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1-C-[4-Chloro-3-[(4-ethoxyphenyl)?methyl]?phenyl]?-D-Glucopyranose is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 461432-27-9. Molecular formula: C21H25ClO7. Mole weight: 424.87.
(1R) -1, 4-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol is an impurity of Dapagliflozin (D185370) which is a sodium-glucose transporter 2 inhibitor and used to treat type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1469910-83-5. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C21H25ClO6, Molecular Weight: 408.87. US Biological Life Sciences.
(1R, S) -1, 4-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol is the racemic mixture of (1R) -1, 4-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol (A637835) and (1S) -1, 4-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol (A637840). It is an impurity of Dapagliflozin (D185370) which is a sodium-glucose transporter 2 inhibitor and used to treat type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C21H25ClO6, Molecular Weight: 408.87. US Biological Life Sciences.
(1S) -1, 4-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol is an impurity of Dapagliflozin (D185370) which is a sodium-glucose transporter 2 inhibitor and used to treat type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1469910-70-0. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C21H25ClO6, Molecular Weight: 408.87. US Biological Life Sciences.
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(2,5-dibromophenyl)(4-ethoxyphenyl)methanone
(2,5-dibromophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 1713015-63-4. Molecular formula: C15H12Br2O2. Mole weight: 384.07.
(2,5-dichlorophenyl)(4-ethoxyphenyl)methanone
(2,5-dichlorophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 1097076-93-1. Molecular formula: C15H12Cl2O2. Mole weight: 295.16.
(2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone
(2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone; 2305949-33-9; CS-0165465; (2-chloro-5-iodophenyl)(2-ethoxyphenyl)methanone? (Dapagliflozin Impurity pound(c). CAS No. 2305949-33-9. Molecular formula: C15H12ClIO2. Mole weight: 386.61.
(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone; 1103738-26-6; (5-Iodo-2-chlorophenyl)(4-ethoxyphenyl)methanone; (2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone; (2-chloro-5-iodophenyl)-(4-ethoxyphenyl)methanone; MFCD18642360; C15H12ClIO2; SCHEMBL1934926; BGRJXWMKCUZBIG-UHFFFAOYSA-N; AMY20632; AKOS030527184; AC-31118; DS-19445; SY126110; W13129; A894908; (2-chloro-5-iodophenyl) (4-ethoxyphenyl)methanone. CAS No. 1103738-26-6. Molecular formula: C15H12ClIO2. Mole weight: 386.61.
(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)phenyl)-6-(hydroxyl methyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 2452300-89-7; Deschloro Dapagliflozin; Dapagliflozin Deschloro Impurity; CS-0011227; (1S)-1,5-Anhydro-1-C-[3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3S,4R,5R,6R)-2-{m-[(p-Ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 2452300-89-7. Molecular formula: C21H26O6. Mole weight: 374.43.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(methoxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Grades: 95%. CAS No. 1318794-28-3. Molecular formula: C22H27ClO7. Mole weight: 438.90.
4-chloro-3-(4-ethoxybenzyl)phenol
4-chloro-3-(4-ethoxybenzyl)phenol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 4-chloro-3-[(4-ethoxyphenyl)methyl]-Phenol. CAS No. 1408077-50-8. Molecular formula: C15H15ClO2. Mole weight: 262.73.
A sodium-glucose transporter 2 inhibitor. Group: Biochemicals. Alternative Names: (1S) -1, 5-Anhydro-1-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-D-glucitol; BMS 512148. Grades: Highly Purified. CAS No. 461432-26-8. Pack Sizes: 10mg. US Biological Life Sciences.
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Dapagliflozin
Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; BMS 512148. Grades: >98%. CAS No. 461432-26-8. Molecular formula: C21H25ClO6. Mole weight: 408.87.
Dapagliflozin 2-O-β-D-Glucuronide
Dapagliflozin 2-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-2-O-β-D-glucopyranuronosyl-D-glucitol. Grades: >95%. Molecular formula: C27H33ClO12. Mole weight: 585.
Dapagliflozin 3-O-β-D-Glucuronide
Dapagliflozin 3-O-β-D-Glucuronide is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol; Dapagliflozin M-15 metabolite. Grades: > 95%. CAS No. 1351438-75-9. Molecular formula: C27H33ClO12. Mole weight: 585.
