Dna Topoisomerase Suppliers USA
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Product | Description | |
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10-Hydroxy-11-methoxycamptothecin Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H18N2O6, Molecular Weight: 394.38. US Biological Life Sciences. | Worldwide |
10-Hydroxy-11-methoxycamptothecin-d3 Quick inquiry Where to buy Suppliers range | 10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H15D3N2O6, Molecular Weight: 397.4. US Biological Life Sciences. | Worldwide |
10-O-Acetyl SN-38-d3 Quick inquiry Where to buy Suppliers range | 10-O-Acetyl SN-38-d3 is the isotope labelled protected metabolite of Irinotecan (I767500), an DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 10-Acetyloxy-7-ethylcamptothecin-d3; (4S)-9-(Acetyloxy)-4, 11-diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 10-Hydroxy-7-ethylcamptothecin 10-Acetate-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
11-Desethyl Irinotecan Quick inquiry Where to buy Suppliers range | 11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500). Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-9-yl Ester [1,4'-Bipiperidine]-1'-carboxylic Acid; 1H-Pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline, [1,4'-Bipiperidine]-1'-carboxylic Acid deriv.; 10- [4- (1-Piperidino) -1-piperidinocarbonyloxy] camptothecin. Grades: Highly Purified. CAS No. 103816-16-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
1,4-Piperazinediethylamine Quick inquiry Where to buy Suppliers range | 1,4-Piperazinediethylamine is used as a reagent in the synthesis of bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors. Also used as a reagent in the synthesis of novel bisnaphthalimides as new DNA topoisomerase II inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6531-38-0. Pack Sizes: 100mg, 1g. Molecular Formula: C8H20N4. US Biological Life Sciences. | Worldwide |
1,4-Piperazinediethylamine-d8 Quick inquiry Where to buy Suppliers range | 1,4-Piperazinediethylamine-d8 is the isotope labelled analog of 1,4-Piperazinediethylamine (P480090); a reagent in the synthesis of bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors. Also used as a reagent in the synthesis of novel bisnaphthalimides as new DNA topoisomerase II inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C8H12D8N4, Molecular Weight: 180.32. US Biological Life Sciences. | Worldwide |
(1R, 6R)-2, 8-Diazabicyclo[4. 3. 0]nonane Quick inquiry Where to buy Suppliers range | (1R, 6R)-2, 8-Diazabicyclo[4. 3. 0]nonane is a chiral reagent used in the synthesis of pyrrolopyrimidine derivatives as dual DNA gyrase B and topoisomerase IV inhibitors and potential antibacterial agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 151213-42-2. Pack Sizes: 250mg, 1g. Molecular Formula: C7H14N2, Molecular Weight: 126.2. US Biological Life Sciences. | Worldwide |
20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin Quick inquiry Where to buy Suppliers range | 20-Desethyl-20-methyl-10-hydroxy-7-ethylcamptothecin is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H18N2O5. US Biological Life Sciences. | Worldwide |
2,?2-?Dimethyl-?4-?oxo-?7-?(phenylmethoxy)?-?4H-?1,?3-?benzodioxin-?5-?yl Ester 1,?1,?1-?Trifluoro-methanesulfonic Acid Quick inquiry Where to buy Suppliers range | 2,?2-?Dimethyl-?4-?oxo-?7-?(phenylmethoxy)?-?4H-?1,?3-?benzodioxin-?5-?yl Ester 1,?1,?1-?Trifluoro-methanesulfonic Acid is an intermediate in synthesizing Alternariol (A575760), an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Group: Biochemicals. Grades: Highly Purified. CAS No. 137571-75-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C18H15F3O7S. US Biological Life Sciences. | Worldwide |
2'',3''-Bis-O-(Dichloroacetyl) Etoposide Quick inquiry Where to buy Suppliers range | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide (E933750). Etoposide is a DNA topoisomerase II inhibitor. Etoposide is semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an Antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 260974-95-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C33H32Cl4O15, Molecular Weight: 810.41. US Biological Life Sciences. | Worldwide |
