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| Product | Description | |
|---|---|---|
| Epibatidine | (±)-Epibatidine is a potent nicotinic agonist (Ki = 0.02 and 233 nM for α4β2 and α7 nicotinic receptors, respectively). Uses: Analgesic. Synonyms: Epibatidine; (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane. CAS No. 140111-52-0. Molecular formula: C11H13ClN2. Mole weight: 208.69. |  |
| (±)-Epibatidine | High affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic. Uses: Analgesics, non-narcotic. Synonyms: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane; 2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane. Grades: ≥99%. CAS No. 148152-66-3. Molecular formula: C11H13ClN2. Mole weight: 208.69. | |
| (-)-Epibatidine dihydrochloride | (-)-Epibatidine dihydrochloride is a highly potent nicotinic agonist and (-)-Enantiomer of (±)-Epibatidine dihydrochloride. Synonyms: (3S)-3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane dihydrochloride. Grades: 99%. CAS No. 152378-30-8. Molecular formula: C11H13ClN2.2HCl. Mole weight: 281.61. | |
| (+)-Epibatidine dihydrochloride | (+)-Epibatidine dihydrochloride is a highly potent nicotinic agonist and (+)-Enantiomer of (±)-Epibatidine dihydrochloride. Synonyms: 3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane dihydrochloride. Grades: 99%. CAS No. 166374-43-2. Molecular formula: C11H13ClN2.2HCl. Mole weight: 281.61. | |
| (±)-Epibatidine dihydrochloride | (±)-Epibatidine dihydrochloride is a highly potent nicotinic agonist used as a non-narcotic analgesic. Uses: Analgesic. Synonyms: (1R,3S,4S)-3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane dihydrochloride. Grades: 99%. CAS No. 162885-01-0. Molecular formula: C11H13ClN2.2HCl. Mole weight: 281.61. | |
| (±)-Epibatidine Dihydrochloride (2-(6-chloropyridin-3-yl)-7-azabicyclo[2. 2. 1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine) | A potent partial agonist selective for alpha7 nAChRs (EC50 = 34uM). Widely used in investigating the roles of alpha7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 501684-93-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClN? 2HCl xH2O. US Biological Life Sciences. |  Worldwide |
| 2-Chloro-5-iodo-4-methylpyridine | 2-Chloro-5-iodo-4-methylpyridine can be used as reactant/reagent of synthesis of conformationally constrained spirodi hydrofuropyridine analogs of epibatidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 550347-54-1. Pack Sizes: 500mg, 1g. Molecular Formula: C6H5ClIN, Molecular Weight: 253.47. US Biological Life Sciences. | Worldwide |
| AT 1001 | AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor ( α3β4 nAChR ) ( K i =2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314801-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135783. |  |
| Hemicholinium 3 | Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a K i value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) [1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [ 3 H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hemicholinium dibromide. CAS No. 312-45-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B2152. | |
| Reboxetine | Reboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression. In vitro: it inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine and does not inhibit the activity of the following isozymes of cytochrome P450: CYP1A2, CYP2C9, CYP2C19, and CYP2E1; In vivo: Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.Besides, it inhibits both CYP2D6 and CYP3A4 with low binding affinities, but has shown no effect on the in vivo clearance of drugs metabolized by these enzymes. Inhibits (±)-epibatidine-induced Ca(2+) influx in human (h) muscle embryonic (hα1β1γδ) and adult (hα1β1εδ) AChRs in a non-competitive manner , with potencies IC50= 3.86±0.49 and 1.92±0.48 μM, respectively. Uses: A selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and add/adhd, it has been approved for treatment of major depression. Synonyms: Norebox; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R,R)-Reboxetine. Grades: ≥ 95.0%. CAS No. 98769-81-4. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
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