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A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC?? values of 4.4, 2.4, and 15.7nm, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 1012054-59-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
3,6-Di-tert-butylcarbazole is a carbazole based material with hole transporting characteristics. The 3,6-Di-tert-butyl component of the carbazole results in an increase in the glass transition temperature (Tg) of the compound. It can be used in combination with another carbazole to form novel electroluminescent materials. Uses: 3,6-di-tert-butylcarbazole is mainly used as a monomeric precursor in the syntheses of new carbazole based materials which consist of ethynylphenyl. these materials include 9-(4-bromophenyl)-3,6-di-tert-butylcarbazol and 2- (4- (2- (4- (3, 6-di-tert-butyl-9h-carbazol-9-yl) phenyl) ethynyl) benzylidene) malononitrile (pbm) which can be further be used in organic light emitting diodes (oleds) and optical switching devices. Group: Small molecule semiconductor building blockselectroluminescence materials synthetic tools and reagents polymers. Alternative Names: 3,6-Di-tert-butyl-9H-carbazole. CAS No. 37500-95-1. Pack Sizes: Packaging 5 g in glass bottle. Product ID: 3,6-ditert-butyl-9H-carbazole. Molecular formula: 279.42. Mole weight: C20H25N. CC (C) (C)c1ccc2[nH]c3ccc (cc3c2c1)C (C) (C)C. 1S/C20H25N/c1-19(2, 3)13-7-9-17-15(11-13)16-12-14(20(4, 5)6)8-10-18(16)21-17/h7-12, 21H, 1-6H3. OYFFSPILVQLRQA-UHFFFAOYSA-N. ≥ 97%.
3-Ethynylaniline
Reagent in the preparation of a metabolite of Erlotinib. Group: Biochemicals. Alternative Names: (3-Ethynylphenyl)amine; (m-Aminophenyl)acetylene; 1-Amino-3-ethynylbenzene; 3-Acetylenylaniline-d4; 3-Amino-1-ethynylbenzene; 3-Ethynylaniline; 3-Ethynylbenzenamine; m-Ethynylaniline. Grades: Highly Purified. CAS No. 54060-30-9. Pack Sizes: 10mg, 100mg, 1g, 5g. Molecular Formula: C8H7N, Form: Brown Oil. US Biological Life Sciences.
CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer. Group: Biochemicals. Alternative Names: 7-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanamide; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide. Grades: Highly Purified. CAS No. 1012054-59-9. Pack Sizes: 10mg. US Biological Life Sciences.
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CX-5011
CX-5011 is a very potent and selective CK2 inhibitor, which induces cell death in tumor cells. Synonyms: CX5011; CX 5011; Pyrimido[4,5-c]quinoline-8-carboxylic acid, 5-[(3-ethynylphenyl)amino]-. Grades: 98%. CAS No. 1009821-06-0. Molecular formula: C20H12N4O2. Mole weight: 340.34.
Desmethyl Erlotinib
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol. Grades: > 95%. CAS No. 183321-86-0. Molecular formula: C21H21N3O4. Mole weight: 379.42.
Desmethyl erlotinib carboxylate acid. Group: Biochemicals. Alternative Names: 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl]oxy]. Grades: Highly Purified. CAS No. 882172-60-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C21H19N3O5. US Biological Life Sciences.
Worldwide
Desmethyl Erlotinib, Free Base
A metabolite of Erlotinib, an anti cancer agent. Group: Biochemicals. Alternative Names: 2- [ [4- [ (3-Ethynylphenyl) amino] -7- (2-methoxyethoxy) -6-quinazolinyl] oxy] ethanol; OSI-420; CP 373420. Grades: Highly Purified. CAS No. 183321-86-0. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Didesmethyl Erlotinib
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Didesmethyl Erlotinib Hydrochloride Salt; 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis-ethanol Monohydrochloride. Grades: > 95%. CAS No. 183320-12-9. Molecular formula: C21H23N3O4. Mole weight: 381.44.
Didesmethyl erlotinib hydrochloride salt
Didesmethyl erlotinib hydrochloride salt. Group: Biochemicals. Alternative Names: 2, 2'-[[4-[ (3-Ethynylphenyl)amino]-6, 7-quinazolinediyl]bis (oxy)]bis-ethanol monohydrochloride. Grades: Highly Purified. CAS No. 183320-12-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C20H20ClN3O4. US Biological Life Sciences.
