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| Product | Description | |
|---|---|---|
| DNA topoisomerase | These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.99.1.3 DNA topoisomerase (ATP-hydrolysing). Group: Enzymes. Synonyms: type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase. Enzyme Commission Number: EC 5.99.1.2. CAS No. 80449-01-0. TOPO I. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5637; DNA topoisomerase; EC 5.99.1.2; 80449-01-0; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase. Cat No: EXWM-5637. |  |
| DNA topoisomerase (ATP-hydrolysing) | The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase). Group: Enzymes. Synonyms: type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II. Enzyme Commission Number: EC 5.99.1.3. CAS No. 142805-56-9. TOPO II. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5638; DNA topoisomerase (ATP-hydrolysing); EC 5.99.1.3; 142805-56-9; type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II. Cat No: EXWM-5638. | |
| 10-Hydroxy-11-methoxycamptothecin | 10-Hydroxy-11-methoxycamptothecin can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H18N2O6, Molecular Weight: 394.38. US Biological Life Sciences. |  Worldwide |
| 10-Hydroxy-11-methoxycamptothecin-d3 | 10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H15D3N2O6, Molecular Weight: 397.4. US Biological Life Sciences. | Worldwide |
| 10-O-Acetyl SN-38-d3 | 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin-d3; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 10-Hydroxy-7-ethylcamptothecin 10-Acetate-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 11-Desethyl Irinotecan | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 1,4-Naphthoquinone | 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130-15-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W015490. |  |
| 1,4-Piperazinediethylamine | 1,4-Piperazinediethylamine is used as a reagent in the synthesis of bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors. Also used as a reagent in the synthesis of novel bisnaphthalimides as new DNA topoisomerase II inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6531-38-0. Pack Sizes: 100mg, 1g. Molecular Formula: C8H20N4. US Biological Life Sciences. | Worldwide |
| 1,4-Piperazinediethylamine-d8 | 1,4-Piperazinediethylamine-d8 is the isotope labelled analog of 1,4-Piperazinediethylamine (P480090); a reagent in the synthesis of bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors. Also used as a reagent in the synthesis of novel bisnaphthalimides as new DNA topoisomerase II inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C8H12D8N4, Molecular Weight: 180.32. US Biological Life Sciences. | Worldwide |
| (1R, 6R)-2, 8-Diazabicyclo[4. 3. 0]nonane | (1R, 6R)-2, 8-Diazabicyclo[4. 3. 0]nonane is a chiral reagent used in the synthesis of pyrrolopyrimidine derivatives as dual DNA gyrase B and topoisomerase IV inhibitors and potential antibacterial agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 151213-42-2. Pack Sizes: 250mg, 1g. Molecular Formula: C7H14N2, Molecular Weight: 126.2. US Biological Life Sciences. | Worldwide |
| 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
| 2, ?2-?Dimethyl-?4-?oxo-?7-? (phenylmethoxy)?-?4H-?1, ?3-?benzodioxin-?5-?yl Ester 1,?1,?1-?Trifluoro-methanesulfonic Acid | 2, ?2-?Dimethyl-?4-?oxo-?7-? (phenylmethoxy)?-?4H-?1, ?3-?benzodioxin-?5-?yl Ester 1,?1,?1-?Trifluoro-methanesulfonic Acid is an intermediate in synthesizing Alternariol (A575760), an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Group: Biochemicals. Grades: Highly Purified. CAS No. 137571-75-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C18H15F3O7S. US Biological Life Sciences. | Worldwide |
| 2'',3''-Bis-O-(Dichloroacetyl) Etoposide | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide (E933750). Etoposide is a DNA topoisomerase II inhibitor. Etoposide is semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an Antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 260974-95-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C33H32Cl4O15, Molecular Weight: 810.41. US Biological Life Sciences. | Worldwide |
| 2'',3''-Bis-O-(Dichloroacetyl) Etoposide | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor. Etoposide is a semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Synonyms: 9-[[2,3-Bis-O-(2,2-dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 6-Acetate; (5R,5aR,8aR,9S)-9-[[2,3-Bis-O-(dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS No. 260974-95-6. Molecular formula: C33H32Cl4O15. Mole weight: 810.41. |  |
| 2,3-Quinolinedimethanol | 2,3-Quinolinedimethanol is a reactant used in the synthesis of camptothecin (C175150), an ntitumor alkaloid which binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 57032-14-1. Pack Sizes: 100mg, 1g. Molecular Formula: C11H11NO2, Molecular Weight: 189.21. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
