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| Product | Description | |
|---|---|---|
| (2E,6E)-farnesyl diphosphate synthase | Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: farnesyl-diphosphate synthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase. Enzyme Commission Number: EC 2.5.1.10. CAS No. 37277-79-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2715; (2E,6E)-farnesyl diphosphate synthase; EC 2.5.1.10; 37277-79-5; farnesyl-diphosphate synthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase. Cat No: EXWM-2715. |  |
| (2Z,6E)-farnesyl diphosphate synthase | Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate. Group: Enzymes. Synonyms: (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase. Enzyme Commission Number: EC 2.5.1.68. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2805; (2Z,6E)-farnesyl diphosphate synthase; EC 2.5.1.68; (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase. Cat No: EXWM-2805. | |
| (2Z,6Z)-farnesyl diphosphate synthase | This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase]. Group: Enzymes. Synonyms: cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Enzyme Commission Number: EC 2.5.1.92. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2831; (2Z,6Z)-farnesyl diphosphate synthase; EC 2.5.1.92; cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Cat No: EXWM-2831. | |
| 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | Isolated from the plant Solanum habrochaites. 7-Epizingiberene is a whitefly repellant. Group: Enzymes. Synonyms: ShZIS (gene name). Enzyme Commission Number: EC 4.2.3.142. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5156; 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.142; ShZIS (gene name). Cat No: EXWM-5156. | |
| (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-β-bergamotene (see EC 4.2.3.53) as well as (-)-endo-α-bergamotene (see EC 4.2.3.54). Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.50. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5210; (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.50; SBS (ambiguous). Cat No: EXWM-5210. | |
| ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] | The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated α-isoprene unit, which serves as a glycosyl carrier in protein glycosylation. The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C80 (16 isoprene residues) extending to C120, while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C290. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C120. Group: Enzymes. Synonyms: RER2; Rer2p; Rer2p Z-prenyltransferase; Srt1p; Srt2p Z-prenyltransferase; ACPT; dehydrodolichyl diphosphate synthase 1. Enzyme Commission Number: EC 2.5.1.87. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2825; ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]; EC 2.5.1.87; RER2; Rer2p; Rer2p Z-prenyltransferase; Srt1p; Srt2p Z-prenyltransferase; ACPT; dehydrodolichyl diphosphate synthase 1. Cat No: EXWM-2825. | |
| ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Group: Enzymes. Synonyms: di-trans,poly-cis-undecaprenyl-diphosphate synthase; undecaprenyl-diphosphate synthase; bactoprenyl-diphosphate synthase; UPP synthetase; undecaprenyl diphosphate synthetase; undecaprenyl pyrophosphate synthetase; di-trans,poly-cis-decaprenylcistransferase. Enzyme Commission Number: EC 2.5.1.31. CAS No. 52350-87-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2769; ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]; EC 2.5.1.31; 52350-87-5; di-trans,poly-cis-undecaprenyl-diphosphate synthase; undecaprenyl-diphosphate synthase; bactoprenyl-diphosphate synthase; UPP synthetase; undecaprenyl diphosphate synthetase; undecaprenyl pyrophosphate synthetase; di-trans,poly-cis-decaprenylcistransferase. Cat No: EXWM-2769. | |
| (-)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-β-bergamotene (EC 4.2.3.53) as well as (-)-endo-α-bergamotene. Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5214; (-)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.54; SBS (ambiguous). Cat No: EXWM-5214. | |
| (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing] | The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-α-bergamotene (see EC 4.2.3.54), as well as (+)-endo-β-bergamotene. Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5213; (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.53; SBS (ambiguous). Cat No: EXWM-5213. | |
