Epoxide Hydrolase Suppliers USA
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Product | Description | |
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1-(1-Ethoxyethoxy)-4-fluoronaphthalene Quick inquiry Where to buy Suppliers range | 1-(1-Ethoxyethoxy)-4-fluoronaphthalene is a derivative of 1-Fluoronaphthalene, a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Duloxetine impurity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15FO2, Molecular Weight: 234.27. US Biological Life Sciences. | Worldwide |
1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester Quick inquiry Where to buy Suppliers range | 1,6-Diazaspiro[3.3]heptane-1-carboxylic Acid 1,1-Dimethylethyl Ester is used to prepare azetidine compounds as soluble epoxide hydrolase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1330763-95-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H18N2O2, Molecular Weight: 198.26. US Biological Life Sciences. | Worldwide |
(±)17(18)-EpETE-Ethanolamide Quick inquiry Where to buy Suppliers range | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grades: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. | |
1-Fluoro-2-naphthaldehyde Quick inquiry Where to buy Suppliers range | 1-Fluoro-2-naphthaldehyde is a synthetic building block that can be synthesized from 1-Fluoronaphthalene (F593760), a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Group: Biochemicals. Grades: Highly Purified. CAS No. 143901-96-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H7FO, Molecular Weight: 174.17. US Biological Life Sciences. | Worldwide |
1-Fluoronaphthalene Quick inquiry Where to buy Suppliers range | A fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. Duloxetine impurity. Group: Biochemicals. Grades: Highly Purified. CAS No. 321-38-0. Pack Sizes: 1g, 10g, 25g. Molecular Formula: C??H?F. US Biological Life Sciences. | Worldwide |
2,6-Dichlorobenzyl Bromide Quick inquiry Where to buy Suppliers range | 2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues. Group: Biochemicals. Alternative Names: 2-(Bromomethyl)-1,3-dichlorobenzene; α-Bromo-2,6-dichloro-toluene; 1-Bromomethyl-2,6-dichlorobenzene; 2,6-Dichloro-α-bromotoluene; 2,6-Dichlorobenzyl Bromide; 2-(Bromomethyl)-1,3-dichlorobenzene; NSC 93898; α-Bromo-2,6-dichlorotoluene. Grades: Highly Purified. CAS No. 20443-98-5. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
2-(Nonylthio)propanamide Quick inquiry Where to buy Suppliers range | 2-(Nonylthio)propanamide is an potential selective inhibitor of epoxide hydrolase virulence factor from pseudomonas aeruginosa which contributes to cystic fibrosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1021343-21-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H25NOS. US Biological Life Sciences. | Worldwide |
4-Phenylchalcone oxide Quick inquiry Where to buy Suppliers range | 4-Phenylchalcone oxide, 82389-34-2, CCRIS 2240, phenyl-[3-(4-phenylphenyl)oxiran-2-yl]methanone, SCHEMBL655373, BDBM6120, CHEMBL3661417, DTXSID901002648, LS-188793, US8815951, Epoxide Hydrolase Inhibitor 8, SR-01000597661, SR-01000597661-1, [3-([1,1'-Biphenyl]-4-yl)oxiran-2-yl](phenyl)methanone. | |
(±)5(6)-DiHET Quick inquiry Where to buy Suppliers range | Epoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. (±)5(6)-DiHET is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro. Synonyms: (±)5,6-DiHETrE; 5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid; (8Z,11Z,14Z)-5,6-Dihydroxyicosa-8,11,14-trienoic acid. Grades: ≥95%. CAS No. 213382-49-1. Molecular formula: C20H34O4. Mole weight: 338.5. | |
5(S),6(R)-DiHETE Quick inquiry Where to buy Suppliers range | 5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. 5(S),6(R)-DiHETE is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM. Synonyms: (5S,6R,7E,9E,11Z,14Z)-5,6-dihydroxyicosa-7,9,11,14-tetraenoic acid. Grades: ≥95%. CAS No. 82948-88-7. Molecular formula: C20H32O4. Mole weight: 336.5. | |
AUDA Quick inquiry Where to buy Suppliers range | AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPAR&gamma. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grades: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6. | |
AUNP-12 Quick inquiry Where to buy Suppliers range | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grades: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
CAY10640 Quick inquiry Where to buy Suppliers range | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grades: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
