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| Product | Description | |
|---|---|---|
| Enzalutamide | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM. It inhibits the activity of prostate cancer cell Ars, which over expressed in prostate cancer. Uses: Potential antineoplastic agent. Synonyms: MDV3100; MDV 3100; MDV-3100; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-; 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; S-Enzalutamide; Xtandi. Grades: >98%. CAS No. 915087-33-1. Molecular formula: C21H16F4N4O2S. Mole weight: 464.44. |  |
| Enzalutamide | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC 50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDV3100. CAS No. 915087-33-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-70002. |  |
| Enzalutamide | Enzalutamide/Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. Group: Fluorinated apis. Alternative Names: MDV3100. CAS No. 915087-33-1. Molecular formula: C21H16F4N4O2S. Mole weight: 464.43. Appearance: White solid powder. Purity: 0.97. IUPACName: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide. Catalog: OFC915087331. |  |
| Enzalutamide Carboxylic Acid | Enzalutamide Carboxylic Acid is a metabolite of Enzalutamide. Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Synonyms: 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-benzoic Acid. CAS No. 1242137-15-0. Molecular formula: C20H13F4N3O3S. Mole weight: 451.4. | |
| Enzalutamide Impurity 1 | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N,N-dimethylbenzamide. Grades: > 95%. Molecular formula: C22H18F4N4O2S. Mole weight: 478.47. | |
| Enzalutamide Impurity 1 | Enzalutamide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid. CAS No. 1242137-15-0. Molecular Formula: C20H13F4N3O3S. Mole Weight: 451.39. Catalog: APB1242137150. |  |
| Enzalutamide Impurity 2 | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 3-Fluoro-4-methylphenylisothiocyanate. Grades: > 95%. CAS No. 143782-23-4. Molecular formula: C9H3F3N2S. Mole weight: 228.20. | |
| Enzalutamide Impurity 2 | Enzalutamide Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(4-cyano-3-(trifluoromethyl)phenyl)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide. Molecular Formula: C28H16F7N5O2S. Mole Weight: 619.51. Catalog: APB05309. | |
| Enzalutamide Impurity 28 | Enzalutamide Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: O-ethyl (4-cyano-3- (trifluoromethyl) phenyl) carbamothioate. CAS No. 2088914-59-2. Molecular Formula: C11H9F3N2OS. Mole Weight: 274.26. Catalog: APB2088914592. | |
| Enzalutamide Impurity 29 | Enzalutamide Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)thioureido)-2-fluoro-N-methylbenzamide. CAS No. 1798807-39-2. Molecular Formula: C17H12F4N4OS. Mole Weight: 396.36. Catalog: APB1798807392. | |
| Enzalutamide Impurity 3 | Enzalutamide Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: O-methyl (4-cyano-3- (trifluoromethyl) phenyl) carbamothioate. CAS No. 1895865-10-7. Molecular Formula: C10H7F3N2OS. Mole Weight: 260.24. Catalog: APB1895865107. | |
| Enzalutamide Impurity 31 | Enzalutamide Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((1-((4-cyano-3-(trifluoromethyl)phenyl)amino)-2-methyl-1-oxopropan-2-yl)amino)-2-fluoro-N-methylbenzamide. CAS No. 1289942-55-7. Molecular Formula: C20H18F4N4O2. Mole Weight: 422.14. Catalog: APB1289942557. | |
| Enzalutamide Impurity 32 | Enzalutamide Impurity 32. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,2,3-tris(4-cyano-3-(trifluoromethyl)phenyl)guanidine. Molecular Formula: C25H11F9N6. Mole Weight: 566.09. Catalog: APB05306. | |
| Enzalutamide Impurity 33 | Enzalutamide Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: phenyl 2-amino-2-methylpropanoate. CAS No. 177960-04-2. Molecular Formula: C10H13NO2. Mole Weight: 179.09. Catalog: APB177960042. | |
