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| Product | Description | |
|---|---|---|
| EDANS | EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 1,5-EDANS. CAS No. 50402-56-7. Pack Sizes: 100 mg. Product ID: HY-D1080. |  |
| EDANS acid | EDANS acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(2-aminoethylamino)-1-naphthalene-*sulfonicaci. Product Category: Other Fluorophores. CAS No. 50402-56-7. Molecular formula: C12H14N2O3S. Mole weight: 266.32. Purity: 95%+. IUPACName: 5-(2-aminoethylamino)naphthalene-1-sulfonicacid. Canonical SMILES: C1=CC2=C(C=CC=C2S(=O)(=O)O)C(=C1)NCCN. Density: 1.432 ± 0.06 g/ml. Product ID: ACM50402567-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| EDANS sodium salt | EDANS sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-((2-Aminoethyl)aminophthalene-1-sulfonicacid,sodiumsalt. Product Category: Other Fluorophores. CAS No. 100900-07-0. Molecular formula: C12H13N2O3S. Mole weight: 288.3. Purity: 95%+. IUPACName: Sodium;5-(2-aminoethylamino)naphthalene-1-sulfonate. Canonical SMILES: C1=CC2=C(C=CC=C2S(=O)(=O)[O-])C(=C1)NCCN.[Na+]. Product ID: ACM100900070-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH trifluoroacetate salt | ?95% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 | Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme degrades extracellular matrix components and may promote the spread of tumor cells. High levels of active cathepsin D were found in senile plaques in the brains of Alzheimer's patients. Synonyms: L-α-Glutamine, N-acetyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-; N-Acetyl-L-α-glutamyl-N-{2-[(5-sulfo-1-naphthyl)amino]ethyl}-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-(4-{[4-(dimethylamino)phenyl]diazenyl}benzoyl)-L-lysyl-L-α-glutamine. Grade: ≥95%. CAS No. 400716-78-1. Molecular formula: C104H146N24O23S. Mole weight: 2132.52. |  |
| Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg | Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg, a fluorogenic (FRET) substrate for pro-memapsin-2, contains the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 μM and kcat = 0.24 min-1. Synonyms: Arg-Glu(EDANS)-(Asn670,Leu671)-APP770 (668-675)-Lys(DABCYL)-Arg; H-Arg-Glu(EDANS)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg-OH. Grade: 95%. CAS No. 310427-94-2. Molecular formula: C91H129N25O25S. Mole weight: 2005.22. | |
| DABCYL-[Asn670, Leu671]-Amyloid ?/A4 Precursor Protein 770 fragment 661-675?EDANS trifluoroacetate salt | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS | DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS, the fluorogenic HIV-1 protease substrate, consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), linked to the COOH- and NH2-terminal. The γ-abu spacer is inserted to avoid the potential steric hindrance of substrate binding by bulky acceptor. The FRET substrate is cleaved by the HIV-1 protease on the Tyr-Pro bond, resulting in increased fluorescence intensity in a time-dependent (excitation at 340 nm, emission at 490 nm). Synonyms: DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS. Grade: 95%. CAS No. 127134-13-8. Molecular formula: C73H97N17O18S. Mole weight: 1532.72. | |
| Dabcyl-KTSAVLQSGFRKME-Edans TFA | Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection[1][2][3]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2295. | |
| DABCYL-LPETG-EDANS | DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.). Uses: Scientific research. Group: Peptides. CAS No. 1807943-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5481. | |
| DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS | DABCYL-Lys-HCoV-SARS Replicase Polyprotein 1ab (3235-3246)-Glu-EDANS. Synonyms: DABCYL-Lys-pp1ab (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS); DABCYL-Lys-ORF1AB (3235-3246)-Glu-EDANS (Human coronavirus) (strain SARS). CAS No. 730985-86-1. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42. | |
| Fmoc-Asp(EDANS)-OH | Fmoc-Asp(EDANS)-OH. Synonyms: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N4-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-asparagine; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-[2-[(5-sulfonaphthalen-1-yl)amino]ethylamino]butanoic acid. Grade: ? 95%. CAS No. 182253-73-2. Molecular formula: C31H29N3O8S. Mole weight: 603.64. | |
