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| Product | Description | |
|---|---|---|
| Fibrin | Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding. Fibrin is the major component of the blood clot and is used for coagulation [1]. Uses: Scientific research. Group: Natural products. CAS No. 9001-31-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B0665. |  |
| Fibrin (Bovine) | Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP). Group: Biochemicals. Alternative Names: Factor I. Grades: Molecular Biology Grade. CAS No. 9001-31-4. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| Fibrinogen Binding Inhibitor Peptide | Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa. Uses: Scientific research. Group: Peptides. CAS No. 89105-94-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1507. | |
| Fibrinogen Binding Inhibitor Peptide | Fibrinogen Binding Inhibitor Peptide is an effective inhibitor of the binding of fibrinogen, fibronectin and von Willebrand factor to thrombin- or ADP-stimulated platelets. It is also a synthetic dodecapeptide that represents the specific platelet receptor recognition site for the human fibrinogen G-chain (residues 400-411). Synonyms: H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH; L-histidyl-L-histidyl-L-leucyl-glycyl-glycyl-L-alanyl-L-lysyl-L-glutaminyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valine; fibrinogen-γ fragment 400-411. Grades: ≥95%. CAS No. 89105-94-2. Molecular formula: C50H80N18O16. Mole weight: 1189.28. |  |
| Fibrinogen-Binding Peptide | Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin [1]. Uses: Scientific research. Group: Peptides. CAS No. 137235-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1741. | |
| Fibrinogen-Binding Peptide | Fibrinogen-Binding Peptide (designed by the anti-complementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. It binds to fibrinogen and inhibits platelet adhesion to fibrinogen and platelet aggregation, as well as platelet adhesion to hyalonectin. Synonyms: H-EHIPA-OH; L-alpha-glutamyl-L-histidyl-L-isoleucyl-L-prolyl-L-alanine; N-(1-(N-(N-L-alpha-glutamyl-L-histidyl)-L-isoleucyl)-L-prolyl)-L-Alanine; EHIPA. Grades: ≥95%. CAS No. 137235-80-4. Molecular formula: C25H39N7O8. Mole weight: 565.62. | |
| Fibrinogen-Binding Peptide butyl acetate | Fibrinogen-Binding Peptide (designed by the anti-complementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. It binds to fibrinogen and inhibits platelet adhesion to fibrinogen and platelet aggregation, as well as platelet adhesion to vitronectin. Synonyms: Fibrinogen-Binding Peptide (fb-acetate); H-Glu-His-Ile-Pro-Ala-OH butyl acetate; EHIPA butyl acetate; L-alpha-glutamyl-L-histidyl-L-isoleucyl-L-prolyl-L-alanine butyl acetate. Grades: ≥95%. Molecular formula: C31H51N7O10. Mole weight: 681.80. | |
| Fibrinogen (Bovine) | Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9001-32-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-125864. | |
| Fibrinopeptide A, human | Fibrinopeptide A, human, located at the NH2-termini of the Aα chain, is a short peptide with 16 residues cleaved from fibrinogen by thrombin. Synonyms: Human fibrinopeptide A; H-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-OH; L-alanyl-L-alpha-aspartyl-L-seryl-glycyl-L-alpha-glutamyl-glycyl-L-alpha-aspartyl-L-phenylalanyl-L-leucyl-L-alanyl-L-alpha-glutamyl-glycyl-glycyl-glycyl-L-valyl-L-arginine. Grades: ≥95%. CAS No. 25422-31-5. Molecular formula: C63H97N19O26. Mole weight: 1536.56. | |
| Fibrinopeptide A, human TFA | Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH 2 -termini of the Aα chain [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human fibrinopeptide A TFA. CAS No. 61533-47-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1538A. | |
| Fibrinopeptide B | Synonyms: Fibrinopeptide B, human. Grades: >95%. CAS No. 36204-23-6. Molecular formula: C66H93N19O25. Mole weight: 1552.56. | |