2'',3''-Bis-O-(Dichloroacetyl) Etoposide Quick inquiry Where to buy Suppliers range | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor. Etoposide is a semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Synonyms: 9-[[2,3-Bis-O-(2,2-dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 6-Acetate; (5R,5aR,8aR,9S)-9-[[2,3-Bis-O-(dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS No. 260974-95-6. Molecular formula: C33H32Cl4O15. Mole weight: 810.41. | |
2,3-Quinolinedimethanol Quick inquiry Where to buy Suppliers range | 2,3-Quinolinedimethanol is a reactant used in the synthesis of camptothecin (C175150), an ntitumor alkaloid which binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 57032-14-1. Pack Sizes: 100mg, 1g. Molecular Formula: C11H11NO2, Molecular Weight: 189.21. US Biological Life Sciences. | Worldwide |
2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide Quick inquiry Where to buy Suppliers range | 2-Hydroxy-2- (6'- (hydroxymethyl) -5'-oxo-3', 5', 8', 8a'-tetrahydro-2'H-spiro[[1, 3]dioxolane-2, 1'-indolizin]-7'-yl) -N- ( (S) -1-phenylethyl) propanamide is an intermediate in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor and also a derivative of Camptothecin (C175145), an antitumor alkaloid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H28N2O6. US Biological Life Sciences. | Worldwide |
(2R)-Amrubicin Quick inquiry Where to buy Suppliers range | Amrubicin, also known as SM-5887, is an anthracycline used in the treatment of lung cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. Uses: Antineoplastic agents. Synonyms: (7S-cis)-9-Acetyl-9-amino-7-[(2-deoxy-alpha-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione; 5,12-Naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-α-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S-cis)-; (1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2-deoxy-α-D-erythro-pentopyranoside. Grades: ≥95%. CAS No. 110267-81-7. Molecular formula: C25H25NO9. Mole weight: 483.47. | |
3,5-Di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofurano-1,4-lactone Quick inquiry Where to buy Suppliers range | 3,5-Di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-2-C-methyl-D-ribofurano-1,4-lactone is a potent chemotherapeutic agent utilized specifically for the successful management of various types of cancer. Its targeted therapeutic mechanism of action functions by significantly blocking the activity of topoisomerase I, a crucial enzyme critically required for DNA replication. This effective inhibition effectively halts the uncontrollable growth and division of malignant cell populations, thereby enabling the eventual eradication of cancerous cells in the body with significant efficacy. Synonyms: (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate). CAS No. 1294481-79-0. Molecular formula: C20H17Cl2FO6. Mole weight: 443.25. | |
3-O-β-D-Glucopyranosyl Alternariol-9-methyl Ether Quick inquiry Where to buy Suppliers range | 3-O-β-D-Glucopyranosyl Alternariol-9-methyl Ether is a derivative of Alternariol which is an alternaria mycotoxin and genotoxin, found in common edible crops. Alternariol inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Alternariol 3-Sulfate Ammonium Salt is currently suspected of being formed during metabolism in contaminated plants. Synonyms: Lysilactone A. CAS No. 1422465-59-5. Molecular formula: C21H22O10. Mole weight: 434.39. | |
4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one Quick inquiry Where to buy Suppliers range | 4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one is an intriguing organic compound that has been extensively researched in the biomedical industry. The compound displays remarkable potential as a DNA topoisomerase inhibitor, a crucial enzyme involved in DNA replication and cell growth. Its distinctive chemical structure is expected to revolutionize drug discovery and development for the treatment of various cancers and microbial infections. Synonyms: 4-amino-1-[2,3-O-(1-methylethylene)pentofuranosyl]-1,3,5-triazine-2(1H)-one. Grades: 98%. CAS No. 686300-58-3. Molecular formula: C11H16N4O5. Mole weight: 284.27. | |
4'-(O-Podophyllotoxin-9-oxy) Etoposide Quick inquiry Where to buy Suppliers range | 4'-(O-Podophyllotoxin-9-oxy) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor, as well as semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Molecular formula: C50H50O20. Mole weight: 970.92. | |