| Fmoc-g-[ß-(5-naphthyl Sulfonic Acid)-ethylenediamine]-L-glutamic Acid (N-Fmoc-L-glu(edans)-OH) | A fluroescent probe. Group: Biochemicals. Alternative Names: N-Fmoc-L-glu(edans)-OH. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| H-Arg-lys(dabcyl)-thr-ser-gly-pro-asn-gln-glu-gln-glu(edans)-arg-oh | H-Arg-lys(dabcyl)-thr-ser-gly-pro-asn-gln-glu-gln-glu(edans)-arg-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-Arg-Lys(DABCYL)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(EDANS)-Arg-OH. Product Category: Heterocyclic Organic Compound. CAS No. 742080-61-1. Molecular formula: C83H121N27O25S. Product ID: ACM742080611. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Glu(EDANS)-Lys-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(DABCYL)-NH2 | H-Glu(EDANS)-Lys-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(DABCYL)-NH2 is a quenched fluorescent (FRET) substrate for ADAM 8, ADAM 15 and MDC-L (ADAM 28) but not for ADAM 17. For ADAM 8 half maximal cleavage was observed at 2.5 μM. Synonyms: L-Lysinamide, N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-lysyl-L-prolyl-L-alanyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-; 5-((2-((S)-4-amino-5-(((S)-6-amino-1-((S)-2-(((7S,10S,13S,16S,19S,22S,25S)-22-(4-aminobutyl)-16,19-dibenzyl-7-carbamoyl-1-(4-((E)-(4-(dimethylamino)phenyl)diazenyl)phenyl)-13-(3-guanidinopropyl)-10-isobutyl-1,9,12,15,18,21,24-heptaoxo-2,8,11,14,17,20,23-heptaazahexacosan-25-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-5-oxopentanamido)ethyl)amino)naphthalene-1-sulfonic acid. Grade: ≥95%. CAS No. 1926163-42-9. Molecular formula: C88H124N22O15S. Mole weight: 1762.12. | |
| H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH | H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (μ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site. Synonyms: N-({5-[(2-Aminoethyl)amino]-1-naphthyl}sulfonyl)-L-α-glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-arginyl-N6-(4-{[4-(dimethylamino)phenyl]diazenyl}benzoyl)-L-lysine. Grade: ≥95%. CAS No. 1914987-47-5. Molecular formula: C72H97N17O16S. Mole weight: 1488.71. | |
| Bacterial Sortase Substrate II | Bacterial Sortase Substrate II. Synonyms: Dabcyl-Gln-Ala-Leu-Pro-Glu-Thr-Gly-Glu-Glu-Edans. Mole weight: 1472.6. | |
| CovidyteTM ED450 | CovidyteTM ED450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 336, emission at 455 nm). Synonyms: EDANS-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(DABCYL)-Met-OH. Molecular formula: C82H125N23O22S2. Mole weight: 1849.14. | |
| CovidyteTM EN450 | CovidyteTM EN450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 350, emission at 460 nm). Synonyms: H-Lys(DABCYL)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42. | |
| CovidyteTM IF670 | CovidyteTM IF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and iFluorTM 670 as a fluorescent donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of iFluorTM 670 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the iFluorTM 670 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of iFluorTM 670 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. Compared to commonly used EDANS substrates, such as CovidyteTM ED450, the iFluorTM 670 substrate has stronger and longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 656, emission at 670 nm). Synonyms: H-Cys(iFluor 647)-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(TQ5)-Met-OH. Molecular formula: C58H105N19O19S2 + dye. Mole weight: 3068. | |
| CovidyteTM TF670 | CovidyteTM TF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and Tide FluorTM 5 (TF5) as a fluorescence donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of TF5 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the TF5 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of TF5 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. TQ5-TF5 pair has proved to be an extremely effective FRET pair for the development of FRET protease substrates. Compared to commonly used EDANS substrates, such as CovidyteTM EN450, the TF670 substrate has stronger, longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 640, emission at 680 nm). Synonyms: H-Lys(TQ5)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-Cys(TF5)-OH. Molecular formula: C71H121N21O22S2 + dye. Mole weight: 3620. | |
| Fluorogenic Human CMV Protease Substrate | Fluorogenic Human CMV Protease Substrate, the FRET substrate, is used to develop a fluorescence-based detection method for human cytomegalovirus proteinase. It specifically cleaves on the Ala-Ser bond, thereby removing the C-terminal peptide-Edans fragment from the proximity quenching effect of DABCYL groups. This represents the first fluorescence-based assay of the herpes virus protease and allows characterization of potential inhibitors. Synonyms: DABCYL-Arg-Gly-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-Ala-EDANS; N2-[4-[2-[4-(Dimethylamino)phenyl]diazenyl]benzoyl]-L-arginylglycyl-L-valyl-L-valyl-L-asparaginyl-L-alanyl-L-seryl-L-seryl-L-arginyl-L-leucyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-alaninamide. Grade: 95%. CAS No. 163265-38-1. Molecular formula: C73H109N23O18S. Mole weight: 1628.85. | |
