: C18H14N4OS. Catalog: ACM1533426720. | |
| SCR7 pyrazine | SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Synonyms: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. Grades: ≥98% by HPLC. CAS No. 14892-97-8. Molecular formula: C18H12N4OS. Mole weight: 332.38. | |
| SCR7 Pyrazine | SCR7 pyrazine also is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. It enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro upt to 19-fold. SCR7 pyrazine is a product of spontaneous cyclization of CRISPR enhancer SCR7 first reported by Srivastava, M., et al.DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.1 It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.1,2,3,4. Group: Biochemicals. Alternative Names: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine. Grades: Highly Purified. CAS No. 14892-97-8. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS, Molecular Weight: 332.38. US Biological Life Sciences. | Worldwide |
| Set I | One unit is defined as the amount of enzyme required to cleave 1 pmol of the double-stranded oligonucleotide of the below indicated structure in 1 hour at 55°C in a total reaction volume of 20 μl. Note! seti cleaves a canonical site and several other sites with a weaker activity. in the case of long incubation with seti dna can be digested to small oligos. Applications: After 5-fold overdigestion with enzyme, approximately 50% of the pbr322 dna fragments can be ligated with t4 dna ligase and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. ASST↑ ↓TSSA. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Set I gene from Streptomyces werraensis 37. Pack: 10 mM Tris-HCl (pH 7.6); 100 mM NaCl; 0.1 mM EDTA; 1 mM DTT; 50% glycerol. Cat No: ET-1171RE. | |
| Sma I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 25°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated (by using of high concentration t4 dna ligase and 10% peg) and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. CCC↑GGG GGG↓CCC. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Sma I gene from Serratia marcescens. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM NaCl; 0.1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1176RE. | |
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