| (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing] | Isolated from the liverwort Heteroscyphus planus. cf EC 4.2.3.92 (+)-γ-cadinene synthase. Group: Enzymes. Synonyms: (-)-γ-cadinene cyclase. Enzyme Commission Number: EC 4.2.3.62. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5223; (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.62; (-)-γ-cadinene cyclase. Cat No: EXWM-5223. | |
| geranylfarnesyl diphosphate synthase | The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids. Group: Enzymes. Synonyms: FGPP synthase; (all-E) geranylfarnesyl diphosphate synthase; GFPS; Fgs. Enzyme Commission Number: EC 2.5.1.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2819; geranylfarnesyl diphosphate synthase; EC 2.5.1.81; FGPP synthase; (all-E) geranylfarnesyl diphosphate synthase; GFPS; Fgs. Cat No: EXWM-2819. | |
| hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Group: Enzymes. Synonyms: HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Enzyme Commission Number: EC 2.5.1.83. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2821; hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]; EC 2.5.1.83; HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Cat No: EXWM-2821. | |
| trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific] | Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.88. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2826; trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]; EC 2.5.1.88. Cat No: EXWM-2826. | |
| Alendronate sodium hydrate | Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC 50 of 460 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Alendronate; MK 217; G-704650 Adronat. CAS No. 121268-17-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-11101. |  |
| Alendronate sodium (MK 217) | Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts. Group: Biochemicals. Alternative Names: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt. Grades: Purified. CAS No. 129318-43-0. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| Alendronate sodium (Sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid, trihydrate, MK-217, Fosamax) | Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC?? value of 2nm. Also acts as a farnesyl diphosphate synthase inhibitor (IC?? =460nm) and CD45 protein tyrosine phosphatase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 121268-17-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Alendronic acid | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Pagets disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66376-36-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0631. | |
| all-trans-decaprenyl-diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: decaprenyl-diphosphate synthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2830; all-trans-decaprenyl-diphosphate synthase; EC 2.5.1.91; decaprenyl-diphosphate synthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Cat No: EXWM-2830. | |
| all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific] | (2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation. Group: Enzymes. Synonyms: nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphate synthase (ambiguous); OsSPS2. Enzyme Commission Number: EC 2.5.1.84. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2822; all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]; EC 2.5.1.84; nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphate synthase (ambiguous); OsSPS2. Cat No: EXWM-2822. | |
| all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. Group: Enzymes. Synonyms: nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Enzyme Commission Number: EC 2.5.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2823; all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.85; nonaprenyl diphosphate synthase (ambiguous); solanesyl diphosphate synthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Cat No: EXWM-2823. | |
| all-trans-octaprenyl-diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: octaprenyl-diphosphate synthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.90. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2829; all-trans-octaprenyl-diphosphate synthase; EC 2.5.1.90; octaprenyl-diphosphate synthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Cat No: EXWM-2829. | |
| α-farnesene synthase | Alpha-farnesene synthase (EC 4.2.3.46) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate lyase ((3E,6E)-alpha-farnesene-forming). Group: Enzymes. Synonyms: (E,E)-α-farnesene synthase; AFS1; MdAFS1. Enzyme Commission Number: EC 4.2.3.46. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5205; α-farnesene synthase; EC 4.2.3.46; (E,E)-α-farnesene synthase; AFS1; MdAFS1. Cat No: EXWM-5205. | |
