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| Product | Description | |
|---|---|---|
| Epoxide Hydrolases | synthesis of chiral alcohols from epoxides. Group: Enzymes. Synonyms: Epoxide Hydrolases; EH. Form: Enzyme Powder: 2 items*50mg / item, or other quantity. Epoxide Hydrolases; EH; Screening Kit; library of enzyme; enzyme library. Cat No: ENLC-013. |  |
| hepoxilin-epoxide hydrolase | Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase). Group: Enzymes. Synonyms: hepoxilin epoxide hydrolase; hepoxylin hydrolase; hepoxilin A3 hydrolase. Enzyme Commission Number: EC 3.3.2.7. CAS No. 122096-98-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4004; hepoxilin-epoxide hydrolase; EC 3.3.2.7; 122096-98-4; hepoxilin epoxide hydrolase; hepoxylin hydrolase; hepoxilin A3 hydrolase. Cat No: EXWM-4004. | |
| limonene-1,2-epoxide hydrolase | Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. The enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC 3.3.2.4 (trans-epoxysuccinate hydrolase), EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase) and EC 3.3.2.10 (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline. Both enantiomers of menth-8-ene-1,2-diol [i.e. (1R,2R,4S)-menth-8-ene-1,2-diol and (1S,2S,4R)-menth-8-ene-1,2-diol] are metabolized. Group: Enzymes. Synonyms: limonene oxide hydrolase. Enzyme Commission Number: EC 3.3.2.8. CAS No. 216503-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4005; limonene-1,2-epoxide hydrolase; EC 3.3.2.8; 216503-88-7; limonene oxide hydrolase. Cat No: EXWM-4005. | |
| microsomal epoxide hydrolase | This is a key hepatic enzyme that is involved in the metabolism of numerous xenobiotics, such as 1,3-butadiene oxide, styrene oxide and the polycyclic aromatic hydrocarbon benzo[a]pyrene 4,5-oxide. In a series of oxiranes with a lipophilic substituent of sufficient size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2-disubstituted oxiranes serve as substrates or inhibitors of the enzyme. However, trans-1,2-disubstituted, tri-and tetra-substituted oxiranes are not substrates. The reaction involves the formation of an hydroxyalkyl-enzyme intermediate. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), ...hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo(a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH. Enzyme Commission Number: EC 3.3.2.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4006; microsomal epoxide hydrolase; EC 3.3.2.9; epoxide hydratase (ambiguous); microsomal epoxide hydratase (ambiguous); epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo(a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH. Cat No: EXWM-4006. | |
| Native Rhodococcus rhodochrous Epoxide Hydrolase | Epoxide hydrolase (also known as epoxide hydratase) functions in detoxification during drug metabolism. It converts epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body. Epoxides result from the degradation of aromatic compounds. Deficiency in this enzyme in patients receiving aromatic-type anti-epileptic drugs such as phenytoin is reported to lead to DRESS syndrome. Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum. Group: Enzymes. Synonyms: EC 3.3.2.3; epoxide hydratase; epoxide hydratase (ambiguous); microsomal epoxide hydratase; epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo (a)pyrene-. Enzyme Commission Number: EC 3.3.2.3. CAS No. 9048-63-9. mEH. Activity: > 0.5 U/g. Storage: -20°C. Form: lyophilized powder, beige. Source: Rhodococcus rhodochrous. EC 3.3.2.3; epoxide hydratase; epoxide hydratase (ambiguous); microsomal epoxide hydratase; epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo (a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH; 9048-63-9. Cat No: NATE-0449. | |
| soluble epoxide hydrolase | Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism. It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76, lipid-phosphate phosphatase. Like EC 3.3.2.9, microsomal epoxide hydrolase, it is probable that the reaction involves...se). Group: Enzymes. Synonyms: epoxide hydrase (ambiguous); epoxide hydratase (ambiguous); arene-oxide hydratase (ambiguous); aryl epoxide hydrase (ambiguous); trans-stilbene oxide hydrolase; sEH; cytosolic epoxide hydrolase. Enzyme Commission Number: EC 3.3.2.10. CAS No. 9048-63-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3995; soluble epoxide hydrolase; EC 3.3.2.10; 9048-63-9; epoxide hydrase (ambiguous); epoxide hydratase (ambiguous); arene-oxide hydratase (ambiguous); aryl epoxide hydrase (ambiguous); trans-stilbene oxide hydrolase; sEH; cytosolic epoxide hydrolase. Cat No: EXWM-3995. | |
| 1-(1-Ethoxyethoxy)-4-fluoronaphthalene | 1-(1-Ethoxyethoxy)-4-fluoronaphthalene is a derivative of 1-Fluoronaphthalene, a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Duloxetine impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15FO2, Molecular Weight: 234.27. US Biological Life Sciences. |  Worldwide |
| 1,3-Dicyclohexylurea | 1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 500 mg. Product ID: HY-W013989. |  |