| Fibrinopeptide b(human),1-L-glutamic acid-(9ci) | Heterocyclic Organic Compound. Alternative Names: GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG;GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-SER-ALA-ARG;(GLU1)-FIBRINOPEPTIDE B;[GLU1]-FIBRINOPEPTIDE B HUMAN;H-GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-OH. CAS No. 103213-49-6. Molecular formula: C66H95N19O26. Mole weight: 1570.57. Purity: 0.96. IUPACName: [Glu1]-Fibrinopeptide B. Canonical SMILES: CC (C)C (C (=O)NC (CC (=O)N)C (=O)NC (CC (=O)O)C (=O)NC (CC (=O)N)C (=O)NC (CCC (=O)O)C (=O)NC (CCC (=O)O)C (=O)NCC (=O)NC (CC1=CC=CC=C1)C (=O)NC (CC2=CC=CC=C2)C (=O)NC (CO)C (=O)NC (C)C (=O)NC (CCCNC (=N)N)C (=O)O)NC (=O)CNC (=O)C (CCC (=O)O)N. Density: 1.561 g/cm³. Catalog: ACM103213496. |  |
| D-Dimer, Human (Fibrin Degradation Product) | Human D-dimer (DD), a specific degradation product of cross-linked fibrin, is released into the bloodstream during clot breakdown and is used as an indicator of a blood clots, venous thromboses or pulmonary embolisms. Group: Biologicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| [Glu1]-Fibrinopeptide B | [Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts. Uses: Scientific research. Group: Peptides. CAS No. 103213-49-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0308. | |
| [Glu1]-Fibrinopeptide B human | [Glu1]-Fibrinopeptide B, generated from fibrinopeptide B amino acid residues 1-14, is used as a mass spec (MS) standard in proteomic research. Synonyms: [Glu1]-Fibrinopeptide B; H-Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-OH; L-alpha-glutamyl-glycyl-L-valyl-L-asparagyl-L-alpha-aspartyl-L-asparagyl-L-alpha-glutamyl-L-alpha-glutamyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-seryl-L-alanyl-L-arginine. Grades: ≥95%. CAS No. 103213-49-6. Molecular formula: C66H95N19O26. Mole weight: 1570.57. | |
| PEG30K-Cys-AEEAc-Fibrinopeptide A (1-15) | Synonyms: PEG30K-Cys-AEEAc-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-OH. Grades: ≥95%. Molecular formula: C66H101N17O29S + PEG30K. Mole weight: 31629. | |
| (Tyr0)-fibrinopeptide a | Heterocyclic Organic Compound. Alternative Names: TYR-ALA-ASP-SER-GLY-GLU-GLY-ASP-PHE-LEU-ALA-GLU-GLY-GLY-GLY-VAL-ARG;(TYR0)-FIBRINOPEPTIDE A;[TYR0] FIBRINOPEPTIDE A, HUMAN;L-TYR FIBRINOPEPTIDE A;L-TYR-ALA-ASP-SER-GLY-GLU-GLY-ASP-PHE-LEU-ALA-GLU-GLY-GLY-GLY-VAL-ARG;H-TYR-ALA-ASP-SER-GLY-GLU-GLY-ASP-PHE-. CAS No. 103226-11-5. Molecular formula: C72H106N20O28. Mole weight: 1699.73. Catalog: ACM103226115. | |
| [Tyr15]-fibrinopeptide b | Heterocyclic Organic Compound. Alternative Names: FIBRINOPEPTIDE B, L-TYR;FIBRINOPEPTIDE B-TYR;GLP-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-TYR;(TYR15)-FIBRINOPEPTIDE B;[TYR15] FIBRINOPEPTIDE B, HUMAN;PGLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-TYR;PYROGLU-GLY-VAL-ASN-ASP-ASN-GLU. CAS No. 125455-56-3. Molecular formula: C75H102N20O27. Mole weight: 1715.73. Purity: 0.96. IUPACName: Fibrinopeptide B-Tyr. Canonical SMILES: CC (C)C (C (=O)NC (CC (=O)N)C (=O)NC (CC (=O)O)C (=O)NC (CC (=O)N)C (=O)NC (CCC (=O)O)C (=O)NC (CCC (=O)O)C (=O)NCC (=O)NC (CC1=CC=CC=C1)C (=O)NC (CC2=CC=CC=C2)C (=O)NC (CO)C (=O)NC (C)C (=O)NC (CCCNC (=N)N)C (=O)NC (CC3=CC=C (C=C3)O)C (=O)O)NC (=O)CNC (=O)C4CCC (=O)N4. Catalog: ACM125455563. | |
| 1-[1, 1-Dimethylethoxy) ?carbonyl]?-?4-piperidinepropanoic Acid Methyl Ester | 1-[1, 1-Dimethylethoxy) ?carbonyl]?-?4-piperidinepropanoic Acid Methyl Ester is used to prepare arginylglycylaspartic acid derivatives as fibrinogen receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 162504-75-8. Pack Sizes: 100mg, 500 mg. Molecular Formula: C14H25NO4, Molecular Weight: 271.35. US Biological Life Sciences. | Worldwide |
| 11-Keto-9(E),12(E)-octadecadienoic acid | 11-Keto-9(E),12(E)-octadecadienoic acid is originally isolated from Trichoderma sp. F5594. It can enhance the fibrinolytic activity of endothelial cells. Molecular formula: C18H30O3. Mole weight: 294.43. | |
| 12-Tungstophosphate Hydrate | 12-Tungstophosphate Hydrate is a heteropoly acid used to stain cell specimens. It binds to fibrin, collagen and fibers of connective tissues. Group: Biochemicals. Grades: Highly Purified. CAS No. 12501-23-4. Pack Sizes: 1g, 5g. Molecular Formula: H3O40PW12 xH2O, Molecular Weight: 2880.051802. US Biological Life Sciences. | Worldwide |