| α-santalene synthase | The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-α-santalene, (-)-β-santalene and (-)-exo-α-bergamotene are formed with traces of (+)-epi-β-santalene. See EC 4.2.3.83 [(-)-β-santalene synthase], and EC 4.2.3.81 [(-)-exo-α-bergamotene synthase]. cf. EC 4.2.3.50 α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5245; α-santalene synthase; EC 4.2.3.82. Cat No: EXWM-5245. | |
| aristolochene synthase | The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23, germacrene-A synthase). The enzyme from Penicillium roqueforti requires Mg2+. Mn2+ can partially substitute, at low concentrations. Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. Group: Enzymes. Synonyms: sesquiterpene cyclase; trans,trans-farnesyl diphosphate aristolochene-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming). Enzyme Commission Number: EC 4.2.3.9. CAS No. 94185-89-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5253; aristolochene synthase; EC 4.2.3.9; 94185-89-4; sesquiterpene cyclase; trans,trans-farnesyl diphosphate aristolochene-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming). Cat No: EXWM-5253. | |
| avermitilol synthase | Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5260; avermitilol synthase; EC 4.2.3.96. Cat No: EXWM-5260. | |
| (-)-β-caryophyllene synthase | Widely distributed in higher plants, cf. EC 4.2.3.89 (+)-β-caryophyllene synthase. Group: Enzymes. Synonyms: β-caryophyllene synthase; (2E,6E)-farnesyl-diphosphate diphosphate-lyase (caryophyllene-forming). Enzyme Commission Number: EC 4.2.3.57. CAS No. 110639-18-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5217; (-)-β-caryophyllene synthase; EC 4.2.3.57; 110639-18-4; β-caryophyllene synthase; (2E,6E)-farnesyl-diphosphate diphosphate-lyase (caryophyllene-forming). Cat No: EXWM-5217. | |
| β-farnesene synthase | Beta-farnesene synthase (EC 4.2.3.47) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-beta-farnesene-forming). Group: Enzymes. Synonyms: farnesene synthase; terpene synthase 10; terpene synthase 10-B73; TPS10. Enzyme Commission Number: EC 4.2.3.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5206; β-farnesene synthase; EC 4.2.3.47; farnesene synthase; terpene synthase 10; terpene synthase 10-B73; TPS10. Cat No: EXWM-5206. | |
| β-santalene synthase | The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-β-santalene (+)-α-santalene and (-)-exo-α-bergamotene are formed with traces of (+)-epi-β-santalene. See EC 4.2.3.82 [(+)-α-santalene synthase], and EC 4.2.3.81 [(-)-exo-α-bergamotene synthase]. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.83. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5246; β-santalene synthase; EC 4.2.3.83. Cat No: EXWM-5246. | |
| β-sesquiphellandrene synthase | Beta-sesquiphellandrene synthase (EC 4.2.3.123) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-sesquiphellandrene-forming). Group: Enzymes. Synonyms: Tps1; Os08g07100 (gene name). Enzyme Commission Number: EC 4.2.3.123. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5136; β-sesquiphellandrene synthase; EC 4.2.3.123; Tps1; Os08g07100 (gene name). Cat No: EXWM-5136. | |
| Botryococcus squalene synthase | Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate. Group: Enzymes. Synonyms: SSL-2 (gene name). Enzyme Commission Number: EC 1.3.1.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1366; Botryococcus squalene synthase; EC 1.3.1.96; SSL-2 (gene name). Cat No: EXWM-1366. | |
| BPH715 | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium;Bisphpshonate-715;[2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate;Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grades: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. |  |
| (+)-caryolan-1-ol synthase | A multifunctional enzyme which also forms (+)-β-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-β-caryophyllene synthase]. Group: Enzymes. Synonyms: GcoA. Enzyme Commission Number: EC 4.2.1.138. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4979; (+)-caryolan-1-ol synthase; EC 4.2.1.138; GcoA. Cat No: EXWM-4979. | |
| (-)-Δ-cadinene synthase | The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-Δ-cadinene. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.97. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5261; (-)-Δ-cadinene synthase; EC 4.2.3.97. Cat No: EXWM-5261. | |