| Enzalutamide Impurity 34 | Enzalutamide Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate. Molecular Formula: C13H17FN2O3. Mole Weight: 268.28. Catalog: APB05305. | |
| Enzalutamide Impurity 35 | Enzalutamide Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl (4-cyano-3-(trifluoromethyl)phenyl)carbamate. Molecular Formula: C10H7F3N2O2. Mole Weight: 244.17. Catalog: APB05304. | |
| Enzalutamide Impurity 36 | Enzalutamide Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-N-methyl-2-(methylamino)benzamide. Molecular Formula: C22H20F3N5O2S. Mole Weight: 475.49. Catalog: APB05303. | |
| Enzalutamide Impurity 37 | Enzalutamide Impurity 37. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-isothiocyanato-2-(trifluoromethyl)benzonitrile. Molecular Formula: C9H3F3N2S. Mole Weight: 228.19. Catalog: APB05302. | |
| Enzalutamide Impurity 39 | Enzalutamide Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-methyl N, N'-bis (4-cyano-3- (trifluoromethyl) phenyl) carbamimidate. Molecular Formula: C18H10F6N4O. Mole Weight: 412.29. Catalog: APB05301. | |
| Enzalutamide Impurity 4 | Enzalutamide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzoate. Molecular Formula: C21H16F3N3O3S. Mole Weight: 447.43. Catalog: APB05308. | |
| Enzalutamide Impurity 40 | Enzalutamide Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-bromo-2-fluorobenzamide. Molecular Formula: C7H5BrFNO. Mole Weight: 218.02. Catalog: APB05300. | |
| Enzalutamide Impurity 41 | Enzalutamide Impurity 41. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((3-hydroxy-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid. Molecular Formula: C12H16N2O4. Mole Weight: 252.27. Catalog: APB05298. | |
| Enzalutamide Impurity 42 | Enzalutamide Impurity 42. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-fluoro-N-methylbenzamide. Molecular Formula: C8H8FNO. Mole Weight: 153.15. Catalog: APB05299. | |
| Enzalutamide Impurity 43 | Enzalutamide Impurity 43. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: benzyl 2-methyl-2- ( (4- (methylcarbamoyl) phenyl) amino) propanoate. Molecular Formula: C19H22N2O3. Mole Weight: 326.39. Catalog: APB05297. | |
| Enzalutamide Impurity 44 | Enzalutamide Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-bromo-N-methyl-2-(methylamino)benzamide. Molecular Formula: C9H11BrN2O. Mole Weight: 243.1. Catalog: APB05296. | |
| Enzalutamide Impurity 45 | Enzalutamide Impurity 45. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: benzyl 2-(benzyl(3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate. Molecular Formula: C26H27FN2O3. Mole Weight: 434.5. Catalog: APB05433. | |
| Enzalutamide Impurity 46 | Enzalutamide Impurity 46. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: O-benzyl (4-cyano-3- (trifluoromethyl) phenyl) carbamothioate. Molecular Formula: C16H11F3N2OS. Mole Weight: 336.33. Catalog: APB05432. | |
| Enzalutamide Impurity 47 | Enzalutamide Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-methyl-2,4-bis(methylamino)benzamide. Molecular Formula: C10H15N3O. Mole Weight: 193.25. Catalog: APB05431. | |
| Enzalutamide Impurity 48 | Enzalutamide Impurity 48. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,2'-((4-(methylcarbamoyl)-1,3-phenylene)bis(azanediyl))bis(2-methylpropanoic acid). Molecular Formula: C16H23N3O5. Mole Weight: 337.37. Catalog: APB05430. | |
| Enzalutamide Impurity 49 | Enzalutamide Impurity 49. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-benzyl-N-ethyl-N-isopropylpropan-2-aminium bromide. Molecular Formula: C15H26BrN. Mole Weight: 300.28. Catalog: APB05428. | |
| Enzalutamide Impurity 5 | Enzalutamide Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzoic acid. Molecular Formula: C20H14F3N3O3S. Mole Weight: 433.4. Catalog: APB05307. | |
| Enzalutamide Impurity 50 | Enzalutamide Impurity 50. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-carbamoyl-3-fluorophenyl)amino)-2-methylpropanoic acid. Molecular Formula: C11H13FN2O3. Mole Weight: 240.23. Catalog: APB05429. | |