| 3-Methylsalicylic acid | 3-Methylsalicylic acid has marked fibrinolytic activity in human plasma by activating its fibrinolytic system. It is a salicylic acid derivative compound, which toxicity is similar to salicylic acid. It is used in manufacturing of dyes. Uses: 3-methylsalicylic acid has marked fibrinolytic activity in human plasma by activating its fibrinolytic system. it is used in manufacturing of dyes. Synonyms: 2-hydroxy-3-methylbenzoic acid. Grades: > 98 %. CAS No. 83-40-9. Molecular formula: C8H8O3. Mole weight: 152.15. | |
| 3-Methylsalicylic acid | 3-Methylsalicylic acid is a salicylic acid derivative that acts on human plasma and has significant fibrinolytic activity by activating the fibrinolytic system. Uses: Scientific research. Group: Natural products. Alternative Names: o-Cresotic acid; Hydroxytoluic acid. CAS No. 83-40-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1399. | |
| 6-Aminocaproic acid | 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid. CAS No. 60-32-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0236. | |
| 6-Aminohexanoic acid (EACA) | 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator. Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Group: Biochemicals. Alternative Names: 6-Amino-n-hexanoic Acid; 6-Aminocaproic Acid; 6-Aminohexanoic Acid; A 14719; ACS; Acepramin; Acepramine; Acikaprin; Afibrin; Amicar; Amikar; Aminokapron; CL 10304; CY 116; Caplamin; Capramol; Caprocid; Caprolisin; EACA; EACS; Epsamon; Epsicapron; Epsikapron; Epsilcapramin; Epsilon S; Hemocaprol; Hemopar; Hepin; Ipsilon; NSC 212532; NSC 26154; NSC 400230; Respramin; ε-Amino-n-caproic. Grades: Highly Purified. CAS No. 60-32-2. Pack Sizes: 500g, 1Kg. Molecular Formula: C6H13NO2, Molecular Weight: 131.17. US Biological Life Sciences. | Worldwide |
| Aaf-Arg-OH HCl | Aaf-Arg-OH HCl, a substrate of carboxypeptidase B-type enzymes, has been used to determine the activation of TAFI (thrombin activatable fibrinolysis inhibitor, carboxypeptidase U) by thrombin and thrombin-thrombomodulin. Synonyms: N-(4-Methoxyphenylazoformyl)-Arg-OH HCl; N2-{[(4-Methoxyphenyl)diazenyl]carbonyl}-L-arginine hydrochloride (1:1); L-Arginine, N2-[[2-(4-methoxyphenyl)diazenyl]carbonyl]-, hydrochloride (1:1). Grades: ≥95% by HPLC. CAS No. 442158-31-8. Molecular formula: C14H20N6O4.HCl. Mole weight: 372.81. | |
| ?Aminocaproic acid | Aminocaproic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. Uses: Antifibrinolytic agents. Synonyms: Aminocaproic acid; NSC 400230; NSC-400230; NSC400230. Grades: >98%. CAS No. 60-32-2. Molecular formula: C6H13NO2. Mole weight: 131.17. | |
| Arg-Gly-Asp-Cys acetate | Arg-Gly-Asp-Cys, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; RGDC peptide. Molecular formula: C17H31N7O9S. Mole weight: 509.54. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| Arg-Gly-Glu-Ser | Arg-Gly-Glu-Ser, a RGD-related peptide, is a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets. Synonyms: H-Arg-Gly-Glu-Ser-OH; L-arginyl-glycyl-L-alpha-glutamyl-L-serine; (4S) -4-[[2-[[ (2S) -2-amino-5- (diaminomethylideneamino) pentanoyl]amino]acetyl]amino]-5-[[ (1S) -1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid; RGES. Molecular formula: C16H29N7O8. Mole weight: 447.45. | |
| atrolysin F | A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the γ chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A. Group: Enzymes. Synonyms: Crotalus atrox metalloendopeptidase; hemorrhagic toxin f; Crotalus atrox metalloendopeptidase f. Enzyme Commission Number: EC 3.4.24.45. CAS No. 172306-52-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4327; atrolysin F; EC 3.4.24.45; 172306-52-4; Crotalus atrox metalloendopeptidase; hemorrhagic toxin f; Crotalus atrox metalloendopeptidase f. Cat No: EXWM-4327. |  |
| atroxase | A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen. In peptidase family M12 (astacin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.24.43. CAS No. 181186-94-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4325; atroxase; EC 3.4.24.43; 181186-94-7. Cat No: EXWM-4325. | |
