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| Product | Description | |
|---|---|---|
| Dovitinib | Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC 50 s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , CSF-1R , FGFR1/FGFR3 , VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ , respectively. Dovitinib has potent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258; TKI258. CAS No. 405169-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50905. |  |
| Dovitinib | Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Synonyms: Dovitinib, TKI258; TKI 258;TKI-258; CHIR 265; CHIR265; CHIR-265; RAF-265; RAF 265; RAF265. Grades: > 95%. CAS No. 405169-16-6. Molecular formula: C21H21FN6O. Mole weight: 392.429. |  |
| Dovitinib Dilactic Acid | Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Synonyms: Dovitinib Dilactic acid; TKI258 Dilactic acid; CHIR-258; CHIR 258; CHIR258; TKI258; TKI 258; TKI-258. Grades: >98%. CAS No. 852433-84-2. Molecular formula: C27H33FN6O7. Mole weight: 572.59. | |
| Dovitinib lactate | Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50 = 5 nM). Synonyms: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779. CAS No. 692737-80-7. Molecular formula: C24H27FN6O4. Mole weight: 482.51. | |
| Dovitinib lactate | Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , FGFR1/3 , VEGFR1/2/3 and PDGFRα/β , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258 lactate; TKI-258 lactate. CAS No. 692737-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10207. | |
| Dovitinib Lactate | Dovitinib is used in treating melanoma. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-Hydroxypropanoic Acid; CHIR 258; TKI 258. Grades: Highly Purified. CAS No. 692737-80-7. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Dovitinib Lactate Hydrate | Dovitinib lactate hydrate is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1). Grades: >98%. CAS No. 915769-50-5. Molecular formula: C24H29FN6O5. Mole weight: 500.52. | |
| N-Desmethyl Dovitinib | Dovitinib derivative; a benzimidazole quinolinone for inhibiting a checkpoint kinase 1 and its use in combination therapy for cancer. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(1-piperazinyl)-1H-benzimidazol-2-yl]-. Grades: Highly Purified. CAS No. 668432-44-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Dovitinib | Dovitinib derivative. Synonyms: 4-Amino-5-fluoro-3-[6-(1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone. Grades: > 95%. CAS No. 668432-44-8. Molecular formula: C20H19FN6O. Mole weight: 378.41. | |
| 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one | 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one. Group: Biochemicals. Alternative Names: Dovitinib. Grades: Highly Purified. CAS No. 405169-16-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H21FN6O. US Biological Life Sciences. | Worldwide |
| Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate | An impurity of Dovitinib, a potent VEGFR inhibitor exhibiting antitumor activity. Synonyms: ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate. CAS No. 402948-37-2. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
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