| Enzalutamide Impurity 51 | Enzalutamide Impurity 51. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluorobenzoic acid. Molecular Formula: C20H13F4N3O4. Mole Weight: 435.33. Catalog: APB05427. | |
| Enzalutamide Impurity 52 | Enzalutamide Impurity 52. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((5-bromo-2-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid. Molecular Formula: C12H15BrN2O3. Mole Weight: 315.16. Catalog: APB05426. | |
| Enzalutamide Impurity 53 | Enzalutamide Impurity 53. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: O-isopropyl (4-cyano-3- (trifluoromethyl) phenyl) carbamothioate. Molecular Formula: C12H11F3N2OS. Mole Weight: 288.29. Catalog: APB05425. | |
| Enzalutamide Impurity 6 | Enzalutamide Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,3-bis(4-cyano-3-(trifluoromethyl)phenyl)thiourea. CAS No. 1839619-50-9. Molecular Formula: C17H8F6N4S. Mole Weight: 414.33. Catalog: APB1839619509. | |
| Enzalutamide Impurity 7 | Enzalutamide Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,3-bis(4-cyano-3-(trifluoromethyl)phenyl)urea. CAS No. 1895865-11-8. Molecular Formula: C17H8F6N4O. Mole Weight: 398.26. Catalog: APB1895865118. | |
| Enzalutamide impurity A | Enzalutamide impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-bromo-2-fluorobenzoic acid. CAS No. 112704-79-7. Molecular Formula: C7H4BrFO2. Mole Weight: 219.01. Catalog: APB112704797. | |
| Enzalutamide impurity B | Enzalutamide impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-bromo-2-fluoro-N-methylbenzamide. CAS No. 749927-69-3. Molecular Formula: C8H7BrFNO. Mole Weight: 232.05. Catalog: APB749927693. | |
| Enzalutamide Impurity B | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-BroMo-2-fluoro-N-MethylbenzaMide. Grades: > 95%. CAS No. 749927-69-3. Molecular formula: C8H7BrFNO. Mole weight: 232.05. | |
| Enzalutamide impurity C | Enzalutamide impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 4-bromo-2-fluorobenzoate. CAS No. 179232-29-2. Molecular Formula: C8H6BrFO2. Mole Weight: 233.03. Catalog: APB179232292. | |
| Enzalutamide Impurity C | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: Methyl 4-broMo-2-fluorobenzoate. Grades: > 95%. CAS No. 179232-29-2. Molecular formula: C8H6BrFO2. Mole weight: 233.04. | |
| Enzalutamide impurity D | Enzalutamide impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((2-carboxypropan-2-yl)amino)-2-fluorobenzoic acid. Molecular Formula: C11H12FNO4. Mole Weight: 241.22. Catalog: APB05321. | |
| Enzalutamide impurity DS | Enzalutamide impurity DS. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4,4'-(hydrazine-1,2-diyl)bis(2-fluoro-N-methylbenzamide). Molecular Formula: C16H16F2N4O2. Mole Weight: 334.32. Catalog: APB05312. | |
| Enzalutamide impurity DZ | Enzalutamide impurity DZ. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-4,4'-(diazene-1,2-diyl)bis(2-fluoro-N-methylbenzamide). Molecular Formula: C16H14F2N4O2. Mole Weight: 332.3. Catalog: APB05310. | |
| Enzalutamide impurity E | Enzalutamide impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate. Molecular Formula: C13H16FNO4. Mole Weight: 269.27. Catalog: APB05320. | |
| Enzalutamide impurity F | Enzalutamide impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoate. Molecular Formula: C21H15F4N3O3S. Mole Weight: 465.42. Catalog: APB05319. | |
| Enzalutamide impurity G | Enzalutamide impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-methyl-2- ( (4- (methylcarbamoyl) phenyl) amino) propanoic acid. Molecular Formula: C12H16N2O3. Mole Weight: 236.27. Catalog: APB05318. | |
| Enzalutamide impurity H | Enzalutamide impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 2-methyl-2- ( (4- (methylcarbamoyl) phenyl) amino) propanoate. Molecular Formula: C13H18N2O3. Mole Weight: 250.29. Catalog: APB05317. | |
