Farnesyl Diphosphate Synthase Suppliers USA
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Product | Description | |
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Alendronate sodium (MK 217) Quick inquiry Where to buy Suppliers range | Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts. Group: Biochemicals. Alternative Names: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt. Grades: Purified. CAS No. 129318-43-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Alendronate sodium (Sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid, trihydrate, MK-217, Fosamax) Quick inquiry Where to buy Suppliers range | Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC?? value of 2nm. Also acts as a farnesyl diphosphate synthase inhibitor (IC?? =460nm) and CD45 protein tyrosine phosphatase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 121268-17-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
BPH715 Quick inquiry Where to buy Suppliers range | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium;Bisphpshonate-715;[2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate;Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grades: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. | |
Pamidronate Disodium Salt (3-Amino-1-hydroxy-1-phosphonopropane phosphonic Acid Disodium Salt) Quick inquiry Where to buy Suppliers range | A bisphosphonate compound that inhibits bone resorption, the natural, ongoing process of bone being destroyed by osteoclasts. Also inhibits farnesyl diphosphate synthase (IC?? = 200nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 57248-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
YM-53601 Quick inquiry Where to buy Suppliers range | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. | |
Zoledronic Acid Hydrate Quick inquiry Where to buy Suppliers range | Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget's disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. Synonyms: Zoledronate monohydrate; CGP 42446 monohydrate; ZOL 446 monohydrate; CGP42446 monohydrate; ZOL446 monohydrate; CGP-42446 monohydrate; ZOL-446 monohydrate; CGP42446A monohydrate. Grades: >98%. CAS No. 165800-06-6. Molecular formula: C5H12N2O8P2. Mole weight: 290.1. | |
Zoledronic Acid Monohydrate Quick inquiry Where to buy Suppliers range | Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget?s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. Group: Biochemicals. Alternative Names: P, P?- [1-Hydroxy-2- (1H-imidazol-1-yl) ethylidene] bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate. Grades: Highly Purified. CAS No. 165800-06-6. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |