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Product | Description | |
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3-Chloro-L-tyrosine Quick inquiry Where to buy Suppliers range | 3-Chloro-L-tyrosine was used in the enzymatic synthesis of halogen derivatives of aromatic amino acids labeled with hydrogen isotope. 3-Chloro-L-tyrosine exhibited stronger antioxidant properties in Hb-induced oxidative stress as was evident by higher efficiency of reduction of ferryl species. Synonyms: 3-Chloro-L-Tyr-OH; 3-Chloro-4-hydroxy-L-phenylalanine; 3-Chlorotyrosine; 3-Cl-Tyr-OH; (S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; (2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; CLY; H-Tyr(3-Cl)-OH. Grades: ≥ 99% (HPLC). CAS No. 7423-93-0. Molecular formula: C9H10NO3Cl. Mole weight: 215.63. | |
Acifran Quick inquiry Where to buy Suppliers range | Acifran is a nicotinic acid receptor agonist with hypolipidemic effects, which shows higher potency than nicotinic acid and clofibrate. It is a potent and full agonist at the human orphan GPCR HM74A/GPR109A and GPR109B. It reduces circulating LDL-cholesterol and serum triglycerides in vivo without affecting liver enzymes or liver weight. Synonyms: AY 25712; AY-25712; AY25712; 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid; (±)-Acifran; Reductol. Grades: ≥99% by HPLC. CAS No. 72420-38-3. Molecular formula: C12H10O4. Mole weight: 218.21. | |
Bz-Nle-Lys-Arg-Arg-AMC Quick inquiry Where to buy Suppliers range | Substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. The kcat/Km value of Bz-NleKRR-AMC for the dengue virus type 4 (DEN4) enzyme is > 800 fold higher than that of Boc-Gly-Arg-Arg-AMC, a widely used NS3 substrate (kcat = 2.9 s?¹, Km = 8.6 μM for DEN4). For yellow fever virus NS3 protease the kcat value was 0.111 s?¹, the Km value 14.6 μM. Uses: Peptide Inhibitors. CAS No. 863975-32-0. Product ID: R1920. | |
c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 Quick inquiry Where to buy Suppliers range | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grades: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
Diethylnorspermine Quick inquiry Where to buy Suppliers range | diethylnorspermine, also known as DENSPM, is a potent inducer of spermidine/spermine N1-acetyltransferase, is able to increase enzyme activity 200-1000 fold. The cell death induced by DENSPM treatment was apoptotic, as evidenced by cleavage of procaspase 3 and induction of caspase-3 activity. The DENSPM-induced polyamine depletion was also caused by the inhibition of ornithine decarboxylase. LA-N-1 cells contained a higher level of the prosurvival protein survivin, which was further increased after DENSPM treatment. Synonyms: DE-333, DE 333; DE333; BE-333, BE 333; BE333; N1,N11-Diethylnorspermine; 1,11-bis(ethylamino)-4,8-diazaundecan. CAS No. 121749-39-1. Molecular formula: C13H36Cl4N4. Mole weight: 244.42. | |
DUB Inhibitor IV, b-AP15 (NSC687852, 3, 5-bis ( (4-Nitrophenyl) methylidene) -1-prop-2-enoylpiperidin-4-one, (3E, 5E) -1-Acryloyl-3, 5-bis (4-nitrobenzylidene) piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50=2.1uM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50=0.8uM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.4. US Biological Life Sciences. | Worldwide |
GIRK Activator, ML297 (1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, N-(3,4-Difluorophenyl)-N?-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, CID 56642816, VU0456810) Quick inquiry Where to buy Suppliers range | A blood-brain barrier-permeable, non-toxic phenyl-pyrazolylurea compound that acts as a direct, potent, fast, and reversible activator of GIRK1 (G-protein activated inward-rectifying K+ channel containing subunit 1) containing channels (EC50 = 162, 914, and 887nM in Thallium influx assay for GIRK1/2, GIRK1/3, and GIRK1/4 expressed in HEK-293 cell lines). Its action does not require the presence of an activated Gi GPCR. Shown to be inactive towards GIRK2, GIRK2/3, Kir2.1, KV7.4 and GABAA, and weakly active against a panel of 61 other receptors, ion channels, enzymes, transporters, and proteins even at higher concentration (~10uM). Exhibits desirable pharmacokinetic properties with good solubility (17.5uM), predicted hepatic clearance (88 ml/min/kg), and Tmax of 640nM and 130nM in plasma and brain, respectively. Shown to reduce locomotor function and seizure frequency in electroshock- and chemically-induced murine epilepsy models (60mg/kg, i.p). Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O. US Biological Life Sciences. | Worldwide |