| 1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester | 1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester is used to prepare azetidine compounds as soluble epoxide hydrolase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1330763-95-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H18N2O2, Molecular Weight: 198.26. US Biological Life Sciences. | Worldwide |
| (±)17(18)-EpETE-Ethanolamide | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grades: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. |  |
| 1-Fluoro-2-naphthaldehyde | 1-Fluoro-2-naphthaldehyde is a synthetic building block that can be synthesized from 1-Fluoronaphthalene (F593760), a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Group: Biochemicals. Grades: Highly Purified. CAS No. 143901-96-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H7FO, Molecular Weight: 174.17. US Biological Life Sciences. | Worldwide |
| 1-Fluoronaphthalene | A fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Duloxetine impurity. Group: Biochemicals. Grades: Highly Purified. CAS No. 321-38-0. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C??H?F. US Biological Life Sciences. | Worldwide |
| 2,6-Dichlorobenzyl Bromide | 2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues. Group: Biochemicals. Alternative Names: 2-(Bromomethyl)-1,3-dichlorobenzene; α-Bromo-2,6-dichloro-toluene; 1-Bromomethyl-2,6-dichlorobenzene; 2,6-Dichloro-α-bromotoluene; 2,6-Dichlorobenzyl Bromide; 2-(Bromomethyl)-1,3-dichlorobenzene; NSC 93898; α-Bromo-2,6-dichlorotoluene. Grades: Highly Purified. CAS No. 20443-98-5. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
| 2-(Nonylthio)propanamide | 2-(Nonylthio)propanamide is an potential selective inhibitor of epoxide hydrolase virulence factor from pseudomonas aeruginosa which contributes to cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1021343-21-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H25NOS. US Biological Life Sciences. | Worldwide |
| (±)5(6)-DiHET | Epoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. (±)5(6)-DiHET is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro. Synonyms: (±)5,6-DiHETrE; 5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid; (8Z,11Z,14Z)-5,6-Dihydroxyicosa-8,11,14-trienoic acid. Grades: ≥95%. CAS No. 213382-49-1. Molecular formula: C20H34O4. Mole weight: 338.5. | |
| 5(S),6(R)-DiHETE | 5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. 5(S),6(R)-DiHETE is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM. Synonyms: (5S,6R,7E,9E,11Z,14Z)-5,6-dihydroxyicosa-7,9,11,14-tetraenoic acid. Grades: ≥95%. CAS No. 82948-88-7. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| ARM1 | ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC 50 7.61 μM and epoxide hydrolase inhibitory activity with an IC 50 12.4 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4BSA. CAS No. 68729-05-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W027340. | |
| AUDA | AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC 50 s of 18 and 69 nM for the mouse and human sEH, respectively [1]. AUDA has anti-inflammatory activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108570. | |
| AUDA | AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPAR&gamma. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grades: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6. | |
| AUNP-12 | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grades: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
| CAY10640 | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grades: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
| cholesterol-5,6-oxide hydrolase | The enzyme appears to work equally well with either epoxide as substrate. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase). Group: Enzymes. Synonyms: cholesterol-epoxide hydrolase; ChEH. Enzyme Commission Number: EC 3.3.2.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3996; cholesterol-5,6-oxide hydrolase; EC 3.3.2.11; cholesterol-epoxide hydrolase; ChEH. Cat No: EXWM-3996. | |
| CUDA | CUDA is an inhibitor of soluble epoxide hydrolase (sEH) which catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity with IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. Synonyms: 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid. Grades: ≥95%. CAS No. 479413-68-8. Molecular formula: C19H36N2O3. Mole weight: 340.5. | |
| CUDA | CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) , with IC 50 s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively [1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121538. | |
| Diflapolin | Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It is selective for FLAP and sEH over other arachidonic acid metabolism enzymes. Diflapolin (1, 3, and 10 mg/kg) decreases inflammation in a mouse model of peritonitis induced by zymosan, reducing the production of LTB4 and LTC4 and inhibiting leukocyte recruitment. Grades: ≥98%. CAS No. 724453-98-9. Molecular formula: C22H17Cl2N3O2S. Mole weight: 458.36. | |
| Elaidamide | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