5-Hydroxy Topotecan Dihydrochloride Salt (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9, 12-trihydroxy-1H-Pyrano[3', 4': 6, 7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione Dihydrochloride Salt; 10-Hydroxy-9-[ (dimethylamino)methyl]-5-hydroxy- (20S, 5RS)-camptothecin Dihydrochloride Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
7-Methyl Camptothecin. Quick inquiry Where to buy Suppliers range | Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin. Grades: Highly Purified. CAS No. 78287-26-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
9-O-(6-O-Malonyl-β-D-glucopyranosyl) Alternariol Quick inquiry Where to buy Suppliers range | 9-O-(6-O-Malonyl-β-D-glucopyranosyl) Alternariol is a derivative of Alternariol which is an alternaria mycotoxin and genotoxin, found in common edible crops. Alternariol inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Alternariol 3- Sulfate Ammonium Salt is currently suspected of being formed during metabolism in contaminated plants. Synonyms: 9-O-(6-O-Malonyl-beta-D-glucopyranosyl) alternariol; 1779520-66-9. CAS No. 1779520-66-9. Molecular formula: C23H22O13. Mole weight: 506.41. | |
ABT-719 Quick inquiry Where to buy Suppliers range | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. Grades: 98%. CAS No. 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. | |
ABT-719 HCl Quick inquiry Where to buy Suppliers range | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. Grades: 98%. CAS No. 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. | |
Aclarubicin A Quick inquiry Where to buy Suppliers range | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. It intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. It has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation. It has been listed. Uses: Aclarubicin has potent antineoplastic activity. it is used in the treatment of cancer. it can induce histone eviction from chromatin upon intercalation. Synonyms: 11-Dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met;1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6;(1R,2R,4S)-methyl 4-(((2R,5S,6S)-4-(dimethylamino)-5-(((2S,4S,5S,6S)-4-hydroxy-6-methyl-5-(((2R,6S). Grades: ≥95%. CAS No. 57576-44-0. Molecular formula: C42H53NO15. Mole weight: 811.88. | |
Aclarubicin hydrochloride Quick inquiry Where to buy Suppliers range | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Uses: Antibiotics, antineoplastic. Synonyms: Aclacinon; Aclaplastin; Aclacinomycin A Hydrochloride; Aclarubicin HCl; Aclarubicina Clorhidrato [Spanish]. Grades: >98%. CAS No. 75443-99-1. Molecular formula: C42H54ClNO15. Mole weight: 848.33. | |
AEZS-108 Quick inquiry Where to buy Suppliers range | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grades: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
AJI-9561 Quick inquiry Where to buy Suppliers range | AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJ9561. It has cytotoxic activity with IC50 of 0.88 μmol/L and 1.63 μmol/L for Jorkat and P388 cells, respectively. Its mechanism of action is the same as that of UK-1, which can inhibit DNA topoisomerase U. Synonyms: (2,4'-Bibenzoxazole)-4-carboxylic acid, 2'-(2-hydroxy-6-methylphenyl)-. CAS No. 339300-34-4. Molecular formula: C22H14N2O5. Mole weight: 386.36. | |
Alalevonadifloxacin Quick inquiry Where to buy Suppliers range | Alalevonadifloxacin is a quinolone antibacterial. It is a DNA gyrase and DNA topoisomerase inhibitor. Alalevonadifloxacin is potentially useful to treat bacterial Gram-positive, Gram-negative and anaerobic infections. Phase II clinical trials for the treatment of Methicillin-resistant Staphylococcus aureus infections and Skin and soft tissue infections are on-going. Uses: Methicillin-resistant staphylococcus aureus infections; skin and soft tissue infections. Synonyms: WCK2349; WCK 2349; WCK-2349; (5S)-8-[4-(L-alanyloxy)piperidin-1-yl]-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. Grades: 98%. CAS No. 706809-20-3. Molecular formula: C22H26FN3O5. Mole weight: 431.46. | |