GSK 962040 Quick inquiry Where to buy Suppliers range | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal;1-[4-(3-fluoroanilino)piperidin-1-yl]-2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone. Grades: >98%. CAS No. 923565-21-3. Molecular formula: C25H33FN4O. Mole weight: 424.55. | |
Hemorphin-7 Quick inquiry Where to buy Suppliers range | Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides activates opioid receptors and inhibiting angiotensin-converting enzyme (ACE). The much lower affinity of hemorphin- 7 for μ-receptors as compared to other opioid peptides may be compensated by its much higher plasma concentration, resulting in biological effects of comparable magnitude. Synonyms: H-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH; L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine; L-Phenylalanine, N-(N2-(N2-(N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)-L-threonyl)-L-glutaminyl)-L-arginyl)-. Grades: ≥97%. CAS No. 152685-85-3. Molecular formula: C49H64N12O11. Mole weight: 997.11. | |
H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH Quick inquiry Where to buy Suppliers range | H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (μ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site. Synonyms: N- ({5-[ (2-Aminoethyl) amino]-1-naphthyl}sulfonyl) -L-α -glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α -glutamyl-L-arginyl-N6- (4-{[4- (dimethylamino) phenyl]diazenyl}benzoyl) -L-lysine. Grades: ≥95%. CAS No. 1914987-47-5. Molecular formula: C72H97N17O16S. Mole weight: 1488.71. | |
Ι-Carrageenan, commercial grade, Type II Quick inquiry Where to buy Suppliers range | Ι-Carrageenan has many advantages over κ-Carrageenan. The gel formed by the interaction of Ι-Carrageenan with calcium ions is soft, elastic, thixotropic and anti-melt stable, and also has good water retention. Ι-Carrageenan is soluble in hot water and its sodium salt is soluble in cold water. However, Ι-Carrageenan is hardly soluble or insoluble in cold milk, mainly because the higher the content of 3,6-lactone-galactose and the lower the content of sulfate group, the more difficult it is to dissolve in cold milk. Both Ι-Carrageenan and λ-Carrageenan are insoluble in organic solvents. As a renewable natural polysaccharide polymer, Ι-Carrageenan has the advantages of naturalness, safety and abundant sources, and is widely used in the fields of food, cosmetics, biomedicine and paints and coatings. Uses: ·Adhesives, thickeners, emulsifiers and stabilizers in the food industry ·Culture medium, medicament, anticoagulant, hypolipidemic agent and laxative in the field of medicine ·Used as an antistatic agent for photosensitive emulsions and photosensitive emulsion layers ·Embedding material for immobilized enzyme carrier and bacteria ·For leather industry, ceramic industry, textile industry and paper industry. Group: Plant Hydrocolloids. CAS No. 9062-7-1. Molecular Weight: 788.66 g/mol. Density: H2O: 5 mg/mL hot, soluble. | |
Lycopene Quick inquiry Where to buy Suppliers range | Lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. Lycopene in tomato puree has decreased indicating an indirect effect on lycopene stability caused by high concentration of hydrogen peroxide and the activation of peroxidase enzymes leading to the reduction of ascorbic acid and its regenerative action towards lycopene. Besides, Lycopene protected β-carotene against isomerization during reactions with singlet oxygen and radicals. These findings can explain the pattern of carotenoid isomers analyzed in fruits and vegetables, where lycopene containing samples showed higher (all-E)/(9Z)-β-carotene ratios, and also in in vivo samples such as human blood plasma. Lycopene can be used as pigment in food processing, and is also used as raw material of antioxidant health food. Uses: Ingredient of health care products. Synonyms: ψ,ψ-Carotene; all-trans-Lycopene; Lyco Vit; Lycopene 7; Lycored; NSC 407322; Redivivo; trans-Lycopene; (all-E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene. Grades: 96%. CAS No. 502-65-8. Molecular formula: C40H56. Mole weight: 536.87. | |