| GSK2256294A | GSK2256294A, an effective inhibitor of human soluble epoxide hydrolase(sEH), was developed by GSK and still under Phase I trial in Chronic obstructive pulmonary disease. IC50: 27pM. Uses: Gsk2256294a is an effective inhibitor of human soluble epoxide hydrolase(seh). Synonyms: GSK2256294; GSK-2256294; GSK 2256294; GSK2256294A; GSK-2256294A; GSK 2256294A. UNII-L33EX3XR0T; GSK2256294A; L33EX3XR0T; SCHEMBL2677671; GSK 2256294A. Grades: 98%. CAS No. 1142090-23-0. Molecular formula: C21H24F3N7O. Mole weight: 447.46. | |
| leukotriene-A4 hydrolase | This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase). Group: Enzymes. Synonyms: LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase. Enzyme Commission Number: EC 3.3.2.6. CAS No. 90119-07-6. LTA4H. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4003; leukotriene-A4 hydrolase; EC 3.3.2.6; 90119-07-6; LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase. Cat No: EXWM-4003. | |
| (+)-Limonene Oxide, mixture of cis and trans | (+)-Limonene oxide (mixture of cis and trans) undergoes biocatalytic resolution in the presence of epoxide hydrolase to form enantiomerically pure cis- and trans-limonene oxides. Used in citrus and minty flavours: at 0.3-0.5ppm in beverages and dairy products, and up to 5ppm in sauces.Note: the epoxide can be lost in alcoholic and aqueous solutions, in acidic conditions.fresh clean citrus minty spearmint herbal. Group: Biochemicals. Alternative Names: D-8-p-menthene-1,2-epoxide; 6-methyl-3-prop-1-en-2-yl-7-oxabicyclo[4. 1. 0]heptane; limonene 1,2-epoxide; limonene 1,2-oxide; limonene epoxide. Grades: Highly Purified. CAS No. 1195-92-2. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C10H16O, Molecular Weight: 152.23. US Biological Life Sciences. | Worldwide |
| lipid-phosphate phosphatase | Requires Mg2+ for maximal activity. The enzyme from mammals is a bifunctional enzyme: the N-terminal domain exhibits lipid-phosphate-phosphatase activity and the C-terminal domain has the activity of EC 3.3.2.10, soluble epoxide hydrolase (sEH). The best substrates for this enzyme are 10-hydroxy-9-(phosphonooxy)octadecanoates, with the threo- form being a better substrate than the erythro- form. The phosphatase activity is not found in plant sEH or in EC 3.3.2.9, microsomal epoxide hydrolase, from mammals. Group: Enzymes. Synonyms: hydroxy fatty acid phosphatase; dihydroxy fatty acid phosphatase; hydroxy lipid phosphatase; sEH (ambiguous); soluble epoxide hydrolase (ambiguous). Enzyme Commission Number: EC 3.1.3.76. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3681; lipid-phosphate phosphatase; EC 3.1.3.76; hydroxy fatty acid phosphatase; dihydroxy fatty acid phosphatase; hydroxy lipid phosphatase; sEH (ambiguous); soluble epoxide hydrolase (ambiguous). Cat No: EXWM-3681. | |
| PHOME | PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1028430-42-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113862. | |
| rac Styrene Oxide | A major (toxic) metabolite of Styrene , catalyzed by epoxide hydrolase. Group: Biochemicals. Alternative Names: 2-Phenyloxirane; (Epoxyethyl)benzene; 1,2-Epoxy-1-phenylethane; Phenyloxirane; (Epoxyethyl)benzene; (±)-Phenylethylene Oxide; (±)-Phenyloxirane; (±)-Styrene Oxide; 1,2-Epoxyethylbenzene; 1-Phenyl-1,2-epoxyethane; 2-Phenyloxirane; Epoxystyrene; NSC 637; NSC 7582; Phenethylene Oxide; Phenylethylene Oxide; Phenyloxirane; STO; Styrene 1',2'-Oxide; Styrene 7,8-Oxide; Styrene epoxide; Styryl Oxide; α, β-Epoxystyrene. Grades: Highly Purified. CAS No. 96-09-3. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
| RB394 | RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 μM and activates PPARγ with an EC50 of 0.3 μM. Synonyms: RB-394; RB 394; 2- [ [4- [ [4-Methoxy-2- (trifluoromethyl) phenyl] methylcarbamoyl] phenyl] methyl] butanoic acid. Grades: ≥98%. CAS No. 1830320-32-5. Molecular formula: C21H22F3NO4. Mole weight: 409.4. | |
| (R)-(+)-Styrene Oxide | Main metabolite of Styrene , catalyzed by epoxide hydrolase. Group: Biochemicals. Alternative Names: (R)-Phenyloxirane; 2-Phenyl-oxirane; (R)-(+)-(Epoxyethyl)benzene; (2R)-2-Phenyloxirane; (R)-Epoxystyrene; (R)-Phenylethylene Oxide. Grades: Highly Purified. CAS No. 20780-53-4. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| TPPU | TTPU is a soluble epoxide hydrolase inhibitor (sEHI) (IC50 = 37, 2.8 nM and 3.7 nM for monkey, mouse and human sEH, respectively) with anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. Synonyms: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea. CAS No. 1222780-33-7. Molecular formula: C16H20F3N3O3. Mole weight: 359.34. | |
| Ubenimex | Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds. Alternative Names: 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU. CAS No. 58970-76-6. Molecular formula: C16H24N2O4. Mole weight: 308.37. Appearance: White crystalline powder. Purity: 0.99. IUPACName: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid. Canonical SMILES: CC (C)CC (C (=O)O)NC (=O)C (C (CC1=CC=CC=C1)N)O. Density: 1.197 g/cm³. ECNumber: 261-529-2. Catalog: ACM58970766. |  |
| Valpromide | Valpromide is an amide derivative of valproic acid and inhibits human epoxide hydrolase. Uses: Scientific research. Group: Signaling pathways. CAS No. 2430-27-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B2117. | |
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