Worldwide
Erlotinib
Erlotinib. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. CAS No. 183321-74-6. Molecular Formula: C22H23N3O4. Mole Weight: 393.44. Catalog: APB183321746.
Erlotinib Impurity 10
Erlotinib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. CAS No. 183319-69-9. Molecular Formula: C22H23N3O4. Mole Weight: 393.17. Catalog: APB183319699.
Erlotinib Impurity 2
Erlotinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-(2-chloroethoxy)-N-(3-ethynylphenyl)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. CAS No. 183320-04-9. Molecular Formula: C21H21Cl2N3O3. Mole Weight: 434.32. Catalog: APB183320049.
Erlotinib Impurity 41
Erlotinib Impurity 41. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C21H21Cl2N3O3. Mole Weight: 434.32. Catalog: APB05338.
Erlotinib Impurity 44
Erlotinib Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-amine. Molecular Formula: C20H19N3O3. Mole Weight: 349.38. Catalog: APB05337.
Erlotinib Impurity 47
Erlotinib Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-chloro-N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C22H23Cl2N3O4. Mole Weight: 464.34. Catalog: APB05335.
Erlotinib Impurity 48
Erlotinib Impurity 48. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-ethynylphenyl)amino)quinazoline-6,7-diol hydrochloride. Molecular Formula: C16H12ClN3O2. Mole Weight: 313.74. Catalog: APB05334.
Erlotinib Impurity 5
Erlotinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethyl acetate. CAS No. 183320-15-2. Molecular Formula: C23H23N3O5. Mole Weight: 421.16. Catalog: APB183320152.
Erlotinib Impurity 6
Erlotinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,2'-((4-((3-ethynylphenyl)amino)quinazoline-6,7-diyl)bis(oxy))diethanol hydrochloride. CAS No. 183320-12-9. Molecular Formula: C20H20ClN3O4. Mole Weight: 401.11. Catalog: APB183320129.
Erlotinib Impurity 61
Erlotinib Impurity 61. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-ol. Molecular Formula: C19H17N3O3. Mole Weight: 335.36. Catalog: APB05324.
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)-4-Quinazolinamine. Grades: > 95%. CAS No. 183321-85-9. Molecular formula: C21H20ClN3O3. Mole weight: 397.86.
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6-(2-chloroethoxy)-N-(3-ethynylphenyl)-7-(2-methoxyethoxy)quinazolin-4-amine. Grades: > 95%. CAS No. 183321-83-7. Molecular formula: C21H20ClN3O3. Mole weight: 397.86.
Erlotinib Impurity 66
Erlotinib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-imine. Molecular Formula: C22H23N3O4. Mole Weight: 393.44. Catalog: APB05322.
Erlotinib Impurity 67
Erlotinib Impurity 67. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)quinazolin-4-amine. CAS No. 183321-85-9. Molecular Formula: C21H20ClN3O3. Mole Weight: 397.85. Catalog: APB183321859.
Erlotinib impurity, 6,7-bis(2-chloroethoxy)
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine. Grades: > 95%. CAS No. 183321-82-6. Molecular formula: C20H17Cl2N3O2. Mole weight: 402.28.
Erlotinib Impurity 68
Erlotinib Impurity 68. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine. CAS No. 183321-82-6. Molecular Formula: C20H17Cl2N3O2. Mole Weight: 402.27. Catalog: APB183321826.
Erlotinib Impurity 71
Erlotinib Impurity 71. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N-(3-ethynylphenyl)acetamide. CAS No. 2055840-54-3. Molecular Formula: C24H25N3O5. Mole Weight: 435.47. Catalog: APB2055840543.
Erlotinib Impurity 9
Erlotinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol. CAS No. 183321-86-0. Molecular Formula: C21H21N3O4. Mole Weight: 379.15. Catalog: APB183321860.
Erlotinib Impurity E
Erlotinib Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C20H20ClN3O3. Mole Weight: 385.84. Catalog: APB05340.