| (2R)-Amrubicin | Amrubicin, also known as SM-5887, is an anthracycline used in the treatment of lung cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. Uses: Antineoplastic agents. Synonyms: (7S-cis)-9-Acetyl-9-amino-7-[(2-deoxy-alpha-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione; 5,12-Naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-α-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S-cis)-; (1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2-deoxy-α-D-erythro-pentopyranoside. Grades: ≥95%. CAS No. 110267-81-7. Molecular formula: C25H25NO9. Mole weight: 483.47. | |
| 3,5-Di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofurano-1,4-lactone | 3,5-Di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofurano-1,4-lactone is a potent chemotherapeutic agent utilized specifically for the successful management of various types of cancer. Its targeted therapeutic mechanism of action functions by significantly blocking the activity of topoisomerase I, a crucial enzyme critically required for DNA replication. This effective inhibition effectively halts the uncontrollable growth and division of malignant cell populations, thereby enabling the eventual eradication of cancerous cells in the body with significant efficacy. Synonyms: (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate). CAS No. 1294481-79-0. Molecular formula: C20H17Cl2FO6. Mole weight: 443.25. | |
| 3-O-β-D-Glucopyranosyl Alternariol-9-methyl Ether | 3-O-β-D-Glucopyranosyl Alternariol-9-methyl Ether is a derivative of Alternariol which is an alternaria mycotoxin and genotoxin, found in common edible crops. Alternariol inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Alternariol 3-Sulfate Ammonium Salt is currently suspected of being formed during metabolism in contaminated plants. Synonyms: Lysilactone A. CAS No. 1422465-59-5. Molecular formula: C21H22O10. Mole weight: 434.39. | |
| 4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one | 4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one is an intriguing organic compound that has been extensively researched in the biomedical industry. The compound displays remarkable potential as a DNA topoisomerase inhibitor, a crucial enzyme involved in DNA replication and cell growth. Its distinctive chemical structure is expected to revolutionize drug discovery and development for the treatment of various cancers and microbial infections. Synonyms: 4-amino-1-[2,3-O-(1-methylethylene)pentofuranosyl]-1,3,5-triazine-2(1H)-one. Grades: 98%. CAS No. 686300-58-3. Molecular formula: C11H16N4O5. Mole weight: 284.27. | |
| 4'-(O-Podophyllotoxin-9-oxy) Etoposide | 4'-(O-Podophyllotoxin-9-oxy) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor, as well as semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Molecular formula: C50H50O20. Mole weight: 970.92. | |
| 5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7-Methyl Camptothecin. | Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin. Grades: Highly Purified. CAS No. 78287-26-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 9-O-(6-O-Malonyl-β-D-glucopyranosyl) Alternariol | 9-O-(6-O-Malonyl-β-D-glucopyranosyl) Alternariol is a derivative of Alternariol which is an alternaria mycotoxin and genotoxin, found in common edible crops. Alternariol inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Alternariol 3- Sulfate Ammonium Salt is currently suspected of being formed during metabolism in contaminated plants. Synonyms: 9-O-(6-O-Malonyl-beta-D-glucopyranosyl) alternariol; 1779520-66-9. CAS No. 1779520-66-9. Molecular formula: C23H22O13. Mole weight: 506.41. | |
| ABT-719 | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. Grades: 98%. CAS No. 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. | |
| ABT-719 HCl | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. Grades: 98%. CAS No. 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. | |
| Aclarubicin A | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. It intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. It has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation. It has been listed. Uses: Aclarubicin has potent antineoplastic activity. it is used in the treatment of cancer. it can induce histone eviction from chromatin upon intercalation. Synonyms: 11-Dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met;1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6;(1R,2R,4S)-methyl 4-(((2R,5S,6S)-4-(dimethylamino)-5-(((2S,4S,5S,6S)-4-hydroxy-6-methyl-5-(((2R,6S). Grades: ≥95%. CAS No. 57576-44-0. Molecular formula: C42H53NO15. Mole weight: 811.88. | |