| Enzalutamide impurity I | Enzalutamide impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-N-methylbenzamide. CAS No. 915087-16-0. Molecular Formula: C21H17F3N4O2S. Mole Weight: 446.45. Catalog: APB915087160. | |
| Enzalutamide impurity J | Enzalutamide impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 1242137-18-3. Molecular Formula: C21H16F4N4O3. Mole Weight: 448.37. Catalog: APB1242137183. | |
| Enzalutamide impurity K | Enzalutamide impurity K. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-carbamoyl-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid. Molecular Formula: C20H15F4N3O4S. Mole Weight: 469.41. Catalog: APB05315. | |
| Enzalutamide Impurity L | Enzalutamide Impurity L. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-carbamoyl-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 2030242-21-6. Molecular Formula: C21H18F4N4O3S. Mole Weight: 482.45. Catalog: APB2030242216. | |
| Enzalutamide impurity M | Enzalutamide impurity M. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 915087-33-1. Molecular Formula: C21H16F4N4O2S. Mole Weight: 464.09. Catalog: APB915087331. | |
| Enzalutamide impurity N | Enzalutamide impurity N. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid. Molecular Formula: C12H15FN2O3. Mole Weight: 254.11. Catalog: APB05316. | |
| Enzalutamide impurity NO | Enzalutamide impurity NO. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-1,2-bis(3-fluoro-4-(methylcarbamoyl)phenyl)diazene oxide. Molecular Formula: C16H14F2N4O3. Mole Weight: 348.3. Catalog: APB05311. | |
| Enzalutamide impurity O | Enzalutamide impurity O. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide. CAS No. 1242137-16-1. Molecular Formula: C20H14F4N4O2S. Mole Weight: 450.41. Catalog: APB1242137161. | |
| Enzalutamide Open-loop impurity | Enzalutamide Open-loop impurity. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile. Molecular Formula: C30H18F6N6O2S2. Mole Weight: 672.62. Catalog: APB05314. | |
| Enzalutamide PO | Enzalutamide PO. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroperoxy-5,5-dimethyl-4-oxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. Molecular Formula: C21H18F4N4O4. Mole Weight: 466.39. Catalog: APB05313. | |
| Deutenzalutamide | Deutenzalutamide (Enzalutamide-d 3 ) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Enzalutamide-d3; MDV3100-d3. CAS No. 1443331-82-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70002S. | |
| N-Desmethyl Enzalutamide | N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors. Uses: The treatment of disorders involving androgen, estrogen and progesterone receptors. Synonyms: N-desmethylenzalutamide; 1242137-16-1; 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzamide; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide; Enzalutamide metabolite. CAS No. 1242137-16-1. Molecular formula: C20H14F4N4O2S. Mole weight: 450.412. | |
| Oxo-MDV 3100 (Oxo-enzalutamide) | Oxo-MDV 3100 (Oxo-enzalutamide). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide. CAS No. 1242137-18-3. Pack Sizes: 10MG. IUPAC Name: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-2-fluoro-N-methyl-benzamide. Molecular Formula: C21H16F4N4O3. Mole Weight: 448.37. Catalog: APS1242137183. SMILES: CNC (=O)c1ccc (cc1F)N2C (=O)N (C (=O)C2 (C)C)c3ccc (C#N)c (c3)C (F) (F)F. Format: Neat. Shipping: Room Temperature. | |
| 2-((4-(tert-Butoxycarbonyl)-3-fluorophenyl)amino)-2-methylpropanoic Acid | 2-((4-(tert-Butoxycarbonyl)-3-fluorophenyl)amino)-2-methylpropanoic Acid is an intermediate in the synthesis of Enzalutamide Carboxylic Acid (E559800). Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C15H20FNO4. US Biological Life Sciences. |  Worldwide |
| 4-Bromo-2-fluorobenzoic acid | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-bromo-2-fluorobenzoic acid. Grades: > 95 %. CAS No. 112704-79-7. Molecular formula: C7H4BrFO2. Mole weight: 219.01. | |
| ARCC-4 | ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. It inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Synonyms: ARCC-4; 1973403-00-7; (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CHEMBL4540528; SCHEMBL17946930; DUPAJELXESPTNF-PPZGWQTASA-N; AKOS040741162; MS-31874; HY-130492; CS-0108331; EN300-7526556; Z3482428589; O1-(ABM-14 ether), O4-(Methylcarboxamide with AHPC) Butanediol; (2S,4R)-1-[(2S)-2-(2-{4-[(4'-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-[1,1'-biphenyl]-4-yl)oxy]butoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide. Grades: 99%. CAS No. 1973403-00-7. Molecular formula: C53H56F3N7O7S2. Mole weight: 1024.18. | |
| AU-15330 | AU-15330 is highly specific and VHL-dependent PROTAC degrader of the SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1). It induces effective inhibition of tumour growth in xenograft models of prostate cancer and acts synergistically with enzalutamide, an AR antagonist. It induces disease remission in castration-resistant prostate cancer (CRPC) models and is nontoxic. Synonyms: AU 15330; AU15330; (2S,4R)-1-((S)-2-(2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 2380274-50-8. Molecular formula: C39H49N9O5S. Mole weight: 755.93. | |
| Bavdegalutamide | Bavdegalutamide, also known as ARV-110, effectively targets the wild type Androgen Receptor (AR) and certain genomic alterations of the AR (amplification, T878A, H875Y, F877L, M895V, but not L702H or AR-V7) for degradation in both enzalutamide sensitive and resistant preclinical models. ARV-110 showed promising anti-tumor activity in heavily pretreated men with metastatic castration-resistant prostate cancer (mCRPC). Group: Others. Alternative Names: ARV-110; ARV 110; ARV110; Bavdegalutamide. CAS No. 2222112-77-6. Molecular formula: C41H43ClFN9O6. Mole weight: 812.3. Appearance: Solid powder. Purity: >98%. IUPACName: N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide. Canonical SMILES: ClC1=CC (O[C@H]2CC[C@@H] (CC2)NC (C3=CC=C (N=N3)N4CCC (CC4)CN5CCN (CC5)C6=CC (C (N7C8CCC (NC8=O)=O)=O)=C (C=C6F)C7=O)=O)=CC=C1C#N. Catalog: ACM2222112776. | |
| GA32 | GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC 50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1386811-71-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163340. | |
| Ketodarolutamide | Ketodarolutamide., also known as ORM-15341 and BAY-1896953, is a potent and full antagonist for human AR (hAR) with IC50 = 38 nM. Ketodarolutamide is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of darolutamide (ODM-201, BAY-1841788), an NSAA which is used in the treatment of prostate cancer in men. Similarly to its parent compound, darolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives. Group: Antagonists. Alternative Names: BAY-1896953; BAY 1896953; BAY1896953; ORM-15341; ORM 15341; ORM15341; Ketodarolutamide. CAS No. 1297537-33-7. Molecular formula: C19H17ClN6O2. Mole weight: 396.84. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide. Canonical SMILES: ClC1=C (C#N)C=CC (C2=NN (C[C@H] (C)NC (C3=NNC (C (C)=O)=C3)=O)C=C2)=C1. Catalog: ACM1297537337. | |
| LX1 | LX1 is an anti-prostate cancer compound that targets androgen receptor ( AR ), AR variants and steroidogenic enzyme AKR1C3. LX1 inhibits the enzymatic activity of AKR1C3 , reduces the conversion of androstenedione to testosterone and reduces the expression of AR and AR-V7 and downregulates their target genes. LX1 overcomes the resistance of tumor cells to Enzalutamide (HY-70002), and the combination with Enzalutamide (HY-70002) further inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2647877-84-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163940. | |
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