CUDA Quick inquiry Where to buy Suppliers range | CUDA is an inhibitor of soluble epoxide hydrolase (sEH) which catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity with IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. Synonyms: 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid. Grades: ≥95%. CAS No. 479413-68-8. Molecular formula: C19H36N2O3. Mole weight: 340.5. | |
Diflapolin Quick inquiry Where to buy Suppliers range | Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). It is selective for FLAP and sEH over other arachidonic acid metabolism enzymes. Diflapolin (1, 3, and 10 mg/kg) decreases inflammation in a mouse model of peritonitis induced by zymosan, reducing the production of LTB4 and LTC4 and inhibiting leukocyte recruitment. Grades: ≥98%. CAS No. 724453-98-9. Molecular formula: C22H17Cl2N3O2S. Mole weight: 458.36. | |
Elaidamide Quick inquiry Where to buy Suppliers range | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
GSK2256294A Quick inquiry Where to buy Suppliers range | GSK2256294A, an effective inhibitor of human soluble epoxide hydrolase(sEH), was developed by GSK and still under Phase I trial in Chronic obstructive pulmonary disease. IC50: 27pM. Uses: Gsk2256294a is an effective inhibitor of human soluble epoxide hydrolase(seh). Synonyms: GSK2256294; GSK-2256294; GSK 2256294; GSK2256294A; GSK-2256294A; GSK 2256294A. UNII-L33EX3XR0T; GSK2256294A; L33EX3XR0T; SCHEMBL2677671; GSK 2256294A. Grades: 98%. CAS No. 1142090-23-0. Molecular formula: C21H24F3N7O. Mole weight: 447.46. | |
(+)-Limonene Oxide, mixture of cis and trans Quick inquiry Where to buy Suppliers range | (+)-Limonene oxide (mixture of cis and trans) undergoes biocatalytic resolution in the presence of epoxide hydrolase to form enantiomerically pure cis- and trans-limonene oxides. Used in citrus and minty flavours: at 0.3-0.5ppm in beverages and dairy products, and up to 5ppm in sauces.Note: the epoxide can be lost in alcoholic and aqueous solutions, in acidic conditions.fresh clean citrus minty spearmint herbal. Group: Biochemicals. Alternative Names: D-8-p-menthene-1,2-epoxide; 6-methyl-3-prop-1-en-2-yl-7-oxabicyclo[4. 1. 0]heptane; limonene 1,2-epoxide; limonene 1,2-oxide; limonene epoxide. Grades: Highly Purified. CAS No. 1195-92-2. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C10H16O, Molecular Weight: 152.23. US Biological Life Sciences. | Worldwide |
rac Styrene Oxide Quick inquiry Where to buy Suppliers range | A major (toxic) metabolite of Styrene , catalyzed by epoxide hydrolase. Group: Biochemicals. Alternative Names: 2-Phenyloxirane; (Epoxyethyl)benzene; 1,2-Epoxy-1-phenylethane; Phenyloxirane; (Epoxyethyl)benzene; (±)-Phenylethylene Oxide; (±)-Phenyloxirane; (±)-Styrene Oxide; 1,2-Epoxyethylbenzene; 1-Phenyl-1,2-epoxyethane; 2-Phenyloxirane; Epoxystyrene; NSC 637; NSC 7582; Phenethylene Oxide; Phenylethylene Oxide; Phenyloxirane; STO; Styrene 1',2'-Oxide; Styrene 7,8-Oxide; Styrene epoxide; Styryl Oxide; α, β-Epoxystyrene. Grades: Highly Purified. CAS No. 96-09-3. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
RB394 Quick inquiry Where to buy Suppliers range | RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 μM and activates PPARγ with an EC50 of 0.3 μM. Synonyms: RB-394; RB 394; 2- [ [4- [ [4-Methoxy-2- (trifluoromethyl) phenyl] methylcarbamoyl] phenyl] methyl] butanoic acid. Grades: ≥98%. CAS No. 1830320-32-5. Molecular formula: C21H22F3NO4. Mole weight: 409.4. | |
(R)-(+)-Styrene Oxide Quick inquiry Where to buy Suppliers range | Main metabolite of Styrene , catalyzed by epoxide hydrolase. Group: Biochemicals. Alternative Names: (R)-Phenyloxirane; 2-Phenyl-oxirane; (R)-(+)-(Epoxyethyl)benzene; (2R)-2-Phenyloxirane; (R)-Epoxystyrene; (R)-Phenylethylene Oxide. Grades: Highly Purified. CAS No. 20780-53-4. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
TPPU Quick inquiry Where to buy Suppliers range | TTPU is a soluble epoxide hydrolase inhibitor (sEHI) (IC50 = 37, 2.8 nM and 3.7 nM for monkey, mouse and human sEH, respectively) with anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. Synonyms: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea. CAS No. 1222780-33-7. Molecular formula: C16H20F3N3O3. Mole weight: 359.34. | |
Ubenimex Quick inquiry Where to buy Suppliers range | Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds. Group: Main Products. Alternative Names: 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU. Grades: 99%. CAS No. 58970-76-6. Product ID: ACM58970766. Molecular formula: C16H24N2O4. Mole weight: 308.37. IUPAC Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid. Appearance: White crystalline powder. EC Number: 261-529-2. Boiling Point: 604.7ºC at 760 mmHg. Melting Point: 245ºC. Flash Point: 319.5ºC. Density: 1.197 g/cm³. |