| Aclarubicin hydrochloride | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Uses: Antibiotics, antineoplastic. Synonyms: Aclacinon; Aclaplastin; Aclacinomycin A Hydrochloride; Aclarubicin HCl; Aclarubicina Clorhidrato [Spanish]. Grades: >98%. CAS No. 75443-99-1. Molecular formula: C42H54ClNO15. Mole weight: 848.33. | |
| AEZS-108 | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grades: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
| AJI-9561 | AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJ9561. It has cytotoxic activity with IC50 of 0.88 μmol/L and 1.63 μmol/L for Jorkat and P388 cells, respectively. Its mechanism of action is the same as that of UK-1, which can inhibit DNA topoisomerase U. Synonyms: (2,4'-Bibenzoxazole)-4-carboxylic acid, 2'-(2-hydroxy-6-methylphenyl)-. CAS No. 339300-34-4. Molecular formula: C22H14N2O5. Mole weight: 386.36. | |
| Alalevonadifloxacin | Alalevonadifloxacin is a quinolone antibacterial. It is a DNA gyrase and DNA topoisomerase inhibitor. Alalevonadifloxacin is potentially useful to treat bacterial Gram-positive, Gram-negative and anaerobic infections. Phase II clinical trials for the treatment of Methicillin-resistant Staphylococcus aureus infections and Skin and soft tissue infections are on-going. Uses: Methicillin-resistant staphylococcus aureus infections; skin and soft tissue infections. Synonyms: WCK2349; WCK 2349; WCK-2349; (5S)-8-[4-(L-alanyloxy)piperidin-1-yl]-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. Grades: 98%. CAS No. 706809-20-3. Molecular formula: C22H26FN3O5. Mole weight: 431.46. | |
| Alatrofloxacin Mesylate | Alatrofloxacin Mesylate is the mesylate salt form of the fluoroquinolone derivative Alatrofloxacin, a type II DNA topoisomerase inhibitor that has been developed as an antibacterial agent. Synonyms: L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, methanesulfonate (1:1); L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, monomethanesulfonate; L-Alaninamide, L-alanyl-N-[3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, (1α,5α,6α)-, monomethanesulfonate; Adrenochrome monoaminoguanidine mesilate; CP 116517; CP 116517-27; Trovan IV; Turvel IV; 7-((1R,5S,6s)-6-((S)-2-((S)-2-aminopropanamido)propanamido)-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1). Grades: ≥95%. CAS No. 146961-77-5. Molecular formula: C27H29F3N6O8S. Mole weight: 654.61. | |
| Aldoxorubicin | Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INNO-206; DOXO-EMCH. CAS No. 1361644-26-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16261. | |
| Alternariol | An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Alternative Names: 3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one; NSC 638263. Grades: Highly Purified. CAS No. 641-38-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Alternariol 9-Methyl Ether 3-Sulfate Ammonium Salt | Alternariol 9-Methyl Ether 3-Sulfate Ammonium Salt is a derivative of Alternariol 9-Methyl Ether (A575770) which is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Grades: Highly Purified. CAS No. 1488351-25-2. Pack Sizes: 1mg. Molecular Formula: C15H12O8S(NH3), Molecular Weight: 352.321703. US Biological Life Sciences. | Worldwide |
| Alternariol monomethyl ether | The 50 ppm acetonitrile solution of Alternariol monomethyl ether, shows activities as a cholinesterase inhibitor as well as an anti-fungal agent, could be commonly used as a standard solution. It is an alternaria mycotoxin and genotoxin, which can inhibit the activity of DNA-topoisomerases. Synonyms: 6H-Dibenzo[b,d]pyran-6-one, 3,7(3,9 or 7,9)-dihydroxy-9(7 or 3)-methoxy-1-methyl-; 3,7(3,9 or 7,9)-Dihydroxy-9(7 or 3)-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one; Alternariol, methyl ether. Grades: >95%. CAS No. 26894-49-5. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| Alternariol Monomethyl Ether | An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Alternative Names: 3,7(3,9 or 7,9)-Dihydroxy-9(7 or 3)-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one. Grades: Highly Purified. CAS No. 26894-49-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Alternariol Monomethyl Ether (9-O-Methylalternariol, Djalonensone, AME, BRN 0253553, 3,7-Dihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one) | Mycotoxin. Antifungal. Phytotoxic. Shown to possess DNA strand-breaking activity. Inhibits the activity of topoisomerase IIalpha (Topo IIalpha) in mammalian cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 26894-49-5. Pack Sizes: 500ug, 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Ametantrone | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Synonyms: CI881; CI 881; CI-881; NSC196473; NSC 287513; NSC-196473; NSC 287513; 1, 4-bis[2- (2-hydroxyethylamino) ethylamino]anthracene-9, 10-dione. CAS No. 64862-96-0. Molecular formula: C22H28N4O4. Mole weight: 412.49. | |
