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Exenatide, naturally occured in the saliva of the Gila monster, an incretin mimetic that has glucoregulatory effect. As a glucagon-like peptide-1 (GLP-1) receptor agonist, it stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways. Uses: Hypoglycemic agents. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-; L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide; Exendin 3 (Heloderma horridum), 2-glycine-3-L-glutamic acid-; Exendin 4 (Heloderma suspectum); AC 2993; AC 2993A; AC 2993LAR; Bydureon; Byetta; DA 3091; EQW; Exatenide; Exenatide LAR; Exendin 4; Exendin-4; ITCA 650; LAEx4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. CAS No. 141758-74-9. Molecular formula: C184H282N50O60S. Mole weight: 4186.56.
Exenatide acetate
Exenatide acetate. Group: Biochemicals. Alternative Names: Exendin-4. Grades: Highly Purified. CAS No. 141732-76-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C184H282N50O60S·C2H4O2 . US Biological Life Sciences.
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Exenatide acetate
Exenatide acetate is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor with Ki value of 136 pM. It is a 39 amino acid peptide, which increases intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. It was first isolated from the venom of H. horridum and consequently synthesized. It stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism. It also stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells. It protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neurodegenerative diseases. It also has anxiolytic and anti-depressant effects and induces satiety. It is an incretin mimetic approved for type 2 diabetes mellitus treatment. It also has neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-, acetate (1:x); Exendin 4 (Heloderma suspectum), acetate; Exendin-4 acetate; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.CH3CO2H. Grades: >98%. CAS No. 914454-01-6. Molecular formula: C184H282N50O60S.C2H4O2. Mole weight: 4246.61.
Acetyl-Exenatide
Acetyl-Exenatide is a potential impurity of exenatide. Synonyms: Acetyl-Exendin-4; Ac-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 305815-28-5. Molecular formula: C186H284N50O61S. Mole weight: 4228.67.
(Asp28)-Exenatide
(Asp28)-Exenatide is an impurity and degradation product of exenatide. Synonyms: (Asp28)-Exendin-4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678417-24-7. Molecular formula: C184H281N49O61S. Mole weight: 4187.62.
(β-Asp28)-Exenatide
(β-Asp28)-Exenatide is a potential degradation product of exenatide produced by the formation and cleavage of aspartimide. Synonyms: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH. Grades: ≥95%. CAS No. 2022972-68-3. Molecular formula: C184H281N49O61S. Mole weight: 4187.62.
(β-D-Asp28)-Exenatide
(β-D-Asp28)-Exenatide is a potential degradation product of exenatide produced by the formation and cleavage of aspartimide. Synonyms: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH. Grades: ≥95%. CAS No. 2022976-04-9. Molecular formula: C184H281N49O61S. Mole weight: 4187.62.
(D-Asn28)-Exenatide
(D-Asn28)-Exenatide is a potential impurity of exenatide. Synonyms: (D-Asn28)-Exendin-4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 2022972-66-1. Molecular formula: C184H282N50O60S. Mole weight: 4186.63.
(D-Asp28)-Exenatide
(D-Asp28)-Exenatide is a potential degradation product of exenatide produced by the formation and cleavage of aspartimide. Synonyms: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 2022972-67-2. Molecular formula: C184H281N49O61S. Mole weight: 4187.62.
(Des-Gly2)-Exenatide
(Des-Gly2)-Exenatide is a potential impurity of exenatide. Synonyms: (Des-Gly2)-Exendin-4; H-His-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678416-78-8. Molecular formula: C182H279N49O59S. Mole weight: 4129.58.
(D-His1)-Exenatide
(D-His1)-Exenatide is an impurity of exenatide. Synonyms: (D-His1)-Exendin-4; H-D-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678417-09-8. Molecular formula: C184H282N50O60S. Mole weight: 4186.63.
Endo-38a-Pro-Exenatide
Endo-38a-Pro-Exenatide is an impurity of exenatide. Synonyms: Endo-38a-Exendin-4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678416-95-9. Molecular formula: C189H289N51O61S. Mole weight: 4283.75.
Met(O)14-Exenatide
Met(O)14-Exenatide is an impurity and degradation product of exenatide. Synonyms: Met(O)14-Exendin-4; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met(O)-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; Exendin-4 sulfoxide. Grades: ≥95%. CAS No. 1678417-38-3. Molecular formula: C184H282N50O61S. Mole weight: 4202.57.
Exendin-4
Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC 50 of 3.22 nM. Uses: Scientific research. Group: Peptides. Alternative Names: Exenatide. CAS No. 141758-74-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13443.
Exendin-4 acetate
Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC 50 of 3.22 nM. Uses: Scientific research. Group: Peptides. Alternative Names: Exenatide acetate. CAS No. 914454-01-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13443A.
Glutaminyl-Methionyl-Glutamyl-Glutamyl-Glutamyl-Alanyl-Valyl-Arginine Trifluoroacetate is a metabolite from Exenatide trypsin (Exenatide Acetate, E957300) digestion. Exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 868249-03-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C41H66F3N12O17S, Molecular Weight: 1088.08999999999. US Biological Life Sciences.
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