Alatrofloxacin Mesylate Quick inquiry Where to buy Suppliers range | Alatrofloxacin Mesylate is the mesylate salt form of the fluoroquinolone derivative Alatrofloxacin, a type II DNA topoisomerase inhibitor that has been developed as an antibacterial agent. Synonyms: L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, methanesulfonate (1:1); L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, monomethanesulfonate; L-Alaninamide, L-alanyl-N-[3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, (1α,5α,6α)-, monomethanesulfonate; Adrenochrome monoaminoguanidine mesilate; CP 116517; CP 116517-27; Trovan IV; Turvel IV; 7-((1R,5S,6s)-6-((S)-2-((S)-2-aminopropanamido)propanamido)-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1). Grades: ≥95%. CAS No. 146961-77-5. Molecular formula: C27H29F3N6O8S. Mole weight: 654.61. | |
Alternariol Quick inquiry Where to buy Suppliers range | An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Alternative Names: 3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one; NSC 638263. Grades: Highly Purified. CAS No. 641-38-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Alternariol 9-Methyl Ether 3-Sulfate Ammonium Salt Quick inquiry Where to buy Suppliers range | Alternariol 9-Methyl Ether 3-Sulfate Ammonium Salt is a derivative of Alternariol 9-Methyl Ether (A575770) which is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Grades: Highly Purified. CAS No. 1488351-25-2. Pack Sizes: 1mg. Molecular Formula: C15H12O8S(NH3), Molecular Weight: 352.321703. US Biological Life Sciences. | Worldwide |
Alternariol monomethyl ether Quick inquiry Where to buy Suppliers range | The 50 ppm acetonitrile solution of Alternariol monomethyl ether, shows activities as a cholinesterase inhibitor as well as an anti-fungal agent, could be commonly used as a standard solution. It is an alternaria mycotoxin and genotoxin, which can inhibit the activity of DNA-topoisomerases. Synonyms: 6H-Dibenzo[b,d]pyran-6-one, 3,7(3,9 or 7,9)-dihydroxy-9(7 or 3)-methoxy-1-methyl-; 3,7(3,9 or 7,9)-Dihydroxy-9(7 or 3)-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one; Alternariol, methyl ether. Grades: >95%. CAS No. 26894-49-5. Molecular formula: C15H12O5. Mole weight: 272.25. | |
Alternariol Monomethyl Ether Quick inquiry Where to buy Suppliers range | An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks. Group: Biochemicals. Alternative Names: 3,7(3,9 or 7,9)-Dihydroxy-9(7 or 3)-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one. Grades: Highly Purified. CAS No. 26894-49-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Alternariol Monomethyl Ether (9-O-Methylalternariol, Djalonensone, AME, BRN 0253553, 3,7-Dihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one) Quick inquiry Where to buy Suppliers range | Mycotoxin. Antifungal. Phytotoxic. Shown to possess DNA strand-breaking activity. Inhibits the activity of topoisomerase IIalpha (Topo IIalpha) in mammalian cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 26894-49-5. Pack Sizes: 500ug, 1mg, 5mg. US Biological Life Sciences. | Worldwide |
Ametantrone Quick inquiry Where to buy Suppliers range | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Synonyms: CI881; CI 881; CI-881; NSC196473; NSC 287513; NSC-196473; NSC 287513; 1, 4-bis[2- (2-hydroxyethylamino) ethylamino]anthracene-9, 10-dione. CAS No. 64862-96-0. Molecular formula: C22H28N4O4. Mole weight: 412.49. | |
Ametantrone Acetate Quick inquiry Where to buy Suppliers range | Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family. It can cause covalent cross-links in DNA, so it can be used as a antineoplastic agent. Uses: Antineoplastic agent. Synonyms: CI-881; CI 881; CI881; NSC 287513; NSC-287513; NSC287513; 1, 4-bis ( (2- ( (2-hydroxyethyl) amino) ethyl) amino) anthracene-9, 10-dione diacetate. Grades: 98%. CAS No. 70711-40-9. Molecular formula: C26H36N4O8. Mole weight: 532.59. | |
Amonafide Quick inquiry Where to buy Suppliers range | Amonafide is an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Uses: Antineoplastic agents. Synonyms: Nafidimide; Quinamed; Xanafide. Grades: 0.98. CAS No. 69408-81-7. Molecular formula: C16H17N3O2. Mole weight: 283.33. | |
Amonafide Quick inquiry Where to buy Suppliers range | Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent. Group: Biochemicals. Alternative Names: 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; FA 142; M-FA 142; MADE-FA 142; NCI 308847; NSC 308847; Nafidimide. Grades: Highly Purified. CAS No. 69408-81-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Amonafide L-malate Quick inquiry Where to buy Suppliers range | Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis. Synonyms: AS1413; AS 1413; AS-1413; XLS-001; XLS001; XLS001; Xanafide. CAS No. 618863-60-8. Molecular formula: C20H24N4O6. Mole weight: 416.43. | |
Amrubicin-13C3 Quick inquiry Where to buy Suppliers range | Synthetic anthracycline antibiotic; inhibits DNA topoisomerase II. Antineoplastic. Group: Biochemicals. Alternative Names: (7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy- β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione-13C3. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Amsacrine Quick inquiry Where to buy Suppliers range | Amsacrine is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. Synonyms: AMSA; m-AMSA; CI 880, CI880, CI-880; SN-11841; SN 11841; SN11841; acridinyl anisidide. Grades: >98%. CAS No. 51264-14-3. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
Amsacrine hydrochloride Quick inquiry Where to buy Suppliers range | Amsacrine hydrochloride is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. Uses: Antineoplastic agents. Synonyms: AMSA hydrochloride; m-AMSA hydrochloride; CI-880 hydrochloride; SN-11841 hydrochloride; CI 880 hydrochloride; SN 11841 hydrochloride; CI880 hydrochloride; SN11841 hydrochloride; acridinyl anisidide hydrochloride. Grades: >98%. CAS No. 54301-15-4. Molecular formula: C21H20ClN3O3S. Mole weight: 429.92. | |
Amsalog Quick inquiry Where to buy Suppliers range | Asulacrine isethionate is the isethionate salt of an amsacrine analogue with antineoplastic properties. Asulacrine inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis. Synonyms: Asulacrine isethionate; CI-921. CAS No. 80841-48-1. Molecular formula: C26H30N4O8S2. Mole weight: 590.67. | |
Annamycin Quick inquiry Where to buy Suppliers range | Annamycin liposomal is a liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. Liposomal annamycin is less toxic and shows improved antitumor activity compared to annamycin. Uses: Antibiotics, antineoplastic. Synonyms: 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; AR-522. CAS No. 92689-49-1. Molecular formula: C26H25IO11. Mole weight: 640.38. | |
Banoxantrone Quick inquiry Where to buy Suppliers range | Banoxantrone is a bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. Synonyms: AQ-4N; AZD-1689; AQ4N; AZD1689; AQ 4N; AZD 1689. CAS No. 136470-65-0. Molecular formula: C22H28N4O6. Mole weight: 444.48. | |
Banoxantrone dihydrochloride Quick inquiry Where to buy Suppliers range | Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and exhibits little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Uses: Antineoplastic agents. Synonyms: 2-[[4-[2-[dimethyl (oxido)azaniumyl]ethylamino]-5, 8-dihydroxy-9, 10-dioxoanthracen-1-yl]amino]-N, N-dimethylethanamine oxide;dihydrochloride; UNII-658876KMFP; Banoxantrone (dihydrochloride). CAS No. 252979-56-9. Molecular formula: C22H30Cl2N4O6. Mole weight: 517.4. | |
BAY 56-3722 Quick inquiry Where to buy Suppliers range | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
BAY 56-3722 hydrochloride Quick inquiry Where to buy Suppliers range | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
Becatecarin Quick inquiry Where to buy Suppliers range | Becatecarin is a synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. Synonyms: NSC 655649; BMS 181176; BMY 27557; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-. Grades: ≥95%. CAS No. 119673-08-4. Molecular formula: C33H34Cl2N4O7. Mole weight: 669.55. | |
Becatecarin (6-N-[2- (Diethylamino) ethyl]rebeccamycin, NSC 655649, BMY-27557-14, BMS-181176, XL119) Quick inquiry Where to buy Suppliers range | Antibiotic. Semisynthetic H2O-soluble derivative of rebeccamycin. Antitumor compound. Topoisomerase II (Topo II) inhibitor. DNA intercalating agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 119673-08-4. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
Belotecan Quick inquiry Where to buy Suppliers range | Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I. Uses: Topoisomerase i inhibitors. Synonyms: Camtobell; CKD602; CKD 602; CKD-602; (4S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione. CAS No. 256411-32-2. Molecular formula: C25H27N3O4. Mole weight: 433.50. | |