| dimethylallyltranstransferase | This enzyme will not accept larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: geranyl-diphosphate synthase; prenyltransferase; dimethylallyltransferase; DMAPP:IPP-dimethylallyltransferase; (2E,6E)-farnesyl diphosphate synthetase; diprenyltransferase; geranyl pyrophosphate synthase; geranyl pyrophosphate synthetase; trans-farnesyl pyrophosphate synthetase. Enzyme Commission Number: EC 2.5.1.1. CAS No. 9032-79-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2714; dimethylallyltranstransferase; EC 2.5.1.1; 9032-79-5; geranyl-diphosphate synthase; prenyltransferase; dimethylallyltransferase; DMAPP:IPP-dimethylallyltransferase; (2E,6E)-farnesyl diphosphate synthetase; diprenyltransferase; geranyl pyrophosphate synthase; geranyl pyrophosphate synthetase; trans-farnesyl pyrophosphate synthetase. Cat No: EXWM-2714. | |
| (E,E)-germacrene B synthase | (E,E)-germacrene B synthase (EC 4.2.3.71) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E,E)-germacrene-B-forming). Group: Enzymes. Enzyme Commission Number: EC 4.2.3.71. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5233; (E,E)-germacrene B synthase; EC 4.2.3.71. Cat No: EXWM-5233. | |
| (E)-γ-bisabolene synthase | (E)-gamma-bisabolene synthase (EC 4.2.3.59) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-gamma-bisabolene-forming). Group: Enzymes. Enzyme Commission Number: EC 4.2.3.59. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5219; (E)-γ-bisabolene synthase; EC 4.2.3.59. Cat No: EXWM-5219. | |
| elisabethatriene synthase | Requires Mg2+ or less efficiently Mn2+. The enzyme is also able to use farnesyl diphosphate and geranyl diphosphate. Group: Enzymes. Synonyms: elisabethatriene cyclase. Enzyme Commission Number: EC 4.2.3.41. CAS No. 334022-59-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5200; elisabethatriene synthase; EC 4.2.3.41; 334022-59-2; elisabethatriene cyclase. Cat No: EXWM-5200. | |
| epi-isozizaene synthase | Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone. Group: Enzymes. Synonyms: SCO5222 protein. Enzyme Commission Number: EC 4.2.3.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5195; epi-isozizaene synthase; EC 4.2.3.37; SCO5222 protein. Cat No: EXWM-5195. | |
| exo-α-bergamotene synthase | The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-exo-α-bergamotene (74%) there were (E)-nerolidol (10%), (Z)-α-bisabolene (6%), (E)-β-farnesene (5%) and β-sesquiphellandrene (1%). Group: Enzymes. Synonyms: trans-α-bergamotene synthase; LaBERS (gene name). Enzyme Commission Number: EC 4.2.3.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5244; exo-α-bergamotene synthase; EC 4.2.3.81; trans-α-bergamotene synthase; LaBERS (gene name). Cat No: EXWM-5244. | |
| (+)-γ-cadinene synthase | The cloned enzyme from the melon, Cucumis melo, gave mainly Δ- and γ-cadinene with traces of several other sesquiterpenoids cf. EC 4.2.3.62 (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.13 (+)-Δ-cadinene synthase. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.92. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5256; (+)-γ-cadinene synthase; EC 4.2.3.92. Cat No: EXWM-5256. | |
| γ-humulene synthase | Gamma-humulene synthase (EC 4.2.3.56) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (gamma-humulene-forming). Group: Enzymes. Synonyms: humulene cyclase. Enzyme Commission Number: EC 4.2.3.56. CAS No. 110639-19-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5216; γ-humulene synthase; EC 4.2.3.56; 110639-19-5; humulene cyclase. Cat No: EXWM-5216. | |
| geranylgeranyl diphosphate synthase | Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Enzyme Commission Number: EC 2.5.1.29. CAS No. 9032-58-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2766; geranylgeranyl diphosphate synthase; EC 2.5.1.29; 9032-58-0; geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Cat No: EXWM-2766. | |
| germacradienol synthase | Requires Mg2+ for activity. H-1si of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. Formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate. Both products are formed from a common intermediate. Other enzymes produce germacrene D as the sole product using a different mechanism. The enzyme mediates a key step in the biosynthesis of geosmin (see EC 4.1.99.16 geosmin synthase), a widely occurring metabolite of many streptomycetes, bacteria and fungi. Also catalyses the reaction of EC 4.2.3.75, (-)-germacrene D synthase. Group: Enzymes. Synonyms: germacradienol/germacrene-D synthase; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]. Enzyme Commission Number: EC 4.2.3.22. CAS No. 211049-88-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5179; germacradienol synthase; EC 4.2.3.22; 211049-88-6; germacradienol/germacrene-D synthase; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]. Cat No: EXWM-5179. | |
