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| Product | Description | |
|---|---|---|
| Enzalutamide | Enzalutamide. CAS No. 915087-33-1. Product ID: 8-05080. Molecular formula: C22H16F4O2S. Mole weight: 464.44. Properties: androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells; increases autophagy. |  |
| Enzalutamide | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM. It inhibits the activity of prostate cancer cell Ars, which over expressed in prostate cancer. Uses: Potential antineoplastic agent. Synonyms: MDV3100; MDV 3100; MDV-3100; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-; 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; S-Enzalutamide; Xtandi. Grades: >98%. CAS No. 915087-33-1. Molecular formula: C21H16F4N4O2S. Mole weight: 464.44. |  |
| Enzalutamide | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC 50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDV3100. CAS No. 915087-33-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-70002. |  |
| Enzalutamide Carboxylic Acid | Enzalutamide Carboxylic Acid is a metabolite of Enzalutamide. Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Synonyms: 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-benzoic Acid. CAS No. 1242137-15-0. Molecular formula: C20H13F4N3O3S. Mole weight: 451.4. | |
| Enzalutamide Impurity 1 | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N,N-dimethylbenzamide. Grades: > 95%. Molecular formula: C22H18F4N4O2S. Mole weight: 478.47. | |
| Enzalutamide Impurity 1 | Enzalutamide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid. CAS No. 1242137-15-0. Molecular formula: C20H13F4N3O3S. Mole weight: 451.39. Catalog: APB1242137150. |  |
| Enzalutamide Impurity 2 | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 3-Fluoro-4-methylphenylisothiocyanate. Grades: > 95%. CAS No. 143782-23-4. Molecular formula: C9H3F3N2S. Mole weight: 228.20. | |
| Enzalutamide impurity A | Enzalutamide impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-bromo-2-fluorobenzoic acid. CAS No. 112704-79-7. Molecular formula: C7H4BrFO2. Mole weight: 219.01. Catalog: APB112704797. | |
| Enzalutamide Impurity B | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-BroMo-2-fluoro-N-MethylbenzaMide. Grades: > 95%. CAS No. 749927-69-3. Molecular formula: C8H7BrFNO. Mole weight: 232.05. | |
| Enzalutamide Impurity C | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: Methyl 4-broMo-2-fluorobenzoate. Grades: > 95%. CAS No. 179232-29-2. Molecular formula: C8H6BrFO2. Mole weight: 233.04. | |
| Enzalutamide impurity J | Enzalutamide impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 1242137-18-3. Molecular formula: C21H16F4N4O3. Mole weight: 448.37. Catalog: APB1242137183. | |
| Enzalutamide impurity O | Enzalutamide impurity O. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide. CAS No. 1242137-16-1. Molecular formula: C20H14F4N4O2S. Mole weight: 450.41. Catalog: APB1242137161. | |
| Deutenzalutamide | Deutenzalutamide (Enzalutamide-d 3 ) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Enzalutamide-d3; MDV3100-d3. CAS No. 1443331-82-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70002S. | |
| N-Desmethyl Enzalutamide | N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors. Uses: The treatment of disorders involving androgen, estrogen and progesterone receptors. Synonyms: N-desmethylenzalutamide; 1242137-16-1; 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzamide; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide; Enzalutamide metabolite. CAS No. 1242137-16-1. Molecular formula: C20H14F4N4O2S. Mole weight: 450.412. | |
| Oxo-MDV 3100 (Oxo-enzalutamide) | Oxo-MDV 3100 (Oxo-enzalutamide). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 1242137-18-3. Pack Sizes: 10MG. IUPAC Name: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-2-fluoro-N-methyl-benzamide. Molecular formula: C21H16F4N4O3. Mole weight: 448.37. Catalog: APS1242137183. SMILES: CNC(=O)c1ccc(cc1F)N2C(=O)N(C(=O)C2(C)C)c3ccc(C#N)c(c3)C(F)(F)F. Format: Neat. Shipping: Room Temperature. | |
| 2-((4-(tert-Butoxycarbonyl)-3-fluorophenyl)amino)-2-methylpropanoic Acid | 2-((4-(tert-Butoxycarbonyl)-3-fluorophenyl)amino)-2-methylpropanoic Acid is an intermediate in the synthesis of Enzalutamide Carboxylic Acid (E559800). Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C15H20FNO4. US Biological Life Sciences. |  Worldwide |
| 4-Bromo-2-fluorobenzoic acid | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-bromo-2-fluorobenzoic acid. Grades: > 95 %. CAS No. 112704-79-7. Molecular formula: C7H4BrFO2. Mole weight: 219.01. | |