| β-(5-Bromo-2-thienyl)-L-alanine | β-(5-Bromo-2-thienyl)-L-alanine is used as a building block to synthesize fibrinogen receptor antagonists. Synonyms: H-Ala{2-Thienyl(5-Br)}-OH; H-Thi(2)(5-Br)-OH; L-2-(5-Bromothienyl)alanine; (S)-2-Amino-3-(5-bromothiophen-2-yl)propanoic acid; 3-(5-Bromothiophen-2-Yl)-L-Alanine; 3-(5-Bromo-2-thienyl)alanine; beta-(5-Bromo-2-thienyl)-L-alanine; L-α-(5-Bromothienyl)alanine; L-Thi(5-Br)-OH. Grades: ≥ 99% (HPLC). CAS No. 154593-58-5. Molecular formula: C7H8BrNO2S. Mole weight: 250.11. | |
| Biotinylated Transglutaminase from Human, Proenzyme (Zymogen) | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. Applications: The transglutaminase 3 catalyzes acyl transfer reactions from glutamin residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. biotinylated transglutaminase 3 may also be used for immunoprecipitation. Group: Enzymes. Synonyms: transglutaminase; EC 2.3.2.13; 80146-85-6; transgl...]. Appearance: Liquid. Storage: Store at -20 °C in working aliquots. Repeated freezing and thawing is not recommended. Form: The transglutaminase is formulated in 10 mM Sodium Phosphate pH 8.0, 15 mM NaCl. Sample contains 50% glycerol. Transglutaminase is a Ca2+-dependent enzyme. Source: E. coli. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine γ-glutamyl transferase; protein-glutamine γ-glutamyltransferase; TG1. Pack: 100 ug. Cat No: NATE-173 | |
| Biotinylated Transglutaminase from Human, Recombinant | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. Applications: Recombinant human transglutaminase is a homodimer (a2) composed of two chains held together by non covalent bonds. after activation of the zymogen by thrombin and ca2+ to its active form (a*2, factor xiiia), factor xiiia catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. the resulting cross-linked fibrin is insoluble and resistant to lysis. Group: Enzymes. Synonyms: transglutamina... Lorand et al., Anal. Biochem. 44 (221-231). Appearance: Liquid. Storage: Store working aliquots at ≤ - 20°C. Avoid repeated freezing and thawing. Form: The transglutaminase is formulated in 10 mM Sodium Phosphate pH 8.0, 15 mM NaCl. Sample contains 50% glycerol. hFXIII is a Ca2+-dependent enzyme. Source: Insect cells. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine γ-glutamyl transferase; protein-glutamine γ-glutamyltransferase; TG1. Pack: 50 | |
| Bovine Protein C | The vitamin K-dependent zymogen, protein C, is synthesized in the liver as a single chain polypeptide and is subsequently converted to a disulfide linked heterodimer, by removal of a dipeptide (Lys-146 and Arg-147) from the precursor molecule. Trace quantities of the single chain form have been observed in plasma. The light chain, which is responsible for the calcium dependent binding of protein C to phospholipid vesicles, contains 11 γ-carboxyglutamic acid (gla) residues, 1 b-hydroxyaspartic acid residue, and 2 epidermal growth factor (EGF) homology domains. The serine protease catalytic triad is located in the heavy chain. Human protein C is susceptible to proteolytic cleavag...g the proteolytic inactivation of factors Va and VIIIa. APC also contributes to the fibrinolytic response by complex formation with plasminogen activator inhibitors.Bovine protein C is prepared from fresh citrated bovine plasma by a modification of the Walker procedure, as described by Haley et al. Human protein C is prepared from fresh frozen citrated human plasma using a combination of immunoaffinity chromatography, and conventional techniques. Protein C is provided in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a chromogenic substrate based assay. Group: Zymogens. Purity: >95% by SDS-PAGE. Prote | |
| Breviscapine | Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Breviscapinun. CAS No. 116122-36-2. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-107802. | |
| Bromelain | Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX -pathway [1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-00-7. Pack Sizes: 100 mg. Product ID: HY-129611. | |