| germacrene-A synthase | Requires Mg2+ for activity. While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 (aristolochene synthase) from some species and EC 4.2.3.21 (vetispiradiene synthase), it is the sole sesquiterpenoid product formed in chicory. Group: Enzymes. Synonyms: germacrene A synthase; (+)-germacrene A synthase; (+)-(10R)-germacrene A synthase; GAS; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming). Enzyme Commission Number: EC 4.2.3.23. CAS No. 213763-55-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5180; germacrene-A synthase; EC 4.2.3.23; 213763-55-4; germacrene A synthase; (+)-germacrene A synthase; (+)-(10R)-germacrene A synthase; GAS; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming). Cat No: EXWM-5180. | |
| germacrene C synthase | Germacrene C synthase (EC 4.2.3.60) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (germacrene-C-forming). Group: Enzymes. Enzyme Commission Number: EC 4.2.3.60. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5221; germacrene C synthase; EC 4.2.3.60. Cat No: EXWM-5221. | |
| heptaprenyl diphosphate synthase | This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: all-trans-heptaprenyl-diphosphate synthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Enzyme Commission Number: EC 2.5.1.30. CAS No. 74506-59-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2768; heptaprenyl diphosphate synthase; EC 2.5.1.30; 74506-59-5; all-trans-heptaprenyl-diphosphate synthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Cat No: EXWM-2768. | |
| hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+. Group: Enzymes. Synonyms: HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Enzyme Commission Number: EC 2.5.1.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2820; hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.82; HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous). Cat No: EXWM-2820. | |
| hydroxysqualene dehydroxylase | This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase. Group: Enzymes. Synonyms: hpnE (gene name). Enzyme Commission Number: EC 1.17.8.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1100; hydroxysqualene dehydroxylase; EC 1.17.8.1; hpnE (gene name). Cat No: EXWM-1100. | |
| hydroxysqualene synthase | This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase. Group: Enzymes. Synonyms: hpnC (gene name). Enzyme Commission Number: EC 4.2.3.156. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5171; hydroxysqualene synthase; EC 4.2.3.156; hpnC (gene name). Cat No: EXWM-5171. | |
| Incadronic acid | Incadronic acid inhibits growth of Dictyostelium discoideum with an IC 50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase ( FPPS ) in Leishmania major with the K i of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC 50 of 48 to 228.6 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 124351-85-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-149149. | |
| Pamidronate Disodium Salt (3-Amino-1-hydroxy-1-phosphonopropane phosphonic Acid Disodium Salt) | A bisphosphonate compound that inhibits bone resorption, the natural, ongoing process of bone being destroyed by osteoclasts. Also inhibits farnesyl diphosphate synthase (IC?? = 200nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 57248-88-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| patchoulol synthase | Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming). Group: Enzymes. Enzyme Commission Number: EC 4.2.3.70. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5232; patchoulol synthase; EC 4.2.3.70. Cat No: EXWM-5232. | |
| pentalenene synthase | Isolated from Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. The 9si hydrogen of farnesyl diphosphate undergoes a 1,2-hydride shift where it becomes the 1α hydrogen of pentalenene. Group: Enzymes. Synonyms: pentalenene synthetase. Enzyme Commission Number: EC 4.2.3.7. CAS No. 90597-46-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5231; pentalenene synthase; EC 4.2.3.7; 90597-46-9; pentalenene synthetase. Cat No: EXWM-5231. | |
| presqualene diphosphate synthase | Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase). Group: Enzymes. Synonyms: SSL-1 (gene name); hpnD (gene name). Enzyme Commission Number: EC 2.5.1.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2719; presqualene diphosphate synthase; EC 2.5.1.103; SSL-1 (gene name); hpnD (gene name). Cat No: EXWM-2719. | |
| R-linalool synthase | Geranyl diphosphate cannot be replaced by isopentenyl diphosphate, dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed. Group: Enzymes. Synonyms: (3R)-linalool synthase; (-)-3R-linalool synthase. Enzyme Commission Number: EC 4.2.3.26. CAS No. 254993-26-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5183; R-linalool synthase; EC 4.2.3.26; 254993-26-5; (3R)-linalool synthase; (-)-3R-linalool synthase. Cat No: EXWM-5183. | |