| ARCC-4 | ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. It inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Synonyms: ARCC-4; 1973403-00-7; (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CHEMBL4540528; SCHEMBL17946930; DUPAJELXESPTNF-PPZGWQTASA-N; AKOS040741162; MS-31874; HY-130492; CS-0108331; EN300-7526556; Z3482428589; O1-(ABM-14 ether), O4-(Methylcarboxamide with AHPC) Butanediol; (2S,4R)-1-[(2S)-2-(2-{4-[(4'-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-[1,1'-biphenyl]-4-yl)oxy]butoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide. Grades: 99%. CAS No. 1973403-00-7. Molecular formula: C53H56F3N7O7S2. Mole weight: 1024.18. | |
| AU-15330 | AU-15330 is highly specific and VHL-dependent PROTAC degrader of the SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1). It induces effective inhibition of tumour growth in xenograft models of prostate cancer and acts synergistically with enzalutamide, an AR antagonist. It induces disease remission in castration-resistant prostate cancer (CRPC) models and is nontoxic. Synonyms: AU 15330; AU15330; (2S,4R)-1-((S)-2-(2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 2380274-50-8. Molecular formula: C39H49N9O5S. Mole weight: 755.93. | |
| Bavdegalutamide | Bavdegalutamide, also known as ARV-110, effectively targets the wild type Androgen Receptor (AR) and certain genomic alterations of the AR (amplification, T878A, H875Y, F877L, M895V, but not L702H or AR-V7) for degradation in both enzalutamide sensitive and resistant preclinical models. ARV-110 showed promising anti-tumor activity in heavily pretreated men with metastatic castration-resistant prostate cancer (mCRPC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ARV-110; ARV 110; ARV110; Bavdegalutamide. Product Category: Others. Appearance: Solid powder. CAS No. 2222112-77-6. Molecular formula: C41H43ClFN9O6. Mole weight: 812.3. Purity: >98%. IUPACName: N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide. Canonical SMILES: ClC1=CC(O[C@H]2CC[C@@H](CC2)NC(C3=CC=C(N=N3)N4CCC(CC4)CN5CCN(CC5)C6=CC(C(N7C8CCC(NC8=O)=O)=O)=C(C=C6F)C7=O)=O)=CC=C1C#N. Product ID: ACM2222112776. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GA32 | GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC 50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1386811-71-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163340. | |
| Ketodarolutamide | Ketodarolutamide., also known as ORM-15341 and BAY-1896953, is a potent and full antagonist for human AR (hAR) with IC50=38 nM. Ketodarolutamide is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of darolutamide (ODM-201, BAY-1841788), an NSAA which is used in the treatment of prostate cancer in men. Similarly to its parent compound, darolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-1896953; BAY 1896953; BAY1896953; ORM-15341; ORM 15341; ORM15341; Ketodarolutamide. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1297537-33-7. Molecular formula: C19H17ClN6O2. Mole weight: 396.84. Purity: >98%. IUPACName: (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide. Canonical SMILES: ClC1=C(C#N)C=CC(C2=NN(C[C@H](C)NC(C3=NNC(C(C)=O)=C3)=O)C=C2)=C1. Product ID: ACM1297537337. Alfa Chemistry ISO 9001:2015 Certified. | |
| LX1 | LX1 is an anti-prostate cancer compound that targets androgen receptor ( AR ), AR variants and steroidogenic enzyme AKR1C3. LX1 inhibits the enzymatic activity of AKR1C3 , reduces the conversion of androstenedione to testosterone and reduces the expression of AR and AR-V7 and downregulates their target genes. LX1 overcomes the resistance of tumor cells to Enzalutamide (HY-70002), and the combination with Enzalutamide (HY-70002) further inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2647877-84-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163940. | |
| MDV 3100 | MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer. Group: Biochemicals. Alternative Names: 4-[3-[4-Cyano-3- (trifluoromethyl) phenyl]-5, 5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; MDV3100; MDV-3100; Enzalutamide. Grades: Highly Purified. CAS No. 915087-33-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C21H16F4N4O2S, Molecular Weight: 464.44. US Biological Life Sciences. | Worldwide |
| ODM-201 | ODM-201 is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Synonyms: ODM-201; ODM 201; ODM201. Grades: 98%. CAS No. 1297538-32-9. Molecular formula: C19H19ClN6O2. Mole weight: 389.85. | |
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