Berubicin Quick inquiry Where to buy Suppliers range | Berubicin has potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Synonyms: Daunorubicin Impurity 9; RTA 744; RTA-744; RTA744; WP 769; WP769; WP-769; 5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-. Grades: ≥95% by HPLC. CAS No. 677017-23-1. Molecular formula: C34H35NO11. Mole weight: 633.65. | |
Celiptium Quick inquiry Where to buy Suppliers range | Celiptium, also known as elliptinium acetate, a topoisomerase II inhibitor, is the acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. Uses: Antineoplastic agents. Synonyms: Ellipticine acetate; Elliptinium acetate; Celiptium; 9-HME; HME; NMHE; 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium acetate. Grades: 98%. CAS No. 58337-35-2. Molecular formula: C20H20N2O3. Mole weight: 336.39. | |
Chartreusin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces chartreusis. It has the activity of anti-gram-positive bacteria and mycobacterium. Chartreusin is an antitumour antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA; inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals; a potent inhibitor of topoisomerase II. Synonyms: Lambdamycin; Antibiotic X-465A; NSC 5159; (1R,2R,3aS,8aR)-1-[(Z)-5-hydroxy-3-(hydroxymethyl)pent-3-enyl]-1-(hydroxymethyl)-2,5-dimethyl-2,3,4,7,8,8a-hexahydroazulene-3a-carbaldehyde; 10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione. Grades: >99% by HPLC. CAS No. 6377-18-0. Molecular formula: C32H32O14. Mole weight: 640.59. | |
Chartreusin (Lambdamycin) Quick inquiry Where to buy Suppliers range | Antibiotic. Antitumor compound. Topoisomerase II inhibitor. Induces single-strand scission in DNA in the presence of reducing agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 6377-18-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Chartreusin (Lambdamycin, NSC 5159, Antibiotic 747, Antibiotic 1293, Antibiotic X465A, Antibiotic G 261A) Quick inquiry Where to buy Suppliers range | Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also potent inhibitor of topoisomerase II. Group: Biochemicals. Alternative Names: Lambdamycin, NSC 5159, Antibiotic 747, Antibiotic 1293, Antibiotic X465A, Antibiotic G 261A. Grades: Highly Purified. CAS No. 6377-18-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Chromomycin A3 Quick inquiry Where to buy Suppliers range | Chromomycin A3 is produced by the strain of Streptomyces olivochromogenes 69895. The major component of the chromomycin complex of the aureolic acid class; isolated from several streptomyces species; exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent; binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. Synonyms: Aburamycin; Toyomycin; NSC 58514; B 599-III; SR1768E. Grades: >98% by HPLC. CAS No. 7059-24-7. Molecular formula: C57H82O26. Mole weight: 1183.24. | |
Chromomycin A3 Quick inquiry Where to buy Suppliers range | Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumor agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA. Group: Biochemicals. Grades: Highly Purified. CAS No. 7059-24-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Chrysomycin A Quick inquiry Where to buy Suppliers range | Chrysomycin A is a C-glycoside antitumor antibiotic isolated from Streptomyces, and it is an inhibitor of the catalytic activity of human topoisomerase II. It has effective antibacterial, antifungal, antiviral and antitumor activities. It may act as a light-activated cross-linking agent between DNA and histones. Synonyms: Chrysomycin V; Virenomycin V; Albacarcin V. Grades: >99% by HPLC. CAS No. 82196-88-1. Molecular formula: C28H28O9. Mole weight: 508.51. | |
Chrysomycin A (Chrysomycin V, Virenomycin V) Quick inquiry Where to buy Suppliers range | Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 82196-88-1. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
Chrysomycin A (Chrysomycin V, Virenomycin V, Albacarcin V) Quick inquiry Where to buy Suppliers range | Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex, which is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated, crosslinkers of DNA to histones. Group: Biochemicals. Alternative Names: Chrysomycin V, Virenomycin V, Albacarcin V. Grades: Highly Purified. CAS No. 82196-88-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Chrysomycin B Quick inquiry Where to buy Suppliers range | Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor active substances isolated from Streptomyces. Its activity is lower than that of its vinyl analogue (Chrysomycin A), but it still has strong anti-tumor activity and is an inhibitor of the catalytic activity of human topoisomerase II. It can be used as a light-activated cross-linking agent for DNA and histones. Synonyms: Chrysomycin M; Virenomycin M; Albacarcin M. Grades: >98% by HPLC. CAS No. 83852-56-6. Molecular formula: C27H28O9. Mole weight: 496.50. | |