| (S)-β-bisabolene synthase | The synthesis of (S)-β-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-β-bisabolene. The second step is the isomerization to (S)-β-macrocarpene (cf. EC 5.5.1.17, (S)-β-macrocarpene synthase). The enzyme requires Mg2+ or Mn2+ for activity. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.55. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5215; (S)-β-bisabolene synthase; EC 4.2.3.55. Cat No: EXWM-5215. | |
| (S)-β-macrocarpene synthase | The synthesis of (S)-β-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-β-bisabolene (cf. EC 4.2.3.55, (S)-β-bisabolene synthase). The second step is the isomerization to (S)-β-macrocarpene. Group: Enzymes. Synonyms: TPS6; TPS11; (S)-β-macrocarpene lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5618; (S)-β-macrocarpene synthase; EC 5.5.1.17; TPS6; TPS11; (S)-β-macrocarpene lyase (decyclizing). Cat No: EXWM-5618. | |
| squalene synthase | This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). High concentrations of FPP inhibit the production of squalene but not of PSPP. Group: Enzymes. Synonyms: farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Enzyme Commission Number: EC 2.5.1.21. CAS No. 9077-14-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2758; squalene synthase; EC 2.5.1.21; 9077-14-9; farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Cat No: EXWM-2758. | |
| terpentetriene synthase | Requires Mg2+ for maximal activity but can use Mn2+, Fe2+ or Co2+ to a lesser extent. Following on from EC 5.5.1.15, terpentedienyl-diphosphate synthase, this enzyme completes the transformation of geranylgeranyl diphosphate (GGDP) into terpentetriene, which is a precursor of the diterpenoid antibiotic terpentecin. Farnesyl diphosphate can also act as a substrate. Group: Enzymes. Synonyms: Cyc2. Enzyme Commission Number: EC 4.2.3.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5194; terpentetriene synthase; EC 4.2.3.36; Cyc2. Cat No: EXWM-5194. | |
| (+)-T-muurolol synthase | The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5262; (+)-T-muurolol synthase; EC 4.2.3.98. Cat No: EXWM-5262. | |
| trichodiene synthase | This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. This enzyme participates in terpenoid biosynthesis. Group: Enzymes. Synonyms: trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. Enzyme Commission Number: EC 4.2.3.6. CAS No. 101915-76-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5220; trichodiene synthase; EC 4.2.3.6; 101915-76-8; trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. Cat No: EXWM-5220. | |
| tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific] | This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2827; tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.89. Cat No: EXWM-2827. | |
| Ym-53601 | YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 182959-33-7. Molecular formula: C21H21FN2O. Mole weight: 372.86. Purity: 0.9926. Canonical SMILES: F/C(COC1=CC(NC2=C3C=CC=C2)=C3C=C1)=C4CN5CCC/4CC5.[H]Cl. Product ID: ACM182959337. Alfa Chemistry ISO 9001:2015 Certified. |  |
| YM-53601 | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. | |
| zingiberene synthase | Zingiberene synthase (EC 4.2.3.65) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (zingiberene-forming). Group: Enzymes. Synonyms: α-zingiberene synthase; ZIS. Enzyme Commission Number: EC 4.2.3.65. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5226; zingiberene synthase; EC 4.2.3.65; α-zingiberene synthase; ZIS. Cat No: EXWM-5226. | |
| Zoledronic Acid Hydrate | Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget's disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. Synonyms: Zoledronate monohydrate; CGP 42446 monohydrate; ZOL 446 monohydrate; CGP42446 monohydrate; ZOL446 monohydrate; CGP-42446 monohydrate; ZOL-446 monohydrate; CGP42446A monohydrate. Grades: >98%. CAS No. 165800-06-6. Molecular formula: C5H12N2O8P2. Mole weight: 290.1. | |
| Zoledronic Acid Monohydrate | Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget?s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. Group: Biochemicals. Alternative Names: P, P?- [1-Hydroxy-2- (1H-imidazol-1-yl) ethylidene] bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate. Grades: Highly Purified. CAS No. 165800-06-6. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
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