Nicotianamine Quick inquiry Where to buy Suppliers range | Phytosiderophores are produced in higher plants as iron chelating amino acids that promote uptake of iron from soil. Nicotianamine is a metal chelator and phytosiderophore precursor produced in plants that has a role in the uptake, translocation, and intracellular transport of metals.1 Treating lettuce (L. sativa) with a Cu(OH)2-based pesticide raises nicotianamine levels 12- to 27-fold compared to non-pesticide treated plants.2 Nicotianamine also inhibits rabbit angiotensin-coverting enzyme (ACE) (IC50 = 0.26 μM) and human recombinant ACE2 (IC50 = 84 nM).3,4. Group: Biochemicals. Alternative Names: (αS,2S)-α-[[(3S)-3-Amino-3-carboxypropyl]amino]-2-carboxy-1-azetidinebutanoic Acid; [2S-[1[αR*(R*)], 2R*]]-α-[(3-Amino-3-carboxypropyl)amino]-2-carboxy- 1-azetidinebutanoic Acid. Grades: Highly Purified. CAS No. 34441-14-0. Pack Sizes: 1mg. Molecular Formula: C12H21N3O6, Molecular Weight: 303.31. US Biological Life Sciences. | Worldwide |
Ovalbumin (154-159) Quick inquiry Where to buy Suppliers range | Ovalbumin (154-159) shows higher inhibition of the angiotensin-converting enzyme (ACE) at a concentration of 70 μM for 50% inhibition of ACE. Synonyms: OVA (154-159); H-Thr-Asn-Gly-Ile-Ile-Arg-OH; Egg white albumen (154-159); L-threonyl-L-asparagyl-glycyl-L-isoleucyl-L-isoleucyl-L-arginine; H-TNGIIR-OH. Grades: ≥95%. CAS No. 1370698-94-4. Molecular formula: C28H52N10O9. Mole weight: 672.78. | |
OXi-4503 Quick inquiry Where to buy Suppliers range | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Synonyms: OXi4503; OXi 4503; CA1P; tetrasodium [3-methoxy-2-phosphonatooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate. Grades: >98%. CAS No. 288847-35-8. Molecular formula: C18H22O12P2. Mole weight: 492.31. | |
Perindopril Erbumine Quick inquiry Where to buy Suppliers range | Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykinin/angiotensin I selectivity ratio of 1.44. Uses: Angiotensin-converting enzyme inhibitors. Synonyms: S9490-3. Grades: >98%. CAS No. 107133-36-8. Molecular formula: C19H32N2O5.C4H11N. Mole weight: 441.6. | |
Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ( (E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3, 4, 5-trimethoxyphenyl) acrylamide, EP2 Antagonist, TG6-10-1) Quick inquiry Where to buy Suppliers range | A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
Syk Inhibitor VI, R406 (N4-(2,2-Dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine, 6- (5-Fluoro-2- (3, 4, 5-trimethoxyphenylamino) pyrimidin-4-ylamino) -2, 2-dimethyl-2H-pyrido[3, 2-b][1, 4]oxazin-3 (4H) -one) Quick inquiry Where to buy Suppliers range | A cell-permeable, orally bioavailable pyrimidinediamino compound with anti-inflammatory and anti-tumor properties. Acts as a potent, reversible and ATP-competitive inhibitor of Syk kinase (IC50 = 41nM; Ki = 30nM). Exhibits high selectivity over a broad panel of other protein kinases (300nM), ion channels, and enzymes. Blocks Syk-dependent FcR-mediated activation of monocytes/macrophages, and neutrophils and inhibits Anti-IgE-mediated degranulation in cultured human mast cells (EC50 = 56nM as measured by tryptase release). At higher concentrations, it is shown to block adenosine A3 receptors, adenosine transporter, and monoamine transporter (IC50 = 81nM, 1.84uM, and 2.74uM, respectively), and Flt3 autophosphorylation. Shown to reduce immune complex-mediated inflammation in murine models (10mg/kg) and diminish airway hyper-responsiveness in asthma models. Group: Biochemicals. Grades: Highly Purified. CAS No. 841290-80-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |