Fatty Acid Synthase Suppliers USA
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Product | Description | |
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2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid Quick inquiry Where to buy Suppliers range | 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid, a promising antifungal agent, possesses potent activity against Candidiasis and Aspergillosis. The compound targets 3-ketoacyl-ACP synthase III (FabH), a key enzyme in the biosynthesis of fungal fatty acids, and reduces fungal growth by inducing cellular membrane disruption through inhibition of FabH activity. With its unique mode of action, 2,3-Dihydrothieno[3,4-b][1,4]dioxine-2-carboxylic acid stands as a notably effective potential antifungal therapeutic candidate. Synonyms: 2H,3H-Thieno[3,4-B][1,4]dioxine-2-carboxylic acid; EDOT carboxylic acid; Carboxyedot. CAS No. 955373-67-8. Molecular formula: C7H6O4S. Mole weight: 186.181. | |
8,11-Eicosadiynoic acid Quick inquiry Where to buy Suppliers range | 8,11-Eicosadiynoic acid is an acetylenic fatty acid which inhibits arachidonic acid metabolism at several unrelated stages. 8,11-Eicosadiynoic acid inhibits the enzymes, arachidonoyl synthase, acyl-CoA synthase, Δ-5-desaturase, COX, and also arachidonic acid uptake by platelets. Synonyms: EDYA; Eicosa-8,11-diynoic acid. Grades: ≥95%. CAS No. 82073-91-4. Molecular formula: C20H32O2. Mole weight: 304.5. | |
9-Bromononanoic acid Quick inquiry Where to buy Suppliers range | 9-Bromononanoic acid, an instrumental biochemical reagent, finds ubiquitous use in several industrial processes including the synthesis of pharmaceutical drugs. Known for its inhibitory properties against fatty acid synthase, its prowess extends to manufacturing surfactants, detergents while also being extensively used as a building block in organic synthesis. This acid's multifunctional attributes coupled with its incomparable industrial benefits are a testament to its quintessential role in modern chemistry. Synonyms: Nonanoic acid, 9-bromo-; 9-bromo-nonanoic acid; 9-bromo-n-nonanoic acid. CAS No. 41059-02-3. Molecular formula: C9H17BrO2. Mole weight: 237.13. | |
C75 Quick inquiry Where to buy Suppliers range | C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer. Synonyms: C 75 trC-75 trans-racemic; trans-C75; C 75; C75; C-75. Grades: >98%. CAS No. 218137-86-1. Molecular formula: C14H22O4. Mole weight: 254.32. | |
C75 trans Quick inquiry Where to buy Suppliers range | trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a cell cycle arrest inducer in hepatocellular carcinoma (HCC) cell lines. It has also been shown to blocks resistin-induced increases in lipid accumulation by human macrophages. Synonyms: C 75 trC-75 trans-racemic; trans-C75. Grades: >98%. CAS No. 191282-48-1. Molecular formula: C14H22O4. Mole weight: 254.32. | |
CDDO Imidazolide Quick inquiry Where to buy Suppliers range | CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers. Group: Biochemicals. Alternative Names: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide; CDDO-Im; RTA 403; TP 235. Grades: Highly Purified. CAS No. 443104-02-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Cerulenin (2,3-Epoxy-4-oxo-7,10-dodecadienamide) Quick inquiry Where to buy Suppliers range | Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to B-keto-acyl- ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes). Group: Biochemicals. Grades: Highly Purified. CAS No. 17397-89-6. Pack Sizes: 5mg. Molecular Formula:C12H17NO3 MOLECULAR WEIGHT: 223.3. US Biological Life Sciences. | Worldwide |
Cerulenin (Helicocerin, NSC 116069, 2,3-Epoxy-4-oxo-7,10-dodecadienamide) Quick inquiry Where to buy Suppliers range | Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens and identified as an antifungal in the 1960s. Over the past 40 years cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to B-keto-acyl-ACP synthase blocking the interaction of malonyl CoA. Cerulenin is also an inhibitor of bacterial fatty acid synthesis acting on the FabH, FabB and FabF condensation enzymes. Cerulenin stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 17397-89-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Denifanstat Quick inquiry Where to buy Suppliers range | Denifanstat is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Synonyms: FASN-IN-2; TVB-2640; 4-(1-(4-Cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile; TVB2640; TVB 2640; FASN inhibitor 2; Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-. Grades: ≥97%. CAS No. 1399177-37-7. Molecular formula: C27H29N5O. Mole weight: 439.55. | |
FAS-IN-1 Quick inquiry Where to buy Suppliers range | FAS-IN-1, a diazaspiro derivative, has been found to be a fatty acid synthase inhibitor that probably have potential biological usage in anticancer study. Uses: Fas-in-1 has been found to be a fatty acid synthase inhibitor that probably have potential biological usage in anticancer study. Synonyms: FAS-IN-1; FAS IN 1; CHEMBL2147032; SCHEMBL4541971; OGGOWHOQMIINAZ-UHFFFAOYSA-N; BDBM50391837; BDBM 50391837; BDBM-50391837; CS 3932; CS3932; CS-3932. Grades: 98%. CAS No. 1375105-96-6. Molecular formula: C26H27N3O4S. Mole weight: 477.58. | |
FAS Inhibitor, C75 (Trans-4-carboxy-5-octyl-3-methylene-butyrolactone) Quick inquiry Where to buy Suppliers range | Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei. Group: Biochemicals. Alternative Names: [Trans-4-carboxy-5-octyl-3-methylene-butyrolactone]. Grades: Highly Purified. CAS No. 191282-48-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Fasnall benzenesulfonate Quick inquiry Where to buy Suppliers range | Fasnall is an inhibitor of fatty acid synthase (FAS) with an IC50 value of 3.71 μM for the human recombinant enzyme. Synonyms: 5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate; N-(1-Benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d] pyrimidin-4-amine benzenesulfonate. Grades: ≥98%. CAS No. 2187367-11-7. Molecular formula: C19H22N4S·C6H6O3S. Mole weight: 496.6. | |
G 28UCM Quick inquiry Where to buy Suppliers range | G 28UCM is a fatty acid synthase inhibitor that potently inhibits the proliferation of breast cancer cell. G 28UCM blocks HER2 signaling, induces apoptosis, and suppresses growth of breast cancer xenografts in mice without causing anorexia. Synonyms: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate; 1,3-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]Naphthalene. Grades: ≥98% by HPLC. CAS No. 1094451-90-7. Molecular formula: C24H16O10. Mole weight: 464.38. | |
Glycerol-d5 1,3-Dipalmitate Quick inquiry Where to buy Suppliers range | A glycidol fatty acid esters in edible oils. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase. Group: Biochemicals. Alternative Names: 1,3-Dipalmitin-d5; 1,3-Dipalmitoylglycerin-d5; 1,3-Dipalmitoylglycerol-d5; Glycerol-d5 1,3-Dihexadecanoate; Hexadecanoic-d5 Acid 2-Hydroxy-1,3-propanediyl Ester. Grades: Highly Purified. CAS No. 65615-82-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
GSK2194069 Quick inquiry Where to buy Suppliers range | GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM. Synonyms: GSK 2194069; GSK-2194069. Grades: >98%. CAS No. 1332331-08-4. Molecular formula: C25H24N4O3. Mole weight: 428.48. | |
GSK837149 Quick inquiry Where to buy Suppliers range | GSK837149 is a selective inhibitor of human fatty acid synthase (FAS; Ki value 30 nM) that acts via suppressing the β-ketoacyl reductase activity of the enzyme. Synonyms: GSK837149A; GSK-837149-A; GSK 837149 A; 1,3-bis[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]urea. Grades: 99%. CAS No. 13616-29-0. Molecular formula: C23H22N8O5S2. Mole weight: 554.6. | |
Heneicosapentaenoic acid Quick inquiry Where to buy Suppliers range | Heneicosapentaenoic acid (HPA) is a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid. Grades: ≥95%. CAS No. 24257-10-1. Molecular formula: C21H32O2. Mole weight: 316.5. | |
Heneicosapentaenoic acid methyl ester Quick inquiry Where to buy Suppliers range | Heneicosapentaenoic acid methyl ester is a derivative of heneicosapentaenoic acid (HPA), a 21:5 ω-3 fatty acid found in the green alga B. pennata and in fish oils. HPA is incorporated into phospholipids and into triacylglycerol in cell culture and inhibits the conversion of linolenic acid to arachidonic acid (AA) in hepatoma cells. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and for 5-lipoxygenase. Synonyms: HPA methyl ester; Methyl 6,9,12,15,18-heneicosapentaenoate; (all-Z)-6,9,12,15,18-heneicosapentaenoic acid methyl ester; (6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-henicosapentaenoic acid methyl ester. Grades: ≥98%. CAS No. 65919-53-1. Molecular formula: C22H34O2. Mole weight: 330.5. | |
Lipid Metabolism Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). - Covers several important targets, key components in lipid metabolism pathway, such as Acetyl-CoA Carboxylase?Acyltransferase?cholesteryl ester transfer protein (CETP)?FAAH?Fatty Acid Synthase (FASN)?HMG-CoA Reductase (HMGCR), etc. - Detailed compound information with structure, target, and biological activity description. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2510. Categories: Lipid Metabolism Compounds Libraries. | |
Luteolin (3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin) Quick inquiry Where to buy Suppliers range | Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-y. inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(e) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator. Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-70-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H10O6. US Biological Life Sciences. | Worldwide |
ML-356 Quick inquiry Where to buy Suppliers range | ML-356 is a potent and selective inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE). It blocks the biosynthesis of palmitate, the end product of FASN. Synonyms: ML 356; ML356; 2-Ethyl-N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]butanamide. Grades: ≥98%. CAS No. 1808260-45-8. Molecular formula: C19H25N3O4S2. Mole weight: 423.5. | |
Orlistat Quick inquiry Where to buy Suppliers range | Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor. Anti-obesity and antihypercholesterolem ic compound. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN). Anti-proliferative. Causes cell cycle arrest at G1 phase. Apoptosis inducer through caspase-3 activation. Sn-1-selective-diacylglycerol lipases alpha (DAGLalpha) inhibitor. Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Source:Synthetic. Originally isolated from Streptomyces sp. Group: Biochemicals. Grades: Highly Purified. CAS No. 96829-58-2. Pack Sizes: 50mg, 250mg. Molecular Formula: C29H53NO5. US Biological Life Sciences. | Worldwide |
Platensimycin Quick inquiry Where to buy Suppliers range | Platensimycin is a broad spectrum, gram-positive antibiotic produced by strains of streptomyces platensis. It inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (fabf) of the fatty acid synthesis pathway. Synonyms: (-)-Platensimycin. Grades: >95% by HPLC. CAS No. 835876-32-9. Molecular formula: C24H27NO7. Mole weight: 441.47. | |
Platensimycin Quick inquiry Where to buy Suppliers range | Platensimycin is a novel broad spectrum Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by target-based whole-cell screening strategy using an antisense differential sensitivity assay based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase FabF of the fatty acid synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 835876-32-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
Pyrazinamide Quick inquiry Where to buy Suppliers range | Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent. It is a prodrug that stops the growth of Mycobacterium tuberculosis. It is thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide; 2-Pyrazinecarboxamide; Zinamide; Aldinamide; Tebrazid; Pirazinamid; Unipyranamide; Farmizina; Eprazin; Novamid. Grades: >98%. CAS No. 98-96-4. Molecular formula: C5H5N3O. Mole weight: 123.11. | |
trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid Quick inquiry Where to buy Suppliers range | trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a cell cycle arrest inducer in hepatocellular carcinoma (HCC) cell lines. It has also been shown to blocks resistin-induced increases in lipid accumulation by human macrophages. Group: Biochemicals. Alternative Names: (2R,3S)-rel-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid; C 75; trans-C 75. Grades: Highly Purified. CAS No. 191282-48-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Valilactone Quick inquiry Where to buy Suppliers range | Valilactone is an esterase and fatty acid synthase (FAS) inhibitor produced by a cultured strain of soil actinomycetes. Synonyms: (-)-Valilactone; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]heptan-2-yl] (2S)-2-formamido-3-methylbutanoate. Grades: ≥98%. CAS No. 113276-96-3. Molecular formula: C22H39NO5. Mole weight: 397.6. |