| Bromelain | Bromelain is a protein-digesting enzyme extracted from the stem, fruit, and juice of the pineapple plant (Ananas comosus). It belongs to a group of enzymes called proteases or proteinases. Bromelain is a complex mixture of enzymes that can hydrolyze (break down) various types of proteins, including collagen, elastin, and fibrin. Uses: 1. anti-inflammatory: bromelain has been found to possess anti-inflammatory properties, which makes it useful in the treatment of arthritis, asthma, allergies, and other conditions characterized by inflammation. 2. digestive aid: bromelain is often used as a digestive aid because it helps break down proteins in the digestive tract, aiding digestion and reducing bloating. 3. wound healing: bromelai. Group: Heterocyclic organic compound. Alternative Names: STEM BROMELAIN; 3.4.22.32; BROMELAIN; BROMELAIN PINEAPPLE;BROMELIN;EC 3.4.22.1;EC 3.4.22.32;EC 3.4.22.4. CAS No. 9001-00-7. Molecular formula: N/A. Mole weight: N/A. Appearance: yellow to beige crystalline powder. Catalog: ACM9001007. | |
| Capreomycin sulfate | Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 1405-37-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-17566. | |
| carboxypeptidase U | Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family). Group: Enzymes. Synonyms: arginine carboxypeptidase; carboxypeptidase R; plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes); thrombin-activatable fibrinolysis inhibitor. Enzyme Commission Number: EC 3.4.17.20. CAS No. 156621-18-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4073; carboxypeptidase U; EC 3.4.17.20; 156621-18-0; arginine carboxypeptidase; carboxypeptidase R; plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes); thrombin-activatable fibrinolysis inhibitor. Cat No: EXWM-4073. | |
| Chaetoglobosin A (NSC366739, BRN1097707) | Antibiotic. Cytochalasin analog with anti-fungal activity. Phytotoxic and anti-bacterial activity. Exhibits cytotoxic effects against human cancer cell lines. Enhances fibrinolytic activity of bovine aortic endothelial cells. Mycotoxin. Group: Biochemicals. Grades: Highly Purified. CAS No. 50335-03-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Cilengitide TFA salt | Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. Synonyms: Cilengitide trifluoroacetate. Grades: >98%. CAS No. 199807-35-7. Molecular formula: C29H41F3N8O9. Mole weight: 702.68. | |
| Clindamycin phosphate | Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis [1] [2] [3].Clindamycin phosphate has no cytotoxicity? Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Clindamycin 2-phosphate; U-28508. CAS No. 24729-96-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1064. | |
| Coagulation Factor Calibrator Plasma | The Coagulation Factor Calibrator Plasma is a lyophilized reference plasma intended for use in the calibration of Antigen assays for factor II, factor VII, factor X, factor XI, factor XIII, Protein C, Protein S, Antithrombin III, von Willebrand Factor and fibrinogen by ELISA. It is prepared from a pool of normal citrated human plasma collected from a minimum of 20 donors, buffered with HEPES and stabilizers and lyophilized. Group: Biologicals. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Crystal Ponceau 6R | Crystal Ponceau 6R is a red azo dye. Crystal Ponceau 6R used in histology, for staining fibrin with the martius, scarlet and blue (MSB) Trichrome stain [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2766-77-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-D1480. | |
| DS-1040 Tosylate | DS-1040 inhibits the activated form of thrombin-activatable fibrinolysis inhibitor (TAFIa), used for the treatment of acute ischemic stroke (AIS). DS-1040 substantially decreased TAFIa activity but had no impact on bleeding time. DS-1040 may provide an option of safer thrombolytic therapy. Synonyms: DS-1040 Tosylate; DS 1040 Tosylate; DS1040 Tosylate; (2S)-5-amino-2-[[1-(4-methylcyclohexyl)imidazol-4-yl]methyl]pentanoic acid;4-methylbenzenesulfonic acid; DS-1040 (Tosylate). CAS No. 1335138-89-0. Molecular formula: C23H35N3O5S. Mole weight: 465.61. | |