Erlotinib metabolite M11
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl]oxy]acetic Acid. Grades: > 95%. CAS No. 882172-60-3. Molecular formula: C21H19N3O5. Mole weight: 393.40.
Erlotinib metabolite M12
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline; 2-(4-(3-Ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl)oxyethanol; 2-[4-(3-ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol. CAS No. 183321-84-8. Molecular formula: C20H19N3O4. Mole weight: 365.389.
Erlotinib O-Desmethyl Metabolite Isomer
A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Erlotinib 7-O-Desmethyl Metabolite; 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl] oxy]ethanol. Grades: > 95%. CAS No. 183320-29-8. Molecular formula: C21H21N3O4. Mole weight: 379.42.
Erlotinib O-Desmethyl Metabolite Isomer (M13)
Erlotinib O-Desmethyl Metabolite Isomer (M13). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-6-(2-methoxyethoxy)quinazolin-7-yl)oxy)ethanol. CAS No. 183320-29-8. Molecular Formula: C21H21N3O4. Mole Weight: 379.41. Catalog: APB183320298.
JNJ7925476 HCl
JNJ7925476 HCl is a novel triple monoamine uptake inhibitor. It blocks the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system. Its ED50 values for SERT, NET, and DATwere 0.18, 0.09 and 2.4 mg/kg, respectively in rat brain. It is used as a TRI antidepressant. It was under the development by Johnson & Johnson. Uses: Jnj7925476 hcl is used as a tri antidepressant. Synonyms: JNJ-7925476; JNJ 7925476; JNJ7925476; JNJ-7925476 HCl. Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride (1:1), (6R,10bS)-rel-;Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride, trans-;JNJ-7925476 HCl;(6S,10bR)-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline hydrochloride. Grades: >98%. CAS No. 109085-56-5. Molecular formula: C20H20ClN. Mole weight: 309.84.
LNK 754
LNK 754 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: LNK 754; LNK-754; LNK754; CP 609754; CP-609,754. CP609754; 6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one;(2R,3R)-2,3-dihydroxybutanedioic acid. Grades: ≥95%. CAS No. 439153-64-7. Molecular formula: C33H28ClN3O8. Mole weight: 630.05.
NRC-2694 is a small molecule antagonist of epidermal growth factor receptor (EGFR) signalling pathways, for the treatment of solid tumors. Synonyms: NRC-2694; NRC 2694; NRC2694; N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; NRC-2694; NRC 2694; NRC2694; 4-Quinazolinamine, N-(3-ethynylphenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-. CAS No. 936446-61-6. Molecular formula: C24H26N4O3. Mole weight: 418.49.
OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
A labeled metabolite of Erlotinib , an anti-cancer agent. Group: Biochemicals. Alternative Names: 2- [ [4- [ (3-Ethynylphenyl-d4) amino] -7- (2-methoxyethoxy) -6-quinazolinyl] oxy] ethanol; CP 373420. Grades: Highly Purified. CAS No. 1216420-11-9. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
TD52
TD52 is an erlotinib derivative. TD52 is a putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells. TD52 induces apoptosis through downregulation of CIP2A (Cancerous inhibitor of protein phosphatase 2A) in HCC, NSCLC and TNBC cells. Group: Inhibitors. Alternative Names: TD52; TD-52; TD 52; erlotinib derivative; erlotinib analogue. CAS No. 1798328-24-1. Molecular formula: C24H16N4. Mole weight: 360.42. Appearance: To be determined. Purity: >98%. IUPACName: N2,N3-bis(3-ethynylphenyl)quinoxaline-2,3-diamine. Canonical SMILES: C#CC1=CC=CC (NC2=NC3=CC=CC=C3N=C2NC4=CC=CC (C#C)=C4)=C1. Catalog: ACM1798328241.
TD52
TD52 is a potent CIP2A inhibitor with increased apoptosis in HCC cells compared to erlotinib (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). CIP2A-dependent p-Akt downregulation modulates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo. Uses: Antitumor agent. Synonyms: N2,N3-bis(3-Ethynylphenyl)-2,3-quinoxalinediamine. Grades: 99%. CAS No. 1798328-24-1. Molecular formula: C24H16N4. Mole weight: 360.41.
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