Dapagliflozin Furanose Isomer
Dapagliflozin Furanose Isomer is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin 1,4-Anhydro impurity; (1S)-1,4-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. Grades: >95%. CAS No. 1469910-70-0. Molecular formula: C21H25ClO6. Mole weight: 408.87.
Dapagliflozin Impurity 1
Dapagliflozin Impurity 1 is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin Bromo Keto Impurity; (5-Bromo-2-Chlorophenyl)(2-Ethoxyphenyl)Methanone. Grades: > 95%. CAS No. 1404477-10-6. Molecular formula: C15H12BrClO2. Mole weight: 339.61.
Dapagliflozin Impurity 10
Dapagliflozin Impurity 10 is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin Hydroxy Impurity; 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-α-D-glucopyranose. Grades: >90%. CAS No. 960404-86-8. Molecular formula: C21H25ClO7. Mole weight: 424.87.
Dapagliflozin Impurity 16
Dapagliflozin Impurity 16 is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 1α-Methyl Dapagliflozin; Dapagliflozin Methoxy Pyranose Impurity; (2S,3R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol; Methyl 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-α-D-glucopyranoside; α-D-Glucopyranoside, methyl 1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-; Methoxy Dapagliflozin. Grades: >95%. CAS No. 714269-57-5. Molecular formula: C22H27ClO7. Mole weight: 438.90.
Dapagliflozin Impurity 17
Dapagliflozin Impurity 17 is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 1,4-Dibromo-2-[(4-ethoxyphenyl)methyl]benzene. Grades: >95%. CAS No. 1807632-93-4. Molecular formula: C15H14Br2O. Mole weight: 370.08.
Dapagliflozin Impurity 24
Dapagliflozin Impurity 24 is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol; BMS-639432. Grades: >95%. CAS No. 1204222-85-4. Molecular formula: C21H25ClO7. Mole weight: 424.87.
Dapagliflozin Impurity 28
Dapagliflozin Impurity 28 is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin Deschloro Impurity; (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (1S)-1,5-Anhydro-1-C-[3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. Grades: >95%. CAS No. 2444702-80-9. Molecular formula: C21H26O6. Mole weight: 374.43.
Dapagliflozin Impurity 5
Dapagliflozin Impurity 5 is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; Dapagliflozin Open Ring Impurity. Grades: >90%. CAS No. 2100872-88-4. Molecular formula: C21H27ClO7. Mole weight: 426.89.
Dapagliflozin Open Sugar Impurity
Dapagliflozin Open Sugar Impurity is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: Dapagliflozin open sugar impurity; 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3R,4R,5R)-1-(4-Chloro-3-(4-ethoxybenzyl)phenyl)hexane-1,2,3,4,5,6-hexaol; Dapagliflozin ring opening impurity; (1R,2S,3R,4R)-1-(4-Chloro-3-(4-ethoxybenzyl)phenyl)hexane-1,2,3,4,5,6-hexaol. Molecular formula: C21H27ClO7. Mole weight: 426.89.
Dapagliflozin-(R)-Furanose
Dapagliflozin-(R)-Furanose is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1R)-1,4-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. Grades: >95%. CAS No. 1469910-83-5. Molecular formula: C21H25ClO6. Mole weight: 408.87.
FQI 1
FQI 1 is a cell-permeable and reversible inhibitor of α-globin transcription factor CP2 (LSF; IC50 = 2.1 μM) and an antiproliferative. FQI 1 induces apoptosis in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 acts via inhibiting LSF-DNA binding. Uses: Antiproliferative. Synonyms: FQI 1; FQI1; FQI-1; 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one; 8-(2-Ethoxy-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one. Grades: 99%. CAS No. 599151-35-6. Molecular formula: C18H17NO4. Mole weight: 311.33.
As an intermediate in the synthesis of Ent-α-C Dapagliflozin, Methyl 1-C-[4-Chloro-3-[(4-ethoxyphenyl)?methyl]?phenyl]?-L-glucopyranoside is an enantiomer of Dapagliflozin and a sodium-glucose transporter 2 inhibitor. Synonyms: (3R, 4S, 5R, 6S)-2- (4-Chloro-3- (4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3, 4, 5-triol. Molecular formula: C22H27ClO7. Mole weight: 438.9.
A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50=2.1uM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50=3.8, 0.79, and 6.3uM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1mg/kg, i.p., once every 3 days). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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