| EDA-ADP - ATTO-425 | EDA-ADP - ATTO-425, a fluorescent molecule, is extensively employed in biomedical research to label and track ADP. It is notably beneficial in comprehending numerous ADP-related processes, including thrombin activity, platelet activation, and fibrinolysis, due to its vivid fluorescence and superior sensitivity. Its application in live-cell imaging and high-throughput screening for ADP-related drugs renders EDA-ADP - ATTO-425 an indispensable constituent of modern research methodologies. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO 425, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C35H46N8O16P2(free acid). Mole weight: 896.74 (free acid). | |
| Endotoxin free Transglutaminase 2 from Human tissue, Recombinant | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. Applications: Transglutaminase 2 catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. transglutaminase 2 may also be used for immunoprecipitation. this product is suitable for cell culture use. Group: Enzymes. Synonyms: transglutaminase; ...rand et al., Anal. Biochem. 44 (221-231). Appearance: Liquid. Storage: Store working aliquots at ≤ - 20°C. Avoid repeated freezing and thawing. Form: The transglutaminase is supplied in 10 mM Tris-HCl pH 7.2, 150 mM NaCl, 0.5 mM EDTA, 0.5 mM DTT, 10% Glycerol. Source: Insect cells. Species: Human. transglutaminase; EC 2.3.2.13; 80146-85-6; transglutaminase; Factor XIIIa; fibrinoligase; fibrin stabilizing factor; glutaminylpeptide γ-glutamyltransferase; polyamine transglutaminase; tissue transglutaminase; R-glutaminyl-peptide:amine γ-glutamyl transferase; protein-glutamine γ-glutamyltransferase; TG1. Pack: 250 μg; 1mg. Cat No: NATE-1729. | |
| fibrolase | A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family). Group: Enzymes. Synonyms: fibrinolytic proteinase; Agkistrodon contortrix contortrix metalloproteinase; Agkistrodon contortrix contortrix venom metalloproteinase. Enzyme Commission Number: EC 3.4.24.72. CAS No. 116036-70-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4356; fibrolase; EC 3.4.24.72; 116036-70-5; fibrinolytic proteinase; Agkistrodon contortrix contortrix metalloproteinase; Agkistrodon contortrix contortrix venom metalloproteinase. Cat No: EXWM-4356. | |
| Fibronectin | Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans [1]. Uses: Scientific research. Group: Natural products. CAS No. 86088-83-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3160. | |
| GPRP | GPRP is an inhibitor of fibrin polymerization. It binds to fibrinogen (Ki = 400 mM). Synonyms: Gly-pro-arg-pro; L-Proline,glycyl-L-prolyl-L-arginyl-; (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid. CAS No. 67869-62-9. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| GR 144053 trihydrochloride | GR 144053 trihydrochloride is a potent and selective orally bioactive platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). GR 144053 potently inhibits thrombus formation in vivo. Synonyms: GR 144053; GR-144053; GR144053; GR 144053 trihydrochloride. 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride. Grades: ≥99% by HPLC. CAS No. 1215333-48-4. Molecular formula: C18H27N5O2.3HCl. Mole weight: 454.83. | |
| H-Arg-Gly-Asp-Cys-OH | H-Arg-Gly-Asp-Cys-OH, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: RGDC; H-RGDC-OH; L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; (6S,12S,15R)-1,6-diamino-12-(carboxymethyl)-1-imino-15-(mercaptomethyl)-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid. Grades: 95%. CAS No. 109292-46-8. Molecular formula: C15H27N7O7S. Mole weight: 449.48. | |
| H-Arg-Gly-Glu-Ser-OH | H-Arg-Gly-Glu-Ser-OH is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES; H-RGES-OH; L-arginyl-glycyl-L-alpha-glutamyl-L-serine; L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-glutamyl)-; rgespeptide. Grades: 95%. CAS No. 93674-97-6. Molecular formula: C16H29N7O8. Mole weight: 447.44. | |
| H-Arg-Gly-Glu-Ser-OH.TFA | H-Arg-Gly-Glu-Ser-OH.TFA is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES.TFA; H-RGES-OH.TFA; L-arginyl-glycyl-L-alpha-glutamyl-L-serine trifluoroacetic acid. Grades: >98%. Molecular formula: C16H29N7O8.C2HF3O2. Mole weight: 561.47. | |
