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| Product | Description | |
|---|---|---|
| Ellipticine | Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE;5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE;5,11-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE;ELLIPTICINE;3-b)carbazole,5,11-dimethyl-6h-pyrido(;icig770;ELLIPTICINE, FOR FLUORESCENCE;ELLIPTICINE(RG). Product Category: Inhibitors. CAS No. 519-23-3. Molecular formula: C17H14N2. Mole weight: 246.31. Density: 1.257±0.06 g/cm³ (20 ºC 760 Torr). Product ID: ACM519233. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Ellipticine | Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 71795. CAS No. 519-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-15753. |  |
| ELLIPTICINE | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. Ellipticine was found to be an extremely promising anticancer drug. The planar polycyclic structure was found to interact with DNA through intercalation, exhibiting a high DNA binding affinity (10(6) M(-1)). The presence of protonatable ring nitrogens distinguished ellipticine from other simple intercalators. Both monocationic and uncharged species were found to be present under physiological conditions. The positive charge stabilized the binding of ellipticine to nucleic acids, while the more lipophilic uncharged compound was shown to readily penetrate membrane barriers. The structural nature of these compounds offers a plausible basis for the implication of multiple modes of action, including DNA binding, interactions with membrane barriers, oxidative bioactivation and modification of enzyme function; most notably that of topoisomerase II and telomerase. (Curr Med Chem Anticancer Agents. 2004 Mar;4(2):149-72). Synonyms: BRN 0221300; CCG-36483; CCRIS 2003; DB-052047; elliptecine; ellipticine; Elliptisine; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. Grade: 0.98. CAS No. 519-23-3. Molecular formula: C17H14N2. Mole weight: 246.31. |  |
| Ellipticine - CAS 519-23-3 | A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Group: Fluorescence/luminescence spectroscopy. |  |
| Ellipticine hydrochloride | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is a natural product isolated from the Australian evergreen tree of the Apocynaceae family. Synonyms: NSC 71795 hydrochloride; Ellipticine HCl; PZE. CAS No. 5081-48-1. Molecular formula: C17H15ClN2. Mole weight: 282.77. | |
| Ellipticine hydrochloride | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 71795 hydrochloride. CAS No. 5081-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15753A. | |
| Ellipticine (NSC 71795) | Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7uM. Group: Biochemicals. Alternative Names: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole, NSC 71795. Grades: Highly Purified. CAS No. 519-23-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H14N2, Molecular Weight: 246.3. US Biological Life Sciences. |  Worldwide |
| 9-Bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole | 9-Bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ellipticine,9-bromo; 9-bromoellipticine; 9-Brom-5,11-dimethyl-6H-pyrido<4.3-b>carbazol. Product Category: Heterocyclic Organic Compound. CAS No. 18073-34-2. Molecular formula: C17H13BrN2. Mole weight: 325.203 g/mol. Purity: 0.96. IUPACName: 9-bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole. Canonical SMILES: CC1=C2C(=C(C3=C1C=CN=C3)C)C4=C(N2)C=CC(=C4)Br. Density: 1.533g/cm³. Product ID: ACM18073342. Alfa Chemistry ISO 9001:2015 Certified. | |
| Celiptium | Celiptium, also known as elliptinium acetate, a topoisomerase II inhibitor, is the acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. Uses: Antineoplastic agents. Synonyms: Ellipticine acetate; Elliptinium acetate; Celiptium; 9-HME; HME; NMHE; 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium acetate. Grade: 98%. CAS No. 58337-35-2. Molecular formula: C20H20N2O3. Mole weight: 336.39. | |
| Datelliptium chloride | Datelliptium chloride, derived from ellipticine, is a DNA-intercalating agent with good activity in murine tumor models over a broad range of doses. Synonyms: 2-[2-(diethylamino)ethyl]-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol; chloride; 2-(diethylamino-2-ethyl)-9-hydroxyellipticinium; 2-DEHE; datelliptium chloride; detalliptinium; detalliptinium acetate salt; detalliptinium chloride; detalliptium acetate; diethylaminoethyl-2-OH-9-ellipticinium; NSC 311152; NSC 626718X; NSC-311152; SR 95156A; SR 95156B; SR-95156A. CAS No. 105118-14-7. Molecular formula: C23H28ClN3O. Mole weight: 397.94. | |
| Datelliptium chloride | Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. Uses: Scientific research. Group: Signaling pathways. CAS No. 105118-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00337. | |
| Datelliptium chloride hydrochloride | Datelliptium chloride hydrochloride, a DNA-intercalating agent derived from Ellipticine, is effective against a variety of mouse solid tumors in vivo. Synonyms: 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium chloride hydrochloride; 6H-Pyrido[4,3-b]carbazolium, 2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-, chloride, hydrochloride (1:1:1). Grade: ≥95%. CAS No. 157000-76-5. Molecular formula: C23H29Cl2N3O. Mole weight: 434.40. | |
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