| Ametantrone Acetate | Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family. It can cause covalent cross-links in DNA, so it can be used as a antineoplastic agent. Uses: Antineoplastic agent. Synonyms: CI-881; CI 881; CI881; NSC 287513; NSC-287513; NSC287513; 1, 4-bis ( (2- ( (2-hydroxyethyl) amino) ethyl) amino) anthracene-9, 10-dione diacetate. Grades: 98%. CAS No. 70711-40-9. Molecular formula: C26H36N4O8. Mole weight: 532.59. | |
| Amonafide | Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent. Group: Biochemicals. Alternative Names: 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; FA 142; M-FA 142; MADE-FA 142; NCI 308847; NSC 308847; Nafidimide. Grades: Highly Purified. CAS No. 69408-81-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Amonafide | Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Uses: Antineoplastic agents. Synonyms: Nafidimide; Quinamed; Xanafide. Grades: 0.98. CAS No. 69408-81-7. Molecular formula: C16H17N3O2. Mole weight: 283.33. | |
| Amonafide | Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS1413. CAS No. 69408-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10982. | |
| Amonafide L-malate | Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis. Synonyms: AS1413; AS 1413; AS-1413; XLS-001; XLS001; XLS001; Xanafide. CAS No. 618863-60-8. Molecular formula: C20H24N4O6. Mole weight: 416.43. | |
| Amrubicin | Amrubicin (SM-5887) is a DNA topoisomerase II inhibitor, used for the research of cancer. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-5887. CAS No. 110267-81-7. Pack Sizes: 1 mg. Product ID: HY-B0067. | |
| Amrubicin-13C3 | Synthetic anthracycline antibiotic; inhibits DNA topoisomerase II. Antineoplastic. Group: Biochemicals. Alternative Names: (7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy- β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione-13C3. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Amsacrine | Amsacrine is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. Synonyms: AMSA; m-AMSA; CI 880, CI880, CI-880; SN-11841; SN 11841; SN11841; acridinyl anisidide. Grades: >98%. CAS No. 51264-14-3. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
| Amsacrine | Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II , and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: m-AMSA; acridinyl anisidide. CAS No. 51264-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13551. | |
| Amsacrine hydrochloride | Amsacrine hydrochloride is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. Uses: Antineoplastic agents. Synonyms: AMSA hydrochloride; m-AMSA hydrochloride; CI-880 hydrochloride; SN-11841 hydrochloride; CI 880 hydrochloride; SN 11841 hydrochloride; CI880 hydrochloride; SN11841 hydrochloride; acridinyl anisidide hydrochloride. Grades: >98%. CAS No. 54301-15-4. Molecular formula: C21H20ClN3O3S. Mole weight: 429.92. | |
| Amsacrine hydrochloride | Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II , and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: m-AMSA hydrochloride; acridinyl anisidide hydrochloride. CAS No. 54301-15-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13551A. | |
| Amsalog | Asulacrine isethionate is the isethionate salt of an amsacrine analogue with antineoplastic properties. Asulacrine inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis. Synonyms: Asulacrine isethionate; CI-921. CAS No. 80841-48-1. Molecular formula: C26H30N4O8S2. Mole weight: 590.67. | |
| Annamycin | Annamycin liposomal is a liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. Liposomal annamycin is less toxic and shows improved antitumor activity compared to annamycin. Uses: Antibiotics, antineoplastic. Synonyms: 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; AR-522. CAS No. 92689-49-1. Molecular formula: C26H25IO11. Mole weight: 640.38. | |
| Anthraquinone | Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 84-65-1. Pack Sizes: 25 g; 50 g. Product ID: HY-N0354. | |
| AQ4 | AQ4 is a topoisomerase II inhibitor and DNA intercalator as a chemically stable cytotoxic agent in many human tumor lines. Group: Inhibitors. Alternative Names: 1,4-bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxy-9,10-anthraquinone, 70476-63-0, 72758-40-8, 1,4-Bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione, 1,4-Bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxyanthracene-9,10-dione, 1,4-bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione, AC1L36GN, AC1Q6J6J, SureCN3148984, CTK8D7828, KST-1B8141, AR-1B7623, 1,4-bis(2-dimethylaminoethylamino)-5,8-dihydroxyanthracene-9,10-dione, 1,4-Bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione, 9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-. CAS No. 70476-63-0. Molecular formula: C22H28N4O4. Mole weight: 412.48. Purity: 0.96. IUPACName: 1,4-bis[2-(dimethylamino)ethylamino]-5,8-dihydroxyanthracene-9,10-dione. Canonical SMILES: CN (C)CCNC1=C2C (=C (C=C1)NCCN (C)C)C (=O)C3=C (C=CC (=C3C2=O)O)O. Catalog: ACM70476630. |  |