| Hematin | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins [1]. Hematin can be used for the research of acute porphyrias and cancer [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15489-90-4. Pack Sizes: 100 mg. Product ID: HY-W040030. | |
| Heparin Sodium | Heparin sodium is an anticoagulant, is a kind of mucosaccharide, is extracted from the intestinal mucosa of pigs, cattle, sheep sodium salt glucosamine sulfate, in the human body is secreted by mast cells and naturally exists in the blood. Heparin sodium Chemicalbook can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and counter the already formed thrombin, prevent the transformation of prothrombin into thrombin and antithrombin. Synonyms: SODIUM HEPARIN;SODIUM HEPARINATE;REVIPARIN SODIUM;PORCINE HEPARIN SODIUM;BOVINE HEPARIN SODIUM;HEP, NA, BOVINE;HEP, NA, PORCINE;HEPARIN PORCINE SODIUM SALT. CAS No. 9041-8-1. Product ID: PAP-0071. Molecular formula: (C12H16NS2Na3)20. Category: Cardiovascular. Product Keywords: Cardiovascular Series; Heparin Sodium; PAP-0071; Cardiovascular; (C12H16NS2Na3)20; 9041-08-1. Standard: CP. Chemical Name: SODIUM HEPARIN;SODIUM HEPARINATE;REVIPARIN SODIUM;PORCINE HEPARIN SODIUM;BOVINE HEPARIN SODIUM;HEP, NA, BOVINE;HEP, NA, PORCINE;HEPARIN PORCINE SODIUM SALT. Grade: Pharmaceutical Grade. Solubility: H2O: 50 mg/mL, clear, faintly yellow. Storage: 2-8°C. Melting Point: >181°C (dec.). Product Description: Heparin sodium is an anticoagulant, is a kind of mucosaccharide, is extracted from the intestinal mucosa of pigs, cattle, sheep sodium salt glucosamine sulfate, in the human body is secreted by ma |  |
| H-Gly-Gly-Cys-OH | H-Gly-Gly-Cys-OH inhibits carboxypeptidase U (thrombin activatable fibrinolysis inhibitor, TAFI), though less efficiently than the dipeptide GC; Ki 0.99 μm. Synonyms: Glycyl-glycyl-cysteine; Gly-gly-cys; glycyl-glycyl-l-cysteine; L-Cysteine, N-(N-glycylglycyl)-. CAS No. 95416-30-1. Molecular formula: C7H13N3O4S. Mole weight: 235.26. | |
| H-Gly-His-Arg-Pro-NH2 | The fibrin central E region contains two sets of polymeric knobs A and B, which are hidden in fibrinogen but are exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions can be known by X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and dual D are crystallized in the presence of two peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH2 (GPRP-amide) interacts with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a to form H bonds, the knob B peptide mimic H-Gly-His-Arg-Pro-NH2 (GHRP-amide) interacts with Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b. Synonyms: GHRP amide; H-GHRP-NH2; glycyl-L-histidyl-L-arginyl-L-prolinamide; Glycyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-prolinamide; (S)-1-((S)-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 209623-54-1. Molecular formula: C19H32N10O4. Mole weight: 464.53. | |
| horrilysin | A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen. Group: Enzymes. Synonyms: Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase. Enzyme Commission Number: EC 3.4.24.47. CAS No. 84056-81-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4329; horrilysin; EC 3.4.24.47; 84056-81-5; Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase. Cat No: EXWM-4329. | |
| Human α-Thrombin | Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 3.4.21.5; Human Alpha Thrombin. CAS No. 9002-4-4. Pack Sizes: 50 U; 100 U. Product ID: HY-114164A. | |
| Human Factor XIII | Factor XIII is the zymogenic form of the glutaminyl-peptide g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. 