Chrysomycin B (Chrysomycin M, Virenomycin M) Quick inquiry Where to buy Suppliers range | Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines. Less potent than chrysomycin A. Group: Biochemicals. Grades: Highly Purified. CAS No. 83852-56-6. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
Chrysomycin B (Chrysomycin M, Virenomycin M, Albacarcin M) Quick inquiry Where to buy Suppliers range | Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones. Group: Biochemicals. Alternative Names: Chrysomycin M, Virenomycin M, Albacarcin M. Grades: Highly Purified. CAS No. 83852-56-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
CJ-12373 Quick inquiry Where to buy Suppliers range | CJ-12373 is produced by the strain of Penicillum sp. CL22557. It inhibits the superhelix and relaxation mediated by DNA gyrase, not form cracking intermediates, also inhibits the relaxation mediated by eukaryotic topoisomerase II. And it also has anti-Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus agalactiae, which are sensitive and resistant to ciprofloxacin. Molecular formula: C17H24O6. Mole weight: 324.37. | |
CKD 602 Quick inquiry Where to buy Suppliers range | CKD-602 is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Synonyms: (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione phosphate; Belotecan hydrochloride. Grades: ≥98% by HPLC. CAS No. 213819-48-8. Molecular formula: C25H27N3O4·H3PO4. Mole weight: 531.49. | |
Clinafloxacin Quick inquiry Where to buy Suppliers range | Clinafloxacin is a fluoroquinolone antibiotic with a broad-range of antibacterial activity. It inhibits both DNA gyrase and topoisomerase IV. Synonyms: 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grades: >98%. CAS No. 105956-97-6. Molecular formula: C17H17ClFN3O3. Mole weight: 365.79. | |
Clinafloxacin hydrochloride Quick inquiry Where to buy Suppliers range | Clinafloxacin hydrochloride is a novel fluoroquinolone antimicrobial agent as a potent intraphagocytic bactericidal agent. It displays broad-spectrum antibacterial activity against gram-negative, gram-positive and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase with IC50 value of 0.92 μg/ml and topoisomerase IV with IC50 value of 1.62 μg/ml. It has been studied for parenteral and oral administration in subjects with serious infections. Uses: Clinafloxacin hydrochloride is used as a potent intraphagocytic bactericidal agent. Synonyms: 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride;7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-keto-quinoline-3-carboxylic acid hydrochloride;7-(3-Azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-Carboxylic acid hydrochloride;3-Quinolinecarboxylic acid, 7-(3-aMino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride;CI-960 HCl;CI960 HCl. Grades: ≥99%. CAS No. 105956-99-8. Molecular formula: C17H18Cl2FN3O3. Mole weight: 402.25. | |
CP 115953 Quick inquiry Where to buy Suppliers range | CP 115953 is a Type II DNA topoisomerase inhibitor originated by Pfizer. CP 115953 inhibits topoisomerase II activity via an interaction with the enzyme and not by DNA unwinding. It can stimulate cytokine production by lymphocytes. Research for treatment of cancer was discontinued. Uses: Cancer. Synonyms: CP 115953; CP115953; CP-115953; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo-3-quinolinecarboxylic acid. Grades: 98%. CAS No. 136440-70-5. Molecular formula: C19H13F2NO4. Mole weight: 357.31. | |
CP 117227 Quick inquiry Where to buy Suppliers range | CP 117227, a dibenzocyclohepten derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in studies of anticancer. Synonyms: CP 117227; CP-117227; CP117227; 1-Piperazineethanol, 4-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)-alpha-((5-quinolinyloxy)methyl)-, (S)-. Grades: 98%. CAS No. 154531-78-9. Molecular formula: C31H33N3O2. Mole weight: 479.61. |