| Banoxantrone | Banoxantrone is a bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. Synonyms: AQ-4N; AZD-1689; AQ4N; AZD1689; AQ 4N; AZD 1689. CAS No. 136470-65-0. Molecular formula: C22H28N4O6. Mole weight: 444.48. | |
| Banoxantrone dihydrochloride | Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and exhibits little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Uses: Antineoplastic agents. Synonyms: 2-[[4-[2-[dimethyl (oxido)azaniumyl]ethylamino]-5, 8-dihydroxy-9, 10-dioxoanthracen-1-yl]amino]-N, N-dimethylethanamine oxide;dihydrochloride; UNII-658876KMFP; Banoxantrone (dihydrochloride). CAS No. 252979-56-9. Molecular formula: C22H30Cl2N4O6. Mole weight: 517.4. | |
| BAY 56-3722 | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
| BAY 56-3722 hydrochloride | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
| Becatecarin | Becatecarin is a synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. Synonyms: NSC 655649; BMS 181176; BMY 27557; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-. Grades: ≥95%. CAS No. 119673-08-4. Molecular formula: C33H34Cl2N4O7. Mole weight: 669.55. | |
| Becatecarin (6-N-[2- (Diethylamino) ethyl]rebeccamycin, NSC 655649, BMY-27557-14, BMS-181176, XL119) | Antibiotic. Semisynthetic H2O-soluble derivative of rebeccamycin. Antitumor compound. Topoisomerase II (Topo II) inhibitor. DNA intercalating agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 119673-08-4. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| Belotecan | Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I. Uses: Topoisomerase i inhibitors. Synonyms: Camtobell; CKD602; CKD 602; CKD-602; (4S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione. CAS No. 256411-32-2. Molecular formula: C25H27N3O4. Mole weight: 433.50. | |
| Belotecan | Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CKD-602 free base. CAS No. 256411-32-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-13566. | |
| Berberine | Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. Group: Inhibitors. Alternative Names: Berbericine. CAS No. 2086-83-1. Molecular formula: C20H18NO4. Mole weight: 336.37. Appearance: White to yellow crystals. Purity: 0.99. IUPACName: 16, 17-Dimethoxy-5, 7-dioxa-13-azoniapentacyclo[11.8.0.02, 10.04, 8.015, 20]henicosa-1(13), 2, 4(8), 9, 14, 16, 18, 20-octaene. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC5=C (C=C4CC3)OCO5)OC. Density: 1.2976 g/cm³. Catalog: ACM2086831. | |
| Berberine chloride | Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species ( ROS ) generation and inhibits DNA topoisomerase. Antineoplastic properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Natural Yellow 18 chloride. CAS No. 633-65-8. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-18258. | |
| Berberine chloride | Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Group: Inhibitors. Alternative Names: Berberine hydrochloride. CAS No. 633-65-8. Molecular formula: C20H18ClNO4. Mole weight: 371.8. Appearance: Solid. Purity: 95%+. Canonical SMILES: COC1=C (OC)C2=C[N+]3=C (C (C (CC3)=C4)=CC5=C4OCO5)C=C2C=C1. [Cl-]. Catalog: ACM633658. | |
| Berberine chloride hydrate | Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species ( ROS ) generation and inhibits DNA topoisomerase. Antineoplastic properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Natural Yellow 18 chloride hydrate. CAS No. 68030-18-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-17577. | |
| Berberine sulfate | Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species ( ROS ) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Natural Yellow 18 sulfate. CAS No. 633-66-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0716B. | |
| Berubicin | Berubicin has potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Synonyms: Daunorubicin Impurity 9; RTA 744; RTA-744; RTA744; WP 769; WP769; WP-769; 5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-. Grades: ≥95% by HPLC. CAS No. 677017-23-1. Molecular formula: C34H35NO11. Mole weight: 633.65. | |
| Bisantrene | Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1 [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CL216942. CAS No. 78186-34-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100875. | |
| Bisantrene | Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1. Group: Inhibitors. Alternative Names: Zantrene; 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone); ADAH; BISANTRENE HCL; 9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]; anthracene-9,10-dicarbaldehyde bis-imidazolidin-2-ylidenehydrazone; Orange Crush. CAS No. 78186-34-2. Molecular formula: C22H22N8. Mole weight: 398.47. Purity: 0.96. IUPACName: N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine. Density: 1.41g/cm³. Catalog: ACM78186342. | |
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