2.3.2.13). Factor XIII is unique among transamidases in that it is a zymogen in vivo. Factor XIII is found both extracellularly in plasma and intracellularly in platelets, megakaryocytes, monocytes, placenta, uterus, liver and prostrate tissues. Plasma factor XIII is synthesized in the liver and circulates as a tetramer (Mr=320,000), composed of 2 pairs of nonidentical subunits (A2B2). The intra-cellular forms are synthesized in the tissues where they reside as dimers (Mr=146,000) of 2 identical A chains (A2). The A ...nly after the Ca2+ (Kd=10-3M) and fibrin(ogen) (Kd=10-8M) dependent dissociation of the B subunit dimer from the A2' dimer.In the coagulation cascade, factor XIIIa functions to stabilize the fibrin clot by crosslinking the a and g-chains of fibrin. Other proteins known to be substrates for Factor XIIIa which may be hemostatically important include fibronectin, α2-antiplasmin, collagen, factor V, von Willebrand Factor and thrombospondin.Factor XIII is purified from fresh frozen human plasma by a modification of the procedures described by Folke and Lorand involving barium citrate, ammonium sulfate and glycine precipitations, ion exchange chromatography and gel filtration. Factor | |
| Human Prekallikrein | Purified from fresh frozen human plasma. Human Prekallikrein is a single chain gamma globulin glycoprotein that participates in the early phase of contract activation, kinin formation and fibrinolysis. Prekallikrein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Activity is determined via clotting assay. Group: Zymogens. Purity: >95% by SDS-PAGE. Prekallikrein. Mole weight: 86000. Storage: 2-8°C. Source: Human. Human Prekallikrein; Prekallikrein. Pack: 1mg. Cat No: CZY-027. | |
| Human Protein C | The vitamin K-dependent zymogen, protein C, is synthesized in the liver as a single chain polypeptide and is subsequently converted to a disulfide linked heterodimer, by removal of a dipeptide (Lys-146 and Arg-147) from the precursor molecule. Trace quantities of the single chain form have been observed in plasma. The light chain, which is responsible for the calcium dependent binding of protein C to phospholipid vesicles, contains 11 γ-carboxyglutamic acid (gla) residues, 1 b-hydroxyaspartic acid residue, and 2 epidermal growth factor (EGF) homology domains. The serine protease catalytic triad is located in the heavy chain. Human protein C is susceptible to proteolytic cleavag...ng the proteolytic inactivation of factors Va and VIIIa. APC also contributes to the fibrinolytic response by complex formation with plasminogen activator inhibitors.Bovine protein C is prepared from fresh citrated bovine plasma by a modification of the Walker procedure, as described by Haley et al. Human protein C is prepared from fresh frozen citrated human plasma using a combination of immunoaffinity chromatography, and conventional techniques. Protein C is provided in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a chromogenic substrate based assay. Group: Zymogens. CAS No. 42617-41-4. Purity: >95 | |
| Immobilized human plasmin | We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form. It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. Group: Enzymes. Synonyms: fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG. Enzyme Commission Number: EC 3. 4. 21. 7. Purity: >95% by SDS-PAGE analysis. Mole weight: 85000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Human plasma. Species: Human. fibrinase; fibrinolysin; actase; serum tryptase; thrombolysin; plasmin; EC 3. 4. 21. 7; 9001-90-5; PLG; Immobilized plasmin. Cat No: NATE-1757. | |
| kallikrein 8 | The enzyme is activated by removal of an N-terminal prepropeptide. The highest amidolytic activity is observed using Boc-Val-Pro-Arg?7-amido-4-methylcoumarin, which is a substrate of α-thrombin. Substrates lacking basic amino acids in the P1 position are not cleaved. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease. Belongs in peptidase family S1A. Group: Enzymes. Synonyms: KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin. Enzyme Commission Number: EC 3.4.21.118. CAS No. 171715-15-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4113; kallikrein 8; EC 3.4.21.118; 171715-15-4; KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin. Cat No: EXWM-4113. | |
| Kartogenin | Kartogenin (KGN) is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN. CAS No. 4727-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16268. | |
| Kartogenin sodium | Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN sodium. CAS No. 1401168-39-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-16268A. | |
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