| Fmoc-L-glutamic acid γ-[β-(5-naphthyl sulfonic acid)-ethylenediamine] ester | Fmoc-L-glutamic acid γ-[β-(5-naphthyl sulfonic acid)-ethylenediamine] ester. Synonyms: Fmoc-L-Glu(Edans)-OH; N-Fmoc-L-glu(edans)-OH; Fmoc-g-[alpha-(5-naphthyl Sulfonic Acid)-ethylenediamine]-L-glutamic Acid; N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-{2-[(5-sulfo-1-naphthyl)amino]ethyl}-L-glutamine; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-[2-[(5-sulfonaphthalen-1-yl)amino]ethylamino]pentanoic acid. Grade: ≥ 97% (HPLC). CAS No. 193475-66-0. Molecular formula: C32H31N3O8S. Mole weight: 617.68. | |
| Fmoc-L-glutamic acid g-[b-(5-naphthyl sulfonic acid)-ethylenediamine] ester | Fmoc-L-glutamic acid g-[b-(5-naphthyl sulfonic acid)-ethylenediamine] ester. Group: Biochemicals. Alternative Names: Fmoc-L-Glu(Edans)-OH. Grades: Highly Purified. CAS No. 193475-66-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
| Fmoc-Lys(Dabcyl)-OH | A modified lysine derivative for the preparation of chromogenically-labeled peptides by Fmoc SPPS. The Dabcyl group quenches the fluorescence of EDANS, Mca, TET, JOE, FAM fluorophores, making it an extremely useful tool for the synthesis of fluorescence-quenched peptide substrates. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Dabcyl)-OH. Product Category: Amino Acids. CAS No. 146998-27-8. Molecular formula: C36H37N5O5. Mole weight: 619.71. Product ID: ACM146998278-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| MMP Substrate III, Fluorogenic | A specific fluorogenic resonance energy transfer (FRET) peptide substrate with an MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencher combination. Group: Fluorescence/luminescence spectroscopy. | |
| N-(Aminoethyl)-5-naphthylamine-1-sulfonic acid sodium salt | N-(Aminoethyl)-5-naphthylamine-1-sulfonic acid sodium salt. Group: Biochemicals. Alternative Names: 5-[(2-Aminoethyl)amino]-1-naphthalenesulfonic acid monosodium salt; 1,5-EDANS, sodium salt. Grades: Highly Purified. CAS No. 100900-07-0. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C12H13N2NaO3S. US Biological Life Sciences. | Worldwide |
| N-(Aminoethyl)-8-naphthylamine-1-sulfonic acid | N-(Aminoethyl)-8-naphthylamine-1-sulfonic acid. Group: Biochemicals. Alternative Names: 1,8-EDANS. Grades: Highly Purified. CAS No. 50402-57-8. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C12H14N2O3S. US Biological Life Sciences. | Worldwide |
| N-(Aminoethyl)-8-naphthylamine-1-sulfonic acid sodium salt | N-(Aminoethyl)-8-naphthylamine-1-sulfonic acid sodium salt. Group: Biochemicals. Alternative Names: 1,8-EDANS sodium salt; 8-[(2-Aminoethyl)amino]-1-naphthalenesulfonic acid sodium salt. Grades: Highly Purified. CAS No. 185503-88-2. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C12H13N2NaO3S. US Biological Life Sciences. | Worldwide |
| N- (Methane thiosulfonyl ethyl carboxamidoethyl ) -5 -naphthylamine-1-sulfonic acid, sodium salt | N- (Methane thiosulfonyl ethyl carboxamidoethyl ) -5 -naphthylamine-1-sulfonic acid, sodium salt. Group: Biochemicals. Alternative Names: 5- [ [2- [ [3- [ (Methylsulfonyl) thio] -1-oxopropyl] amino] ethyl] amino] -1-naphthalenesulfonic acid monosodium salt; MTS-1,5-EDANS-carboxyethyl. Grades: Highly Purified. CAS No. 359436-83-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H19N2NaO6S3. US Biological Life Sciences. | Worldwide |
| N-(Methanethiosulfonylethylcarboxamidoethyl)-5-naphthylamine-1-sulfonic acid sodium salt | N-(Methanethiosulfonylethylcarboxamidoethyl)-5-naphthylamine-1-sulfonic acid sodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MTS-1,5-EDANS-CARBOXYETHYL;N-(METHANETHIOSULFONYLETHYLCARBOXAMIDOETHYL)-5-NAPHTHYLAMINE-1-SULFONIC ACID, SODIUM SALT. Product Category: Heterocyclic Organic Compound. Appearance: Dark Yellow Powder. CAS No. 359436-83-2. Molecular formula: C16H18NNaO6S3. Mole weight: 439.5. Product ID: ACM359436832. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID90404396. | |
| Renin Substrate 1 | A fluorogenic substrate for human renin. Upon cleavage by renin, the product (peptide-EDANS) emits fluorescence and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm. Synonyms: H-Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg-OH; L-Arginine, L-arginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-L-threonyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-. Grade: ≥95%. CAS No. 791068-69-4. Molecular formula: C109H156N32O21S. Mole weight: 2282.67. | |
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